Antibody constructs for cdh19 and cd3

ABSTRACT

The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

RELATED APPLICATIONS

This application is related to a U.S. provisional application entitled“Antibodies targeting CDH19 for melanoma”, filed on Mar. 15, 2013, thesame day as the present application is filed. This related applicationis incorporated in its entirety by reference.

FIELD OF THE INVENTION

The present invention relates to an antibody construct comprising afirst human binding domain capable of binding to human CDH19 on thesurface of a target cell and a second domain capable of binding to humanCD3 on the surface of a T cell. Moreover, the invention provides anucleic acid sequence encoding the antibody construct, a vectorcomprising said nucleic acid sequence and a host cell transformed ortransfected with said vector. Furthermore, the invention provides aprocess for the production of the antibody construct of the invention, amedical use of said antibody construct and a kit comprising saidantibody construct.

BACKGROUND OF THE INVENTION

Melanoma is a skin cancer that is caused by the oncogenic transformationof melanocytes, which are pigment producing skin cells. As of 2009,Melanoma had a prevalence of more than 870,000 cases in the US alone (USNational Institutes of Health). Each year, over 75,000 new cases ofmelanoma are diagnosed in the US, and approximately 25% of patients haveadvanced disease at the time of diagnosis. Despite the fact that casesof primary melanoma can be cured by surgery if they are detected earlyenough, melanoma is the leading cause of death from skin disease in theUS, responsible for about 10,000 deaths per year in the US. Once thedisease has spread and became metastatic, the prognosis is poor, with a5 year relative survival of 15%.

There are four basic types of melanomas. Three types are found in thetop layers of the skin and the fourth one is invasive and has penetrateddeeper into the skin and may have spread to other areas of the body.

Superficial spreading melanoma is the most common type of melanoma whichaccounts for about 70% of all cases. It grows along the top layer of theskin for a fairly long time before penetrating more deeply. It firstappears as a flat or slightly raised discolored patch that has irregularborders and may be somewhat asymmetrical in form. The color varies, andyou may see areas of tan, brown, black, red, blue or white. This type ofmelanoma can occur in a previously benign mole and is found most oftenin young people.

Lentigo maligna is similar to the superficial spreading type, as it alsoremains close to the skin surface for quite a while, and usually appearsas a flat or mildly elevated mottled tan, brown or dark browndiscoloration. It is found most often in the elderly. When this cancerbecomes invasive, it is referred to as lentigo maligna melanoma.

Acral lentiginous melanoma also spreads superficially before penetratingmore deeply. It is quite different from the others, though, as itusually appears as a black or brown discoloration under the nails or onthe soles of the feet or palms of the hands. This type of melanoma issometimes found on dark-skinned people, and can often advance morequickly than superficial spreading melanoma and lentigo maligna.

Nodular melanoma is usually invasive at the time it is first diagnosed.The malignancy is recognized when it becomes a bump. It is usuallyblack, but occasionally is blue, gray, white, brown, tan, red or skintone. This is the most aggressive of the melanomas, and is found in 10to 15 percent of cases.

Common treatments for metastatic melanoma include chemotherapy, targetedtherapies for eligible patients (e.g. BRAF inhibitor treatment forpatients with BRAF mutations) and immunotherapy. Metastatic melanoma isa tumor type where immunotherapy has been demonstrated to not only slowdisease progression, but to lead to cures in late stage patients.Interleukin-2 was approved for the use in metastatic melanoma in 1998,and in 2011 an antibody targeting CTLA4, a member of a new generation ofimmune checkpoint inhibitors, gained approval by the FDA.

CDH19 is a type II cadherin transmembrane protein of unknown function.The human gene was cloned in 2000 based on its sequence similarity toCDH7 (Kools, P. et al. Genomics. 2000). Expressed Sequence Tags (ESTs)for CDH19 were isolated from melanocyte cDNA libraries, indicating thatexpression of CDH19 may be limited to cells of neural crest origin(Kools, P. et al. Genomics. 2000). In support of this notion, rat CDH19was found to be expressed primarily in nerve ganglia and in Schwanncells during rat embryonic development (Takahashi, M. and Osumi, O. DevlDynamics. 2005.).

Diagnostic antibodies detecting CDH19 in Western Blot,immunohistochemitstry or flow cytometry are known in the art andcommercially available. Those antibodies comprise poly- and monoclonalantibodies generated in animal hosts.

SUMMARY OF THE INVENTION

The present invention provides an isolated multispecific antibodyconstruct comprising a first human binding domain capable of binding tohuman CDH19 on the surface of a target cell and a second domain capableof binding to human CD3 on the surface of a T cell.

In one embodiment the antibody construct of the invention the firstbinding domain comprises a VH region comprising CDR-H1, CDR-H2 andCDR-H3 and a VL region comprising CDR-L1, CDR-L2 and CDR-L3 selectedfrom the group consisting of:

-   (a) CDR-H1 as depicted in SEQ ID NO: 52, CDR-H2 as depicted in SEQ    ID NO: 53, CDR-H3 as depicted in SEQ ID NO: 54, CDR-L1 as depicted    in SEQ ID NO: 220, CDR-L2 as depicted in SEQ ID NO: 221 and CDR-L3    as depicted in SEQ ID NO: 222, CDR-H1 as depicted in SEQ ID NO: 82,    CDR-H2 as depicted in SEQ ID NO: 83, CDR-H3 as depicted in SEQ ID    NO: 84, CDR-L1 as depicted in SEQ ID NO: 250, CDR-L2 as depicted in    SEQ ID NO: 251 and CDR-L3 as depicted in SEQ ID NO: 252, CDR-H1 as    depicted in SEQ ID NO: 82, CDR-H2 as depicted in SEQ ID NO: 83,    CDR-H3 as depicted in SEQ ID NO: 84, CDR-L1 as depicted in SEQ ID    NO: 250, CDR-L2 as depicted in SEQ ID NO: 251 and CDR-L3 as depicted    in SEQ ID NO: 927, CDR-H1 as depicted in SEQ ID NO: 82, CDR-H2 as    depicted in SEQ ID NO: 83, CDR-H3 as depicted in SEQ ID NO: 909,    CDR-L1 as depicted in SEQ ID NO: 250, CDR-L2 as depicted in SEQ ID    NO: 251 and CDR-L3 as depicted in SEQ ID NO: 927, CDR-H1 as depicted    in SEQ ID NO: 52, CDR-H2 as depicted in SEQ ID NO: 53, CDR-H3 as    depicted in SEQ ID NO: 54, CDR-L1 as depicted in SEQ ID NO: 220,    CDR-L2 as depicted in SEQ ID NO: 221 and CDR-L3 as depicted in SEQ    ID NO: 926, CDR-H1 as depicted in SEQ ID NO: 52, CDR-H2 as depicted    in SEQ ID NO: 53, CDR-H3 as depicted in SEQ ID NO: 904, CDR-L1 as    depicted in SEQ ID NO: 220, CDR-L2 as depicted in SEQ ID NO: 221 and    CDR-L3 as depicted in SEQ ID NO: 926,    -   CDR-H1 as depicted in SEQ ID NO: 1126, CDR-H2 as depicted in SEQ        ID NO: 1127, CDR-H3 as depicted in SEQ ID NO: 1128, CDR-L1 as        depicted in SEQ ID NO: 1129, CDR-L2 as depicted in SEQ ID NO:        1130 and CDR-L3 as depicted in SEQ ID NO: 1131,    -   CDR-H1 as depicted in SEQ ID NO: 1165, CDR-H2 as depicted in SEQ        ID NO: 1166, CDR-H3 as depicted in SEQ ID NO: 1167, CDR-L1 as        depicted in SEQ ID NO: 1168, CDR-L2 as depicted in SEQ ID NO:        1169 and CDR-L3 as depicted in SEQ ID NO: 1170,    -   CDR-H1 as depicted in SEQ ID NO: 1334, CDR-H2 as depicted in SEQ        ID NO: 1335, CDR-H3 as depicted in SEQ ID NO: 1336, CDR-L1 as        depicted in SEQ ID NO: 1337, CDR-L2 as depicted in SEQ ID NO:        1338 and CDR-L3 as depicted in SEQ ID NO: 1339,    -   CDR-H1 as depicted in SEQ ID NO: 1347, CDR-H2 as depicted in SEQ        ID NO: 1348, CDR-H3 as depicted in SEQ ID NO: 1349, CDR-L1 as        depicted in SEQ ID NO: 1350, CDR-L2 as depicted in SEQ ID NO:        1351 and CDR-L3 as depicted in SEQ ID NO: 1352,    -   CDR-H1 as depicted in SEQ ID NO: 1360 CDR-H2 as depicted in SEQ        ID NO: 1361, CDR-H3 as depicted in SEQ ID NO: 1362, CDR-L1 as        depicted in SEQ ID NO: 1363, CDR-L2 as depicted in SEQ ID NO:        1364 and CDR-L3 as depicted in SEQ ID NO: 1365,    -   CDR-H1 as depicted in SEQ ID NO: 1425 CDR-H2 as depicted in SEQ        ID NO: 1426, CDR-H3 as depicted in SEQ ID NO: 1427, CDR-L1 as        depicted in SEQ ID NO: 1428, CDR-L2 as depicted in SEQ ID NO:        1429 and CDR-L3 as depicted in SEQ ID NO: 1430,    -   CDR-H1 as depicted in SEQ ID NO: 1438 CDR-H2 as depicted in SEQ        ID NO: 1439, CDR-H3 as depicted in SEQ ID NO: 1440, CDR-L1 as        depicted in SEQ ID NO: 1441, CDR-L2 as depicted in SEQ ID NO:        1442 and CDR-L3 as depicted in SEQ ID NO: 1443, and    -   CDR-H1 as depicted in SEQ ID NO: 2167 CDR-H2 as depicted in SEQ        ID NO: 2168, CDR-H3 as depicted in SEQ ID NO: 2169, CDR-L1 as        depicted in SEQ ID NO: 2170, CDR-L2 as depicted in SEQ ID NO:        2171 and CDR-L3 as depicted in SEQ ID NO: 2172;-   (b) CDR-H1 as depicted in SEQ ID NO: 124, CDR-H2 as depicted in SEQ    ID NO: 125, CDR-H3 as depicted in SEQ ID NO: 126, CDR-L1 as depicted    in SEQ ID NO: 292, CDR-L2 as depicted in SEQ ID NO: 293 and CDR-L3    as depicted in SEQ ID NO: 294, CDR-H1 as depicted in SEQ ID NO: 130,    CDR-H2 as depicted in SEQ ID NO: 131, CDR-H3 as depicted in SEQ ID    NO: 132, CDR-L1 as depicted in SEQ ID NO: 298, CDR-L2 as depicted in    SEQ ID NO: 299 and CDR-L3 as depicted in SEQ ID NO: 300, CDR-H1 as    depicted in SEQ ID NO: 136, CDR-H2 as depicted in SEQ ID NO: 137,    CDR-H3 as depicted in SEQ ID NO: 138, CDR-L1 as depicted in SEQ ID    NO: 304, CDR-L2 as depicted in SEQ ID NO: 305 and CDR-L3 as depicted    in SEQ ID NO: 306, CDR-H1 as depicted in SEQ ID NO: 142, CDR-H2 as    depicted in SEQ ID NO: 143, CDR-H3 as depicted in SEQ ID NO: 144,    CDR-L1 as depicted in SEQ ID NO: 310, CDR-L2 as depicted in SEQ ID    NO: 311 and CDR-L3 as depicted in SEQ ID NO: 312, CDR-H1 as depicted    in SEQ ID NO: 148, CDR-H2 as depicted in SEQ ID NO: 149, CDR-H3 as    depicted in SEQ ID NO: 150, CDR-L1 as depicted in SEQ ID NO: 316,    CDR-L2 as depicted in SEQ ID NO: 317 and CDR-L3 as depicted in SEQ    ID NO: 318, CDR-H1 as depicted in SEQ ID NO: 166, CDR-H2 as depicted    in SEQ ID NO: 167, CDR-H3 as depicted in SEQ ID NO: 168, CDR-L1 as    depicted in SEQ ID NO: 334, CDR-L2 as depicted in SEQ ID NO: 335 and    CDR-L3 as depicted in SEQ ID NO: 336, CDR-H1 as depicted in SEQ ID    NO: 124, CDR-H2 as depicted in SEQ ID NO: 125, CDR-H3 as depicted in    SEQ ID NO: 915, CDR-L1 as depicted in SEQ ID NO: 292, CDR-L2 as    depicted in SEQ ID NO: 293 and CDR-L3 as depicted in SEQ ID NO: 294,    CDR-H1 as depicted in SEQ ID NO: 124, CDR-H2 as depicted in SEQ ID    NO: 125, CDR-H3 as depicted in SEQ ID NO: 915, CDR-L1 as depicted in    SEQ ID NO: 292, CDR-L2 as depicted in SEQ ID NO: 293 and CDR-L3 as    depicted in SEQ ID NO: 928, CDR-H1 as depicted in SEQ ID NO: 124,    CDR-H2 as depicted in SEQ ID NO: 125, CDR-H3 as depicted in SEQ ID    NO: 915, CDR-L1 as depicted in SEQ ID NO: 292, CDR-L2 as depicted in    SEQ ID NO: 293 and CDR-L3 as depicted in SEQ ID NO: 929, CDR-H1 as    depicted in SEQ ID NO: 166, CDR-H2 as depicted in SEQ ID NO: 167,    CDR-H3 as depicted in SEQ ID NO: 168, CDR-L1 as depicted in SEQ ID    NO: 334, CDR-L2 as depicted in SEQ ID NO: 335 and CDR-L3 as depicted    in SEQ ID NO: 336, CDR-H1 as depicted in SEQ ID NO: 166, CDR-H2 as    depicted in SEQ ID NO: 167, CDR-H3 as depicted in SEQ ID NO: 168,    CDR-L1 as depicted in SEQ ID NO: 334, CDR-L2 as depicted in SEQ ID    NO: 335 and CDR-L3 as depicted in SEQ ID NO: 942, CDR-H1 as depicted    in SEQ ID NO: 166, CDR-H2 as depicted in SEQ ID NO: 167, CDR-H3 as    depicted in SEQ ID NO: 168, CDR-L1 as depicted in SEQ ID NO: 334,    CDR-L2 as depicted in SEQ ID NO: 335 and CDR-L3 as depicted in SEQ    ID NO: 943, CDR-H1 as depicted in SEQ ID NO: 148, CDR-H2 as depicted    in SEQ ID NO: 149, CDR-H3 as depicted in SEQ ID NO: 150, CDR-L1 as    depicted in SEQ ID NO: 316, CDR-L2 as depicted in SEQ ID NO: 317 and    CDR-L3 as depicted in SEQ ID NO: 318, CDR-H1 as depicted in SEQ ID    NO: 148, CDR-H2 as depicted in SEQ ID NO: 149, CDR-H3 as depicted in    SEQ ID NO: 150, CDR-L1 as depicted in SEQ ID NO: 316, CDR-L2 as    depicted in SEQ ID NO: 317 and CDR-L3 as depicted in SEQ ID NO: 937,    CDR-H1 as depicted in SEQ ID NO: 148, CDR-H2 as depicted in SEQ ID    NO: 149, CDR-H3 as depicted in SEQ ID NO: 150, CDR-L1 as depicted in    SEQ ID NO: 316, CDR-L2 as depicted in SEQ ID NO: 317 and CDR-L3 as    depicted in SEQ ID NO: 938, CDR-H1 as depicted in SEQ ID NO: 148,    CDR-H2 as depicted in SEQ ID NO: 149, CDR-H3 as depicted in SEQ ID    NO: 919, CDR-L1 as depicted in SEQ ID NO: 316, CDR-L2 as depicted in    SEQ ID NO: 317 and CDR-L3 as depicted in SEQ ID NO: 938, CDR-H1 as    depicted in SEQ ID NO: 142, CDR-H2 as depicted in SEQ ID NO: 143,    CDR-H3 as depicted in SEQ ID NO: 144, CDR-L1 as depicted in SEQ ID    NO: 310, CDR-L2 as depicted in SEQ ID NO: 311 and CDR-L3 as depicted    in SEQ ID NO: 935, CDR-H1 as depicted in SEQ ID NO: 142, CDR-H2 as    depicted in SEQ ID NO: 143, CDR-H3 as depicted in SEQ ID NO: 918,    CDR-L1 as depicted in SEQ ID NO: 310, CDR-L2 as depicted in SEQ ID    NO: 311 and CDR-L3 as depicted in SEQ ID NO: 935, CDR-H1 as depicted    in SEQ ID NO: 142, CDR-H2 as depicted in SEQ ID NO: 143, CDR-H3 as    depicted in SEQ ID NO: 918, CDR-L1 as depicted in SEQ ID NO: 310,    CDR-L2 as depicted in SEQ ID NO: 311 and CDR-L3 as depicted in SEQ    ID NO: 936, CDR-H1 as depicted in SEQ ID NO: 136, CDR-H2 as depicted    in SEQ ID NO: 137, CDR-H3 as depicted in SEQ ID NO: 138, CDR-L1 as    depicted in SEQ ID NO: 304, CDR-L2 as depicted in SEQ ID NO: 305 and    CDR-L3 as depicted in SEQ ID NO: 933, CDR-H1 as depicted in SEQ ID    NO: 136, CDR-H2 as depicted in SEQ ID NO: 137, CDR-H3 as depicted in    SEQ ID NO: 917, CDR-L1 as depicted in SEQ ID NO: 304, CDR-L2 as    depicted in SEQ ID NO: 305 and CDR-L3 as depicted in SEQ ID NO: 934,    CDR-H1 as depicted in SEQ ID NO: 130, CDR-H2 as depicted in SEQ ID    NO: 131, CDR-H3 as depicted in SEQ ID NO: 132, CDR-L1 as depicted in    SEQ ID NO: 298, CDR-L2 as depicted in SEQ ID NO: 299 and CDR-L3 as    depicted in SEQ ID NO: 930, CDR-H1 as depicted in SEQ ID NO: 130,    CDR-H2 as depicted in SEQ ID NO: 131, CDR-H3 as depicted in SEQ ID    NO: 916, CDR-L1 as depicted in SEQ ID NO: 298, CDR-L2 as depicted in    SEQ ID NO: 299 and CDR-L3 as depicted in SEQ ID NO: 931, CDR-H1 as    depicted in SEQ ID NO: 130, CDR-H2 as depicted in SEQ ID NO: 131,    CDR-H3 as depicted in SEQ ID NO: 916, CDR-L1 as depicted in SEQ ID    NO: 298, CDR-L2 as depicted in SEQ ID NO: 299 and CDR-L3 as depicted    in SEQ ID NO: 932, CDR-H1 as depicted in SEQ ID NO: 1009, CDR-H2 as    depicted in SEQ ID NO: 1010, CDR-H3 as depicted in SEQ ID NO: 1011,    CDR-L1 as depicted in SEQ ID NO: 1012, CDR-L2 as depicted in SEQ ID    NO: 1013 and CDR-L3 as depicted in SEQ ID NO: 1014,    -   CDR-H1 as depicted in SEQ ID NO: 1022, CDR-H2 as depicted in SEQ        ID NO: 1023, CDR-H3 as depicted in SEQ ID NO: 1024, CDR-L1 as        depicted in SEQ ID NO: 1025, CDR-L2 as depicted in SEQ ID NO:        1026 and CDR-L3 as depicted in SEQ ID NO: 1027,    -   CDR-H1 as depicted in SEQ ID NO: 1035, CDR-H2 as depicted in SEQ        ID NO: 1036, CDR-H3 as depicted in SEQ ID NO: 1037, CDR-L1 as        depicted in SEQ ID NO: 1038, CDR-L2 as depicted in SEQ ID NO:        1039 and CDR-L3 as depicted in SEQ ID NO: 1040,    -   CDR-H1 as depicted in SEQ ID NO: 1074, CDR-H2 as depicted in SEQ        ID NO: 1075, CDR-H3 as depicted in SEQ ID NO: 1076, CDR-L1 as        depicted in SEQ ID NO: 1077, CDR-L2 as depicted in SEQ ID NO:        1078 and CDR-L3 as depicted in SEQ ID NO: 1079,    -   CDR-H1 as depicted in SEQ ID NO: 1100, CDR-H2 as depicted in SEQ        ID NO: 1101, CDR-H3 as depicted in SEQ ID NO: 1102, CDR-L1 as        depicted in SEQ ID NO: 1103, CDR-L2 as depicted in SEQ ID NO:        1104 and CDR-L3 as depicted in SEQ ID NO: 1105,    -   CDR-H1 as depicted in SEQ ID NO: 1113, CDR-H2 as depicted in SEQ        ID NO: 1114, CDR-H3 as depicted in SEQ ID NO: 1115, CDR-L1 as        depicted in SEQ ID NO: 1116, CDR-L2 as depicted in SEQ ID NO:        1117 and CDR-L3 as depicted in SEQ ID NO: 1118,    -   CDR-H1 as depicted in SEQ ID NO: 1243, CDR-H2 as depicted in SEQ        ID NO: 1244, CDR-H3 as depicted in SEQ ID NO: 1245, CDR-L1 as        depicted in SEQ ID NO: 1246, CDR-L2 as depicted in SEQ ID NO:        1247 and CDR-L3 as depicted in SEQ ID NO: 1248,    -   CDR-H1 as depicted in SEQ ID NO: 1256, CDR-H2 as depicted in SEQ        ID NO: 1257, CDR-H3 as depicted in SEQ ID NO: 1258, CDR-L1 as        depicted in SEQ ID NO: 1259, CDR-L2 as depicted in SEQ ID NO:        1260 and CDR-L3 as depicted in SEQ ID NO: 1261,    -   CDR-H1 as depicted in SEQ ID NO: 1269, CDR-H2 as depicted in SEQ        ID NO: 1270, CDR-H3 as depicted in SEQ ID NO: 1271, CDR-L1 as        depicted in SEQ ID NO: 1272, CDR-L2 as depicted in SEQ ID NO:        1273 and CDR-L3 as depicted in SEQ ID NO: 1274,    -   CDR-H1 as depicted in SEQ ID NO: 1282, CDR-H2 as depicted in SEQ        ID NO: 1283, CDR-H3 as depicted in SEQ ID NO: 1284, CDR-L1 as        depicted in SEQ ID NO: 1285, CDR-L2 as depicted in SEQ ID NO:        1286 and CDR-L3 as depicted in SEQ ID NO: 1287,    -   CDR-H1 as depicted in SEQ ID NO: 1295, CDR-H2 as depicted in SEQ        ID NO: 1296, CDR-H3 as depicted in SEQ ID NO: 1297, CDR-L1 as        depicted in SEQ ID NO: 1298, CDR-L2 as depicted in SEQ ID NO:        1299 and CDR-L3 as depicted in SEQ ID NO: 1300,    -   CDR-H1 as depicted in SEQ ID NO: 1647, CDR-H2 as depicted in SEQ        ID NO: 1648, CDR-H3 as depicted in SEQ ID NO: 1649, CDR-L1 as        depicted in SEQ ID NO: 1650, CDR-L2 as depicted in SEQ ID NO:        1651 and CDR-L3 as depicted in SEQ ID NO: 1652,    -   CDR-H1 as depicted in SEQ ID NO: 1660, CDR-H2 as depicted in SEQ        ID NO: 1661, CDR-H3 as depicted in SEQ ID NO: 1662, CDR-L1 as        depicted in SEQ ID NO: 1663, CDR-L2 as depicted in SEQ ID NO:        1664 and CDR-L3 as depicted in SEQ ID NO: 1665,    -   CDR-H1 as depicted in SEQ ID NO: 1894, CDR-H2 as depicted in SEQ        ID NO: 1895, CDR-H3 as depicted in SEQ ID NO: 1896, CDR-L1 as        depicted in SEQ ID NO: 1897, CDR-L2 as depicted in SEQ ID NO:        1898 and CDR-L3 as depicted in SEQ ID NO: 1899,    -   CDR-H1 as depicted in SEQ ID NO: 1907, CDR-H2 as depicted in SEQ        ID NO: 1908, CDR-H3 as depicted in SEQ ID NO: 1909, CDR-L1 as        depicted in SEQ ID NO: 1910, CDR-L2 as depicted in SEQ ID NO:        1911 and CDR-L3 as depicted in SEQ ID NO: 1912,    -   CDR-H1 as depicted in SEQ ID NO: 1933, CDR-H2 as depicted in SEQ        ID NO: 1934, CDR-H3 as depicted in SEQ ID NO: 1935, CDR-L1 as        depicted in SEQ ID NO: 1936, CDR-L2 as depicted in SEQ ID NO:        1937 and CDR-L3 as depicted in SEQ ID NO: 1938,    -   CDR-H1 as depicted in SEQ ID NO: 1946, CDR-H2 as depicted in SEQ        ID NO: 1947, CDR-H3 as depicted in SEQ ID NO: 1948, CDR-L1 as        depicted in SEQ ID NO: 1949, CDR-L2 as depicted in SEQ ID NO:        1950 and CDR-L3 as depicted in SEQ ID NO: 1951,    -   CDR-H1 as depicted in SEQ ID NO: 1959, CDR-H2 as depicted in SEQ        ID NO: 1960, CDR-H3 as depicted in SEQ ID NO: 1961, CDR-L1 as        depicted in SEQ ID NO: 1962, CDR-L2 as depicted in SEQ ID NO:        1963 and CDR-L3 as depicted in SEQ ID NO: 1964,    -   CDR-H1 as depicted in SEQ ID NO: 1972, CDR-H2 as depicted in SEQ        ID NO: 1973, CDR-H3 as depicted in SEQ ID NO: 1974, CDR-L1 as        depicted in SEQ ID NO: 1975, CDR-L2 as depicted in SEQ ID NO:        1976 and CDR-L3 as depicted in SEQ ID NO: 1977,    -   CDR-H1 as depicted in SEQ ID NO: 1985, CDR-H2 as depicted in SEQ        ID NO: 1986, CDR-H3 as depicted in SEQ ID NO: 1987, CDR-L1 as        depicted in SEQ ID NO: 1988, CDR-L2 as depicted in SEQ ID NO:        1989 and CDR-L3 as depicted in SEQ ID NO: 1990,    -   CDR-H1 as depicted in SEQ ID NO: 1998, CDR-H2 as depicted in SEQ        ID NO: 1999, CDR-H3 as depicted in SEQ ID NO: 2000, CDR-L1 as        depicted in SEQ ID NO: 2001, CDR-L2 as depicted in SEQ ID NO:        2002 and CDR-L3 as depicted in SEQ ID NO: 2003,    -   CDR-H1 as depicted in SEQ ID NO: 2011, CDR-H2 as depicted in SEQ        ID NO: 2012, CDR-H3 as depicted in SEQ ID NO: 2013, CDR-L1 as        depicted in SEQ ID NO: 2014, CDR-L2 as depicted in SEQ ID NO:        2015 and CDR-L3 as depicted in SEQ ID NO: 2016,    -   CDR-H1 as depicted in SEQ ID NO: 2024, CDR-H2 as depicted in SEQ        ID NO: 2025, CDR-H3 as depicted in SEQ ID NO: 2026, CDR-L1 as        depicted in SEQ ID NO: 2027, CDR-L2 as depicted in SEQ ID NO:        2028 and CDR-L3 as depicted in SEQ ID NO: 2029,    -   CDR-H1 as depicted in SEQ ID NO: 2037, CDR-H2 as depicted in SEQ        ID NO: 2038, CDR-H3 as depicted in SEQ ID NO: 2039, CDR-L1 as        depicted in SEQ ID NO: 2040, CDR-L2 as depicted in SEQ ID NO:        2041 and CDR-L3 as depicted in SEQ ID NO: 2042, and    -   CDR-H1 as depicted in SEQ ID NO: 2050, CDR-H2 as depicted in SEQ        ID NO: 2051, CDR-H3 as depicted in SEQ ID NO: 2052, CDR-L1 as        depicted in SEQ ID NO: 2053, CDR-L2 as depicted in SEQ ID NO:        2054 and CDR-L3 as depicted in SEQ ID NO: 2055;-   (c) CDR-H1 as depicted in SEQ ID NO: 94, CDR-H2 as depicted in SEQ    ID NO: 95, CDR-H3 as depicted in SEQ ID NO: 96, CDR-L1 as depicted    in SEQ ID NO: 262, CDR-L2 as depicted in SEQ ID NO: 263 and CDR-L3    as depicted in SEQ ID NO: 264, CDR-H1 as depicted in SEQ ID NO: 100,    CDR-H2 as depicted in SEQ ID NO: 101, CDR-H3 as depicted in SEQ ID    NO: 102, CDR-L1 as depicted in SEQ ID NO: 268, CDR-L2 as depicted in    SEQ ID NO: 269 and CDR-L3 as depicted in SEQ ID NO: 270, CDR-H1 as    depicted in SEQ ID NO: 118, CDR-H2 as depicted in SEQ ID NO: 119,    CDR-H3 as depicted in SEQ ID NO: 120, CDR-L1 as depicted in SEQ ID    NO: 286, CDR-L2 as depicted in SEQ ID NO: 287 and CDR-L3 as depicted    in SEQ ID NO: 288, CDR-H1 as depicted in SEQ ID NO: 154, CDR-H2 as    depicted in SEQ ID NO: 155, CDR-H3 as depicted in SEQ ID NO: 156,    CDR-L1 as depicted in SEQ ID NO: 322, CDR-L2 as depicted in SEQ ID    NO: 323 and CDR-L3 as depicted in SEQ ID NO: 324, CDR-H1 as depicted    in SEQ ID NO: 100, CDR-H2 as depicted in SEQ ID NO: 101, CDR-H3 as    depicted in SEQ ID NO: 912, CDR-L1 as depicted in SEQ ID NO: 268,    CDR-L2 as depicted in SEQ ID NO: 269 and CDR-L3 as depicted in SEQ    ID NO: 270, CDR-H1 as depicted in SEQ ID NO: 100, CDR-H2 as depicted    in SEQ ID NO: 101, CDR-H3 as depicted in SEQ ID NO: 913, CDR-L1 as    depicted in SEQ ID NO: 268, CDR-L2 as depicted in SEQ ID NO: 269 and    CDR-L3 as depicted in SEQ ID NO: 270, CDR-H1 as depicted in SEQ ID    NO: 94, CDR-H2 as depicted in SEQ ID NO: 95, CDR-H3 as depicted in    SEQ ID NO: 910, CDR-L1 as depicted in SEQ ID NO: 262, CDR-L2 as    depicted in SEQ ID NO: 263 and CDR-L3 as depicted in SEQ ID NO: 264,    CDR-H1 as depicted in SEQ ID NO: 94, CDR-H2 as depicted in SEQ ID    NO: 95, CDR-H3 as depicted in SEQ ID NO: 911, CDR-L1 as depicted in    SEQ ID NO: 262, CDR-L2 as depicted in SEQ ID NO: 263 and CDR-L3 as    depicted in SEQ ID NO: 264, CDR-H1 as depicted in SEQ ID NO: 118,    CDR-H2 as depicted in SEQ ID NO: 119, CDR-H3 as depicted in SEQ ID    NO: 120, CDR-L1 as depicted in SEQ ID NO: 286, CDR-L2 as depicted in    SEQ ID NO: 287 and CDR-L3 as depicted in SEQ ID NO: 288, CDR-H1 as    depicted in SEQ ID NO: 118, CDR-H2 as depicted in SEQ ID NO: 914,    CDR-H3 as depicted in SEQ ID NO: 120, CDR-L1 as depicted in SEQ ID    NO: 286, CDR-L2 as depicted in SEQ ID NO: 287 and CDR-L3 as depicted    in SEQ ID NO: 288, CDR-H1 as depicted in SEQ ID NO: 154, CDR-H2 as    depicted in SEQ ID NO: 155, CDR-H3 as depicted in SEQ ID NO: 920,    CDR-L1 as depicted in SEQ ID NO: 322, CDR-L2 as depicted in SEQ ID    NO: 323 and CDR-L3 as depicted in SEQ ID NO: 324, CDR-H1 as depicted    in SEQ ID NO: 996, CDR-H2 as depicted in SEQ ID NO: 997, CDR-H3 as    depicted in SEQ ID NO: 998, CDR-L1 as depicted in SEQ ID NO: 999,    CDR-L2 as depicted in SEQ ID NO: 1000 and CDR-L3 as depicted in SEQ    ID NO: 1001,    -   CDR-H1 as depicted in SEQ ID NO: 1048, CDR-H2 as depicted in SEQ        ID NO: 1049, CDR-H3 as depicted in SEQ ID NO: 1050, CDR-L1 as        depicted in SEQ ID NO: 1051, CDR-L2 as depicted in SEQ ID NO:        1052 and CDR-L3 as depicted in SEQ ID NO: 1053,    -   CDR-H1 as depicted in SEQ ID NO: 1087, CDR-H2 as depicted in SEQ        ID NO: 1088, CDR-H3 as depicted in SEQ ID NO: 1089, CDR-L1 as        depicted in SEQ ID NO: 1090, CDR-L2 as depicted in SEQ ID NO:        1091 and CDR-L3 as depicted in SEQ ID NO: 1092,    -   CDR-H1 as depicted in SEQ ID NO: 1608, CDR-H2 as depicted in SEQ        ID NO: 1609, CDR-H3 as depicted in SEQ ID NO: 1610, CDR-L1 as        depicted in SEQ ID NO: 1611, CDR-L2 as depicted in SEQ ID NO:        1612 and CDR-L3 as depicted in SEQ ID NO: 1613,    -   CDR-H1 as depicted in SEQ ID NO: 1621, CDR-H2 as depicted in SEQ        ID NO: 1622, CDR-H3 as depicted in SEQ ID NO: 1623, CDR-L1 as        depicted in SEQ ID NO: 1624, CDR-L2 as depicted in SEQ ID NO:        1625 and CDR-L3 as depicted in SEQ ID NO: 1626,    -   CDR-H1 as depicted in SEQ ID NO: 1634, CDR-H2 as depicted in SEQ        ID NO: 1635, CDR-H3 as depicted in SEQ ID NO: 1636, CDR-L1 as        depicted in SEQ ID NO: 1637, CDR-L2 as depicted in SEQ ID NO:        1638 and CDR-L3 as depicted in SEQ ID NO: 1639,    -   CDR-H1 as depicted in SEQ ID NO: 1673, CDR-H2 as depicted in SEQ        ID NO: 1674, CDR-H3 as depicted in SEQ ID NO: 1675, CDR-L1 as        depicted in SEQ ID NO: 1676, CDR-L2 as depicted in SEQ ID NO:        1677 and CDR-L3 as depicted in SEQ ID NO: 1678,    -   CDR-H1 as depicted in SEQ ID NO: 1686, CDR-H2 as depicted in SEQ        ID NO: 1687, CDR-H3 as depicted in SEQ ID NO: 1688, CDR-L1 as        depicted in SEQ ID NO: 1689, CDR-L2 as depicted in SEQ ID NO:        1690 and CDR-L3 as depicted in SEQ ID NO: 1691,    -   CDR-H1 as depicted in SEQ ID NO: 1699, CDR-H2 as depicted in SEQ        ID NO: 1700, CDR-H3 as depicted in SEQ ID NO: 1701, CDR-L1 as        depicted in SEQ ID NO: 1702, CDR-L2 as depicted in SEQ ID NO:        1703 and CDR-L3 as depicted in SEQ ID NO: 1704,    -   CDR-H1 as depicted in SEQ ID NO: 1712, CDR-H2 as depicted in SEQ        ID NO: 1713, CDR-H3 as depicted in SEQ ID NO: 1714, CDR-L1 as        depicted in SEQ ID NO: 1715, CDR-L2 as depicted in SEQ ID NO:        1716 and CDR-L3 as depicted in SEQ ID NO: 1717,    -   CDR-H1 as depicted in SEQ ID NO: 1725, CDR-H2 as depicted in SEQ        ID NO: 1726, CDR-H3 as depicted in SEQ ID NO: 1727, CDR-L1 as        depicted in SEQ ID NO: 1728, CDR-L2 as depicted in SEQ ID NO:        1729 and CDR-L3 as depicted in SEQ ID NO: 1730,    -   CDR-H1 as depicted in SEQ ID NO: 1738, CDR-H2 as depicted in SEQ        ID NO: 1739, CDR-H3 as depicted in SEQ ID NO: 1740, CDR-L1 as        depicted in SEQ ID NO: 1741, CDR-L2 as depicted in SEQ ID NO:        1742 and CDR-L3 as depicted in SEQ ID NO: 1743,    -   CDR-H1 as depicted in SEQ ID NO: 1751, CDR-H2 as depicted in SEQ        ID NO: 1752, CDR-H3 as depicted in SEQ ID NO: 1753, CDR-L1 as        depicted in SEQ ID NO: 1754, CDR-L2 as depicted in SEQ ID NO:        1755 and CDR-L3 as depicted in SEQ ID NO: 1756,    -   CDR-H1 as depicted in SEQ ID NO: 1764, CDR-H2 as depicted in SEQ        ID NO: 1765, CDR-H3 as depicted in SEQ ID NO: 1766, CDR-L1 as        depicted in SEQ ID NO: 1767, CDR-L2 as depicted in SEQ ID NO:        1768 and CDR-L3 as depicted in SEQ ID NO: 1769, and    -   CDR-H1 as depicted in SEQ ID NO: 1920, CDR-H2 as depicted in SEQ        ID NO: 1921, CDR-H3 as depicted in SEQ ID NO: 1922, CDR-L1 as        depicted in SEQ ID NO: 1923, CDR-L2 as depicted in SEQ ID NO:        1924 and CDR-L3 as depicted in SEQ ID NO: 1925;-   (d) CDR-H1 as depicted in SEQ ID NO: 4, CDR-H2 as depicted in SEQ ID    NO: 5, CDR-H3 as depicted in SEQ ID NO: 6, CDR-L1 as depicted in SEQ    ID NO: 172, CDR-L2 as depicted in SEQ ID NO: 173 and CDR-L3 as    depicted in SEQ ID NO: 174, CDR-H1 as depicted in SEQ ID NO: 10,    CDR-H2 as depicted in SEQ ID NO: 11, CDR-H3 as depicted in SEQ ID    NO: 12, CDR-L1 as depicted in SEQ ID NO: 178, CDR-L2 as depicted in    SEQ ID NO: 179 and CDR-L3 as depicted in SEQ ID NO: 180, CDR-H1 as    depicted in SEQ ID NO: 28, CDR-H2 as depicted in SEQ ID NO: 29,    CDR-H3 as depicted in SEQ ID NO: 30, CDR-L1 as depicted in SEQ ID    NO: 196, CDR-L2 as depicted in SEQ ID NO: 197 and CDR-L3 as depicted    in SEQ ID NO: 198, CDR-H1 as depicted in SEQ ID NO: 34, CDR-H2 as    depicted in SEQ ID NO: 35, CDR-H3 as depicted in SEQ ID NO: 36,    CDR-L1 as depicted in SEQ ID NO: 202, CDR-L2 as depicted in SEQ ID    NO: 203 and CDR-L3 as depicted in SEQ ID NO: 204, CDR-H1 as depicted    in SEQ ID NO: 46, CDR-H2 as depicted in SEQ ID NO: 47, CDR-H3 as    depicted in SEQ ID NO: 48, CDR-L1 as depicted in SEQ ID NO: 214,    CDR-L2 as depicted in SEQ ID NO: 215 and CDR-L3 as depicted in SEQ    ID NO: 216, CDR-H1 as depicted in SEQ ID NO: 58, CDR-H2 as depicted    in SEQ ID NO: 59, CDR-H3 as depicted in SEQ ID NO: 60, CDR-L1 as    depicted in SEQ ID NO: 226, CDR-L2 as depicted in SEQ ID NO: 227 and    CDR-L3 as depicted in SEQ ID NO: 228, CDR-H1 as depicted in SEQ ID    NO: 64, CDR-H2 as depicted in SEQ ID NO: 65, CDR-H3 as depicted in    SEQ ID NO: 66, CDR-L1 as depicted in SEQ ID NO: 232, CDR-L2 as    depicted in SEQ ID NO: 233 and CDR-L3 as depicted in SEQ ID NO: 234,    CDR-H1 as depicted in SEQ ID NO: 70, CDR-H2 as depicted in SEQ ID    NO: 71, CDR-H3 as depicted in SEQ ID NO: 72, CDR-L1 as depicted in    SEQ ID NO: 238, CDR-L2 as depicted in SEQ ID NO: 239 and CDR-L3 as    depicted in SEQ ID NO: 240, CDR-H1 as depicted in SEQ ID NO: 160,    CDR-H2 as depicted in SEQ ID NO: 161, CDR-H3 as depicted in SEQ ID    NO: 162, CDR-L1 as depicted in SEQ ID NO: 328, CDR-L2 as depicted in    SEQ ID NO: 329 and CDR-L3 as depicted in SEQ ID NO: 330, CDR-H1 as    depicted in SEQ ID NO: 46, CDR-H2 as depicted in SEQ ID NO: 47,    CDR-H3 as depicted in SEQ ID NO: 48, CDR-L1 as depicted in SEQ ID    NO: 924, CDR-L2 as depicted in SEQ ID NO: 215 and CDR-L3 as depicted    in SEQ ID NO: 216, CDR-H1 as depicted in SEQ ID NO: 46, CDR-H2 as    depicted in SEQ ID NO: 47, CDR-H3 as depicted in SEQ ID NO: 902,    CDR-L1 as depicted in SEQ ID NO: 924, CDR-L2 as depicted in SEQ ID    NO: 215 and CDR-L3 as depicted in SEQ ID NO: 216, CDR-H1 as depicted    in SEQ ID NO: 46, CDR-H2 as depicted in SEQ ID NO: 47, CDR-H3 as    depicted in SEQ ID NO: 903, CDR-L1 as depicted in SEQ ID NO: 924,    CDR-L2 as depicted in SEQ ID NO: 215 and CDR-L3 as depicted in SEQ    ID NO: 216, CDR-H1 as depicted in SEQ ID NO: 46, CDR-H2 as depicted    in SEQ ID NO: 47, CDR-H3 as depicted in SEQ ID NO: 48, CDR-L1 as    depicted in SEQ ID NO: 925, CDR-L2 as depicted in SEQ ID NO: 215 and    CDR-L3 as depicted in SEQ ID NO: 216, CDR-H1 as depicted in SEQ ID    NO: 70, CDR-H2 as depicted in SEQ ID NO: 907, CDR-H3 as depicted in    SEQ ID NO: 72, CDR-L1 as depicted in SEQ ID NO: 238, CDR-L2 as    depicted in SEQ ID NO: 239 and CDR-L3 as depicted in SEQ ID NO: 240,    CDR-H1 as depicted in SEQ ID NO: 70, CDR-H2 as depicted in SEQ ID    NO: 907, CDR-H3 as depicted in SEQ ID NO: 908, CDR-L1 as depicted in    SEQ ID NO: 238, CDR-L2 as depicted in SEQ ID NO: 239 and CDR-L3 as    depicted in SEQ ID NO: 240, CDR-H1 as depicted in SEQ ID NO: 28,    CDR-H2 as depicted in SEQ ID NO: 901, CDR-H3 as depicted in SEQ ID    NO: 30, CDR-L1 as depicted in SEQ ID NO: 922, CDR-L2 as depicted in    SEQ ID NO: 197 and CDR-L3 as depicted in SEQ ID NO: 923, CDR-H1 as    depicted in SEQ ID NO: 58, CDR-H2 as depicted in SEQ ID NO: 905,    CDR-H3 as depicted in SEQ ID NO: 906, CDR-L1 as depicted in SEQ ID    NO: 226, CDR-L2 as depicted in SEQ ID NO: 227 and CDR-L3 as depicted    in SEQ ID NO: 228, CDR-H1 as depicted in SEQ ID NO: 58, CDR-H2 as    depicted in SEQ ID NO: 905, CDR-H3 as depicted in SEQ ID NO: 60,    CDR-L1 as depicted in SEQ ID NO: 226, CDR-L2 as depicted in SEQ ID    NO: 227 and CDR-L3 as depicted in SEQ ID NO: 228, CDR-H1 as depicted    in SEQ ID NO: 160, CDR-H2 as depicted in SEQ ID NO: 161, CDR-H3 as    depicted in SEQ ID NO: 162, CDR-L1 as depicted in SEQ ID NO: 939,    CDR-L2 as depicted in SEQ ID NO: 329 and CDR-L3 as depicted in SEQ    ID NO: 330, CDR-H1 as depicted in SEQ ID NO: 160, CDR-H2 as depicted    in SEQ ID NO: 921, CDR-H3 as depicted in SEQ ID NO: 162, CDR-L1 as    depicted in SEQ ID NO: 939, CDR-L2 as depicted in SEQ ID NO: 329 and    CDR-L3 as depicted in SEQ ID NO: 940, CDR-H1 as depicted in SEQ ID    NO: 160, CDR-H2 as depicted in SEQ ID NO: 161, CDR-H3 as depicted in    SEQ ID NO: 162, CDR-L1 as depicted in SEQ ID NO: 941, CDR-L2 as    depicted in SEQ ID NO: 329 and CDR-L3 as depicted in SEQ ID NO: 330,    CDR-H1 as depicted in SEQ ID NO: 28, CDR-H2 as depicted in SEQ ID    NO: 29, CDR-H3 as depicted in SEQ ID NO: 30, CDR-L1 as depicted in    SEQ ID NO: 196, CDR-L2 as depicted in SEQ ID NO: 197 and CDR-L3 as    depicted in SEQ ID NO: 923, CDR-H1 as depicted in SEQ ID NO: 28,    CDR-H2 as depicted in SEQ ID NO: 29, CDR-H3 as depicted in SEQ ID    NO: 30, CDR-L1 as depicted in SEQ ID NO: 922, CDR-L2 as depicted in    SEQ ID NO: 197 and CDR-L3 as depicted in SEQ ID NO: 923, CDR-H1 as    depicted in SEQ ID NO: 28, CDR-H2 as depicted in SEQ ID NO: 901,    CDR-H3 as depicted in SEQ ID NO: 30, CDR-L1 as depicted in SEQ ID    NO: 922, CDR-L2 as depicted in SEQ ID NO: 197 and CDR-L3 as depicted    in SEQ ID NO: 923, CDR-H1 as depicted in SEQ ID NO: 28, CDR-H2 as    depicted in SEQ ID NO: 29, CDR-H3 as depicted in SEQ ID NO: 30,    CDR-L1 as depicted in SEQ ID NO: 939, CDR-L2 as depicted in SEQ ID    NO: 329 and CDR-L3 as depicted in SEQ ID NO: 330, CDR-H1 as depicted    in SEQ ID NO: 970, CDR-H2 as depicted in SEQ ID NO: 971, CDR-H3 as    depicted in SEQ ID NO: 972, CDR-L1 as depicted in SEQ ID NO: 973,    CDR-L2 as depicted in SEQ ID NO: 974 and CDR-L3 as depicted in SEQ    ID NO: 975, CDR-H1 as depicted in SEQ ID NO: 1061, CDR-H2 as    depicted in SEQ ID NO: 1062, CDR-H3 as depicted in SEQ ID NO: 1063,    CDR-L1 as depicted in SEQ ID NO: 1064, CDR-L2 as depicted in SEQ ID    NO: 1065 and CDR-L3 as depicted in SEQ ID NO: 1066,    -   CDR-H1 as depicted in SEQ ID NO: 1139, CDR-H2 as depicted in SEQ        ID NO: 1140, CDR-H3 as depicted in SEQ ID NO: 1141, CDR-L1 as        depicted in SEQ ID NO: 1142, CDR-L2 as depicted in SEQ ID NO:        1143 and CDR-L3 as depicted in SEQ ID NO: 1144,    -   CDR-H1 as depicted in SEQ ID NO: 1152, CDR-H2 as depicted in SEQ        ID NO: 1153, CDR-H3 as depicted in SEQ ID NO: 1154, CDR-L1 as        depicted in SEQ ID NO: 1155, CDR-L2 as depicted in SEQ ID NO:        1156 and CDR-L3 as depicted in SEQ ID NO: 1157,    -   CDR-H1 as depicted in SEQ ID NO: 1178, CDR-H2 as depicted in SEQ        ID NO: 1179, CDR-H3 as depicted in SEQ ID NO: 1180, CDR-L1 as        depicted in SEQ ID NO: 1181, CDR-L2 as depicted in SEQ ID NO:        1182 and CDR-L3 as depicted in SEQ ID NO: 1183,    -   CDR-H1 as depicted in SEQ ID NO: 1191, CDR-H2 as depicted in SEQ        ID NO: 1192, CDR-H3 as depicted in SEQ ID NO: 1193, CDR-L1 as        depicted in SEQ ID NO: 1194, CDR-L2 as depicted in SEQ ID NO:        1195 and CDR-L3 as depicted in SEQ ID NO: 1196,    -   CDR-H1 as depicted in SEQ ID NO: 1204, CDR-H2 as depicted in SEQ        ID NO: 1205, CDR-H3 as depicted in SEQ ID NO: 1206, CDR-L1 as        depicted in SEQ ID NO: 1207, CDR-L2 as depicted in SEQ ID NO:        1208 and CDR-L3 as depicted in SEQ ID NO: 1209,    -   CDR-H1 as depicted in SEQ ID NO: 1217, CDR-H2 as depicted in SEQ        ID NO: 1218, CDR-H3 as depicted in SEQ ID NO: 1219, CDR-L1 as        depicted in SEQ ID NO: 1220, CDR-L2 as depicted in SEQ ID NO:        1221 and CDR-L3 as depicted in SEQ ID NO: 1222,    -   CDR-H1 as depicted in SEQ ID NO: 1230, CDR-H2 as depicted in SEQ        ID NO: 1231, CDR-H3 as depicted in SEQ ID NO: 1232, CDR-L1 as        depicted in SEQ ID NO: 1233, CDR-L2 as depicted in SEQ ID NO:        1234 and CDR-L3 as depicted in SEQ ID NO: 1235,    -   CDR-H1 as depicted in SEQ ID NO: 1308, CDR-H2 as depicted in SEQ        ID NO: 1309, CDR-H3 as depicted in SEQ ID NO: 1310, CDR-L1 as        depicted in SEQ ID NO: 1311, CDR-L2 as depicted in SEQ ID NO:        1312 and CDR-L3 as depicted in SEQ ID NO: 1313,    -   CDR-H1 as depicted in SEQ ID NO: 1321, CDR-H2 as depicted in SEQ        ID NO: 1322, CDR-H3 as depicted in SEQ ID NO: 1323, CDR-L1 as        depicted in SEQ ID NO: 1324, CDR-L2 as depicted in SEQ ID NO:        1325 and CDR-L3 as depicted in SEQ ID NO: 1326,    -   CDR-H1 as depicted in SEQ ID NO: 1373, CDR-H2 as depicted in SEQ        ID NO: 1374, CDR-H3 as depicted in SEQ ID NO: 1375, CDR-L1 as        depicted in SEQ ID NO: 1376, CDR-L2 as depicted in SEQ ID NO:        1377 and CDR-L3 as depicted in SEQ ID NO: 1378,    -   CDR-H1 as depicted in SEQ ID NO: 1386, CDR-H2 as depicted in SEQ        ID NO: 1387, CDR-H3 as depicted in SEQ ID NO: 1388, CDR-L1 as        depicted in SEQ ID NO: 1389, CDR-L2 as depicted in SEQ ID NO:        1390 and CDR-L3 as depicted in SEQ ID NO: 1391,    -   CDR-H1 as depicted in SEQ ID NO: 1399, CDR-H2 as depicted in SEQ        ID NO: 1400, CDR-H3 as depicted in SEQ ID NO: 1401, CDR-L1 as        depicted in SEQ ID NO: 1402, CDR-L2 as depicted in SEQ ID NO:        1403 and CDR-L3 as depicted in SEQ ID NO: 1404,    -   CDR-H1 as depicted in SEQ ID NO: 1412, CDR-H2 as depicted in SEQ        ID NO: 1413, CDR-H3 as depicted in SEQ ID NO: 1414, CDR-L1 as        depicted in SEQ ID NO: 1415, CDR-L2 as depicted in SEQ ID NO:        1416 and CDR-L3 as depicted in SEQ ID NO: 1417,    -   CDR-H1 as depicted in SEQ ID NO: 1777, CDR-H2 as depicted in SEQ        ID NO: 1778, CDR-H3 as depicted in SEQ ID NO: 1779, CDR-L1 as        depicted in SEQ ID NO: 1780, CDR-L2 as depicted in SEQ ID NO:        1781 and CDR-L3 as depicted in SEQ ID NO: 1782,    -   CDR-H1 as depicted in SEQ ID NO: 1790, CDR-H2 as depicted in SEQ        ID NO: 1791, CDR-H3 as depicted in SEQ ID NO: 1792, CDR-L1 as        depicted in SEQ ID NO: 1793, CDR-L2 as depicted in SEQ ID NO:        1794 and CDR-L3 as depicted in SEQ ID NO: 1795,    -   CDR-H1 as depicted in SEQ ID NO: 1803, CDR-H2 as depicted in SEQ        ID NO: 1804, CDR-H3 as depicted in SEQ ID NO: 1805, CDR-L1 as        depicted in SEQ ID NO: 1806, CDR-L2 as depicted in SEQ ID NO:        1807 and CDR-L3 as depicted in SEQ ID NO: 1808,    -   CDR-H1 as depicted in SEQ ID NO: 1816, CDR-H2 as depicted in SEQ        ID NO: 1817, CDR-H3 as depicted in SEQ ID NO: 1818, CDR-L1 as        depicted in SEQ ID NO: 1819, CDR-L2 as depicted in SEQ ID NO:        1820 and CDR-L3 as depicted in SEQ ID NO: 1821,    -   CDR-H1 as depicted in SEQ ID NO: 1829, CDR-H2 as depicted in SEQ        ID NO: 1830, CDR-H3 as depicted in SEQ ID NO: 1831, CDR-L1 as        depicted in SEQ ID NO: 1832, CDR-L2 as depicted in SEQ ID NO:        1833 and CDR-L3 as depicted in SEQ ID NO: 1834,    -   CDR-H1 as depicted in SEQ ID NO: 1842, CDR-H2 as depicted in SEQ        ID NO: 1843, CDR-H3 as depicted in SEQ ID NO: 1844, CDR-L1 as        depicted in SEQ ID NO: 1845, CDR-L2 as depicted in SEQ ID NO:        1846 and CDR-L3 as depicted in SEQ ID NO: 1847,    -   CDR-H1 as depicted in SEQ ID NO: 1855, CDR-H2 as depicted in SEQ        ID NO: 1856, CDR-H3 as depicted in SEQ ID NO: 1857, CDR-L1 as        depicted in SEQ ID NO: 1858, CDR-L2 as depicted in SEQ ID NO:        1859 and CDR-L3 as depicted in SEQ ID NO: 1860,    -   CDR-H1 as depicted in SEQ ID NO: 1868, CDR-H2 as depicted in SEQ        ID NO: 1869, CDR-H3 as depicted in SEQ ID NO: 1870, CDR-L1 as        depicted in SEQ ID NO: 1871, CDR-L2 as depicted in SEQ ID NO:        1872 and CDR-L3 as depicted in SEQ ID NO: 1873,    -   CDR-H1 as depicted in SEQ ID NO: 1881, CDR-H2 as depicted in SEQ        ID NO: 1882, CDR-H3 as depicted in SEQ ID NO: 1883, CDR-L1 as        depicted in SEQ ID NO: 1884, CDR-L2 as depicted in SEQ ID NO:        1885 and CDR-L3 as depicted in SEQ ID NO: 1886,    -   CDR-H1 as depicted in SEQ ID NO: 2063, CDR-H2 as depicted in SEQ        ID NO: 2064, CDR-H3 as depicted in SEQ ID NO: 2065, CDR-L1 as        depicted in SEQ ID NO: 2066, CDR-L2 as depicted in SEQ ID NO:        2067 and CDR-L3 as depicted in SEQ ID NO: 2068,    -   CDR-H1 as depicted in SEQ ID NO: 2076, CDR-H2 as depicted in SEQ        ID NO: 2077, CDR-H3 as depicted in SEQ ID NO: 2078, CDR-L1 as        depicted in SEQ ID NO: 2079, CDR-L2 as depicted in SEQ ID NO:        2080 and CDR-L3 as depicted in SEQ ID NO: 2081,    -   CDR-H1 as depicted in SEQ ID NO: 2089, CDR-H2 as depicted in SEQ        ID NO: 2090, CDR-H3 as depicted in SEQ ID NO: 2091, CDR-L1 as        depicted in SEQ ID NO: 2092, CDR-L2 as depicted in SEQ ID NO:        2093 and CDR-L3 as depicted in SEQ ID NO: 2094,    -   CDR-H1 as depicted in SEQ ID NO: 2102, CDR-H2 as depicted in SEQ        ID NO: 2103, CDR-H3 as depicted in SEQ ID NO: 2104, CDR-L1 as        depicted in SEQ ID NO: 2105, CDR-L2 as depicted in SEQ ID NO:        2106 and CDR-L3 as depicted in SEQ ID NO: 2107,    -   CDR-H1 as depicted in SEQ ID NO: 2115, CDR-H2 as depicted in SEQ        ID NO: 2116, CDR-H3 as depicted in SEQ ID NO: 2117, CDR-L1 as        depicted in SEQ ID NO: 2118, CDR-L2 as depicted in SEQ ID NO:        2119 and CDR-L3 as depicted in SEQ ID NO: 2120,    -   CDR-H1 as depicted in SEQ ID NO: 2128, CDR-H2 as depicted in SEQ        ID NO: 2129, CDR-H3 as depicted in SEQ ID NO: 2130, CDR-L1 as        depicted in SEQ ID NO: 2131, CDR-L2 as depicted in SEQ ID NO:        2132 and CDR-L3 as depicted in SEQ ID NO: 2133,    -   CDR-H1 as depicted in SEQ ID NO: 2141, CDR-H2 as depicted in SEQ        ID NO: 2142, CDR-H3 as depicted in SEQ ID NO: 2143, CDR-L1 as        depicted in SEQ ID NO: 2144, CDR-L2 as depicted in SEQ ID NO:        2145 and CDR-L3 as depicted in SEQ ID NO: 2146,    -   CDR-H1 as depicted in SEQ ID NO: 2154, CDR-H2 as depicted in SEQ        ID NO: 2155, CDR-H3 as depicted in SEQ ID NO: 2156, CDR-L1 as        depicted in SEQ ID NO: 2157, CDR-L2 as depicted in SEQ ID NO:        2158 and CDR-L3 as depicted in SEQ ID NO: 2159,    -   CDR-H1 as depicted in SEQ ID NO: 2180, CDR-H2 as depicted in SEQ        ID NO: 2181, CDR-H3 as depicted in SEQ ID NO: 2182, CDR-L1 as        depicted in SEQ ID NO: 2183, CDR-L2 as depicted in SEQ ID NO:        2184 and CDR-L3 as depicted in SEQ ID NO: 2185,    -   CDR-H1 as depicted in SEQ ID NO: 2193, CDR-H2 as depicted in SEQ        ID NO: 2194, CDR-H3 as depicted in SEQ ID NO: 2195, CDR-L1 as        depicted in SEQ ID NO: 2196, CDR-L2 as depicted in SEQ ID NO:        2197 and CDR-L3 as depicted in SEQ ID NO: 2198, and    -   CDR-H1 as depicted in SEQ ID NO: 2206, CDR-H2 as depicted in SEQ        ID NO: 2207, CDR-H3 as depicted in SEQ ID NO: 2208, CDR-L1 as        depicted in SEQ ID NO: 2209, CDR-L2 as depicted in SEQ ID NO:        2210 and CDR-L3 as depicted in SEQ ID NO: 2211; and-   (e) CDR-H1 as depicted in SEQ ID NO: 76, CDR-H2 as depicted in SEQ    ID NO: 77, CDR-H3 as depicted in SEQ ID NO: 78, CDR-L1 as depicted    in SEQ ID NO: 244, CDR-L2 as depicted in SEQ ID NO: 245 and CDR-L3    as depicted in SEQ ID NO: 246, CDR-H1 as depicted in SEQ ID NO: 88,    CDR-H2 as depicted in SEQ ID NO: 89, CDR-H3 as depicted in SEQ ID    NO: 90, CDR-L1 as depicted in SEQ ID NO: 256, CDR-L2 as depicted in    SEQ ID NO: 257 and CDR-L3 as depicted in SEQ ID NO: 258, CDR-H1 as    depicted in SEQ ID NO: 106, CDR-H2 as depicted in SEQ ID NO: 107,    CDR-H3 as depicted in SEQ ID NO: 108, CDR-L1 as depicted in SEQ ID    NO: 274, CDR-L2 as depicted in SEQ ID NO: 275 and CDR-L3 as depicted    in SEQ ID NO: 276, CDR-H1 as depicted in SEQ ID NO: 112, CDR-H2 as    depicted in SEQ ID NO: 113, CDR-H3 as depicted in SEQ ID NO: 114,    CDR-L1 as depicted in SEQ ID NO: 280, CDR-L2 as depicted in SEQ ID    NO: 281 and CDR-L3 as depicted in SEQ ID NO: 282, CDR-H1 as depicted    in SEQ ID NO: 106, CDR-H2 as depicted in SEQ ID NO: 107, CDR-H3 as    depicted in SEQ ID NO: 108, CDR-L1 as depicted in SEQ ID NO: 274,    CDR-L2 as depicted in SEQ ID NO: 275 and CDR-L3 as depicted in SEQ    ID NO: 276, CDR-H1 as depicted in SEQ ID NO: 983, CDR-H2 as depicted    in SEQ ID NO: 984, CDR-H3 as depicted in SEQ ID NO: 985, CDR-L1 as    depicted in SEQ ID NO: 986, CDR-L2 as depicted in SEQ ID NO: 987 and    CDR-L3 as depicted in SEQ ID NO: 988,    -   CDR-H1 as depicted in SEQ ID NO: 1582, CDR-H2 as depicted in SEQ        ID NO: 1583, CDR-H3 as depicted in SEQ ID NO: 1584, CDR-L1 as        depicted in SEQ ID NO: 1585, CDR-L2 as depicted in SEQ ID NO:        1586 and CDR-L3 as depicted in SEQ ID NO: 1587, and    -   CDR-H1 as depicted in SEQ ID NO: 1595, CDR-H2 as depicted in SEQ        ID NO: 1596, CDR-H3 as depicted in SEQ ID NO: 1597, CDR-L1 as        depicted in SEQ ID NO: 1598, CDR-L2 as depicted in SEQ ID NO:        1599 and CDR-L3 as depicted in SEQ ID NO: 1600.

In a further embodiment of the antibody construct of the invention thefirst binding domain comprises a VH region selected from the groupconsisting of VH regions

-   (a) as depicted in SEQ ID NO: 362, SEQ ID NO: 364, SEQ ID NO: 485,    SEQ ID NO: 486, SEQ ID NO: 487, SEQ ID NO: 492, SEQ ID NO: 493, SEQ    ID NO: 494, SEQ ID NO: 495, SEQ ID NO: 1133, SEQ ID NO: 1172, SEQ ID    NO: 1341, SEQ ID NO: 1354, SEQ ID NO: 1367, SEQ ID NO: 1432, SEQ ID    NO: 1445 and SEQ ID NO: 2174;-   (b) as depicted in SEQ ID NO: 342, SEQ ID NO: 366, SEQ ID NO: 370,    SEQ ID NO: 344, SEQ ID NO: 372, SEQ ID NO: 368, SEQ ID NO: 496, SEQ    ID NO: 497, SEQ ID NO: 498, SEQ ID NO: 499, SEQ ID NO: 500, SEQ ID    NO: 508, SEQ ID NO: 509, SEQ ID NO: 510, SEQ ID NO: 511, SEQ ID NO:    512, SEQ ID NO: 519, SEQ ID NO: 520, SEQ ID NO: 521, SEQ ID NO: 522,    SEQ ID NO: 523, SEQ ID NO: 524, SEQ ID NO: 525, SEQ ID NO: 526, SEQ    ID NO: 527, SEQ ID NO: 528, SEQ ID NO: 529, SEQ ID NO: 530, SEQ ID    NO: 531, SEQ ID NO: 532, SEQ ID NO: 533, SEQ ID NO: 534, SEQ ID NO:    535, SEQ ID NO: 536, SEQ ID NO: 537, SEQ ID NO: 538, SEQ ID NO:    1016, SEQ ID NO: 1029, SEQ ID NO: 1042, SEQ ID NO: 1081, SEQ ID NO:    1107, SEQ ID NO: 1120, SEQ ID NO: 1250, SEQ ID NO: 1263, SEQ ID NO:    1276, SEQ ID NO: 1289, SEQ ID NO: 1302, SEQ ID NO: 1654, SEQ ID NO:    1667, SEQ ID NO: 1901, SEQ ID NO: 1914, SEQ ID NO: 1940, SEQ ID NO:    1953, SEQ ID NO: 1966, SEQ ID NO: 1979, SEQ ID NO: 1992, SEQ ID NO:    2005, SEQ ID NO: 2018, SEQ ID NO: 2031, SEQ ID NO: 2044, and SEQ ID    NO: 2057;-   (c) as depicted in SEQ ID NO: 338, SEQ ID NO: 354, SEQ ID NO: 378,    SEQ ID NO: 356, SEQ ID NO: 476, SEQ ID NO: 477, SEQ ID NO: 478, SEQ    ID NO: 479, SEQ ID NO: 480, SEQ ID NO: 481, SEQ ID NO: 482, SEQ ID    NO: 483, SEQ ID NO: 484, SEQ ID NO: 501, SEQ ID NO: 502, SEQ ID NO:    503, SEQ ID NO: 504, SEQ ID NO: 505, SEQ ID NO: 506, SEQ ID NO: 517,    SEQ ID NO: 518, SEQ ID NO: 1003, SEQ ID NO: 1055, SEQ ID NO: 1094,    SEQ ID NO: 1615, SEQ ID NO: 1628, SEQ ID NO: 1641, SEQ ID NO: 1680,    SEQ ID NO: 1693, SEQ ID NO: 1706, SEQ ID NO: 1719, SEQ ID NO: 1732,    SEQ ID NO: 1745, SEQ ID NO: 1758, SEQ ID NO: 1771, and SEQ ID NO:    1927;-   (d) as depicted in SEQ ID NO: 352, SEQ ID NO: 360, SEQ ID NO: 388,    SEQ ID NO: 386, SEQ ID NO: 340, SEQ ID NO: 346, SEQ ID NO: 374, SEQ    ID NO: 348, SEQ ID NO: 390, SEQ ID NO: 463, SEQ ID NO: 464, SEQ ID    NO: 465, SEQ ID NO: 466, SEQ ID NO: 467, SEQ ID NO: 468, SEQ ID NO:    469, SEQ ID NO: 470, SEQ ID NO: 471, SEQ ID NO: 472, SEQ ID NO: 473,    SEQ ID NO: 474, SEQ ID NO: 475, SEQ ID NO: 488, SEQ ID NO: 489, SEQ    ID NO: 490, SEQ ID NO: 491, SEQ ID NO: 513, SEQ ID NO: 514, SEQ ID    NO: 515, SEQ ID NO: 516, SEQ ID NO: 540, SEQ ID NO: 541, SEQ ID NO:    542, SEQ ID NO: 543, SEQ ID NO: 977, SEQ ID NO: 1068, SEQ ID NO:    1146, SEQ ID NO: 1159, SEQ ID NO: 1185, SEQ ID NO: 1198, SEQ ID NO:    1211, SEQ ID NO: 1224, SEQ ID NO: 1237, SEQ ID NO: 1315, SEQ ID NO:    1328, SEQ ID NO: 1380, SEQ ID NO: 1393, SEQ ID NO: 1406, SEQ ID NO:    1419, SEQ ID NO: 1469, SEQ ID NO: 1478, SEQ ID NO: 1485, SEQ ID NO:    1494, SEQ ID NO: 1501, SEQ ID NO: 1508, SEQ ID NO: 1519, SEQ ID NO:    1526, SEQ ID NO: 1533, SEQ ID NO: 1542, SEQ ID NO: 1549, SEQ ID NO:    1558, SEQ ID NO: 1565, SEQ ID NO: 1784, SEQ ID NO: 1797, SEQ ID NO:    1810, SEQ ID NO: 1823, SEQ ID NO: 1836, SEQ ID NO: 1849, SEQ ID NO:    1862, SEQ ID NO: 1875, SEQ ID NO: 1888, SEQ ID NO: 2070, SEQ ID NO:    2083, SEQ ID NO: 2096, SEQ ID NO: 2109, SEQ ID NO: 2122, SEQ ID NO:    2135, SEQ ID NO: 2148, SEQ ID NO: 2161, SEQ ID NO: 2187, SEQ ID NO:    2200, and SEQ ID NO: 2213; and-   (e) as depicted in SEQ ID NO: 376, SEQ ID NO: 392, SEQ ID NO: 358,    SEQ ID NO: 350, SEQ ID NO: 507, SEQ ID NO: 990, SEQ ID NO: 1589, and    SEQ ID NO: 1602.

In another embodiment of the antibody construct of the invention thefirst binding domain comprises a VL region selected from the groupconsisting of VL regions

-   (a) as depicted in SEQ ID NO: 418, SEQ ID NO: 420, SEQ ID NO: 580,    SEQ ID NO: 581, SEQ ID NO: 582, SEQ ID NO: 587, SEQ ID NO: 588, SEQ    ID NO: 589, SEQ ID NO: 590, SEQ ID NO: 1135, SEQ ID NO: 1174, SEQ ID    NO: 1343, SEQ ID NO: 1356, SEQ ID NO: 1369, SEQ ID NO: 1434, SEQ ID    NO: 1447 and SEQ ID NO: 2176;-   (b) as depicted in SEQ ID NO: 398, SEQ ID NO: 422, SEQ ID NO: 426,    SEQ ID NO: 400, SEQ ID NO: 428, SEQ ID NO: 424, SEQ ID NO: 591, SEQ    ID NO: 592, SEQ ID NO: 593, SEQ ID NO: 594, SEQ ID NO: 595, SEQ ID    NO: 603, SEQ ID NO: 604, SEQ ID NO: 605, SEQ ID NO: 606, SEQ ID NO:    607, SEQ ID NO: 614, SEQ ID NO: 615, SEQ ID NO: 616, SEQ ID NO: 617,    SEQ ID NO: 618, SEQ ID NO: 619, SEQ ID NO: 620, SEQ ID NO: 621, SEQ    ID NO: 622, SEQ ID NO: 623, SEQ ID NO: 624, SEQ ID NO: 625, SEQ ID    NO: 626, SEQ ID NO: 627, SEQ ID NO: 628, SEQ ID NO: 629, SEQ ID NO:    630, SEQ ID NO: 631, SEQ ID NO: 632, SEQ ID NO: 633, SEQ ID NO:    1018, SEQ ID NO: 1031, SEQ ID NO: 1044, SEQ ID NO: 1083, SEQ ID NO:    1109, SEQ ID NO: 1122, SEQ ID NO: 1252, SEQ ID NO: 1265, SEQ ID NO:    1278, SEQ ID NO: 1291, SEQ ID NO: 1304, SEQ ID NO: 1656, SEQ ID NO:    1669, SEQ ID NO: 1903, SEQ ID NO: 1916, SEQ ID NO: 1942, SEQ ID NO:    1955, SEQ ID NO: 1968, SEQ ID NO: 1981, SEQ ID NO: 1994, SEQ ID NO:    2007, SEQ ID NO: 2020, SEQ ID NO: 2033, SEQ ID NO: 2046, and SEQ ID    NO: 2059;-   (c) as depicted in SEQ ID NO: 394, SEQ ID NO: 410, SEQ ID NO: 434,    SEQ ID NO: 412, SEQ ID NO: 571, SEQ ID NO: 572, SEQ ID NO: 573, SEQ    ID NO: 574, SEQ ID NO: 575, SEQ ID NO: 576, SEQ ID NO: 577, SEQ ID    NO: 578, SEQ ID NO: 579, SEQ ID NO: 596, SEQ ID NO: 597, SEQ ID NO:    598, SEQ ID NO: 599, SEQ ID NO: 600, SEQ ID NO: 601, SEQ ID NO: 612,    SEQ ID NO: 613, SEQ ID NO: 1005, SEQ ID NO: 1057, SEQ ID NO: 1096,    SEQ ID NO: 1617, SEQ ID NO: 1630, SEQ ID NO: 1643, SEQ ID NO: 1682,    SEQ ID NO: 1695, SEQ ID NO: 1708, SEQ ID NO: 1721, SEQ ID NO: 1734,    SEQ ID NO: 1747, SEQ ID NO: 1760, SEQ ID NO: 1773, and SEQ ID NO:    1929;-   (d) as depicted in SEQ ID NO: 408, SEQ ID NO: 416, SEQ ID NO: 444,    SEQ ID NO: 442, SEQ ID NO: 396, SEQ ID NO: 402, SEQ ID NO: 430, SEQ    ID NO: 404, SEQ ID NO: 446, SEQ ID NO: 558, SEQ ID NO: 559, SEQ ID    NO: 560, SEQ ID NO: 561, SEQ ID NO: 562, SEQ ID NO: 563, SEQ ID NO:    564, SEQ ID NO: 565, SEQ ID NO: 566, SEQ ID NO: 567, SEQ ID NO: 568,    SEQ ID NO: 569, SEQ ID NO: 570, SEQ ID NO: 583, SEQ ID NO: 584, SEQ    ID NO: 585, SEQ ID NO: 586, SEQ ID NO: 608, SEQ ID NO: 609, SEQ ID    NO: 610, SEQ ID NO: 611, SEQ ID NO: 635, SEQ ID NO: 636, SEQ ID NO:    637, SEQ ID NO: 638, SEQ ID NO: 979, SEQ ID NO: 1070, SEQ ID NO:    1148, SEQ ID NO: 1161, SEQ ID NO: 1187, SEQ ID NO: 1200, SEQ ID NO:    1213, SEQ ID NO: 1226, SEQ ID NO: 1239, SEQ ID NO: 1317, SEQ ID NO:    1330, SEQ ID NO: 1382, SEQ ID NO: 1395, SEQ ID NO: 1408, SEQ ID NO:    1421, SEQ ID NO: 1471, SEQ ID NO: 1480, SEQ ID NO: 1487, SEQ ID NO:    1496, SEQ ID NO: 1503, SEQ ID NO: 1510, SEQ ID NO: 1521, SEQ ID NO:    1528, SEQ ID NO: 1535, SEQ ID NO: 1544, SEQ ID NO: 1551, SEQ ID NO:    1560, SEQ ID NO: 1567, SEQ ID NO: 1786, SEQ ID NO: 1799, SEQ ID NO:    1812, SEQ ID NO: 1825, SEQ ID NO: 1838, SEQ ID NO: 1851, SEQ ID NO:    1864, SEQ ID NO: 1877, SEQ ID NO: 1890, SEQ ID NO: 2072, SEQ ID NO:    2085, SEQ ID NO: 2098, SEQ ID NO: 2111, SEQ ID NO: 2124, SEQ ID NO:    2137, SEQ ID NO: 2150, SEQ ID NO: 2163, SEQ ID NO: 2189, SEQ ID NO:    2202, and SEQ ID NO: 2215; and-   (e) as depicted in SEQ ID NO: 432, SEQ ID NO: 448, SEQ ID NO: 414,    SEQ ID NO: 406, SEQ ID NO: 602, SEQ ID NO: 992, SEQ ID NO: 1591, and    SEQ ID NO: 1604.

The invention further provides an embodiment of the antibody constructof the invention, wherein the first binding domain comprises a VH regionand a VL region selected from the group consisting of:

-   (1) pairs of a VH region and a VL region as depicted in SEQ ID NOs:    362+418, SEQ ID NOs: 364+420, SEQ ID NOs: 485+580, SEQ ID NOs:    486+581, SEQ ID NOs: 487+582, SEQ ID NOs: 492+587, SEQ ID NOs:    493+588, SEQ ID NOs: 494+589, SEQ ID NOs: 495+590, SEQ ID NOs:    1133+1135, SEQ ID NOs: 1172+1174, SEQ ID NOs: 1341+1343, SEQ ID NOs:    1354+1356, SEQ ID NOs: 1367+1369, SEQ ID NOs: 1432+1434, SEQ ID NOs:    1445+1447, and SEQ ID NOs: 2174+2176;-   (2) pairs of a VH region and a VL region as depicted in SEQ ID NOs:    342+398, SEQ ID NOs: 366+422, SEQ ID NOs: 370+426, SEQ ID NOs:    344+400, SEQ ID NOs: 372+428, SEQ ID NOs: 368+424, SEQ ID NOs:    496+591, SEQ ID NOs: 497+592, SEQ ID NOs: 498+593, SEQ ID NOs:    499+594, SEQ ID NOs: 500+595, SEQ ID NOs: 508+603, SEQ ID NOs:    509+604, SEQ ID NOs: 510+605, SEQ ID NOs: 511+606, SEQ ID NOs:    512+607, SEQ ID NOs: 519+614, SEQ ID NOs: 520+615, SEQ ID NOs:    521+616, SEQ ID NOs: 522+617, SEQ ID NOs: 523+618, SEQ ID NOs:    524+619, SEQ ID NOs: 525+620, SEQ ID NOs: 526+621, SEQ ID NOs:    527+622, SEQ ID NOs: 528+623, SEQ ID NOs: 529+624, SEQ ID NOs:    530+625, SEQ ID NOs: 531+626, SEQ ID NOs: 532+627, SEQ ID NOs:    533+628, SEQ ID NOs: 534+629, SEQ ID NOs: 535+630, SEQ ID NOs:    536+631, SEQ ID NOs: 537+632, SEQ ID NOs: 538+633, SEQ ID NOs:    1016+1018, SEQ ID NOs: 1029+1031, SEQ ID NOs: 1042+1044, SEQ ID NOs:    1081+1083, SEQ ID NOs: 1107+1109, SEQ ID NOs: 1120+1122, SEQ ID NOs:    1250+1252, SEQ ID NOs: 1263+1265, SEQ ID NOs: 1276+1278, SEQ ID NOs:    1289+1291, SEQ ID NOs: 1302+1304, SEQ ID NOs: 1654+1656, SEQ ID NOs:    1667+1669, SEQ ID NOs: 1901+1903, SEQ ID NOs: 1914+1916, SEQ ID NOs:    1940+1942, SEQ ID NOs: 1953+1955, SEQ ID NOs: 1966+1968, SEQ ID NOs:    1979+1981, SEQ ID NOs: 1992+1994, SEQ ID NOs: 2005+2007, SEQ ID NOs:    2018+2020, SEQ ID NOs: 2031+2033, SEQ ID NOs: 2044+2046, and SEQ ID    NOs: 2057+2059;-   (3) pairs of a VH region and a VL region as depicted in SEQ ID NOs:    338+394, SEQ ID NOs: 354+410, SEQ ID NOs: 378+434, SEQ ID NOs:    356+412, SEQ ID NOs: 476+571, SEQ ID NOs: 477+572, SEQ ID NOs:    478+573, SEQ ID NOs: 479+574, SEQ ID NOs: 480+575, SEQ ID NOs:    481+576, SEQ ID NOs: 482+577, SEQ ID NOs: 483+578, SEQ ID NOs:    484+579, SEQ ID NOs: 501+596, SEQ ID NOs: 502+597, SEQ ID NOs:    503+598, SEQ ID NOs: 504+599, SEQ ID NOs: 505+600, SEQ ID NOs:    506+601, SEQ ID NOs: 517+612, SEQ ID NOs: 518+613, SEQ ID NOs:    1003+1005, SEQ ID NOs: 1055+1057, SEQ ID NOs: 1094+1096, SEQ ID NOs:    1615+1617, SEQ ID NOs: 1628+1630, SEQ ID NOs: 1641+1643, SEQ ID NOs:    1680+1682, SEQ ID NOs: 1693+1695, SEQ ID NOs: 1706+1708, SEQ ID NOs:    1719+1721, SEQ ID NOs: 1732+1734, SEQ ID NOs: 1745+1747, SEQ ID NOs:    1758+1760, SEQ ID NOs: 1771+1773, and SEQ ID NOs: 1927+1929;-   (4) pairs of a VH region and a VL region as depicted in SEQ ID NOs:    352+408, SEQ ID NOs: 360+416, SEQ ID NOs: 388+444, SEQ ID NOs:    386+442, SEQ ID NOs: 340+396, SEQ ID NOs: 346+402, SEQ ID NOs:    374+430, SEQ ID NOs: 348+404, SEQ ID NOs: 390+446, SEQ ID NOs:    463+558, SEQ ID NOs: 464+559, SEQ ID NOs: 465+560, SEQ ID NOs:    466+561, SEQ ID NOs: 467+562, SEQ ID NOs: 468+563, SEQ ID NOs:    469+564, SEQ ID NOs: 470+565, SEQ ID NOs: 471+566, SEQ ID NOs:    472+567, SEQ ID NOs: 473+568, SEQ ID NOs: 474+569, SEQ ID NOs:    475+570, SEQ ID NOs: 488+583, SEQ ID NOs: 489+584, SEQ ID NOs:    490+585, SEQ ID NOs: 491+586, SEQ ID NOs: 513+608, SEQ ID NOs:    514+609, SEQ ID NOs: 515+610, SEQ ID NOs: 516+611, SEQ ID NOs:    540+635, SEQ ID NOs: 541+636, SEQ ID NOs: 542+637, SEQ ID NOs:    543+638, SEQ ID NOs: 977+979, SEQ ID NOs: 1068+1070, SEQ ID NOs:    1146+1148, SEQ ID NOs: 1159+1161, SEQ ID NOs: 1185+1187, SEQ ID NOs:    1198+1200, SEQ ID NOs: 1211+1213, SEQ ID NOs: 1224+1226, SEQ ID NOs:    1237+1239, SEQ ID NOs: 1315+1317, SEQ ID NOs: 1328+1330, SEQ ID NOs:    1380+1382 SEQ ID NOs: 1393+1395, SEQ ID NOs: 1406+1408, SEQ ID NOs:    1419+1421, SEQ ID NOs: 1469+1471, SEQ ID NOs: 1478+1480, SEQ ID NOs:    1485+1487, SEQ ID NOs: 1494+1496, SEQ ID NOs: 1501+1503, SEQ ID NOs:    1508+1510, SEQ ID NOs: 1519+1521, SEQ ID NOs: 1526+1528, SEQ ID NOs:    1533+1535, SEQ ID NOs: 1542+1544, SEQ ID NOs: 1549+1551, SEQ ID NOs:    1558+1560, SEQ ID NOs: 1565+1567, SEQ ID NOs: 1784+1786, SEQ ID NOs:    1797+1799, SEQ ID NOs: 1810+1812, SEQ ID NOs: 1823+1825, SEQ ID NOs:    1836+1838, SEQ ID NOs: 1849+1851, SEQ ID NOs: 1862+1864, SEQ ID NOs:    1875+1877, SEQ ID NOs: 1888+1890, SEQ ID NOs: 2070+2072, SEQ ID NOs:    2083+2085, SEQ ID NOs: 2096+2098, SEQ ID NOs: 2109+2111, SEQ ID NOs:    2122+2124, SEQ ID NOs: 2135+2137, SEQ ID NOs: 2148+2150, SEQ ID NOs:    2161+2163, SEQ ID NOs: 2187+2189, SEQ ID NOs: 2200+2202, and SEQ ID    NOs: 2213+2215; and-   (5) pairs of a VH region and a VL region as depicted in SEQ ID NOs:    376+432, SEQ ID NOs: 392+448, SEQ ID NOs: 358+414, SEQ ID NOs:    350+406, SEQ ID NOs: 507+602, SEQ ID NOs: 990+992, SEQ ID NOs:    1589+1591, and SEQ ID NOs: 1602+1604.

In a further embodiment of the invention the antibody construct is in aformat selected from the group consisting of (scFv)₂, (single domainmAb)₂, scFv-single domain mAb, diabodies and oligomers thereof.

In a preferred embodiment the first binding domain comprises an aminoacid sequence selected from the group consisting of

-   (a) as depicted in SEQ ID NO: 117, SEQ ID NO: 1137, SEQ ID NO: 1176,    SEQ ID NO: 1345, SEQ ID NO: 1358, SEQ ID NO: 1371, SEQ ID NO: 1436,    SEQ ID NO: 1449 and SEQ ID NO: 2178;-   (b) as depicted in SEQ ID NO: 1020, SEQ ID NO: 1033, SEQ ID NO:    1046, SEQ ID NO: 1085, SEQ ID NO: 1111, SEQ ID NO: 1124, SEQ ID NO:    1254, SEQ ID NO: 1267, SEQ ID NO: 1280, SEQ ID NO: 1293, SEQ ID NO:    1306, SEQ ID NO: 1658, SEQ ID NO: 1671, SEQ ID NO: 1905, SEQ ID NO:    1918, SEQ ID NO: 1944, SEQ ID NO: 1957, SEQ ID NO: 1970, SEQ ID NO:    1983, SEQ ID NO: 1996, SEQ ID NO: 2009, SEQ ID NO: 2022, SEQ ID NO:    2035, SEQ ID NO: 2048, and SEQ ID NO: 2061;-   (c) as depicted in SEQ ID NO: 1007, SEQ ID NO: 1059, SEQ ID NO:    1098, SEQ ID NO: 1619, SEQ ID NO: 1632, SEQ ID NO: 1645, SEQ ID NO:    1684, SEQ ID NO: 1697, SEQ ID NO: 1710, SEQ ID NO: 1723, SEQ ID NO:    1736, SEQ ID NO: 1749, SEQ ID NO: 1762, SEQ ID NO: 1775, and SEQ ID    NO: 1931;-   (d) as depicted in SEQ ID NO: 981, SEQ ID NO: 1072, SEQ ID NO: 1150,    SEQ ID NO: 1163, SEQ ID NO: 1189, SEQ ID NO: 1202, SEQ ID NO: 1215,    SEQ ID NO: 1228, SEQ ID NO: 1241, SEQ ID NO: 1319, SEQ ID NO: 1332,    SEQ ID NO: 1384, SEQ ID NO: 1397, SEQ ID NO: 1410, SEQ ID NO: 1423,    SEQ ID NO: 1473, SEQ ID NO: 1482, SEQ ID NO: 1489, SEQ ID NO: 1498,    SEQ ID NO: 1505, SEQ ID NO: 1512, SEQ ID NO: 1523, SEQ ID NO: 1530,    SEQ ID NO: 1537, SEQ ID NO: 1546, SEQ ID NO: 1553, SEQ ID NO: 1562,    SEQ ID NO: 1569, SEQ ID NO: 1788, SEQ ID NO: 1801, SEQ ID NO: 1814,    SEQ ID NO: 1827, SEQ ID NO: 1840, SEQ ID NO: 1853, SEQ ID NO: 1866,    SEQ ID NO: 1879, SEQ ID NO: 1892, SEQ ID NO: 2074, SEQ ID NO: 2087,    SEQ ID NO: 2100, SEQ ID NO: 2113, SEQ ID NO: 2126, SEQ ID NO: 2139,    SEQ ID NO: 2152, SEQ ID NO: 2165, SEQ ID NO: 2191, SEQ ID NO: 2204,    and SEQ ID NO: 2217; and-   (e) as depicted in SEQ ID NO: 994, SEQ ID NO: 1593, and SEQ ID NO:    1606.

In another embodiment of the antibody construct of the invention thesecond binding domain is capable of binding to human and Callithrixjacchus, Saguinus Oedipus or Saimiri sciureus CD3 epsilon.

In a preferred embodiment the antibody construct of the invention has anamino acid sequence selected from the group consisting of

-   (a) as depicted in SEQ ID NO: 1138, SEQ ID NO: 1177, SEQ ID NO:    1346, SEQ ID NO: 1359, SEQ ID NO: 1372, SEQ ID NO: 1437, SEQ ID NO:    14501450 and SEQ ID NO: 2179;-   (b) as depicted in SEQ ID NO: 1021, SEQ ID NO: 1034, SEQ ID NO:    1047, SEQ ID NO: 1086, SEQ ID NO: 1112, SEQ ID NO: 1125, SEQ ID NO:    1255, SEQ ID NO: 1268, SEQ ID NO: 1281, SEQ ID NO: 1294, SEQ ID NO:    1307, SEQ ID NO: 1659, SEQ ID NO: 1672, SEQ ID NO: 1906, SEQ ID NO:    1919, SEQ ID NO: 1945, SEQ ID NO: 1958, SEQ ID NO: 1971, SEQ ID NO:    1984, SEQ ID NO: 1997, SEQ ID NO: 2010, SEQ ID NO: 2023, SEQ ID NO:    2036, SEQ ID NO: 2049, and SEQ ID NO: 2062;-   (c) as depicted in SEQ ID NO: 1008, SEQ ID NO: 1060, SEQ ID NO:    1099, SEQ ID NO: 1620, SEQ ID NO: 1633, SEQ ID NO: 1646, SEQ ID NO:    1685, SEQ ID NO: 1698, SEQ ID NO: 1711, SEQ ID NO: 1724, SEQ ID NO:    1737, SEQ ID NO: 1750, SEQ ID NO: 1763, SEQ ID NO: 1776, and SEQ ID    NO: 1932;-   (d) as depicted in SEQ ID NO: 982, SEQ ID NO: 1073, SEQ ID NO: 1151,    SEQ ID NO: 1164, SEQ ID NO: 1190, SEQ ID NO: 1203, SEQ ID NO: 1216,    SEQ ID NO: 1229, SEQ ID NO: 1242, SEQ ID NO: 1320, SEQ ID NO: 1333,    SEQ ID NO: 1385, SEQ ID NO: 1398, SEQ ID NO: 1411, SEQ ID NO: 1424,    SEQ ID NO: 1474, SEQ ID NO: 1475, SEQ ID NO: 1476, SEQ ID NO: 1483,    SEQ ID NO: 1490, SEQ ID NO: 1491, SEQ ID NO: 1492, SEQ ID NO: 1499,    SEQ ID NO: 1506, SEQ ID NO: 1513, SEQ ID NO: 1514, SEQ ID NO: 1515,    SEQ ID NO: 1516, SEQ ID NO: 1517, SEQ ID NO: 1524, SEQ ID NO: 1531,    SEQ ID NO: 1538, SEQ ID NO: 1539, SEQ ID NO: 1540, SEQ ID NO: 1547,    SEQ ID NO: 1554, SEQ ID NO: 1555, SEQ ID NO: 1556, SEQ ID NO: 1563,    SEQ ID NO: 1570, SEQ ID NO: 1571, SEQ ID NO: 1572, SEQ ID NO: 1573,    SEQ ID NO: 1574, SEQ ID NO: 1575, SEQ ID NO: 1576, SEQ ID NO: 1577,    SEQ ID NO: 1578, SEQ ID NO: 1579, SEQ ID NO: 1580, SEQ ID NO: 1581,    SEQ ID NO: 1789, SEQ ID NO: 1802, SEQ ID NO: 1815, SEQ ID NO: 1828,    SEQ ID NO: 1841, SEQ ID NO: 1854, SEQ ID NO: 1867, SEQ ID NO: 1880,    SEQ ID NO: 1893, SEQ ID NO: 2075, SEQ ID NO: 2088, SEQ ID NO: 2101,    SEQ ID NO: 2114, SEQ ID NO: 2127, SEQ ID NO: 2140, SEQ ID NO: 2153,    SEQ ID NO: 2166, SEQ ID NO: 2192, SEQ ID NO: 2205, and SEQ ID NO:    2218 to 2228; and-   (e) as depicted in SEQ ID NO: 995, SEQ ID NO: 1594, and SEQ ID NO:    1607.

The invention further provides a nucleic acid sequence encoding anantibody construct of the invention.

Furthermore, the invention provides a vector comprising a nucleic acidsequence of the invention. Moreover, the invention provides a host celltransformed or transfected with the nucleic acid sequence of theinvention.

In a further embodiment the invention provides a process for theproduction of a antibody construct of the invention, said processcomprising culturing a host cell of the invention under conditionsallowing the expression of the antibody construct of the invention andrecovering the produced antibody construct from the culture.

Moreover, the invention provides a pharmaceutical composition comprisingan antibody construct of the invention or produced according to theprocess of the invention

In one embodiment the invention provides the antibody construct of theinvention or produced according to the process of the invention for usein the prevention, treatment or amelioration of a melanoma disease ormetastatic melanoma disease.

The invention also provides a method for the treatment or ameliorationof a melanoma disease or metastatic melanoma disease, comprising thestep of administering to a subject in need thereof the antibodyconstruct of the invention or produced according to the process of theinvention.

In a preferred embodiment method of use of the invention the melanomadisease or metastatic melanoma disease is selected from the groupconsisting of superficial spreading melanoma, lentigo maligna, lentigomaligna melanoma, acral lentiginous melanoma and nodular melanoma.

In a further embodiment, the invention provides a kit comprising anantibody construct of the invention, or produced according to theprocess of the invention, a vector of the invention, and/or a host cellof the invention.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 depicts cell viability data of Colo-699 cells that have beentreated with fully human anti-CDH19 antibodies and a high concentrationof a goat anti-human Fc monovalent Fab conjugated with DM1 (DM1-Fab) ata drug-antibody ratio (DAR) (˜1.3).

FIG. 2 depicts the average cell viability data from a CHL-1 assayplotted against the average cell viability data from the Colo-699 assay.

FIG. 3 shows the relative expression of CDH19 mRNA in metastatic andprimary melanoma samples.

FIG. 4 shows the expression of CDH19 protein in human tumor samples byIHC.

FIG. 5 shows the results of the analysis of tumor cell lines by flowcytometry and IHC to identify model systems with CDH19 expressionsimilar to human tumors based on the number of CDH19 receptors presenton the cell surface.

FIG. 6:

FACS analysis of CDH19/CD3 bispecific antibodies on indicated celllines:

1) untransfected L1.2. 2) L1.2 cells stably transfected with humanCDH19, 3) melanoma cell line CHL-1, 4) melanoma cell line A2058, 5)human CD3 positive human T cell line HBP-ALL, 6) macaque T cell line4119 LnPx. Negative controls [1) to 6)]: detection antibodies withoutprior CDH19/CD3 bispecific antibody.

FIG. 7:

Cytotoxic activity of CDH19/CD3 bispecific antibodies as measured in a48-hour FACS-based cytotoxicity assay. Effector cells: unstimulatedhuman PBMC. Target cells: as indicated. Effector to target cell(E:T)-ratio: 10:1.

FIG. 8:

Tumor growth in vivo inhibition of Colo699 cells by administration ofCDH19 BiTE 2G6. The bispecific antibody construct inhibits growth oftumors at 0.5 mg/kg dose.

FIG. 9:

Tumor growth in vivo inhibition of CHL-1 cells by administration ofCDH19 BiTE 2G6. The bispecific antibody construct inhibits growth oftumors at 0.5 mg/kg dose.

FIGS. 10A-10B:

Cytotoxic activity of CDH19/CD3 bispecific antibodies as measured in a48-hour imaging-based cytotoxicity assay. Effector cells: unstimulatedhuman T cells. Target cells: as indicated. Effector to target cell(E:T)-ratio: 10:1.

FIG. 11:

Chromatogram IMAC capture and elution CH19 2G6 302×I2C SA21

Typical IMAC elution profile obtained during purification of an CDH19BiTE antibody. The red line indicates absorption at 254 nm, the blueline indicates absorption at 280 nm. Brown line indicates conductivity.1—Capture. 2—Pre-Elution 50 mM Imidazole. 3. BiTE Elution 500 mMImidazole

FIG. 12:

Chromatogram Protein_A capture and elution CH19 2G6 302×F120

Typical Protein_A elution profile obtained during purification of anCDH19 BiTE antibody. The red line indicates absorption at 254 nm, theblue line indicates absorption at 280 nm. Brown line indicatesconductivity. Green line indicates the applied gradient percentage.1—Capture. 2—BiTE Elution

FIG. 13:

SEC elution profile of CDH19 BiTE antibody 2G6 302×I2C SA21

Typical SEC elution profile obtained during purification of an CDH19BiTE antibody. Protein peaks corresponding to the monomeric and dimericBiTE antibody isoforms are indicated. LMW=low molecular weight. The redline indicates absorption at 254 nm, the blue line indicates absorptionat 280 nm. Brown line indicates conductivity. 1—non BiTE aggregates inSEC exclusion volume. 2. BiTE dimer. 3. BiTE monomer. 4. Low molecularweight contaminants and salts

FIG. 14:

Reduced SDS PAGE analytics of CDH19 BiTE Monomer CH19 2G6 302×I2C SA21(left) and molecular weight marker Novex Sharp Protein Standard (LifeTechnologies).

FIG. 15:

HP-SEC chromatogram showing the elution of CDH19 BiTE CH19 2G6 302×I2CSA21 after seven day of storage at 37° C. Pink line indicating opticalabsorption at 210 nm wavelength.

Brown line indicating conductivity.

1 BiTE Dimer. 2. BiTE Monomer

FIG. 16:

HP-SEC chromatogram showing the elution of CDH19 BiTE CH19 2G6 302×I2CSA21 after three freeze/thaw cycles. Pink line indicating opticalabsorption at 210 nm wavelength. Brown line indicating conductivity. 1.BiTE Monomer

FIG. 17:

CatIEX chromatogramm of elution of CDH19 BiTE CH19 2G6 302×I2C SA21.Blue line indicating optical absorption at 280 nm. Red line indicatingoptical absorption at 254 nm.

FIG. 18:

HIC elution profile of CDH19 BiTE CH19 2G6 302×I2C SA21. Blue lineindicating optical absorption at 280 nm. Red line indicating opticalabsorption at 254 nm. Brown line indicating conductivity.

FIG. 19:

FACS analysis of CDH19/CD3 bispecific antibodies on indicated celllines: 1) HEK293 cells stably transfected with human CDH19, 2) human CD3positive human T cell line HBP-ALL; Negative controls [1) and 2)]:detection antibodies without prior CDH19/CD3 bispecific antibody cellculture supernatant.

FIG. 20:

Cytotoxic activity of CDH19/CD3 bispecific antibodies as measured in an18-hour Chromium release-based cytotoxicity assay. Effector cells:stimulated human CD8+ T-cells. Target cells: HEK293 transfected withhuman CDH19. Effector to target cell (E:T)-ratio: 10:1.

DETAILED DESCRIPTION OF THE INVENTION Definitions

It must be noted that as used herein, the singular forms “a”, “an”, and“the”, include plural references unless the context clearly indicatesotherwise. Thus, for example, reference to “a reagent” includes one ormore of such different reagents and reference to “the method” includesreference to equivalent steps and methods known to those of ordinaryskill in the art that could be modified or substituted for the methodsdescribed herein.

Unless otherwise indicated, the term “at least” preceding a series ofelements is to be understood to refer to every element in the series.Those skilled in the art will recognize, or be able to ascertain usingno more than routine experimentation, many equivalents to the specificembodiments of the invention described herein. Such equivalents areintended to be encompassed by the present invention.

The term “and/or” wherever used herein includes the meaning of “and”,“or” and “all or any other combination of the elements connected by saidterm”.

The term “about” or “approximately” as used herein means within ±20%,preferably within ±15%, more preferably within ±10%, and most preferablywithin ±5% of a given value or range.

Throughout this specification and the claims which follow, unless thecontext requires otherwise, the word “comprise”, and variations such as“comprises” and “comprising”, will be understood to imply the inclusionof a stated integer or step or group of integers or steps but not theexclusion of any other integer or step or group of integer or step. Whenused herein the term “comprising” can be substituted with the term“containing” or “including” or sometimes when used herein with the term“having”.

When used herein “consisting of” excludes any element, step, oringredient not specified in the claim element. When used herein,“consisting essentially of” does not exclude materials or steps that donot materially affect the basic and novel characteristics of the claim.

In each instance herein any of the terms “comprising”, “consistingessentially of” and “consisting of” may be replaced with either of theother two terms.

The definition of the term “antibody” includes embodiments such asmonoclonal, chimeric, single chain, humanized and human antibodies, aswell as antibody fragments, like, inter alia, Fab fragments. Antibodyfragments or derivatives further comprise F(ab′)₂, Fv, scFv fragments orsingle domain antibodies such as domain antibodies or nanobodies, singlevariable domain antibodies or immunoglobulin single variable domaincomprising merely one variable domain, which might be VHH, VH or VL,that specifically bind an antigen or epitope independently of other Vregions or domains; see, for example, Harlow and Lane (1988) and (1999),loc. cit.; Kontermann and Dübel, Antibody Engineering, Springer, 2nd ed.2010 and Little, Recombinant Antibodies for Immunotherapy, CambridgeUniversity Press 2009. Such immunoglobulin single variable domainencompasses not only an isolated antibody single variable domainpolypeptide, but also larger polypeptides that comprise one or moremonomers of an antibody single variable domain polypeptide sequence.

In line with this definition all above described embodiments of the termantibody can be subsumed under the term “antibody construct”. Said termalso includes diabodies or Dual-Affinity Re-Targeting (DART) antibodies.Further envisaged are (bispecific) single chain diabodies, tandemdiabodies (Tandab's), “minibodies” exemplified by a structure which isas follows: (VH-VL-CH3)₂, (scFv-CH3)₂ or (scFv-CH3-scFv)₂, “Fc DART”antibodies and “IgG DART” antibodies, and multibodies such astriabodies. Immunoglobulin single variable domains encompass not only anisolated antibody single variable domain polypeptide, but also largerpolypeptides that comprise one or more monomers of an antibody singlevariable domain polypeptide sequence.

Various procedures are known in the art and may be used for theproduction of such antibody constructs (antibodies and/or fragments).Thus, (antibody) derivatives can be produced by peptidomimetics.Further, techniques described for the production of single chainantibodies (see, inter alia, U.S. Pat. No. 4,946,778, Kontermann andDübel (2010), loc. cit. and Little(2009), loc. cit.) can be adapted toproduce single chain antibodies specific for elected polypeptide(s).Also, transgenic animals may be used to express humanized antibodiesspecific for polypeptides and fusion proteins of this invention. For thepreparation of monoclonal antibodies, any technique, providingantibodies produced by continuous cell line cultures can be used.Examples for such techniques include the hybridoma technique (Köhler andMilstein Nature 256 (1975), 495-497), the trioma technique, the humanB-cell hybridoma technique (Kozbor, Immunology Today 4 (1983), 72) andthe EBV-hybridoma technique to produce human monoclonal antibodies (Coleet al., Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, Inc.(1985), 77-96). Surface plasmon resonance as employed in the BIAcoresystem can be used to increase the efficiency of phage antibodies whichbind to an epitope of a target polypeptide, such as CD3 epsilon (Schier,Human Antibodies Hybridomas 7 (1996), 97-105; Malmborg, J. Immunol.Methods 183 (1995), 7-13). It is also envisaged in the context of thisinvention that the term “antibody” comprises antibody constructs, whichmay be expressed in a host as described herein below, e.g. antibodyconstructs which may be transfected and/or transduced via, inter alia,viruses or plasmid vectors.

Furthermore, the term “antibody” as employed in the invention alsorelates to derivatives or variants of the antibodies described hereinwhich display the same specificity as the described antibodies.

The terms “antigen-binding domain”, “antigen-binding fragment” and“antibody binding region” when used herein refer to a part of anantibody molecule that comprises amino acids responsible for thespecific binding between antibody and antigen. The part of the antigenthat is specifically recognized and bound by the antibody is referred toas the “epitope” as described herein above. As mentioned above, anantigen-binding domain may typically comprise an antibody light chainvariable region (VL) and an antibody heavy chain variable region (VH);however, it does not have to comprise both. Fd fragments, for example,have two VH regions and often retain some antigen-binding function ofthe intact antigen-binding domain. Examples of antigen-binding fragmentsof an antibody include (1) a Fab fragment, a monovalent fragment havingthe VL, VH, CL and CH1 domains; (2) a F(ab′)2 fragment, a bivalentfragment having two Fab fragments linked by a disulfide bridge at thehinge region; (3) a Fd fragment having the two VH and CH1 domains; (4) aFv fragment having the VL and VH domains of a single arm of an antibody,(5) a dAb fragment (Ward et al., (1989) Nature 341:544-546), which has aVH domain; (6) an isolated complementarity determining region (CDR), and(7) a single chain Fv (scFv). Although the two domains of the Fvfragment, VL and VH are coded for by separate genes, they can be joined,using recombinant methods, by a synthetic linker that enables them to bemade as a single protein chain in which the VL and VH regions pair toform monovalent molecules (known as single chain Fv (scFv); see e.g.,Huston et al. (1988) Proc. Natl. Acad. Sci USA 85:5879-5883). Theseantibody fragments are obtained using conventional techniques known tothose with skill in the art, and the fragments are evaluated forfunction in the same manner as are intact antibodies.

The term “monoclonal antibody” as used herein refers to an antibodyobtained from a population of substantially homogeneous antibodies,i.e., the individual antibodies comprising the population are identicalexcept for possible naturally occurring mutations and/orpost-translation modifications (e.g., isomerizations, amidations) thatmay be present in minor amounts. Monoclonal antibodies are highlyspecific, being directed against a single antigenic site. Furthermore,in contrast to conventional (polyclonal) antibody preparations whichtypically include different antibodies directed against differentdeterminants (epitopes), each monoclonal antibody is directed against asingle determinant on the antigen. In addition to their specificity, themonoclonal antibodies are advantageous in that they are synthesized bythe hybridoma culture, uncontaminated by other immunoglobulins. Themodifier “monoclonal” indicates the character of the antibody as beingobtained from a substantially homogeneous population of antibodies, andis not to be construed as requiring production of the antibody by anyparticular method. For example, the monoclonal antibodies to be used inaccordance with the present invention may be made by the hybridomamethod first described by Kohler et al., Nature, 256: 495 (1975), or maybe made by recombinant DNA methods (see, e.g., U.S. Pat. No. 4,816,567).The “monoclonal antibodies” may also be isolated from phage antibodylibraries using the techniques described in Clackson et al., Nature,352: 624-628 (1991) and Marks et al., J. Mol. Biol., 222: 581-597(1991), for example.

The term “human antibody” includes antibodies having variable andconstant regions corresponding substantially to human germlineimmunoglobulin sequences known in the art, including, for example, thosedescribed by Kabat et al. (See Kabat et al. (1991) loc. cit.). The humanantibodies of the invention may include amino acid residues not encodedby human germline immunoglobulin sequences (e.g., mutations introducedby random or site-specific mutagenesis in vitro or by somatic mutationin vivo), for example in the CDRs, and in particular, CDR3. The humanantibody can have at least one, two, three, four, five, or morepositions replaced with an amino acid residue that is not encoded by thehuman germline immunoglobulin sequence. It is emphasized that thedefinition of human antibodies as used herein also contemplates fullyhuman antibodies, which include only non-artificially and/or geneticallyaltered human sequences of antibodies as those can be derived by usingtechnologies using systems such as the Xenomice.

Examples of “antibody variants” include humanized variants of non-humanantibodies, “affinity matured” antibodies (see, e.g. Hawkins et al. J.Mol. Biol. 254, 889-896 (1992) and Lowman et al., Biochemistry 30,10832-10837 (1991)) and antibody mutants with altered effector function(s) (see, e.g., U.S. Pat. No. 5,648,260, Kontermann and Dübel (2010),loc. cit. and Little(2009), loc. cit.).

As used herein, “in vitro generated antibody” refers to an antibodywhere all or part of the variable region (e.g., at least one CDR) isgenerated in a non-immune cell selection (e.g., an in vitro phagedisplay, protein chip or any other method in which candidate sequencescan be tested for their ability to bind to an antigen). This term thuspreferably excludes sequences generated by genomic rearrangement in animmune cell.

The pairing of a VH and VL together forms a single antigen-binding site.The CH domain most proximal to VH is designated as CH1. Each L chain islinked to an H chain by one covalent disulfide bond, while the two Hchains are linked to each other by one or more disulfide bonds dependingon the H chain isotype. The VH and VL domains consist of four regions ofrelatively conserved sequences called framework regions (FR1, FR2, FR3,and FR4), which form a scaffold for three regions of hypervariablesequences (complementarity determining regions, CDRs). The CDRs containmost of the residues responsible for specific interactions of theantibody with the antigen. CDRs are referred to as CDR 1, CDR2, andCDR3. Accordingly, CDR constituents on the heavy chain are referred toas H1, H2, and H3, while CDR constituents on the light chain arereferred to as L1, L2, and L3.

The term “variable” refers to the portions of the immunoglobulin domainsthat exhibit variability in their sequence and that are involved indetermining the specificity and binding affinity of a particularantibody (i.e., the “variable domain(s)”). Variability is not evenlydistributed throughout the variable domains of antibodies; it isconcentrated in sub-domains of each of the heavy and light chainvariable regions. These sub-domains are called “hypervariable” regionsor “complementarity determining regions” (CDRs). The more conserved(i.e., non-hypervariable) portions of the variable domains are calledthe “framework” regions (FRM). The variable domains of naturallyoccurring heavy and light chains each comprise four FRM regions, largelyadopting a β-sheet configuration, connected by three hypervariableregions, which form loops connecting, and in some cases forming part of,the β-sheet structure. The hypervariable regions in each chain are heldtogether in close proximity by the FRM and, with the hypervariableregions from the other chain, contribute to the formation of theantigen-binding site (see Kabat et al., loc. cit.). The constant domainsare not directly involved in antigen binding, but exhibit variouseffector functions, such as, for example, antibody-dependent,cell-mediated cytotoxicity and complement activation.

The terms “CDR”, and its plural “CDRs”, refer to a complementaritydetermining region (CDR) of which three make up the binding character ofa light chain variable region (CDRL1, CDRL2 and CDRL3) and three make upthe binding character of a heavy chain variable region (CDRH1, CDRH2 andCDRH3). CDRs contribute to the functional activity of an antibodymolecule and are separated by amino acid sequences that comprisescaffolding or framework regions. The exact definitional CDR boundariesand lengths are subject to different classification and numberingsystems. CDRs may therefore be referred to by Kabat, Chothia, contact orany other boundary definitions, including the numbering system describedherein. Despite differing boundaries, each of these systems has somedegree of overlap in what constitutes the so called “hypervariableregions” within the variable sequences. CDR definitions according tothese systems may therefore differ in length and boundary areas withrespect to the adjacent framework region. See for example Kabat,Chothia, and/or MacCallum (Kabat et al., loc. cit.; Chothia et al., J.Mol. Biol, 1987, 196: 901; and MacCallum et al., J. Mol. Biol, 1996,262: 732). However, the numbering in accordance with the so-called Kabatsystem is preferred. The CDR3 of the light chain and, particularly, CDR3of the heavy chain may constitute the most important determinants inantigen binding within the light and heavy chain variable regions. Insome antibody constructs, the heavy chain CDR3 appears to constitute themajor area of contact between the antigen and the antibody. In vitroselection schemes in which CDR3 alone is varied can be used to vary thebinding properties of an antibody or determine which residues contributeto the binding of an antigen.

“Consisting essentially of” means that the amino acid sequence can varyby about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15% relativeto the recited SEQ ID NO: sequence and still retain biological activity,as described herein.

In some embodiments, the antibody constructs of the invention areisolated proteins or substantially pure proteins. An “isolated” proteinis unaccompanied by at least some of the material with which it isnormally associated in its natural state, for example constituting atleast about 5%, or at least about 50% by weight of the total protein ina given sample. It is understood that the isolated protein mayconstitute from 5 to 99.9% by weight of the total protein contentdepending on the circumstances. For example, the protein may be made ata significantly higher concentration through the use of an induciblepromoter or high expression promoter, such that the protein is made atincreased concentration levels. The definition includes the productionof an antigen binding protein in a wide variety of organisms and/or hostcells that are known in the art.

For amino acid sequences, sequence identity and/or similarity isdetermined by using standard techniques known in the art, including, butnot limited to, the local sequence identity algorithm of Smith andWaterman, 1981, Adv. Appl. Math. 2:482, the sequence identity alignmentalgorithm of Needleman and Wunsch, 1970, J. Mol. Biol. 48:443, thesearch for similarity method of Pearson and Lipman, 1988, Proc. Nat.Acad. Sci. U.S.A. 85:2444, computerized implementations of thesealgorithms (GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin GeneticsSoftware Package, Genetics Computer Group, 575 Science Drive, Madison,Wis.), the Best Fit sequence program described by Devereux et al., 1984,Nucl. Acid Res. 12:387-395, preferably using the default settings, or byinspection. Preferably, percent identity is calculated by FastDB basedupon the following parameters: mismatch penalty of 1; gap penalty of 1;gap size penalty of 0.33; and joining penalty of 30, “Current Methods inSequence Comparison and Analysis,” Macromolecule Sequencing andSynthesis, Selected Methods and Applications, pp 127-149 (1988), Alan R.Liss, Inc.

An example of a useful algorithm is PILEUP. PILEUP creates a multiplesequence alignment from a group of related sequences using progressive,pairwise alignments. It can also plot a tree showing the clusteringrelationships used to create the alignment. PILEUP uses a simplificationof the progressive alignment method of Feng & Doolittle, 1987, J. Mol.Evol. 35:351-360; the method is similar to that described by Higgins andSharp, 1989, CAB/OS 5:151-153. Useful PILEUP parameters including adefault gap weight of 3.00, a default gap length weight of 0.10, andweighted end gaps.

Another example of a useful algorithm is the BLAST algorithm, describedin: Altschul et al., 1990, J. Mol. Biol. 215:403-410; Altschul et al.,1997, Nucleic Acids Res. 25:3389-3402; and Karin et al., 1993, Proc.Natl. Acad. Sci. U.S.A. 90:5873-5787. A particularly useful BLASTprogram is the WU-BLAST-2 program which was obtained from Altschul etal., 1996, Methods in Enzymology 266:460-480. WU-BLAST-2 uses severalsearch parameters, most of which are set to the default values. Theadjustable parameters are set with the following values: overlap span=1,overlap fraction=0.125, word threshold (T)=II. The HSP S and HSP S2parameters are dynamic values and are established by the program itselfdepending upon the composition of the particular sequence andcomposition of the particular database against which the sequence ofinterest is being searched; however, the values may be adjusted toincrease sensitivity.

An additional useful algorithm is gapped BLAST as reported by Altschulet al., 1993, Nucl. Acids Res. 25:3389-3402. Gapped BLAST uses BLOSUM-62substitution scores; threshold T parameter set to 9; the two-hit methodto trigger ungapped extensions, charges gap lengths of k a cost of 10+k;Xu set to 16, and Xg set to 40 for database search stage and to 67 forthe output stage of the algorithms. Gapped alignments are triggered by ascore corresponding to about 22 bits.

Generally, the amino acid homology, similarity, or identity betweenindividual variant CDRs are at least 80% to the sequences depictedherein, and more typically with preferably increasing homologies oridentities of at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%,99%, and almost 100%. In a similar manner, “percent (%) nucleic acidsequence identity” with respect to the nucleic acid sequence of thebinding proteins identified herein is defined as the percentage ofnucleotide residues in a candidate sequence that are identical with thenucleotide residues in the coding sequence of the antigen bindingprotein. A specific method utilizes the BLASTN module of WU-BLAST-2 setto the default parameters, with overlap span and overlap fraction set to1 and 0.125, respectively.

Generally, the nucleic acid sequence homology, similarity, or identitybetween the nucleotide sequences encoding individual variant CDRs andthe nucleotide sequences depicted herein are at least 80%, and moretypically with preferably increasing homologies or identities of atleast 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%,93%, 94%, 95%, 96%, 97%, 98%, or 99%, and almost 100%.

Thus, a “variant CDR” is one with the specified homology, similarity, oridentity to the parent CDR of the invention, and shares biologicalfunction, including, but not limited to, at least 80%, 81%, 82%, 83%,84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%,98%, or 99% of the specificity and/or activity of the parent CDR.

While the site or region for introducing an amino acid sequencevariation is predetermined, the mutation per se need not bepredetermined. For example, in order to optimize the performance of amutation at a given site, random mutagenesis may be conducted at thetarget codon or region and the expressed antigen binding protein CDRvariants screened for the optimal combination of desired activity.Techniques for making substitution mutations at predetermined sites inDNA having a known sequence are well known, for example, M13 primermutagenesis and PCR mutagenesis. Screening of the mutants is done usingassays of antigen binding protein activities, such as CDH19 binding.

The term “amino acid” or “amino acid residue” typically refers to anamino acid having its art recognized definition such as an amino acidselected from the group consisting of: alanine (Ala or A); arginine (Argor R); asparagine (Asn or N); aspartic acid (Asp or D); cysteine (Cys orC); glutamine (Gln or Q); glutamic acid (Glu or E); glycine (Gly or G);histidine (His or H); isoleucine (He or I): leucine (Leu or L); lysine(Lys or K); methionine (Met or M); phenylalanine (Phe or F); pro line(Pro or P); serine (Ser or S); threonine (Thr or T); tryptophan (Trp orW); tyrosine (Tyr or Y); and valine (Val or V), although modified,synthetic, or rare amino acids may be used as desired. Generally, aminoacids can be grouped as having a nonpolar side chain (e.g., Ala, Cys,He, Leu, Met, Phe, Pro, Val); a negatively charged side chain (e.g.,Asp, Glu); a positively charged sidechain (e.g., Arg, His, Lys); or anuncharged polar side chain (e.g., Asn, Cys, Gln, Gly, His, Met, Phe,Ser, Thr, Trp, and Tyr).

The term “hypervariable region” (also known as “complementaritydetermining regions” or CDRs) when used herein refers to the amino acidresidues of an antibody which are (usually three or four short regionsof extreme sequence variability) within the V-region domain of animmunoglobulin which form the antigen-binding site and are the maindeterminants of antigen specificity. There are at least two methods foridentifying the CDR residues: (1) An approach based on cross-speciessequence variability (i. e., Kabat et al., loc. cit.); and (2) Anapproach based on crystallographic studies of antigen-antibody complexes(Chothia, C. et al., J. Mol. Biol. 196: 901-917 (1987)). However, to theextent that two residue identification techniques define regions ofoverlapping, but not identical regions, they can be combined to define ahybrid CDR. However, in general, the CDR residues are preferablyidentified in accordance with the so-called Kabat (numbering) system.

The term “framework region” refers to the art-recognized portions of anantibody variable region that exist between the more divergent (i.e.,hypervariable) CDRs. Such framework regions are typically referred to asframeworks 1 through 4 (FR1, FR2, FR3, and FR4) and provide a scaffoldfor the presentation of the six CDRs (three from the heavy chain andthree from the light chain) in three dimensional space, to form anantigen-binding surface.

Typically, CDRs form a loop structure that can be classified as acanonical structure. The term “canonical structure” refers to the mainchain conformation that is adopted by the antigen binding (CDR) loops.From comparative structural studies, it has been found that five of thesix antigen binding loops have only a limited repertoire of availableconformations. Each canonical structure can be characterized by thetorsion angles of the polypeptide backbone. Correspondent loops betweenantibodies may, therefore, have very similar three dimensionalstructures, despite high amino acid sequence variability in most partsof the loops (Chothia and Lesk, J. Mol. Biol., 1987, 196: 901; Chothiaet al., Nature, 1989, 342: 877; Martin and Thornton, J. Mol. Biol, 1996,263: 800, each of which is incorporated by reference in its entirety).Furthermore, there is a relationship between the adopted loop structureand the amino acid sequences surrounding it. The conformation of aparticular canonical class is determined by the length of the loop andthe amino acid residues residing at key positions within the loop, aswell as within the conserved framework (i.e., outside of the loop).Assignment to a particular canonical class can therefore be made basedon the presence of these key amino acid residues. The term “canonicalstructure” may also include considerations as to the linear sequence ofthe antibody, for example, as catalogued by Kabat (Kabat et al., loc.cit.). The Kabat numbering scheme (system) is a widely adopted standardfor numbering the amino acid residues of an antibody variable domain ina consistent manner and is the preferred scheme applied in the presentinvention as also mentioned elsewhere herein. Additional structuralconsiderations can also be used to determine the canonical structure ofan antibody. For example, those differences not fully reflected by Kabatnumbering can be described by the numbering system of Chothia et aland/or revealed by other techniques, for example, crystallography andtwo or three-dimensional computational modeling. Accordingly, a givenantibody sequence may be placed into a canonical class which allows for,among other things, identifying appropriate chassis sequences (e.g.,based on a desire to include a variety of canonical structures in alibrary). Kabat numbering of antibody amino acid sequences andstructural considerations as described by Chothia et al., loc. cit. andtheir implications for construing canonical aspects of antibodystructure, are described in the literature.

CDR3 is typically the greatest source of molecular diversity within theantibody-binding site. H3, for example, can be as short as two aminoacid residues or greater than 26 amino acids. The subunit structures andthree-dimensional configurations of different classes of immunoglobulinsare well known in the art. For a review of the antibody structure, seeAntibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, eds.Harlow et al., 1988. One of skill in the art will recognize that eachsubunit structure, e.g., a CH, VH, CL, VL, CDR, FR structure, comprisesactive fragments, e.g., the portion of the VH, VL, or CDR subunit thebinds to the antigen, i.e., the antigen-binding fragment, or, e.g., theportion of the CH subunit that binds to and/or activates, e.g., an Fcreceptor and/or complement. The CDRs typically refer to the Kabat CDRs,as described in Sequences of Proteins of immunological Interest, USDepartment of Health and Human Services (1991), eds. Kabat et al.Another standard for characterizing the antigen binding site is to referto the hypervariable loops as described by Chothia. See, e.g., Chothia,et al. (1987; J. Mol. Biol. 227:799-817); and Tomlinson et al. (1995)EMBO J. 14: 4628-4638. Still another standard is the AbM definition usedby Oxford Molecular's AbM antibody modeling software. See, generally,e.g., Protein Sequence and Structure Analysis of Antibody VariableDomains. In: Antibody Engineering Lab Manual (Ed.: Duebel, S. andKontermann, R., Springer-Verlag, Heidelberg). Embodiments described withrespect to Kabat CDRs can alternatively be implemented using similardescribed relationships with respect to Chothia hypervariable loops orto the AbM-defined loops.

The sequence of antibody genes after assembly and somatic mutation ishighly varied, and these varied genes are estimated to encode 10¹⁰different antibody molecules (Immunoglobulin Genes, 2^(nd) ed., eds.Jonio et al., Academic Press, San Diego, Calif., 1995). Accordingly, theimmune system provides a repertoire of immunoglobulins. The term“repertoire” refers to at least one nucleotide sequence derived whollyor partially from at least one sequence encoding at least oneimmunoglobulin. The sequence(s) may be generated by rearrangement invivo of the V, D, and J segments of heavy chains, and the V and Jsegments of light chains. Alternatively, the sequence(s) can begenerated from a cell in response to which rearrangement occurs, e.g.,in vitro stimulation. Alternatively, part or all of the sequence(s) maybe obtained by DNA splicing, nucleotide synthesis, mutagenesis, andother methods, see, e.g., U.S. Pat. No. 5,565,332. A repertoire mayinclude only one sequence or may include a plurality of sequences,including ones in a genetically diverse collection.

The term “binding molecule” or “antibody construct” in the sense of thepresent disclosure indicates any molecule capable of (specifically)binding to, interacting with or recognizing the target molecules CDH19and CD3. Such molecules or constructs may include proteinaceous partsand non-proteinaceous parts (e.g. chemical linkers or chemicalcross-linking agents such as glutaraldehyde).

In the event that a linker is used, this linker is preferably of alength and sequence sufficient to ensure that each of the first andsecond domains can, independently from one another, retain theirdifferential binding specificities. Most preferably and as documented inthe appended examples, the antibody construct of the invention is a“bispecific single chain antibody construct”, more preferably abispecific single chain Fv (scFv). Bispecific single chain molecules areknown in the art and are described in WO 99/54440, Mack, J. Immunol.(1997), 158, 3965-3970, Mack, PNAS, (1995), 92, 7021-7025, Kufer, CancerImmunol. Immunother., (1997), 45, 193-197, Löffler, Blood, (2000), 95,6, 2098-2103, Brühl, Immunol., (2001), 166, 2420-2426, Kipriyanov, J.Mol. Biol., (1999), 293, 41-56.

The said variable domains comprised in the herein described antibodyconstructs may be connected by additional linker sequences. The term“peptide linker” defines in accordance with the present invention anamino acid sequence by which the amino acid sequences of the firstdomain and the second domain of the antibody construct of the inventionare linked with each other. An essential technical feature of suchpeptide linker is that said peptide linker does not comprise anypolymerization activity. Among the suitable peptide linkers are thosedescribed in U.S. Pat. Nos. 4,751,180 and 4,935,233 or WO 88/09344. Apreferred embodiment of a peptide linker is characterized by the aminoacid sequence Gly-Gly-Gly-Gly-Ser, i.e. Gly₄Ser, or polymers thereof,i.e. (Gly₄Ser)x, where x is an integer 1 or greater. The characteristicsof said peptide linker, which comprise the absence of the promotion ofsecondary structures are known in the art and described e.g. inDall'Acqua et al. (Biochem. (1998) 37, 9266-9273), Cheadle et al. (MolImmunol (1992) 29, 21-30) and Raag and Whitlow (FASEB (1995) 9(1),73-80). Peptide linkers which also do not promote any secondarystructures are preferred. The linkage of said domains to each other canbe provided by, e.g. genetic engineering, as described in the examples.Methods for preparing fused and operatively linked bispecific singlechain constructs and expressing them in mammalian cells or bacteria arewell-known in the art (e.g. WO 99/54440 or Sambrook et al., MolecularCloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, ColdSpring Harbor, N.Y., 2001).

For peptide linkers, which connect the at least two binding domains inthe antibody construct of the invention peptide linkers are preferredwhich comprise only a few number of amino acid residues, e.g. 12 aminoacid residues or less. Thus, peptide linker of 12, 11, 10, 9, 8, 7, 6 or5 amino acid residues are preferred. An envisaged peptide linker withless than 5 amino acids comprises 4, 3, 2 or one amino acid(s) whereinGly-rich linkers are preferred. A particularly preferred “single” aminoacid in context of said “peptide linker” is Gly. Accordingly, saidpeptide linker may consist of the single amino acid Gly.

The term “multispecific” as used herein refers to a binding moleculewhich is an antibody construct and comprises at least a first and asecond binding domain, wherein the first binding domain is capable ofbinding to one antigen or target, and the second binding domain iscapable of binding to another antigen or target. Accordingly, antibodyconstructs according to the invention comprise at least specificitiesfor two different antigens or targets and are at least bispecific. The“antibody construct” of the invention also comprises multispecificbinding molecules such as e.g. trispecific binding molecules, the latterones including three binding domains.

It is also envisaged that the antibody construct of the invention has,in addition to its function to bind to the target molecules CDH19 andCD3, a further function. In this format, the antibody construct is atri- or multifunctional antibody construct by targeting plasma cellsthrough binding to CDH19, mediating cytotoxic T cell activity throughCD3 binding and providing a further function such as a fully functionalFc constant domain mediating antibody-dependent cellular cytotoxicitythrough recruitment of effector cells like NK cells, a label(fluorescent etc.), a therapeutic agent such as, e.g. a toxin orradionuclide, and/or means to enhance serum half-life, etc.

The term “binding domain” characterizes in connection with the presentinvention a domain which is capable of specifically bindingto/interacting with a given target epitope or a given target site on thetarget molecules CDH19 and CD3.

Binding domains can be derived from a binding domain donor such as forexample an antibody. It is envisaged that a binding domain of thepresent invention comprises at least said part of any of theaforementioned binding domains that is required for bindingto/interacting with a given target epitope or a given target site on thetarget molecules CDH19 and CD3.

It is envisaged that the binding domain of the aforementioned bindingdomain donors is characterized by that part of these donors that isresponsible for binding the respective target, i.e. when that part isremoved from the binding domain donor, said donor loses its bindingcapability. “Loses” means a reduction of at least 50% of the bindingcapability when compared with the binding donor. Methods to map thesebinding sites are well known in the art—it is therefore within thestandard knowledge of the skilled person to locate/map the binding siteof a binding domain donor and, thereby, to “derive” said binding domainfrom the respective binding domain donors.

The term “epitope” refers to a site on an antigen to which a bindingdomain, such as an antibody or immunoglobulin or derivative or fragmentof an antibody or of an immunoglobulin, specifically binds. An “epitope”is antigenic and thus the term epitope is sometimes also referred toherein as “antigenic structure” or “antigenic determinant”. Thus, thebinding domain is an “antigen-interaction-site”. Saidbinding/interaction is also understood to define a “specificrecognition”. In one example, said binding domain which (specifically)binds to/interacts with a given target epitope or a given target site onthe target molecules CDH19 and CD3 is an antibody or immunoglobulin, andsaid binding domain is a VH and/or VL region of an antibody or of animmunoglobulin.

“Epitopes” can be formed both by contiguous amino acids ornon-contiguous amino acids juxtaposed by tertiary folding of a protein.A “linear epitope” is an epitope where an amino acid primary sequencecomprises the recognized epitope. A linear epitope typically includes atleast 3 or at least 4, and more usually, at least 5 or at least 6 or atleast 7, for example, about 8 to about 10 amino acids in a uniquesequence.

A “conformational epitope”, in contrast to a linear epitope, is anepitope wherein the primary sequence of the amino acids comprising theepitope is not the sole defining component of the epitope recognized(e.g., an epitope wherein the primary sequence of amino acids is notnecessarily recognized by the binding domain). Typically aconformational epitope comprises an increased number of amino acidsrelative to a linear epitope. With regard to recognition ofconformational epitopes, the binding domain recognizes athree-dimensional structure of the antigen, preferably a peptide orprotein or fragment thereof (in the context of the present invention,the antigen for one of the binding domains is comprised within the CDH19protein). For example, when a protein molecule folds to form athree-dimensional structure, certain amino acids and/or the polypeptidebackbone forming the conformational epitope become juxtaposed enablingthe antibody to recognize the epitope. Methods of determining theconformation of epitopes include, but are not limited to, x-raycrystallography, two-dimensional nuclear magnetic resonance (2D-NMR)spectroscopy and site-directed spin labelling and electron paramagneticresonance (EPR) spectroscopy. Moreover, the provided examples describe afurther method to characterize a given binding domain by way of binning,which includes a test whether the given binding domain binds to one ormore epitope cluster(s) of a given protein, in particular CDH19.

As used herein, the term “epitope cluster” denotes the entirety ofepitopes lying in a defined contiguous stretch of an antigen. An epitopecluster can comprise one, two or more epitopes. The concept of epitopecluster is also used in the characterization of the features of theantibody constructs of the invention.

The terms “(capable of) binding to”, “specifically recognizing”,“directed to” and “reacting with” mean in accordance with this inventionthat a binding domain is capable of specifically interacting with one ormore, preferably at least two, more preferably at least three and mostpreferably at least four amino acids of an epitope.

As used herein, the terms “specifically interacting”, “specificallybinding” or “specifically bind(s)” mean that a binding domain exhibitsappreciable affinity for a particular protein or antigen and, generally,does not exhibit significant reactivity with proteins or antigens otherthan CDH19 or CD3. “Appreciable affinity” includes binding with anaffinity of about 10⁻⁶M (KD) or stronger. Preferably, binding isconsidered specific when binding affinity is about 10⁻¹² to 10⁻⁸ M,10⁻¹² to 10⁻⁹ M, 10⁻¹² to 10⁻¹⁰ M, 10⁻¹¹ to 10⁻⁸ M, preferably of about10⁻¹¹ to 10⁻⁹ M. Whether a binding domain specifically reacts with orbinds to a target can be tested readily by, inter alia, comparing thereaction of said binding domain with a target protein or antigen withthe reaction of said binding domain with proteins or antigens other thanCDH19 or CD3. Preferably, a binding domain of the invention does notessentially bind or is not capable of binding to proteins or antigensother than CDH19 or CD3 (i.e. the first binding domain is not capable ofbinding to proteins other than CDH19 and the second binding domain isnot capable of binding to proteins other than CD3).

The term “does not essentially bind”, or “is not capable of binding”means that a binding domain of the present invention does not bindanother protein or antigen other than CDH19 or CD3, i.e., does not showreactivity of more than 30%, preferably not more than 20%, morepreferably not more than 10%, particularly preferably not more than 9%,8%, 7%, 6% or 5% with proteins or antigens other than CDH19 or CD3,whereby binding to CDH19 or CD3, respectively, is set to be 100%.

Specific binding is believed to be effected by specific motifs in theamino acid sequence of the binding domain and the antigen. Thus, bindingis achieved as a result of their primary, secondary and/or tertiarystructure as well as the result of secondary modifications of saidstructures. The specific interaction of the antigen-interaction-sitewith its specific antigen may result in a simple binding of said site tothe antigen. Moreover, the specific interaction of theantigen-interaction-site with its specific antigen may alternatively oradditionally result in the initiation of a signal, e.g. due to theinduction of a change of the conformation of the antigen, anoligomerization of the antigen, etc.

Proteins (including fragments thereof, preferably biologically activefragments, and peptides, usually having less than 30 amino acids)comprise one or more amino acids coupled to each other via a covalentpeptide bond (resulting in a chain of amino acids). The term“polypeptide” as used herein describes a group of molecules, whichconsist of more than 30 amino acids. Polypeptides may further formmultimers such as dimers, trimers and higher oligomers, i.e. consistingof more than one polypeptide molecule. Polypeptide molecules formingsuch dimers, trimers etc. may be identical or non-identical. Thecorresponding higher order structures of such multimers are,consequently, termed homo- or heterodimers, homo- or heterotrimers etc.An example for a hereteromultimer is an antibody molecule, which, in itsnaturally occurring form, consists of two identical light polypeptidechains and two identical heavy polypeptide chains. The terms“polypeptide” and “protein” also refer to naturally modifiedpolypeptides/proteins wherein the modification is effected e.g. bypost-translational modifications like glycosylation, acetylation,phosphorylation and the like. A “polypeptide” when referred to hereinmay also be chemically modified such as pegylated. Such modificationsare well known in the art.

“Isolated” when used to describe the antibody construct disclosedherein, means a antibody construct that has been identified, separatedand/or recovered from a component of its production environment.Preferably, the isolated antibody construct is free of association withall other components from its production environment. Contaminantcomponents of its production environment, such as that resulting fromrecombinant transfected cells, are materials that would typicallyinterfere with diagnostic or therapeutic uses for the polypeptide, andmay include enzymes, hormones, and other proteinaceous ornon-proteinaceous solutes. In preferred embodiments, the antibodyconstruct will be purified (1) to a degree sufficient to obtain at least15 residues of N-terminal or internal amino acid sequence by use of aspinning cup sequenator, or (2) to homogeneity by SDS-PAGE undernon-reducing or reducing conditions using Coomassie blue or, preferably,silver stain. Ordinarily, however, an isolated antibody will be preparedby at least one purification step.

Amino acid sequence modifications of the antibody constructs describedherein are contemplated. For example, it may be desirable to improve thebinding affinity and/or other biological properties of the antibody.Amino acid sequence variants of the antibody constructs are prepared byintroducing appropriate nucleotide changes into the antibody constructsnucleic acid, or by peptide synthesis.

Such modifications include, for example, deletions from, and/orinsertions into, and/or substitutions of, residues within the amino acidsequences of the antibody constructs. Any combination of deletion,insertion, and substitution is made to arrive at the final construct,provided that the final construct possesses the desired characteristics.The amino acid changes also may alter post-translational processes ofthe antibody constructs, such as changing the number or position ofglycosylation sites. Preferably, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 aminoacids may be substituted in a CDR, while 1, 2, 3, 4, 5, 6, 7, 8, 9, 10,11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 25 amino acids may besubstituted in the framework regions (FRs). The substitutions arepreferably conservative substitutions as described herein. Additionallyor alternatively, 1, 2, 3, 4, 5, or 6 amino acids may be inserted ordeleted in each of the CDRs (of course, dependent on their length),while 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19,20, or 25 amino acids may be inserted or deleted in each of the FRs.

A useful method for identification of certain residues or regions of theantibody constructs that are preferred locations for mutagenesis iscalled “alanine scanning mutagenesis” as described by Cunningham andWells in Science, 244: 1081-1085 (1989). Here, a residue or group oftarget residues within the antibody construct is/are identified (e.g.charged residues such as arg, asp, his, lys, and glu) and replaced by aneutral or negatively charged amino acid (most preferably alanine orpolyalanine) to affect the interaction of the amino acids with theepitope.

Those amino acid locations demonstrating functional sensitivity to thesubstitutions then are refined by introducing further or other variantsat, or for, the sites of substitution. Thus, while the site forintroducing an amino acid sequence variation is predetermined, thenature of the mutation per se needs not to be predetermined. Forexample, to analyze the performance of a mutation at a given site, alascanning or random mutagenesis is conducted at a target codon or regionand the expressed antibody construct variants are screened for thedesired activity.

Preferably, amino acid sequence insertions include amino- and/orcarboxyl-terminal fusions ranging in length from 1, 2, 3, 4, 5, 6, 7, 8,9 or 10 residues to polypeptides containing a hundred or more residues,as well as intrasequence insertions of single or multiple amino acidresidues. An insertional variant of the antibody construct includes thefusion to the N- or C-terminus of the antibody to an enzyme or a fusionto a polypeptide which increases the serum half-life of the antibody.

Another type of variant is an amino acid substitution variant. Thesevariants have preferably at least 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 aminoacid residues in the antibody construct replaced by a different residue.The sites of greatest interest for substitutional mutagenesis includethe CDRs of the heavy and/or light chain, in particular thehypervariable regions, but FR alterations in the heavy and/or lightchain are also contemplated.

For example, if a CDR sequence encompasses 6 amino acids, it isenvisaged that one, two or three of these amino acids are substituted.Similarly, if a CDR sequence encompasses 15 amino acids it is envisagedthat one, two, three, four, five or six of these amino acids aresubstituted.

Generally, if amino acids are substituted in one or more or all of theCDRs of the heavy and/or light chain, it is preferred that thethen-obtained “substituted” sequence is at least 60%, more preferably65%, even more preferably 70%, particularly preferably 75%, moreparticularly preferably 80% identical to the “original” CDR sequence.This means that it is dependent of the length of the CDR to which degreeit is identical to the “substituted” sequence. For example, a CDR having5 amino acids is preferably 80% identical to its substituted sequence inorder to have at least one amino acid substituted. Accordingly, the CDRsof the antibody construct may have different degrees of identity totheir substituted sequences, e.g., CDRL1 may have 80%, while CDRL3 mayhave 90%.

Preferred substitutions (or replacements) are conservativesubstitutions. However, any substitution (including non-conservativesubstitution or one or more from the “exemplary substitutions” listed inTable 1, below) is envisaged as long as the antibody construct retainsits capability to bind to CDH19 via the first binding domain and to CD3epsilon via the second binding domain and/or its CDRs have an identityto the then substituted sequence (at least 60%, more preferably 65%,even more preferably 70%, particularly preferably 75%, more particularlypreferably 80% identical to the “original” CDR sequence).

Conservative substitutions are shown in Table 1 under the heading of“preferred substitutions”. If such substitutions result in a change inbiological activity, then more substantial changes, denominated“exemplary substitutions” in Table 1, or as further described below inreference to amino acid classes, may be introduced and the productsscreened for a desired characteristic.

TABLE 1 Amino Acid Substitutions Preferred Original ExemplarySubstitutions Substitutions Ala (A) val, leu, ile val Arg (R) lys, gln,asn lys Asn (N) gln, his, asp, lys, arg gln Asp (D) glu, asn glu Cys (C)ser, ala ser Gln (Q) asn, glu asn Glu (E) asp, gln asp Gly (G) ala alaHis (H) asn, gln, lys, arg arg Ile (I) leu, val, met, ala, phe leu Leu(L) norleucine, ile, val, met, ala ile Lys (K) arg, gln, asn arg Met (M)leu, phe, ile leu Phe (F) leu, val, ile, ala, tyr tyr Pro (P) ala alaSer (S) thr thr Thr (T) ser ser Trp (W) tyr, phe tyr Tyr (Y) trp, phe,thr, ser phe Val (V) ile, leu, met, phe, ala leu

Substantial modifications in the biological properties of the antibodyconstruct of the present invention are accomplished by selectingsubstitutions that differ significantly in their effect on maintaining(a) the structure of the polypeptide backbone in the area of thesubstitution, for example, as a sheet or helical conformation, (b) thecharge or hydrophobicity of the molecule at the target site, or (c) thebulk of the side chain. Naturally occurring residues are divided intogroups based on common side-chain properties: (1) hydrophobic:norleucine, met, ala, val, leu, ile; (2) neutral hydrophilic: cys, ser,thr; (3) acidic: asp, glu; (4) basic: asn, gin, his, lys, arg; (5)residues that influence chain orientation: gly, pro; and (6)aromatic:trp, tyr, phe.

Non-conservative substitutions will entail exchanging a member of one ofthese classes for another class. Any cysteine residue not involved inmaintaining the proper conformation of the antibody construct may besubstituted, generally with serine, to improve the oxidative stabilityof the molecule and prevent aberrant crosslinking. Conversely, cysteinebond(s) may be added to the antibody to improve its stability(particularly where the antibody is an antibody fragment such as an Fvfragment).

A particularly preferred type of substitutional variant involvessubstituting one or more hypervariable region residues of a parentantibody (e. g. a humanized or human antibody). Generally, the resultingvariant(s) selected for further development will have improvedbiological properties relative to the parent antibody from which theyare generated. A convenient way for generating such substitutionalvariants involves affinity maturation using phage display. Briefly,several hypervariable region sites (e. g. 6-7 sites) are mutated togenerate all possible amino acid substitutions at each site. Theantibody variants thus generated are displayed in a monovalent fashionfrom filamentous phage particles as fusions to the gene III product ofM13 packaged within each particle. The phage-displayed variants are thenscreened for their biological activity (e. g. binding affinity) asherein disclosed. In order to identify candidate hypervariable regionsites for modification, alanine scanning mutagenesis can be performed toidentify hypervariable region residues contributing significantly toantigen binding. Alternatively, or additionally, it may be beneficial toanalyze a crystal structure of the antigen-antibody complex to identifycontact points between the binding domain and, e.g., human CDH19. Suchcontact residues and neighbouring residues are candidates forsubstitution according to the techniques elaborated herein. Once suchvariants are generated, the panel of variants is subjected to screeningas described herein and antibodies with superior properties in one ormore relevant assays may be selected for further development.

Other modifications of the antibody construct are contemplated herein.For example, the antibody construct may be linked to one of a variety ofnon-proteinaceous polymers, e.g., polyethylene glycol, polypropyleneglycol, polyoxyalkylenes, or copolymers of polyethylene glycol andpolypropylene glycol. The antibody construct may also be entrapped inmicrocapsules prepared, for example, by coacervation techniques or byinterfacial polymerization (for example, hydroxymethylcellulose orgelatine-microcapsules and poly (methylmethacylate) microcapsules,respectively), in colloidal drug delivery systems (for example,liposomes, albumin microspheres, microemulsions, nanoparticles andnanocapsules), or in macroemulsions. Such techniques are disclosed inRemington's Pharmaceutical Sciences, 16th edition, Oslo, A., Ed.,(1980).

The antibody constructs disclosed herein may also be formulated asimmuno-liposomes. A “liposome” is a small vesicle composed of varioustypes of lipids, phospholipids and/or surfactant which is useful fordelivery of a drug to a mammal. The components of the liposome arecommonly arranged in a bilayer formation, similar to the lipidarrangement of biological membranes. Liposomes containing the antibodyare prepared by methods known in the art, such as described in Epsteinet al., Proc. Natl. Acad. Sci. USA, 82: 3688 (1985); Hwang et al., Proc.Natl Acad. Sci. USA, 77: 4030 (1980); U.S. Pat. Nos. 4,485,045 and4,544,545; and WO 97/38731 published Oct. 23, 1997. Liposomes withenhanced circulation time are disclosed in U.S. Pat. No. 5,013,556.Particularly useful liposomes can be generated by the reverse phaseevaporation method with a lipid composition comprisingphosphatidylcholine, cholesterol and PEG-derivatizedphosphatidylethanolamine (PEG-PE). Liposomes are extruded throughfilters of defined pore size to yield liposomes with the desireddiameter. Fab′ fragments of the antibody of the present invention can beconjugated to the liposomes as described in Martin et al. J. Biol. Chem.257: 286-288 (1982) via a disulfide interchange reaction. Achemotherapeutic agent is optionally contained within the liposome. SeeGabizon et al. J. National Cancer Inst. 81 (19) 1484 (1989).

When using recombinant techniques, the antibody construct can beproduced intracellularly, in the periplasmic space, or directly secretedinto the medium. If the antibody construct is produced intracellularly,as a first step, the particulate debris, either host cells or lysedfragments, are removed, for example, by centrifugation orultrafiltration. Carter et al., Bio/Technology 10: 163-167 (1992)describe a procedure for isolating antibodies which are secreted to theperiplasmic space of E. coll.

The antibody construct composition prepared from the cells can bepurified using, for example, hydroxylapatite chromatography, gelelectrophoresis, dialysis, and affinity chromatography, with affinitychromatography being the preferred purification technique.

The term “nucleic acid” is well known to the skilled person andencompasses DNA (such as cDNA) and RNA (such as mRNA). The nucleic acidcan be double stranded and single stranded, linear and circular. Saidnucleic acid molecule is preferably comprised in a vector which ispreferably comprised in a host cell. Said host cell is, e.g. aftertransformation or transfection with the nucleic acid sequence of theinvention, capable of expressing the antibody construct. For thatpurpose the nucleic acid molecule is operatively linked with controlsequences.

A vector is a nucleic acid molecule used as a vehicle to transfer(foreign) genetic material into a cell. The term “vector”encompasses—but is not restricted to—plasmids, viruses, cosmids andartificial chromosomes. In general, engineered vectors comprise anorigin of replication, a multicloning site and a selectable marker. Thevector itself is generally a nucleotide sequence, commonly a DNAsequence, that comprises an insert (transgene) and a larger sequencethat serves as the “backbone” of the vector. Modern vectors mayencompass additional features besides the transgene insert and abackbone: promoter, genetic marker, antibiotic resistance, reportergene, targeting sequence, protein purification tag. Vectors calledexpression vectors (expression constructs) specifically are for theexpression of the transgene in the target cell, and generally havecontrol sequences such as a promoter sequence that drives expression ofthe transgene. Insertion of a vector into the target cell is usuallycalled “transformation” for bacteria, “transfection” for eukaryoticcells, although insertion of a viral vector is also called“transduction”.

As used herein, the term “host cell” is intended to refer to a cell intowhich a nucleic acid encoding the antibody construct of the invention isintroduced by way of transformation, transfection and the like. Itshould be understood that such terms refer not only to the particularsubject cell but to the progeny or potential progeny of such a cell.Because certain modifications may occur in succeeding generations due toeither mutation or environmental influences, such progeny may not, infact, be identical to the parent cell, but are still included within thescope of the term as used herein.

As used herein, the term “expression” includes any step involved in theproduction of a antibody construct of the invention including, but notlimited to, transcription, post-transcriptional modification,translation, post-translational modification, and secretion.

The term “control sequences” refers to DNA sequences necessary for theexpression of an operably linked coding sequence in a particular hostorganism. The control sequences that are suitable for prokaryotes, forexample, include a promoter, optionally an operator sequence, and aribosome binding site. Eukaryotic cells are known to utilize promoters,polyadenylation signals, and enhancers.

A nucleic acid is “operably linked” when it is placed into a functionalrelationship with another nucleic acid sequence. For example, DNA for apresequence or secretory leader is operably linked to DNA for apolypeptide if it is expressed as a preprotein that participates in thesecretion of the polypeptide; a promoter or enhancer is operably linkedto a coding sequence if it affects the transcription of the sequence; ora ribosome binding site is operably linked to a coding sequence if it ispositioned so as to facilitate translation. Generally, “operably linked”means that the DNA sequences being linked are contiguous, and, in thecase of a secretory leader, contiguous and in reading phase. However,enhancers do not have to be contiguous. Linking is accomplished byligation at convenient restriction sites. If such sites do not exist,the synthetic oligonucleotide adaptors or linkers are used in accordancewith conventional practice.

The terms “host cell,” “target cell” or “recipient cell” are intended toinclude any individual cell or cell culture that can be or has/have beenrecipients for vectors or the incorporation of exogenous nucleic acidmolecules, polynucleotides and/or proteins. It also is intended toinclude progeny of a single cell, and the progeny may not necessarily becompletely identical (in morphology or in genomic or total DNAcomplement) to the original parent cell due to natural, accidental, ordeliberate mutation. The cells may be prokaryotic or eukaryotic, andinclude but are not limited to bacteria, yeast cells, animal cells, andmammalian cells, e.g., murine, rat, macaque or human.

Suitable host cells include prokaryotes and eukaryotic host cellsincluding yeasts, fungi, insect cells and mammalian cells.

The antibody construct of the invention can be produced in bacteria.After expression, the antibody construct of the invention, preferablythe antibody construct is isolated from the E. coli cell paste in asoluble fraction and can be purified through, e.g., affinitychromatography and/or size exclusion. Final purification can be carriedout similar to the process for purifying antibody expressed e. g, in CHOcells.

In addition to prokaryotes, eukaryotic microbes such as filamentousfungi or yeast are suitable cloning or expression hosts for the antibodyconstruct of the invention. Saccharomyces cerevisiae, or common baker'syeast, is the most commonly used among lower eukaryotic hostmicroorganisms. However, a number of other genera, species, and strainsare commonly available and useful herein, such as Schizosaccharomycespombe, Kluyveromyces hosts such as, e.g., K. lactis, K. fragilis (ATCC12424), K. bulgaricus (ATCC 16045), K. wickeramii (ATCC 24178), K.waltii (ATCC 56500), K. drosophilarum (ATCC 36906), K. thermotolerans,and K. marxianus; yarrowia (EP 402 226); Pichia pastoris (EP 183 070);Candida; Trichoderma reesia (EP 244 234); Neurospora crassa;Schwanniomyces such as Schwanniomyces occidentalis; and filamentousfungi such as, e.g., Neurospora, Penicillium, Tolypocladium, andAspergillus hosts such as A. nidulans and A. niger.

Suitable host cells for the expression of glycosylated antibodyconstruct of the invention, preferably antibody derived antibodyconstructs are derived from multicellular organisms.

Examples of invertebrate cells include plant and insect cells. Numerousbaculoviral strains and variants and corresponding permissive insecthost cells from hosts such as Spodoptera frugiperda (caterpillar), Aedesaegypti (mosquito), Aedes albopictus (mosquito), Drosophila melanogaster(fruit fly), and Bombyx mori have been identified. A variety of viralstrains for transfection are publicly available, e. g., the L-1 variantof Autographa californica NPV and the Bm-5 strain of Bombyx mori NPV,and such viruses may be used as the virus herein according to thepresent invention, particularly for transfection of Spodopterafrugiperda cells.

Plant cell cultures of cotton, corn, potato, soybean, petunia, tomato,Arabidopsis and tobacco can also be utilized as hosts. Cloning andexpression vectors useful in the production of proteins in plant cellculture are known to those of skill in the art. See e.g. Hiatt et al.,Nature (1989) 342: 76-78, Owen et al. (1992) Bio/Technology 10: 790-794,Artsaenko et al. (1995) The Plant J 8: 745-750, and Fecker et al. (1996)Plant Mol Biol 32: 979-986.

However, interest has been greatest in vertebrate cells, and propagationof vertebrate cells in culture (tissue culture) has become a routineprocedure. Examples of useful mammalian host cell lines are monkeykidney CV1 line transformed by SV40 (COS-7, ATCC CRL 1651); humanembryonic kidney line (293 or 293 cells subcloned for growth insuspension culture, Graham et al., J. Gen Virol. 36: 59 (1977)); babyhamster kidney cells (BHK, ATCC CCL 10); Chinese hamster ovarycells/-DHFR (CHO, Urlaub et al., Proc. Natl. Acad. Sci. USA 77: 4216(1980)); mouse sertoli cells (TM4, Mather, Biol. Reprod. 23: 243-251(1980)); monkey kidney cells (CVI ATCC CCL 70); African green monkeykidney cells (VERO-76, ATCC CRL1587); human cervical carcinoma cells(HELA, ATCC CCL 2); canine kidney cells (MDCK, ATCC CCL 34); buffalo ratliver cells (BRL 3A, ATCC CRL 1442); human lung cells (W138, ATCC CCL75); human liver cells (Hep G2, 1413 8065); mouse mammary tumor (MMT060562, ATCC CCL5 1); TRI cells (Mather et al., Annals N. Y Acad. Sci.383: 44-68 (1982)); MRC 5 cells; FS4 cells; and a human hepatoma line(Hep G2).

When using recombinant techniques, the antibody construct of theinvention can be produced intracellularly, in the periplasmic space, ordirectly secreted into the medium. If the antibody construct is producedintracellularly, as a first step, the particulate debris, either hostcells or lysed fragments, are removed, for example, by centrifugation orultrafiltration. Carter et al., Bio/Technology 10: 163-167 (1992)describe a procedure for isolating antibodies which are secreted to theperiplasmic space of E. coli. Briefly, cell paste is thawed in thepresence of sodium acetate (pH 3.5), EDTA, andphenylmethylsulfonylfluoride (PMSF) over about 30 min. Cell debris canbe removed by centrifugation. Where the antibody is secreted into themedium, supernatants from such expression systems are generally firstconcentrated using a commercially available protein concentrationfilter, for example, an Amicon or Millipore Pellicon ultrafiltrationunit. A protease inhibitor such as PMSF may be included in any of theforegoing steps to inhibit proteolysis and antibiotics may be includedto prevent the growth of adventitious contaminants.

The antibody construct of the invention prepared from the host cells canbe purified using, for example, hydroxylapatite chromatography, gelelectrophoresis, dialysis, and affinity chromatography, with affinitychromatography being the preferred purification technique.

The matrix to which the affinity ligand is attached is most oftenagarose, but other matrices are available. Mechanically stable matricessuch as controlled pore glass or poly (styrenedivinyl) benzene allow forfaster flow rates and shorter processing times than can be achieved withagarose. Where the antibody construct of the invention comprises a CH3domain, the Bakerbond ABXMresin (J. T. Baker, Phillipsburg, N.J.) isuseful for purification. Other techniques for protein purification suchas fractionation on an ion-exchange column, ethanol precipitation,Reverse Phase HPLC, chromatography on silica, chromatography on heparinSEPHAROSE™ chromatography on an anion or cation exchange resin (such asa polyaspartic acid column), chromato-focusing, SDS-PAGE, and ammoniumsulfate precipitation are also available depending on the antibody to berecovered.

The term “culturing” refers to the in vitro maintenance,differentiation, growth, proliferation and/or propagation of cells undersuitable conditions in a medium.

As used herein, the term “pharmaceutical composition” relates to acomposition for administration to a patient, preferably a human patient.The particular preferred pharmaceutical composition of this inventioncomprises the antibody construct of the invention. Preferably, thepharmaceutical composition comprises suitable formulations of carriers,stabilizers and/or excipients. In a preferred embodiment, thepharmaceutical composition comprises a composition for parenteral,transdermal, intraluminal, intraarterial, intrathecal and/or intranasaladministration or by direct injection into tissue. It is in particularenvisaged that said composition is administered to a patient viainfusion or injection. Administration of the suitable compositions maybe effected by different ways, e.g., by intravenous, intraperitoneal,subcutaneous, intramuscular, topical or intradermal administration. Inparticular, the present invention provides for an uninterruptedadministration of the suitable composition. As a non-limiting example,uninterrupted, i.e. continuous administration may be realized by a smallpump system worn by the patient for metering the influx of therapeuticagent into the body of the patient. The pharmaceutical compositioncomprising the antibody construct of the invention can be administeredby using said pump systems. Such pump systems are generally known in theart, and commonly rely on periodic exchange of cartridges containing thetherapeutic agent to be infused. When exchanging the cartridge in such apump system, a temporary interruption of the otherwise uninterruptedflow of therapeutic agent into the body of the patient may ensue. Insuch a case, the phase of administration prior to cartridge replacementand the phase of administration following cartridge replacement wouldstill be considered within the meaning of the pharmaceutical means andmethods of the invention together make up one “uninterruptedadministration” of such therapeutic agent.

The continuous or uninterrupted administration of these antibodyconstructs of the invention may be intravenous or subcutaneous by way ofa fluid delivery device or small pump system including a fluid drivingmechanism for driving fluid out of a reservoir and an actuatingmechanism for actuating the driving mechanism. Pump systems forsubcutaneous administration may include a needle or a cannula forpenetrating the skin of a patient and delivering the suitablecomposition into the patient's body. Said pump systems may be directlyfixed or attached to the skin of the patient independently of a vein,artery or blood vessel, thereby allowing a direct contact between thepump system and the skin of the patient. The pump system can be attachedto the skin of the patient for 24 hours up to several days. The pumpsystem may be of small size with a reservoir for small volumes. As anon-limiting example, the volume of the reservoir for the suitablepharmaceutical composition to be administered can be between 0.1 and 50ml.

The continuous administration may be transdermal by way of a patch wornon the skin and replaced at intervals. One of skill in the art is awareof patch systems for drug delivery suitable for this purpose. It is ofnote that transdermal administration is especially amenable touninterrupted administration, as exchange of a first exhausted patch canadvantageously be accomplished simultaneously with the placement of anew, second patch, for example on the surface of the skin immediatelyadjacent to the first exhausted patch and immediately prior to removalof the first exhausted patch. Issues of flow interruption or power cellfailure do not arise.

The inventive compositions may further comprise a pharmaceuticallyacceptable carrier. Examples of suitable pharmaceutical carriers arewell known in the art and include solutions, e.g. phosphate bufferedsaline solutions, water, emulsions, such as oil/water emulsions, varioustypes of wetting agents, sterile solutions, liposomes, etc. Compositionscomprising such carriers can be formulated by well known conventionalmethods. Formulations can comprise carbohydrates, buffer solutions,amino acids and/or surfactants. Carbohydrates may be non-reducingsugars, preferably trehalose, sucrose, octasulfate, sorbitol or xylitol.In general, as used herein, “pharmaceutically acceptable carrier” meansany and all solvents, dispersion media, coatings, antibacterial andantifungal agents, isotonic and absorption delaying agents, compatiblewith pharmaceutical administration. The use of such media and agents forpharmaceutically active substances is well known in the art. Acceptablecarriers, excipients, or stabilizers are nontoxic to recipients at thedosages and concentrations employed and include: additional bufferingagents; preservatives; co-solvents; antioxidants, including ascorbicacid and methionine; chelating agents such as EDTA; metal complexes(e.g., Zn-protein complexes); biodegradable polymers, such aspolyesters; salt-forming counter-ions, such as sodium, polyhydric sugaralcohols; amino acids, such as alanine, glycine, asparagine,2-phenylalanine, and threonine; sugars or sugar alcohols, such astrehalose, sucrose, octasulfate, sorbitol or xylitol stachyose, mannose,sorbose, xylose, ribose, myoinisitose, galactose, lactitol, ribitol,myoinisitol, galactitol, glycerol, cyclitols (e.g., inositol),polyethylene glycol; sulfur containing reducing agents, such asglutathione, thioctic acid, sodium thioglycolate, thioglycerol,[alpha]-monothioglycerol, and sodium thio sulfate; low molecular weightproteins, such as human serum albumin, bovine serum albumin, gelatin, orother immunoglobulins; and hydrophilic polymers, such aspolyvinylpyrrolidone. Such formulations may be used for continuousadministrations which may be intravenous or subcutaneous with and/orwithout pump systems. Amino acids may be charged amino acids, preferablylysine, lysine acetate, arginine, glutamate and/or histidine.Surfactants may be detergents, preferably with a molecular weightof >1.2 KD and/or a polyether, preferably with a molecular weight of >3KD. Non-limiting examples for preferred detergents are Tween 20, Tween40, Tween 60, Tween 80 or Tween 85. Non-limiting examples for preferredpolyethers are PEG 3000, PEG 3350, PEG 4000 or PEG 5000. Buffer systemsused in the present invention can have a preferred pH of 5-9 and maycomprise citrate, succinate, phosphate, histidine and acetate.

The compositions of the present invention can be administered to thesubject at a suitable dose which can be determined e.g. by doseescalating studies by administration of increasing doses of thepolypeptide of the invention exhibiting cross-species specificitydescribed herein to non-chimpanzee primates, for instance macaques. Asset forth above, the antibody construct of the invention exhibitingcross-species specificity described herein can be advantageously used inidentical form in preclinical testing in non-chimpanzee primates and asdrug in humans. These compositions can also be administered incombination with other proteinaceous and non-proteinaceous drugs. Thesedrugs may be administered simultaneously with the composition comprisingthe polypeptide of the invention as defined herein or separately beforeor after administration of said polypeptide in timely defined intervalsand doses. The dosage regimen will be determined by the attendingphysician and clinical factors. As is well known in the medical arts,dosages for any one patient depend upon many factors, including thepatient's size, body surface area, age, the particular compound to beadministered, sex, time and route of administration, general health, andother drugs being administered concurrently.

Preparations for parenteral administration include sterile aqueous ornon-aqueous solutions, suspensions, and emulsions. Examples ofnon-aqueous solvents are propylene glycol, polyethylene glycol,vegetable oils such as olive oil, and injectable organic esters such asethyl oleate. Aqueous carriers include water, alcoholic/aqueoussolutions, emulsions or suspensions, including saline and bufferedmedia. Parenteral vehicles include sodium chloride solution, Ringer'sdextrose, dextrose and sodium chloride, lactated Ringer's, or fixedoils. Intravenous vehicles include fluid and nutrient replenishers,electrolyte replenishers (such as those based on Ringer's dextrose), andthe like. Preservatives and other additives may also be present such as,for example, antimicrobials, anti-oxidants, chelating agents, inertgases and the like. In addition, the composition of the presentinvention might comprise proteinaceous carriers, like, e.g., serumalbumin or immunoglobulin, preferably of human origin. It is envisagedthat the composition of the invention might comprise, in addition to thepolypeptide of the invention defined herein, further biologically activeagents, depending on the intended use of the composition. Such agentsmight be drugs acting on the gastro-intestinal system, drugs acting ascytostatica, drugs preventing hyperurikemia, drugs inhibitingimmunoreaction (e.g. corticosteroids), drugs modulating the inflammatoryresponse, drugs acting on the circulatory system and/or agents such ascytokines known in the art. It is also envisaged that the antibodyconstruct of the present invention is applied in a co-therapy, i.e., incombination with another anti-cancer medicament.

The biological activity of the pharmaceutical composition defined hereincan be determined for instance by cytotoxicity assays, as described inthe following examples, in WO 99/54440 or by Schlereth et al. (CancerImmunol. Immunother. 20 (2005), 1-12). “Efficacy” or “in vivo efficacy”as used herein refers to the response to therapy by the pharmaceuticalcomposition of the invention, using e.g. standardized NCI responsecriteria. The success or in vivo efficacy of the therapy using apharmaceutical composition of the invention refers to the effectivenessof the composition for its intended purpose, i.e. the ability of thecomposition to cause its desired effect, i.e. depletion of pathologiccells, e.g. tumor cells. The in vivo efficacy may be monitored byestablished standard methods for the respective disease entitiesincluding, but not limited to white blood cell counts, differentials,Fluorescence Activated Cell Sorting, bone marrow aspiration. Inaddition, various disease specific clinical chemistry parameters andother established standard methods may be used. Furthermore,computer-aided tomography, X-ray, nuclear magnetic resonance tomography(e.g. for National Cancer Institute-criteria based response assessment[Cheson B D, Horning S J, Coiffier B, Shipp M A, Fisher R I, Connors JM, Lister T A, Vose J, Grillo-Lopez A, Hagenbeek A, Cabanillas F,Klippensten D, Hiddemann W, Castellino R, Harris N L, Armitage J O,Carter W, Hoppe R, Canellos G P. Report of an international workshop tostandardize response criteria for non-Hodgkin's lymphomas. NCI SponsoredInternational Working Group. J Clin Oncol. 1999 April; 17(4):1244]),positron-emission tomography scanning, white blood cell counts,differentials, Fluorescence Activated Cell Sorting, bone marrowaspiration, lymph node biopsies/histologies, and various lymphomaspecific clinical chemistry parameters (e.g. lactate dehydrogenase) andother established standard methods may be used.

Another major challenge in the development of drugs such as thepharmaceutical composition of the invention is the predictablemodulation of pharmacokinetic properties. To this end, a pharmacokineticprofile of the drug candidate, i.e. a profile of the pharmacokineticparameters that affect the ability of a particular drug to treat a givencondition, can be established. Pharmacokinetic parameters of the druginfluencing the ability of a drug for treating a certain disease entityinclude, but are not limited to: half-life, volume of distribution,hepatic first-pass metabolism and the degree of blood serum binding. Theefficacy of a given drug agent can be influenced by each of theparameters mentioned above.

“Half-life” means the time where 50% of an administered drug areeliminated through biological processes, e.g. metabolism, excretion,etc.

By “hepatic first-pass metabolism” is meant the propensity of a drug tobe metabolized upon first contact with the liver, i.e. during its firstpass through the liver.

“Volume of distribution” means the degree of retention of a drugthroughout the various compartments of the body, like e.g. intracellularand extracellular spaces, tissues and organs, etc. and the distributionof the drug within these compartments.

“Degree of blood serum binding” means the propensity of a drug tointeract with and bind to blood serum proteins, such as albumin, leadingto a reduction or loss of biological activity of the drug.

Pharmacokinetic parameters also include bioavailability, lag time(Tlag), Tmax, absorption rates, more onset and/or Cmax for a givenamount of drug administered. “Bioavailability” means the amount of adrug in the blood compartment. “Lag time” means the time delay betweenthe administration of the drug and its detection and measurability inblood or plasma.

“Tmax” is the time after which maximal blood concentration of the drugis reached, and “Cmax” is the blood concentration maximally obtainedwith a given drug. The time to reach a blood or tissue concentration ofthe drug which is required for its biological effect is influenced byall parameters. Pharmacokinetic parameters of bispecific single chainantibodies exhibiting cross-species specificity, which may be determinedin preclinical animal testing in non-chimpanzee primates as outlinedabove, are also set forth e.g. in the publication by Schlereth et al.(Cancer Immunol. Immunother. 20 (2005), 1-12).

The term “toxicity” as used herein refers to the toxic effects of a drugmanifested in adverse events or severe adverse events. These side eventsmight refer to a lack of tolerability of the drug in general and/or alack of local tolerance after administration. Toxicity could alsoinclude teratogenic or carcinogenic effects caused by the drug.

The term “safety”, “in vivo safety” or “tolerability” as used hereindefines the administration of a drug without inducing severe adverseevents directly after administration (local tolerance) and during alonger period of application of the drug. “Safety”, “in vivo safety” or“tolerability” can be evaluated e.g. at regular intervals during thetreatment and follow-up period. Measurements include clinicalevaluation, e.g. organ manifestations, and screening of laboratoryabnormalities. Clinical evaluation may be carried out and deviations tonormal findings recorded/coded according to NCI-CTC and/or MedDRAstandards. Organ manifestations may include criteria such asallergy/immunology, blood/bone marrow, cardiac arrhythmia, coagulationand the like, as set forth e.g. in the Common Terminology Criteria foradverse events v 3.0 (CTCAE). Laboratory parameters which may be testedinclude for instance hematology, clinical chemistry, coagulation profileand urine analysis and examination of other body fluids such as serum,plasma, lymphoid or spinal fluid, liquor and the like. Safety can thusbe assessed e.g. by physical examination, imaging techniques (i.e.ultrasound, x-ray, CT scans, Magnetic Resonance Imaging (MRI), othermeasures with technical devices (i.e. electrocardiogram), vital signs,by measuring laboratory parameters and recording adverse events. Forexample, adverse events in non-chimpanzee primates in the uses andmethods according to the invention may be examined by histopathologicaland/or histochemical methods.

The term “effective dose” or “effective dosage” is defined as an amountsufficient to achieve or at least partially achieve the desired effect.The term “therapeutically effective dose” is defined as an amountsufficient to cure or at least partially arrest the disease and itscomplications in a patient already suffering from the disease. Amountseffective for this use will depend upon the severity of the infectionand the general state of the subject's own immune system. The term“patient” includes human and other mammalian subjects that receiveeither prophylactic or therapeutic treatment.

The term “effective and non-toxic dose” as used herein refers to atolerable dose of an inventive antibody construct which is high enoughto cause depletion of pathologic cells, tumor elimination, tumorshrinkage or stabilization of disease without or essentially withoutmajor toxic effects. Such effective and non-toxic doses may bedetermined e.g. by dose escalation studies described in the art andshould be below the dose inducing severe adverse side events (doselimiting toxicity, DLT).

The above terms are also referred to e.g. in the Preclinical safetyevaluation of biotechnology-derived pharmaceuticals S6; ICH HarmonisedTripartite Guideline; ICH Steering Committee meeting on Jul. 16, 1997.

The appropriate dosage, or therapeutically effective amount, of theantibody construct of the invention will depend on the condition to betreated, the severity of the condition, prior therapy, and the patient'sclinical history and response to the therapeutic agent. The proper dosecan be adjusted according to the judgment of the attending physiciansuch that it can be administered to the patient one time or over aseries of administrations. The pharmaceutical composition can beadministered as a sole therapeutic or in combination with additionaltherapies such as anti-cancer therapies as needed.

The pharmaceutical compositions of this invention are particularlyuseful for parenteral administration, i.e., subcutaneously,intramuscularly, intravenously, intra-articular and/or intra-synovial.Parenteral administration can be by bolus injection or continuousinfusion.

If the pharmaceutical composition has been lyophilized, the lyophilizedmaterial is first reconstituted in an appropriate liquid prior toadministration. The lyophilized material may be reconstituted in, e.g.,bacteriostatic water for injection (BWFI), physiological saline,phosphate buffered saline (PBS), or the same formulation the protein hadbeen in prior to lyophilization.

In an internal analysis of proprietary mRNA expression data it has beensurprisingly found that CDH19 expression is elevated in both primary andmetastatic melanoma tumors compared to normal, untransformed tissues.Internal analysis also confirmed that expression of CDH19 in normaltissues is limited to neural crest derived peripheral nerve ganglia andnerve fibers. The differential CDH19 expression in normal and tumortissues makes this protein attractive for cell-surface targetingtherapeutics. Although CDH 19 was discussed as one marker as part oflong lists of markers associated with some cancer types (see e.g.WO2009/055937) or Parkinson's disease (see e.g. WO2005/067391) CDH19 wasnever discussed as a prognostic marker or a drug target in connectionwith melanoma tumors.

As stated above, the present invention provides an isolatedmultispecific antibody construct comprising a first human binding domaincapable of binding to human CDH19 on the surface of a target cell and asecond domain capable of binding to human CD3 on the surface of a Tcell.

The “CDH19 extracellular domain” or “CDH19 ECD” refers to a form ofCDH19 which is essentially free of transmembrane and cytoplasmic domainsof CDH19. It will be understood by the skilled artisan that thetransmembrane domain identified for the CDH19 polypeptide of the presentinvention is identified pursuant to criteria routinely employed in theart for identifying that type of hydrophobic domain. The exactboundaries of a transmembrane domain may vary but most likely by no morethan about 5 amino acids at either end of the domain specificallymentioned herein. A preferred human CDH19 ECD is shown in SEQ ID NO:948. In this context it is understood that the CDH19 ECD represents thepart of CDH19 on the surface of a target cell.

The T cell CD3 receptor complex is a protein complex and is composed offour distinct chains. In mammals, the complex contains a CD3γ chain, aCD3δ chain, and two CD3ε (epsilon) chains. These chains associate with amolecule known as the T cell receptor (TCR) and the ζ chain to generatean activation signal in T lymphocytes.

The redirected lysis of target cells via the recruitment of T cells by amultispecific, at least bispecific, antibody construct involvescytolytic synapse formation and delivery of perforin and granzymes. Theengaged T cells are capable of serial target cell lysis, and are notaffected by immune escape mechanisms interfering with peptide antigenprocessing and presentation, or clonal T cell differentiation; see, forexample, WO 2007/042261.

The affinity of the first binding domain for human CDH19 is preferably≤15 nM, more preferably ≤10 nM, even more preferably ≤5 nM, even morepreferably ≤1 nM, even more preferably ≤0.5 nM, even more preferably≤0.1 nM, and most preferably ≤0.05 nM. The affinity of the first bindingdomain for macaque CDH19 is preferably ≤15 nM, more preferably ≤10 nM,even more preferably ≤5 nM, even more preferably ≤1 nM, even morepreferably ≤0.5 nM, even more preferably ≤0.1 nM, and most preferably≤0.05 nM or even ≤0.01 nM. The affinity can be measured for example in aBiacore assay or in a Scatchard assay, e.g. as described in theExamples. The affinity gap for binding to macaque CDH19 versus humanCDH19 is preferably [1:10-1:5] or [5:1-10:1], more preferably [1:5-5:1],and most preferably [1:2-3:1] or even [1:1-3:1]. Other methods ofdetermining the affinity are well-known to the skilled person.

Human antibodies, respectively human antibody constructs, avoid some ofthe problems associated with antibodies/antibody constructs that possessmurine or rat variable and/or constant regions. The presence of suchmurine or rat derived proteins can lead to the rapid clearance of theantibodies/antibody constructs or can lead to the generation of animmune response against the antibody/antibody construct by a patient. Inorder to avoid the utilization of murine or rat derivedantibodies/antibody constructs, human or fully human antibodies can begenerated through the introduction of human antibody function into arodent so that the rodent produces fully human antibodies.

The ability to clone and reconstruct megabase-sized human loci in YACsand to introduce them into the mouse germline provides a powerfulapproach to elucidating the functional components of very large orcrudely mapped loci as well as generating useful models of humandisease. Furthermore, the utilization of such technology forsubstitution of mouse loci with their human equivalents could provideunique insights into the expression and regulation of human geneproducts during development, their communication with other systems, andtheir involvement in disease induction and progression.

An important practical application of such a strategy is the“humanization” of the mouse humoral immune system. Introduction of humanimmunoglobulin (Ig) loci into mice in which the endogenous Ig genes havebeen inactivated offers the opportunity to study the mechanismsunderlying programmed expression and assembly of antibodies as well astheir role in B-cell development. Furthermore, such a strategy couldprovide an ideal source for production of fully human monoclonalantibodies (mAbs)—an important milestone towards fulfilling the promiseof antibody therapy in human disease. Fully human antibodies/antibodyconstructs are expected to minimize the immunogenic and allergicresponses intrinsic to mouse or mouse-derivatized mAbs and thus toincrease the efficacy and safety of the administered antibodies/antibodyconstructs. The use of fully human antibodies/antibody constructs can beexpected to provide a substantial advantage in the treatment of chronicand recurring human diseases, such as inflammation, autoimmunity, andcancer, which require repeated compound administrations.

One approach towards this goal was to engineer mouse strains deficientin mouse antibody production with large fragments of the human Ig lociin anticipation that such mice would produce a large repertoire of humanantibodies in the absence of mouse antibodies. Large human Ig fragmentswould preserve the large variable gene diversity as well as the properregulation of antibody production and expression. By exploiting themouse machinery for antibody diversification and selection and the lackof immunological tolerance to human proteins, the reproduced humanantibody repertoire in these mouse strains should yield high affinityantibodies against any antigen of interest, including human antigens.Using the hybridoma technology, antigen-specific human mAbs with thedesired specificity could be readily produced and selected. This generalstrategy was demonstrated in connection with our generation of the firstXenoMouse mouse strains, as published in 1994. (See Green et al. NatureGenetics 7:13-21 (1994)) The XenoMouse strains were engineered withyeast artificial chromosomes (YACs) containing 245 kb and 190 kb-sizedgermline configuration fragments of the human heavy chain locus andkappa light chain locus, respectively, which contained core variable andconstant region sequences. Id. The human Ig containing YACs proved to becompatible with the mouse system for both rearrangement and expressionof antibodies and were capable of substituting for the inactivated mouseIg genes. This was demonstrated by their ability to induce B-celldevelopment, to produce an adult-like human repertoire of fully humanantibodies, and to generate antigen-specific human mAbs. These resultsalso suggested that introduction of larger portions of the human Ig locicontaining greater numbers of V genes, additional regulatory elements,and human Ig constant regions might recapitulate substantially the fullrepertoire that is characteristic of the human humoral response toinfection and immunization. The work of Green et al. was recentlyextended to the introduction of greater than approximately 80% of thehuman antibody repertoire through introduction of megabase sized,germline configuration YAC fragments of the human heavy chain loci andkappa light chain loci, respectively. See Mendez et al. Nature Genetics15:146-156 (1997) and U.S. patent application Ser. No. 08/759,620, filedDec. 3, 1996, the disclosures of which are hereby incorporated byreference.

The production of the XenoMouse mice is further discussed and delineatedin U.S. patent application Ser. No. 07/466,008, filed Jan. 12, 1990,Ser. No. 07/610,515, filed Nov. 8, 1990, Ser. No. 07/919,297, filed Jul.24, 1992, Ser. No. 07/922,649, filed Jul. 30, 1992, filed Ser. No.08/031,801, filed Mar. 15, 1993, Ser. No. 08/112,848, filed Aug. 27,1993, Ser. No. 08/234,145, filed Apr. 28, 1994, Ser. No. 08/376,279,filed Jan. 20, 1995, Ser. No. 08/430,938, Apr. 27, 1995, Ser. No.08/464,584, filed Jun. 5, 1995, Ser. No. 08/464,582, filed Jun. 5, 1995,Ser. No. 08/463,191, filed Jun. 5, 1995, Ser. No. 08/462,837, filed Jun.5, 1995, Ser. No. 08/486,853, filed Jun. 5, 1995, Ser. No. 08/486,857,filed Jun. 5, 1995, Ser. No. 08/486,859, filed Jun. 5, 1995, Ser. No.08/462,513, filed Jun. 5, 1995, Ser. No. 08/724,752, filed Oct. 2, 1996,and Ser. No. 08/759,620, filed Dec. 3, 1996 and U.S. Pat. Nos.6,162,963, 6,150,584, 6,114,598, 6,075,181, and 5,939,598 and JapanesePatent Nos. 3 068 180 B2, 3 068 506 B2, and 3 068 507 B2. See alsoMendez et al. Nature Genetics 15:146-156 (1997) and Green and JakobovitsJ. Exp. Med. 188:483-495 (1998). See also European Patent No., EP 0463151 B1, grant published Jun. 12, 1996, International PatentApplication No., WO 94/02602, published Feb. 3, 1994, InternationalPatent Application No., WO 96/34096, published Oct. 31, 1996, WO98/24893, published Jun. 11, 1998, WO 00/76310, published Dec. 21, 2000,WO 03/47336. The disclosures of each of the above-cited patents,applications, and references are hereby incorporated by reference intheir entirety.

In an alternative approach, others, including GenPharm International,Inc., have utilized a “minilocus” approach. In the minilocus approach,an exogenous Ig locus is mimicked through the inclusion of pieces(individual genes) from the Ig locus. Thus, one or more V.sub.H genes,one or more D.sub.H genes, one or more J.sub.H genes, a mu constantregion, and a second constant region (preferably a gamma constantregion) are formed into a construct for insertion into an animal. Thisapproach is described in U.S. Pat. No. 5,545,807 to Surani et al. andU.S. Pat. Nos. 5,545,806, 5,625,825, 5,625,126, 5,633,425, 5,661,016,5,770,429, 5,789,650, 5,814,318, 5,877,397, 5,874,299, and 6,255,458each to Lonberg and Kay, U.S. Pat. Nos. 5,591,669 and 6,023,010 toKrimpenfort and Berns, U.S. Pat. Nos. 5,612,205, 5,721,367, and5,789,215 to Berns et al., and U.S. Pat. No. 5,643,763 to Choi and Dunn,and GenPharm International U.S. patent application Ser. No. 07/574,748,filed Aug. 29, 1990, Ser. No. 07/575,962, filed Aug. 31, 1990, Ser. No.07/810,279, filed Dec. 17, 1991, Ser. No. 07/853,408, filed Mar. 18,1992, Ser. No. 07/904,068, filed Jun. 23, 1992, Ser. No. 07/990,860,filed Dec. 16, 1992, Ser. No. 08/053,131, filed Apr. 26, 1993, Ser. No.08/096,762, filed Jul. 22, 1993, Ser. No. 08/155,301, filed Nov. 18,1993, Ser. No. 08/161,739, filed Dec. 3, 1993, Ser. No. 08/165,699,filed Dec. 10, 1993, Ser. No. 08/209,741, filed Mar. 9, 1994, thedisclosures of which are hereby incorporated by reference. See alsoEuropean Patent No. 0 546 073 B 1, International Patent Application Nos.WO 92/03918, WO 92/22645, WO 92/22647, WO 92/22670, WO 93/12227, WO94/00569, WO 94/25585, WO 96/14436, WO 97/13852, and WO 98/24884 andU.S. Pat. No. 5,981,175, the disclosures of which are herebyincorporated by reference in their entirety. See further Taylor et al.,1992, Chen et al., 1993, Tuaillon et al., 1993, Choi et al., 1993,Lonberg et al., (1994), Taylor et al., (1994), and Tuaillon et al.,(1995), Fishwild et al., (1996), the disclosures of which are herebyincorporated by reference in their entirety.

Kirin has also demonstrated the generation of human antibodies from micein which, through microcell fusion, large pieces of chromosomes, orentire chromosomes, have been introduced. See European PatentApplication Nos. 773 288 and 843 961, the disclosures of which arehereby incorporated by reference. Xenerex Biosciences is developing atechnology for the potential generation of human antibodies. In thistechnology, SCID mice are reconstituted with human lymphatic cells,e.g., B and/or T cells. Mice are then immunized with an antigen and cangenerate an immune response against the antigen. See U.S. Pat. Nos.5,476,996, 5,698,767, and 5,958,765.

Human anti-mouse antibody (HAMA) responses have led the industry toprepare chimeric or otherwise humanized antibodies. While chimericantibodies have a human constant region and a murine variable region, itis expected that certain human anti-chimeric antibody (HACA) responseswill be observed, particularly in chronic or multi-dose utilizations ofthe antibody. Thus, it would be desirable to provide fully humanantibodies against EGFRvIII in order to vitiate concerns and/or effectsof HAMA or HACA response.

Cytotoxicity mediated by CDH19/CD3 bispecific antibody constructs can bemeasured in various ways. Effector cells can be e.g. stimulated enriched(human) CD8 positive T cells or unstimulated (human) peripheral bloodmononuclear cells (PBMC). If the target cells are of macaque origin orexpress or are transfected with macaque CDH19, the effector cells shouldalso be of macaque origin such as a macaque T cell line, e.g. 4119LnPx.The target cells should express (at least the extracellular domain of)CDH19, e.g. human or macaque CDH19. Target cells can be a cell line(such as CHO) which is stably or transiently transfected with CDH19,e.g. human or macaque CDH19. Alternatively, the target cells can be aCDH19 positive natural expresser cell line, such as the human myelomacell line CHL-1 or Colo-699. Usually EC50-values are expected to belower with target cell lines expressing higher levels of CDH19on thecell surface. The effector to target cell (E:T) ratio is usually about10:1, but can also vary. Cytotoxic activity of CDH19/CD3 bispecificantibody constructs can be measured in an 51-chromium release assay(incubation time of about 18 hours) or in a in a FACS-based cytotoxicityassay (incubation time of about 48 hours). Modifications of the assayincubation time (cytotoxic reaction) are also possible. Other methods ofmeasuring cytotoxicity are well-known to the skilled person and compriseMTT or MTS assays, ATP-based assays including bioluminescent assays, thesulforhodamine B (SRB) assay, WST assay, clonogenic assay and the ECIStechnology.

The cytotoxic activity mediated by CDH19/CD3 bispecific antibodyconstructs of the present invention is preferably measured in acell-based cytotoxicity assay. It is represented by the EC₅₀ value,which corresponds to the half maximal effective concentration(concentration of the antibody construct which induces a cytotoxicresponse halfway between the baseline and maximum). Preferably, the EC₅₀value of the CDH19/CD3 bispecific antibody constructs is ≤20.000 pg/ml,more preferably ≤5000 pg/ml, even more preferably ≤1000 pg/ml, even morepreferably ≤500 pg/ml, even more preferably ≤350 pg/ml, even morepreferably ≤320 pg/ml, even more preferably ≤250 pg/ml, even morepreferably ≤100 pg/ml, even more preferably ≤50 pg/ml, even morepreferably ≤10 pg/ml, and most preferably ≤5 pg/ml.

Any of the above given EC₅₀ values can be combined with any one of theindicated scenarios of a cell-based cytotoxicity assay. For example,when (human) CD8 positive T cells or a macaque T cell line are used aseffector cells, the EC₅₀ value of the CDH19/CD3 bispecific antibodyconstruct is preferably ≤1000 pg/ml, more preferably ≤500 pg/ml, evenmore preferably ≤250 pg/ml, even more preferably ≤100 pg/ml, even morepreferably ≤50 pg/ml, even more preferably ≤10 pg/ml, and mostpreferably ≤5 pg/ml. If in this assay the target cells are (human ormacaque) CDH19 transfected cells such as CHO cells, the EC₅₀ value ofthe CDH19/CD3 bispecific antibody construct is preferably ≤150 pg/ml,more preferably ≤100 pg/ml, even more preferably ≤50 pg/ml, even morepreferably ≤30 pg/ml, even more preferably ≤10 pg/ml, and mostpreferably ≤5 pg/ml.

If the target cells are a CDH19 positive natural expresser cell line,then the EC₅₀ value is preferably ≤350 pg/ml, more preferably ≤320pg/ml, even more preferably ≤250 pg/ml, even more preferably ≤200 pg/ml,even more preferably ≤100 pg/ml, even more preferably 5150 pg/ml, evenmore preferably ≤100 pg/ml, and most preferably ≤50 pg/ml, or lower.When (human) PBMCs are used as effector cells, the EC₅₀ value of theCDH19/CD3 bispecific antibody construct is preferably ≤1000 pg/ml, morepreferably 5750 pg/ml, more preferably ≤500 pg/ml, even more preferably≤350 pg/ml, even more preferably ≤320 pg/ml, even more preferably ≤250pg/ml, even more preferably ≤100 pg/ml, and most preferably 550 pg/ml,or lower.

The difference in cytotoxic activity between the monomeric and thedimeric isoform of individual CDH19/CD3 bispecific antibody constructsis referred to as “potency gap”. This potency gap can e.g. be calculatedas ratio between EC₅₀ values of the molecule's monomeric and dimericform. Potency gaps of the CDH19/CD3 bispecific antibody constructs ofthe present invention are preferably ≤5, more preferably 54, even morepreferably ≤3, even more preferably ≤2 and most preferably ≤1.

The antibody construct of the invention is a fusion protein comprisingat least two binding domains, with or without peptide linkers (spacerpeptides). Among the suitable peptide linkers are those described inU.S. Pat. Nos. 4,751,180 and 4,935,233 or WO 88/09344. Another methodfor preparing oligomeric antibody construct derivatives involves use ofa leucine zipper. Leucine zipper domains are peptides that promoteoligomerization of the proteins in which they are found. Leucine zipperswere originally identified in several DNA-binding proteins (Landschulzet al., 1988, Science 240:1759), and have since been found in a varietyof different proteins. Among the known leucine zippers are naturallyoccurring peptides and derivatives thereof that dimerize or trimerize.Examples of leucine zipper domains suitable for producing solubleoligomeric proteins are described in PCT application WO 94/10308, andthe leucine zipper derived from lung surfactant protein D (SPD)described in Hoppe et al., 1994, FEBS Letters 344:191, herebyincorporated by reference. The use of a modified leucine zipper thatallows for stable trimerization of a heterologous protein fused theretois described in Fanslow et al., 1994, Semin. Immunol. 6:267-78. In oneapproach, recombinant fusion proteins comprising CDH19 antibody fragmentor derivative fused to a leucine zipper peptide are expressed insuitable host cells, and the soluble oligomeric CDH19 antibody fragmentsor derivatives that form are recovered from the culture supernatant.

Covalent modifications of antigen binding proteins are included withinthe scope of this invention, and are generally, but not always, donepost-translationally. For example, several types of covalentmodifications of the antigen binding protein are introduced into themolecule by reacting specific amino acid residues of the antigen bindingprotein with an organic derivatizing agent that is capable of reactingwith selected side chains or the N- or C-terminal residues.

Cysteinyl residues most commonly are reacted with α-haloacetates (andcorresponding amines), such as chloroacetic acid or chloroacetamide, togive carboxymethyl or carboxyamidomethyl derivatives. Cysteinyl residuesalso are derivatized by reaction with bromotrifluoroacetone,α-bromo-β-(5-imidozoyl)propionic acid, chloroacetyl phosphate,N-alkylmaleimides, 3-nitro-2-pyridyl disulfide, methyl 2-pyridyldisulfide, p-chloromercuribenzoate, 2-chloromercuri-4-nitrophenol, orchloro-7-nitrobenzo-2-oxa-1,3-diazole.

Histidyl residues are derivatized by reaction with diethylpyrocarbonateat pH 5.5-7.0 because this agent is relatively specific for the histidylside chain. Para-bromophenacyl bromide also is useful; the reaction ispreferably performed in 0.1M sodium cacodylate at pH 6.0.

Lysinyl and amino terminal residues are reacted with succinic or othercarboxylic acid anhydrides. Derivatization with these agents has theeffect of reversing the charge of the lysinyl residues. Other suitablereagents for derivatizing alpha-amino-containing residues includeimidoesters such as methyl picolinimidate; pyridoxal phosphate;pyridoxal; chloroborohydride; trinitrobenzenesulfonic acid;O-methylisourea; 2,4-pentanedione; and transaminase-catalyzed reactionwith glyoxylate.

Arginyl residues are modified by reaction with one or severalconventional reagents, among them phenylglyoxal, 2,3-butanedione,1,2-cyclohexanedione, and ninhydrin. Derivatization of arginine residuesrequires that the reaction be performed in alkaline conditions becauseof the high pKa of the guanidine functional group. Furthermore, thesereagents may react with the groups of lysine as well as the arginineepsilon-amino group.

The specific modification of tyrosyl residues may be made, withparticular interest in introducing spectral labels into tyrosyl residuesby reaction with aromatic diazonium compounds or tetranitromethane. Mostcommonly, N-acetylimidizole and tetranitromethane are used to formO-acetyl tyrosyl species and 3-nitro derivatives, respectively. Tyrosylresidues are iodinated using ¹²⁵I or ¹³¹I to prepare labeled proteinsfor use in radioimmunoassay, the chloramine T method described abovebeing suitable.

Carboxyl side groups (aspartyl or glutamyl) are selectively modified byreaction with carbodiimides (R′—N═C═N—R′), where R and R′ are optionallydifferent alkyl groups, such as 1-cyclohexyl-3-(2-morpholinyl-4-ethyl)carbodiimide or 1-ethyl-3-(4-azonia-4,4-dimethylpentyl) carbodiimide.Furthermore, aspartyl and glutamyl residues are converted to asparaginyland glutaminyl residues by reaction with ammonium ions.

Derivatization with bifunctional agents is useful for crosslinkingantigen binding proteins to a water-insoluble support matrix or surfacefor use in a variety of methods. Commonly used crosslinking agentsinclude, e.g., 1,1-bis(diazoacetyl)-2-phenylethane, glutaraldehyde,N-hydroxysuccinimide esters, for example, esters with 4-azidosalicylicacid, homobifunctional imidoesters, including disuccinimidyl esters suchas 3,3′-dithiobis(succinimidylpropionate), and bifunctional maleimidessuch as bis-N-maleimido-1,8-octane. Derivatizing agents such asmethyl-3-[(p-azidophenyl)dithio]propioimidate yield photoactivatableintermediates that are capable of forming crosslinks in the presence oflight. Alternatively, reactive water-insoluble matrices such as cyanogenbromide-activated carbohydrates and the reactive substrates described inU.S. Pat. Nos. 3,969,287; 3,691,016; 4,195,128; 4,247,642; 4,229,537;and 4,330,440 are employed for protein immobilization.

Glutaminyl and asparaginyl residues are frequently deamidated to thecorresponding glutamyl and aspartyl residues, respectively.Alternatively, these residues are deamidated under mildly acidicconditions. Either form of these residues falls within the scope of thisinvention.

Other modifications include hydroxylation of proline and lysine,phosphorylation of hydroxyl groups of seryl or threonyl residues,methylation of the α-amino groups of lysine, arginine, and histidineside chains (T. E. Creighton, Proteins: Structure and MolecularProperties, W. H. Freeman & Co., San Francisco, 1983, pp. 79-86),acetylation of the N-terminal amine, and amidation of any C-terminalcarboxyl group.

Another type of covalent modification of the antigen binding proteinincluded within the scope of this invention comprises altering theglycosylation pattern of the protein. As is known in the art,glycosylation patterns can depend on both the sequence of the protein(e.g., the presence or absence of particular glycosylation amino acidresidues, discussed below), or the host cell or organism in which theprotein is produced. Particular expression systems are discussed below.

Glycosylation of polypeptides is typically either N-linked or O-linked.N-linked refers to the attachment of the carbohydrate moiety to the sidechain of an asparagine residue. The tri-peptide sequencesasparagine-X-serine and asparagine-X-threonine, where X is any aminoacid except proline, are the recognition sequences for enzymaticattachment of the carbohydrate moiety to the asparagine side chain.Thus, the presence of either of these tri-peptide sequences in apolypeptide creates a potential glycosylation site. O-linkedglycosylation refers to the attachment of one of the sugarsN-acetylgalactosamine, galactose, or xylose, to a hydroxyamino acid,most commonly serine or threonine, although 5-hydroxyproline or5-hydroxylysine may also be used.

Addition of glycosylation sites to the antigen binding protein isconveniently accomplished by altering the amino acid sequence such thatit contains one or more of the above-described tri-peptide sequences(for N-linked glycosylation sites). The alteration may also be made bythe addition of, or substitution by, one or more serine or threonineresidues to the starting sequence (for O-linked glycosylation sites).For ease, the antigen binding protein amino acid sequence is preferablyaltered through changes at the DNA level, particularly by mutating theDNA encoding the target polypeptide at preselected bases such thatcodons are generated that will translate into the desired amino acids.

Another means of increasing the number of carbohydrate moieties on theantigen binding protein is by chemical or enzymatic coupling ofglycosides to the protein. These procedures are advantageous in thatthey do not require production of the protein in a host cell that hasglycosylation capabilities for N- and O-linked glycosylation. Dependingon the coupling mode used, the sugar(s) may be attached to (a) arginineand histidine, (b) free carboxyl groups, (c) free sulfhydryl groups suchas those of cysteine, (d) free hydroxyl groups such as those of serine,threonine, or hydroxyproline, (e) aromatic residues such as those ofphenylalanine, tyrosine, or tryptophan, or (f) the amide group ofglutamine. These methods are described in WO 87/05330 published Sep. 11,1987, and in Aplin and Wriston, 1981, CRC Crit. Rev. Biochem., pp.259-306.

Removal of carbohydrate moieties present on the starting antigen bindingprotein may be accomplished chemically or enzymatically. Chemicaldeglycosylation requires exposure of the protein to the compoundtrifluoromethanesulfonic acid, or an equivalent compound. This treatmentresults in the cleavage of most or all sugars except the linking sugar(N-acetylglucosamine or N-acetylgalactosamine), while leaving thepolypeptide intact. Chemical deglycosylation is described by Hakimuddinet al., 1987, Arch. Biochem. Biophys. 259:52 and by Edge et al., 1981,Anal. Biochem. 118:131. Enzymatic cleavage of carbohydrate moieties onpolypeptides can be achieved by the use of a variety of endo- andexo-glycosidases as described by Thotakura et al., 1987, Meth. Enzymol.138:350. Glycosylation at potential glycosylation sites may be preventedby the use of the compound tunicamycin as described by Duskin et al.,1982, J. Biol. Chem. 257:3105. Tunicamycin blocks the formation ofprotein-N-glycoside linkages.

Another type of covalent modification of the antigen binding proteincomprises linking the antigen binding protein to variousnon-proteinaceous polymers, including, but not limited to, variouspolyols such as polyethylene glycol, polypropylene glycol orpolyoxyalkylenes, in the manner set forth in U.S. Pat. Nos. 4,640,835;4,496,689; 4,301,144; 4,670,417; 4,791,192 or 4,179,337. In addition, asis known in the art, amino acid substitutions may be made in variouspositions within the antigen binding protein to facilitate the additionof polymers such as PEG.

In some embodiments, the covalent modification of the antigen bindingproteins of the invention comprises the addition of one or more labels.

The term “labelling group” means any detectable label. Examples ofsuitable labelling groups include, but are not limited to, thefollowing: radioisotopes or radionuclides (e.g., ³H, ¹⁴C, ¹⁵N, ³⁵S,⁸⁹Zr, ⁹⁰Y, ⁹⁹Tc, ¹¹¹In, ¹²⁵I, ¹³¹I), fluorescent groups (e.g., FITC,rhodamine, lanthanide phosphors), enzymatic groups (e.g., horseradishperoxidase, β-galactosidase, luciferase, alkaline phosphatase),chemiluminescent groups, biotinyl groups, or predetermined polypeptideepitopes recognized by a secondary reporter (e.g., leucine zipper pairsequences, binding sites for secondary antibodies, metal bindingdomains, epitope tags). In some embodiments, the labelling group iscoupled to the antigen binding protein via spacer arms of variouslengths to reduce potential steric hindrance. Various methods forlabelling proteins are known in the art and may be used in performingthe present invention.

In general, labels fall into a variety of classes, depending on theassay in which they are to be detected: a) isotopic labels, which may beradioactive or heavy isotopes; b) magnetic labels (e.g., magneticparticles); c) redox active moieties; d) optical dyes; enzymatic groups(e.g. horseradish peroxidase, β-galactosidase, luciferase, alkalinephosphatase); e) biotinylated groups; and f) predetermined polypeptideepitopes recognized by a secondary reporter (e.g., leucine zipper pairsequences, binding sites for secondary antibodies, metal bindingdomains, epitope tags, etc.). In some embodiments, the labelling groupis coupled to the antigen binding protein via spacer arms of variouslengths to reduce potential steric hindrance. Various methods forlabelling proteins are known in the art and may be used in performingthe present invention.

Specific labels include optical dyes, including, but not limited to,chromophores, phosphors and fluorophores, with the latter being specificin many instances. Fluorophores can be either “small molecule” fluores,or proteinaceous fluores.

By “fluorescent label” is meant any molecule that may be detected viaits inherent fluorescent properties. Suitable fluorescent labelsinclude, but are not limited to, fluorescein, rhodamine,tetramethylrhodamine, eosin, erythrosin, coumarin, methyl-coumarins,pyrene, Malacite green, stilbene, Lucifer Yellow, Cascade BlueJ, TexasRed, IAEDANS, EDANS, BODIPY FL, LC Red 640, Cy 5, Cy 5.5, LC Red 705,Oregon green, the Alexa-Fluor dyes (Alexa Fluor 350, Alexa Fluor 430,Alexa Fluor 488, Alexa Fluor 546, Alexa Fluor 568, Alexa Fluor 594,Alexa Fluor 633, Alexa Fluor 660, Alexa Fluor 680), Cascade Blue,Cascade Yellow and R-phycoerythrin (PE) (Molecular Probes, Eugene,Oreg.), FITC, Rhodamine, and Texas Red (Pierce, Rockford, Ill.), Cy5,Cy5.5, Cy7 (Amersham Life Science, Pittsburgh, Pa.). Suitable opticaldyes, including fluorophores, are described in Molecular Probes Handbookby Richard P. Haugland, hereby expressly incorporated by reference.

Suitable proteinaceous fluorescent labels also include, but are notlimited to, green fluorescent protein, including a Renilla, Ptilosarcus,or Aequorea species of GFP (Chalfie et al., 1994, Science 263:802-805),EGFP (Clontech Laboratories, Inc., Genbank Accession Number U55762),blue fluorescent protein (BFP, Quantum Biotechnologies, Inc. 1801 deMaisonneuve Blvd. West, 8th Floor, Montreal, Quebec, Canada H3H 1J9;Stauber, 1998, Biotechniques 24:462-471; Heim et al., 1996, Curr. Biol.6:178-182), enhanced yellow fluorescent protein (EYFP, ClontechLaboratories, Inc.), luciferase (Ichiki et al., 1993, J. Immunol.150:5408-5417), β galactosidase (Nolan et al., 1988, Proc. Natl. Acad.Sci. U.S.A. 85:2603-2607) and Renilla (WO92/15673, WO95/07463,WO98/14605, WO98/26277, WO99/49019, U.S. Pat. Nos. 5,292,658, 5,418,155,5,683,888, 5,741,668, 5,777,079, 5,804,387, 5,874,304, 5,876,995,5,925,558). All of the above-cited references are expressly incorporatedherein by reference.

The antibody construct of the invention may also comprise additionaldomains, which e.g. are helpful in the isolation of the molecule orrelate to an adapted pharmacokinetic profile of the molecule.

Domains helpful for the isolation of an antibody construct may beelected from peptide motives or secondarily introduced moieties, whichcan be captured in an isolation method, e.g. an isolation column. Anon-limiting embodiments of such additional domains comprise peptidemotives known as Myc-tag, HAT-tag, HA-tag, TAP-tag, GST-tag, chitinbinding domain (CBD-tag), maltose binding protein (MBP-tag), Flag-tag,Strep-tag and variants thereof (e.g. Strepll-tag) and His-tag. Allherein disclosed antibody constructs characterized by the identifiedCDRs are preferred to comprise a His-tag domain, which is generallyknown as a repeat of consecutive His residues in the amino acid sequenceof a molecule, preferably of six His residues.

As described in appended example 2 a broad number of CDH19 specificbinder has been characterized with respect to identified bindingcharacteristics and those binders were grouped into five different bins,which refers to five different subgroups of CDH19 specific bindingdomains. Accordingly, in one embodiment the antibody construct of theinvention the first binding domain comprises a VH region comprisingCDR-H1, CDR-H2 and CDR-H3 and a VL region comprising CDR-L1, CDR-L2 andCDR-L3 selected from the group consisting of:

-   (a) CDR-H1 as depicted in SEQ ID NO: 52, CDR-H2 as depicted in SEQ    ID NO: 53, CDR-H3 as depicted in SEQ ID NO: 54, CDR-L1 as depicted    in SEQ ID NO: 220, CDR-L2 as depicted in SEQ ID NO: 221 and CDR-L3    as depicted in SEQ ID NO: 222, CDR-H1 as depicted in SEQ ID NO: 82,    CDR-H2 as depicted in SEQ ID NO: 83, CDR-H3 as depicted in SEQ ID    NO: 84, CDR-L1 as depicted in SEQ ID NO: 250, CDR-L2 as depicted in    SEQ ID NO: 251 and CDR-L3 as depicted in SEQ ID NO: 252, CDR-H1 as    depicted in SEQ ID NO: 82, CDR-H2 as depicted in SEQ ID NO: 83,    CDR-H3 as depicted in SEQ ID NO: 84, CDR-L1 as depicted in SEQ ID    NO: 250, CDR-L2 as depicted in SEQ ID NO: 251 and CDR-L3 as depicted    in SEQ ID NO: 927, CDR-H1 as depicted in SEQ ID NO: 82, CDR-H2 as    depicted in SEQ ID NO: 83, CDR-H3 as depicted in SEQ ID NO: 909,    CDR-L1 as depicted in SEQ ID NO: 250, CDR-L2 as depicted in SEQ ID    NO: 251 and CDR-L3 as depicted in SEQ ID NO: 927, CDR-H1 as depicted    in SEQ ID NO: 52, CDR-H2 as depicted in SEQ ID NO: 53, CDR-H3 as    depicted in SEQ ID NO: 54, CDR-L1 as depicted in SEQ ID NO: 220,    CDR-L2 as depicted in SEQ ID NO: 221 and CDR-L3 as depicted in SEQ    ID NO: 926,    -   CDR-H1 as depicted in SEQ ID NO: 52, CDR-H2 as depicted in SEQ        ID NO: 53, CDR-H3 as depicted in SEQ ID NO: 904, CDR-L1 as        depicted in SEQ ID NO: 220, CDR-L2 as depicted in SEQ ID NO: 221        and CDR-L3 as depicted in SEQ ID NO: 926,    -   CDR-H1 as depicted in SEQ ID NO: 1126, CDR-H2 as depicted in SEQ        ID NO: 1127, CDR-H3 as depicted in SEQ ID NO: 1128, CDR-L1 as        depicted in SEQ ID NO: 1129, CDR-L2 as depicted in SEQ ID NO:        1130 and CDR-L3 as depicted in SEQ ID NO: 1131,    -   CDR-H1 as depicted in SEQ ID NO: 1165, CDR-H2 as depicted in SEQ        ID NO: 1166, CDR-H3 as depicted in SEQ ID NO: 1167, CDR-L1 as        depicted in SEQ ID NO: 1168, CDR-L2 as depicted in SEQ ID NO:        1169 and CDR-L3 as depicted in SEQ ID NO: 1170,    -   CDR-H1 as depicted in SEQ ID NO: 1334, CDR-H2 as depicted in SEQ        ID NO: 1335, CDR-H3 as depicted in SEQ ID NO: 1336, CDR-L1 as        depicted in SEQ ID NO: 1337, CDR-L2 as depicted in SEQ ID NO:        1338 and CDR-L3 as depicted in SEQ ID NO: 1339,    -   CDR-H1 as depicted in SEQ ID NO: 1347, CDR-H2 as depicted in SEQ        ID NO: 1348, CDR-H3 as depicted in SEQ ID NO: 1349, CDR-L1 as        depicted in SEQ ID NO: 1350, CDR-L2 as depicted in SEQ ID NO:        1351 and CDR-L3 as depicted in SEQ ID NO: 1352, and    -   CDR-H1 as depicted in SEQ ID NO: 1360 CDR-H2 as depicted in SEQ        ID NO: 1361, CDR-H3 as depicted in SEQ ID NO: 1362, CDR-L1 as        depicted in SEQ ID NO: 1363, CDR-L2 as depicted in SEQ ID NO:        1364 and CDR-L3 as depicted in SEQ ID NO: 1365,    -   CDR-H1 as depicted in SEQ ID NO: 1425 CDR-H2 as depicted in SEQ        ID NO: 1426, CDR-H3 as depicted in SEQ ID NO: 1427, CDR-L1 as        depicted in SEQ ID NO: 1428, CDR-L2 as depicted in SEQ ID NO:        1429 and CDR-L3 as depicted in SEQ ID NO: 1430,    -   CDR-H1 as depicted in SEQ ID NO: 1438 CDR-H2 as depicted in SEQ        ID NO: 1439, CDR-H3 as depicted in SEQ ID NO: 1440, CDR-L1 as        depicted in SEQ ID NO: 1441, CDR-L2 as depicted in SEQ ID NO:        1442 and CDR-L3 as depicted in SEQ ID NO: 1443, and    -   CDR-H1 as depicted in SEQ ID NO: 2167 CDR-H2 as depicted in SEQ        ID NO: 2168, CDR-H3 as depicted in SEQ ID NO: 2169, CDR-L1 as        depicted in SEQ ID NO: 2170, CDR-L2 as depicted in SEQ ID NO:        2171 and CDR-L3 as depicted in SEQ ID NO: 2172,    -   which all characterize binding domains for CDH19 grouped into        bin 1;-   (b) CDR-H1 as depicted in SEQ ID NO: 124, CDR-H2 as depicted in SEQ    ID NO: 125, CDR-H3 as depicted in SEQ ID NO: 126, CDR-L1 as depicted    in SEQ ID NO: 292, CDR-L2 as depicted in SEQ ID NO: 293 and CDR-L3    as depicted in SEQ ID NO: 294, CDR-H1 as depicted in SEQ ID NO: 130,    CDR-H2 as depicted in SEQ ID NO: 131, CDR-H3 as depicted in SEQ ID    NO: 132, CDR-L1 as depicted in SEQ ID NO: 298, CDR-L2 as depicted in    SEQ ID NO: 299 and CDR-L3 as depicted in SEQ ID NO: 300, CDR-H1 as    depicted in SEQ ID NO: 136, CDR-H2 as depicted in SEQ ID NO: 137,    CDR-H3 as depicted in SEQ ID NO: 138, CDR-L1 as depicted in SEQ ID    NO: 304, CDR-L2 as depicted in SEQ ID NO: 305 and CDR-L3 as depicted    in SEQ ID NO: 306, CDR-H1 as depicted in SEQ ID NO: 142, CDR-H2 as    depicted in SEQ ID NO: 143, CDR-H3 as depicted in SEQ ID NO: 144,    CDR-L1 as depicted in SEQ ID NO: 310, CDR-L2 as depicted in SEQ ID    NO: 311 and CDR-L3 as depicted in SEQ ID NO: 312, CDR-H1 as depicted    in SEQ ID NO: 148, CDR-H2 as depicted in SEQ ID NO: 149, CDR-H3 as    depicted in SEQ ID NO: 150, CDR-L1 as depicted in SEQ ID NO: 316,    CDR-L2 as depicted in SEQ ID NO: 317 and CDR-L3 as depicted in SEQ    ID NO: 318, CDR-H1 as depicted in SEQ ID NO: 166, CDR-H2 as depicted    in SEQ ID NO: 167, CDR-H3 as depicted in SEQ ID NO: 168, CDR-L1 as    depicted in SEQ ID NO: 334, CDR-L2 as depicted in SEQ ID NO: 335 and    CDR-L3 as depicted in SEQ ID NO: 336, CDR-H1 as depicted in SEQ ID    NO: 124, CDR-H2 as depicted in SEQ ID NO: 125, CDR-H3 as depicted in    SEQ ID NO: 915, CDR-L1 as depicted in SEQ ID NO: 292, CDR-L2 as    depicted in SEQ ID NO: 293 and CDR-L3 as depicted in SEQ ID NO: 294,    CDR-H1 as depicted in SEQ ID NO: 124, CDR-H2 as depicted in SEQ ID    NO: 125, CDR-H3 as depicted in SEQ ID NO: 915, CDR-L1 as depicted in    SEQ ID NO: 292, CDR-L2 as depicted in SEQ ID NO: 293 and CDR-L3 as    depicted in SEQ ID NO: 928, CDR-H1 as depicted in SEQ ID NO: 124,    CDR-H2 as depicted in SEQ ID NO: 125, CDR-H3 as depicted in SEQ ID    NO: 915, CDR-L1 as depicted in SEQ ID NO: 292, CDR-L2 as depicted in    SEQ ID NO: 293 and CDR-L3 as depicted in SEQ ID NO: 929, CDR-H1 as    depicted in SEQ ID NO: 166, CDR-H2 as depicted in SEQ ID NO: 167,    CDR-H3 as depicted in SEQ ID NO: 168, CDR-L1 as depicted in SEQ ID    NO: 334, CDR-L2 as depicted in SEQ ID NO: 335 and CDR-L3 as depicted    in SEQ ID NO: 336, CDR-H1 as depicted in SEQ ID NO: 166, CDR-H2 as    depicted in SEQ ID NO: 167, CDR-H3 as depicted in SEQ ID NO: 168,    CDR-L1 as depicted in SEQ ID NO: 334, CDR-L2 as depicted in SEQ ID    NO: 335 and CDR-L3 as depicted in SEQ ID NO: 942, CDR-H1 as depicted    in SEQ ID NO: 166, CDR-H2 as depicted in SEQ ID NO: 167, CDR-H3 as    depicted in SEQ ID NO: 168, CDR-L1 as depicted in SEQ ID NO: 334,    CDR-L2 as depicted in SEQ ID NO: 335 and CDR-L3 as depicted in SEQ    ID NO: 943, CDR-H1 as depicted in SEQ ID NO: 148, CDR-H2 as depicted    in SEQ ID NO: 149, CDR-H3 as depicted in SEQ ID NO: 150, CDR-L1 as    depicted in SEQ ID NO: 316, CDR-L2 as depicted in SEQ ID NO: 317 and    CDR-L3 as depicted in SEQ ID NO: 318, CDR-H1 as depicted in SEQ ID    NO: 148, CDR-H2 as depicted in SEQ ID NO: 149, CDR-H3 as depicted in    SEQ ID NO: 150, CDR-L1 as depicted in SEQ ID NO: 316, CDR-L2 as    depicted in SEQ ID NO: 317 and CDR-L3 as depicted in SEQ ID NO: 937,    CDR-H1 as depicted in SEQ ID NO: 148, CDR-H2 as depicted in SEQ ID    NO: 149, CDR-H3 as depicted in SEQ ID NO: 150, CDR-L1 as depicted in    SEQ ID NO: 316, CDR-L2 as depicted in SEQ ID NO: 317 and CDR-L3 as    depicted in SEQ ID NO: 938, CDR-H1 as depicted in SEQ ID NO: 148,    CDR-H2 as depicted in SEQ ID NO: 149, CDR-H3 as depicted in SEQ ID    NO: 919, CDR-L1 as depicted in SEQ ID NO: 316, CDR-L2 as depicted in    SEQ ID NO: 317 and CDR-L3 as depicted in SEQ ID NO: 938, CDR-H1 as    depicted in SEQ ID NO: 142, CDR-H2 as depicted in SEQ ID NO: 143,    CDR-H3 as depicted in SEQ ID NO: 144, CDR-L1 as depicted in SEQ ID    NO: 310, CDR-L2 as depicted in SEQ ID NO: 311 and CDR-L3 as depicted    in SEQ ID NO: 935, CDR-H1 as depicted in SEQ ID NO: 142, CDR-H2 as    depicted in SEQ ID NO: 143, CDR-H3 as depicted in SEQ ID NO: 918,    CDR-L1 as depicted in SEQ ID NO: 310, CDR-L2 as depicted in SEQ ID    NO: 311 and CDR-L3 as depicted in SEQ ID NO: 935, CDR-H1 as depicted    in SEQ ID NO: 142, CDR-H2 as depicted in SEQ ID NO: 143, CDR-H3 as    depicted in SEQ ID NO: 918, CDR-L1 as depicted in SEQ ID NO: 310,    CDR-L2 as depicted in SEQ ID NO: 311 and CDR-L3 as depicted in SEQ    ID NO: 936, CDR-H1 as depicted in SEQ ID NO: 136, CDR-H2 as depicted    in SEQ ID NO: 137, CDR-H3 as depicted in SEQ ID NO: 138, CDR-L1 as    depicted in SEQ ID NO: 304, CDR-L2 as depicted in SEQ ID NO: 305 and    CDR-L3 as depicted in SEQ ID NO: 933, CDR-H1 as depicted in SEQ ID    NO: 136, CDR-H2 as depicted in SEQ ID NO: 137, CDR-H3 as depicted in    SEQ ID NO: 917, CDR-L1 as depicted in SEQ ID NO: 304, CDR-L2 as    depicted in SEQ ID NO: 305 and CDR-L3 as depicted in SEQ ID NO: 934,    CDR-H1 as depicted in SEQ ID NO: 130, CDR-H2 as depicted in SEQ ID    NO: 131, CDR-H3 as depicted in SEQ ID NO: 132, CDR-L1 as depicted in    SEQ ID NO: 298, CDR-L2 as depicted in SEQ ID NO: 299 and CDR-L3 as    depicted in SEQ ID NO: 930, CDR-H1 as depicted in SEQ ID NO: 130,    CDR-H2 as depicted in SEQ ID NO: 131, CDR-H3 as depicted in SEQ ID    NO: 916, CDR-L1 as depicted in SEQ ID NO: 298, CDR-L2 as depicted in    SEQ ID NO: 299 and CDR-L3 as depicted in SEQ ID NO: 931, CDR-H1 as    depicted in SEQ ID NO: 130, CDR-H2 as depicted in SEQ ID NO: 131,    CDR-H3 as depicted in SEQ ID NO: 916, CDR-L1 as depicted in SEQ ID    NO: 298, CDR-L2 as depicted in SEQ ID NO: 299 and CDR-L3 as depicted    in SEQ ID NO: 932, CDR-H1 as depicted in SEQ ID NO: 1009, CDR-H2 as    depicted in SEQ ID NO: 1010, CDR-H3 as depicted in SEQ ID NO: 1011,    CDR-L1 as depicted in SEQ ID NO: 1012, CDR-L2 as depicted in SEQ ID    NO: 1013 and CDR-L3 as depicted in SEQ ID NO: 1014,    -   CDR-H1 as depicted in SEQ ID NO: 1022, CDR-H2 as depicted in SEQ        ID NO: 1023, CDR-H3 as depicted in SEQ ID NO: 1024, CDR-L1 as        depicted in SEQ ID NO: 1025, CDR-L2 as depicted in SEQ ID NO:        1026 and CDR-L3 as depicted in SEQ ID NO: 1027,    -   CDR-H1 as depicted in SEQ ID NO: 1035, CDR-H2 as depicted in SEQ        ID NO: 1036, CDR-H3 as depicted in SEQ ID NO: 1037, CDR-L1 as        depicted in SEQ ID NO: 1038, CDR-L2 as depicted in SEQ ID NO:        1039 and CDR-L3 as depicted in SEQ ID NO: 1040,    -   CDR-H1 as depicted in SEQ ID NO: 1074, CDR-H2 as depicted in SEQ        ID NO: 1075, CDR-H3 as depicted in SEQ ID NO: 1076, CDR-L1 as        depicted in SEQ ID NO: 1077, CDR-L2 as depicted in SEQ ID NO:        1078 and CDR-L3 as depicted in SEQ ID NO: 1079,    -   CDR-H1 as depicted in SEQ ID NO: 1100, CDR-H2 as depicted in SEQ        ID NO: 1101, CDR-H3 as depicted in SEQ ID NO: 1102, CDR-L1 as        depicted in SEQ ID NO: 1103, CDR-L2 as depicted in SEQ ID NO:        1104 and CDR-L3 as depicted in SEQ ID NO: 1105,    -   CDR-H1 as depicted in SEQ ID NO: 1113, CDR-H2 as depicted in SEQ        ID NO: 1114, CDR-H3 as depicted in SEQ ID NO: 1115, CDR-L1 as        depicted in SEQ ID NO: 1116, CDR-L2 as depicted in SEQ ID NO:        1117 and CDR-L3 as depicted in SEQ ID NO: 1118,    -   CDR-H1 as depicted in SEQ ID NO: 1243, CDR-H2 as depicted in SEQ        ID NO: 1244, CDR-H3 as depicted in SEQ ID NO: 1245, CDR-L1 as        depicted in SEQ ID NO: 1246, CDR-L2 as depicted in SEQ ID NO:        1247 and CDR-L3 as depicted in SEQ ID NO: 1248,    -   CDR-H1 as depicted in SEQ ID NO: 1256, CDR-H2 as depicted in SEQ        ID NO: 1257, CDR-H3 as depicted in SEQ ID NO: 1258, CDR-L1 as        depicted in SEQ ID NO: 1259, CDR-L2 as depicted in SEQ ID NO:        1260 and CDR-L3 as depicted in SEQ ID NO: 1261,    -   CDR-H1 as depicted in SEQ ID NO: 1269, CDR-H2 as depicted in SEQ        ID NO: 1270, CDR-H3 as depicted in SEQ ID NO: 1271, CDR-L1 as        depicted in SEQ ID NO: 1272, CDR-L2 as depicted in SEQ ID NO:        1273 and CDR-L3 as depicted in SEQ ID NO: 1274,    -   CDR-H1 as depicted in SEQ ID NO: 1282, CDR-H2 as depicted in SEQ        ID NO: 1283, CDR-H3 as depicted in SEQ ID NO: 1284, CDR-L1 as        depicted in SEQ ID NO: 1285, CDR-L2 as depicted in SEQ ID NO:        1286 and CDR-L3 as depicted in SEQ ID NO: 1287, and    -   CDR-H1 as depicted in SEQ ID NO: 1295, CDR-H2 as depicted in SEQ        ID NO: 1296, CDR-H3 as depicted in SEQ ID NO: 1297, CDR-L1 as        depicted in SEQ ID NO: 1298, CDR-L2 as depicted in SEQ ID NO:        1299 and CDR-L3 as depicted in SEQ ID NO: 1300,    -   CDR-H1 as depicted in SEQ ID NO: 1647, CDR-H2 as depicted in SEQ        ID NO: 1648, CDR-H3 as depicted in SEQ ID NO: 1649, CDR-L1 as        depicted in SEQ ID NO: 1650, CDR-L2 as depicted in SEQ ID NO:        1651 and CDR-L3 as depicted in SEQ ID NO: 1652,    -   CDR-H1 as depicted in SEQ ID NO: 1660, CDR-H2 as depicted in SEQ        ID NO: 1661, CDR-H3 as depicted in SEQ ID NO: 1662, CDR-L1 as        depicted in SEQ ID NO: 1663, CDR-L2 as depicted in SEQ ID NO:        1664 and CDR-L3 as depicted in SEQ ID NO: 1665,    -   CDR-H1 as depicted in SEQ ID NO: 1894, CDR-H2 as depicted in SEQ        ID NO: 1895, CDR-H3 as depicted in SEQ ID NO: 1896, CDR-L1 as        depicted in SEQ ID NO: 1897, CDR-L2 as depicted in SEQ ID NO:        1898 and CDR-L3 as depicted in SEQ ID NO: 1899,    -   CDR-H1 as depicted in SEQ ID NO: 1907, CDR-H2 as depicted in SEQ        ID NO: 1908, CDR-H3 as depicted in SEQ ID NO: 1909, CDR-L1 as        depicted in SEQ ID NO: 1910, CDR-L2 as depicted in SEQ ID NO:        1911 and CDR-L3 as depicted in SEQ ID NO: 1912,    -   CDR-H1 as depicted in SEQ ID NO: 1933, CDR-H2 as depicted in SEQ        ID NO: 1934, CDR-H3 as depicted in SEQ ID NO: 1935, CDR-L1 as        depicted in SEQ ID NO: 1936, CDR-L2 as depicted in SEQ ID NO:        1937 and CDR-L3 as depicted in SEQ ID NO: 1938,    -   CDR-H1 as depicted in SEQ ID NO: 1946, CDR-H2 as depicted in SEQ        ID NO: 1947, CDR-H3 as depicted in SEQ ID NO: 1948, CDR-L1 as        depicted in SEQ ID NO: 1949, CDR-L2 as depicted in SEQ ID NO:        1950 and CDR-L3 as depicted in SEQ ID NO: 1951,    -   CDR-H1 as depicted in SEQ ID NO: 1959, CDR-H2 as depicted in SEQ        ID NO: 1960, CDR-H3 as depicted in SEQ ID NO: 1961, CDR-L1 as        depicted in SEQ ID NO: 1962, CDR-L2 as depicted in SEQ ID NO:        1963 and CDR-L3 as depicted in SEQ ID NO: 1964,    -   CDR-H1 as depicted in SEQ ID NO: 1972, CDR-H2 as depicted in SEQ        ID NO: 1973, CDR-H3 as depicted in SEQ ID NO: 1974, CDR-L1 as        depicted in SEQ ID NO: 1975, CDR-L2 as depicted in SEQ ID NO:        1976 and CDR-L3 as depicted in SEQ ID NO: 1977,    -   CDR-H1 as depicted in SEQ ID NO: 1985, CDR-H2 as depicted in SEQ        ID NO: 1986, CDR-H3 as depicted in SEQ ID NO: 1987, CDR-L1 as        depicted in SEQ ID NO: 1988, CDR-L2 as depicted in SEQ ID NO:        1989 and CDR-L3 as depicted in SEQ ID NO: 1990,    -   CDR-H1 as depicted in SEQ ID NO: 1998, CDR-H2 as depicted in SEQ        ID NO: 1999, CDR-H3 as depicted in SEQ ID NO: 2000, CDR-L1 as        depicted in SEQ ID NO: 2001, CDR-L2 as depicted in SEQ ID NO:        2002 and CDR-L3 as depicted in SEQ ID NO: 2003,    -   CDR-H1 as depicted in SEQ ID NO: 2011, CDR-H2 as depicted in SEQ        ID NO: 2012, CDR-H3 as depicted in SEQ ID NO: 2013, CDR-L1 as        depicted in SEQ ID NO: 2014, CDR-L2 as depicted in SEQ ID NO:        2015 and CDR-L3 as depicted in SEQ ID NO: 2016,    -   CDR-H1 as depicted in SEQ ID NO: 2024, CDR-H2 as depicted in SEQ        ID NO: 2025, CDR-H3 as depicted in SEQ ID NO: 2026, CDR-L1 as        depicted in SEQ ID NO: 2027, CDR-L2 as depicted in SEQ ID NO:        2028 and CDR-L3 as depicted in SEQ ID NO: 2029,    -   CDR-H1 as depicted in SEQ ID NO: 2037, CDR-H2 as depicted in SEQ        ID NO: 2038, CDR-H3 as depicted in SEQ ID NO: 2039, CDR-L1 as        depicted in SEQ ID NO: 2040, CDR-L2 as depicted in SEQ ID NO:        2041 and CDR-L3 as depicted in SEQ ID NO: 2042, and    -   CDR-H1 as depicted in SEQ ID NO: 2050, CDR-H2 as depicted in SEQ        ID NO: 2051, CDR-H3 as depicted in SEQ ID NO: 2052, CDR-L1 as        depicted in SEQ ID NO: 2053, CDR-L2 as depicted in SEQ ID NO:        2054 and CDR-L3 as depicted in SEQ ID NO: 2055,    -   which all characterize binding domains for CDH19 grouped into        bin 2;-   (c) CDR-H1 as depicted in SEQ ID NO: 94, CDR-H2 as depicted in SEQ    ID NO: 95, CDR-H3 as depicted in SEQ ID NO: 96, CDR-L1 as depicted    in SEQ ID NO: 262, CDR-L2 as depicted in SEQ ID NO: 263 and CDR-L3    as depicted in SEQ ID NO: 264,    -   CDR-H1 as depicted in SEQ ID NO: 100, CDR-H2 as depicted in SEQ        ID NO: 101, CDR-H3 as depicted in SEQ ID NO: 102, CDR-L1 as        depicted in SEQ ID NO: 268, CDR-L2 as depicted in SEQ ID NO: 269        and CDR-L3 as depicted in SEQ ID NO: 270, CDR-H1 as depicted in        SEQ ID NO: 118, CDR-H2 as depicted in SEQ ID NO: 119, CDR-H3 as        depicted in SEQ ID NO: 120, CDR-L1 as depicted in SEQ ID NO:        286, CDR-L2 as depicted in SEQ ID NO: 287 and CDR-L3 as depicted        in SEQ ID NO: 288, CDR-H1 as depicted in SEQ ID NO: 154, CDR-H2        as depicted in SEQ ID NO: 155, CDR-H3 as depicted in SEQ ID NO:        156, CDR-L1 as depicted in SEQ ID NO: 322, CDR-L2 as depicted in        SEQ ID NO: 323 and CDR-L3 as depicted in SEQ ID NO: 324, CDR-H1        as depicted in SEQ ID NO: 100, CDR-H2 as depicted in SEQ ID NO:        101, CDR-H3 as depicted in SEQ ID NO: 912, CDR-L1 as depicted in        SEQ ID NO: 268, CDR-L2 as depicted in SEQ ID NO: 269 and CDR-L3        as depicted in SEQ ID NO: 270, CDR-H1 as depicted in SEQ ID NO:        100, CDR-H2 as depicted in SEQ ID NO: 101, CDR-H3 as depicted in        SEQ ID NO: 913, CDR-L1 as depicted in SEQ ID NO: 268, CDR-L2 as        depicted in SEQ ID NO: 269 and CDR-L3 as depicted in SEQ ID NO:        270, CDR-H1 as depicted in SEQ ID NO: 94, CDR-H2 as depicted in        SEQ ID NO: 95, CDR-H3 as depicted in SEQ ID NO: 910, CDR-L1 as        depicted in SEQ ID NO: 262, CDR-L2 as depicted in SEQ ID NO: 263        and CDR-L3 as depicted in SEQ ID NO: 264, CDR-H1 as depicted in        SEQ ID NO: 94, CDR-H2 as depicted in SEQ ID NO: 95, CDR-H3 as        depicted in SEQ ID NO: 911, CDR-L1 as depicted in SEQ ID NO:        262, CDR-L2 as depicted in SEQ ID NO: 263 and CDR-L3 as depicted        in SEQ ID NO: 264, CDR-H1 as depicted in SEQ ID NO: 118, CDR-H2        as depicted in SEQ ID NO: 119, CDR-H3 as depicted in SEQ ID NO:        120, CDR-L1 as depicted in SEQ ID NO: 286, CDR-L2 as depicted in        SEQ ID NO: 287 and CDR-L3 as depicted in SEQ ID NO: 288, CDR-H1        as depicted in SEQ ID NO: 118, CDR-H2 as depicted in SEQ ID NO:        914, CDR-H3 as depicted in SEQ ID NO: 120, CDR-L1 as depicted in        SEQ ID NO: 286, CDR-L2 as depicted in SEQ ID NO: 287 and CDR-L3        as depicted in SEQ ID NO: 288, CDR-H1 as depicted in SEQ ID NO:        154, CDR-H2 as depicted in SEQ ID NO: 155, CDR-H3 as depicted in        SEQ ID NO: 920, CDR-L1 as depicted in SEQ ID NO: 322, CDR-L2 as        depicted in SEQ ID NO: 323 and CDR-L3 as depicted in SEQ ID NO:        324, CDR-H1 as depicted in SEQ ID NO: 996, CDR-H2 as depicted in        SEQ ID NO: 997, CDR-H3 as depicted in SEQ ID NO: 998, CDR-L1 as        depicted in SEQ ID NO: 999, CDR-L2 as depicted in SEQ ID NO:        1000 and CDR-L3 as depicted in SEQ ID NO: 1001,    -   CDR-H1 as depicted in SEQ ID NO: 1048, CDR-H2 as depicted in SEQ        ID NO: 1049, CDR-H3 as depicted in SEQ ID NO: 1050, CDR-L1 as        depicted in SEQ ID NO: 1051, CDR-L2 as depicted in SEQ ID NO:        1052 and CDR-L3 as depicted in SEQ ID NO: 1053,    -   CDR-H1 as depicted in SEQ ID NO: 1087, CDR-H2 as depicted in SEQ        ID NO: 1088, CDR-H3 as depicted in SEQ ID NO: 1089, CDR-L1 as        depicted in SEQ ID NO: 1090, CDR-L2 as depicted in SEQ ID NO:        1091 and CDR-L3 as depicted in SEQ ID NO: 1092,    -   CDR-H1 as depicted in SEQ ID NO: 1608, CDR-H2 as depicted in SEQ        ID NO: 1609, CDR-H3 as depicted in SEQ ID NO: 1610, CDR-L1 as        depicted in SEQ ID NO: 1611, CDR-L2 as depicted in SEQ ID NO:        1612 and CDR-L3 as depicted in SEQ ID NO: 1613,    -   CDR-H1 as depicted in SEQ ID NO: 1621, CDR-H2 as depicted in SEQ        ID NO: 1622, CDR-H3 as depicted in SEQ ID NO: 1623, CDR-L1 as        depicted in SEQ ID NO: 1624, CDR-L2 as depicted in SEQ ID NO:        1625 and CDR-L3 as depicted in SEQ ID NO: 1626,    -   CDR-H1 as depicted in SEQ ID NO: 1634, CDR-H2 as depicted in SEQ        ID NO: 1635, CDR-H3 as depicted in SEQ ID NO: 1636, CDR-L1 as        depicted in SEQ ID NO: 1637, CDR-L2 as depicted in SEQ ID NO:        1638 and CDR-L3 as depicted in SEQ ID NO: 1639,    -   CDR-H1 as depicted in SEQ ID NO: 1673, CDR-H2 as depicted in SEQ        ID NO: 1674, CDR-H3 as depicted in SEQ ID NO: 1675, CDR-L1 as        depicted in SEQ ID NO: 1676, CDR-L2 as depicted in SEQ ID NO:        1677 and CDR-L3 as depicted in SEQ ID NO: 1678,    -   CDR-H1 as depicted in SEQ ID NO: 1686, CDR-H2 as depicted in SEQ        ID NO: 1687, CDR-H3 as depicted in SEQ ID NO: 1688, CDR-L1 as        depicted in SEQ ID NO: 1689, CDR-L2 as depicted in SEQ ID NO:        1690 and CDR-L3 as depicted in SEQ ID NO: 1691,    -   CDR-H1 as depicted in SEQ ID NO: 1699, CDR-H2 as depicted in SEQ        ID NO: 1700, CDR-H3 as depicted in SEQ ID NO: 1701, CDR-L1 as        depicted in SEQ ID NO: 1702, CDR-L2 as depicted in SEQ ID NO:        1703 and CDR-L3 as depicted in SEQ ID NO: 1704,    -   CDR-H1 as depicted in SEQ ID NO: 1712, CDR-H2 as depicted in SEQ        ID NO: 1713, CDR-H3 as depicted in SEQ ID NO: 1714, CDR-L1 as        depicted in SEQ ID NO: 1715, CDR-L2 as depicted in SEQ ID NO:        1716 and CDR-L3 as depicted in SEQ ID NO: 1717,    -   CDR-H1 as depicted in SEQ ID NO: 1725, CDR-H2 as depicted in SEQ        ID NO: 1726, CDR-H3 as depicted in SEQ ID NO: 1727, CDR-L1 as        depicted in SEQ ID NO: 1728, CDR-L2 as depicted in SEQ ID NO:        1729 and CDR-L3 as depicted in SEQ ID NO: 1730,    -   CDR-H1 as depicted in SEQ ID NO: 1738, CDR-H2 as depicted in SEQ        ID NO: 1739, CDR-H3 as depicted in SEQ ID NO: 1740, CDR-L1 as        depicted in SEQ ID NO: 1741, CDR-L2 as depicted in SEQ ID NO:        1742 and CDR-L3 as depicted in SEQ ID NO: 1743,    -   CDR-H1 as depicted in SEQ ID NO: 1751, CDR-H2 as depicted in SEQ        ID NO: 1752, CDR-H3 as depicted in SEQ ID NO: 1753, CDR-L1 as        depicted in SEQ ID NO: 1754, CDR-L2 as depicted in SEQ ID NO:        1755 and CDR-L3 as depicted in SEQ ID NO: 1756,    -   CDR-H1 as depicted in SEQ ID NO: 1764, CDR-H2 as depicted in SEQ        ID NO: 1765, CDR-H3 as depicted in SEQ ID NO: 1766, CDR-L1 as        depicted in SEQ ID NO: 1767, CDR-L2 as depicted in SEQ ID NO:        1768 and CDR-L3 as depicted in SEQ ID NO: 1769, and    -   CDR-H1 as depicted in SEQ ID NO: 1920, CDR-H2 as depicted in SEQ        ID NO: 1921, CDR-H3 as depicted in SEQ ID NO: 1922, CDR-L1 as        depicted in SEQ ID NO: 1923, CDR-L2 as depicted in SEQ ID NO:        1924 and CDR-L3 as depicted in SEQ ID NO: 1925,    -   which all characterize binding domains for CDH19 grouped into        bin 3;-   (d) CDR-H1 as depicted in SEQ ID NO: 4, CDR-H2 as depicted in SEQ ID    NO: 5, CDR-H3 as depicted in SEQ ID NO: 6, CDR-L1 as depicted in SEQ    ID NO: 172, CDR-L2 as depicted in SEQ ID NO: 173 and CDR-L3 as    depicted in SEQ ID NO: 174, CDR-H1 as depicted in SEQ ID NO: 10,    CDR-H2 as depicted in SEQ ID NO: 11, CDR-H3 as depicted in SEQ ID    NO: 12, CDR-L1 as depicted in SEQ ID NO: 178, CDR-L2 as depicted in    SEQ ID NO: 179 and CDR-L3 as depicted in SEQ ID NO: 180, CDR-H1 as    depicted in SEQ ID NO: 28, CDR-H2 as depicted in SEQ ID NO: 29,    CDR-H3 as depicted in SEQ ID NO: 30, CDR-L1 as depicted in SEQ ID    NO: 196, CDR-L2 as depicted in SEQ ID NO: 197 and CDR-L3 as depicted    in SEQ ID NO: 198, CDR-H1 as depicted in SEQ ID NO: 34, CDR-H2 as    depicted in SEQ ID NO: 35, CDR-H3 as depicted in SEQ ID NO: 36,    CDR-L1 as depicted in SEQ ID NO: 202, CDR-L2 as depicted in SEQ ID    NO: 203 and CDR-L3 as depicted in SEQ ID NO: 204, CDR-H1 as depicted    in SEQ ID NO: 46, CDR-H2 as depicted in SEQ ID NO: 47, CDR-H3 as    depicted in SEQ ID NO: 48, CDR-L1 as depicted in SEQ ID NO: 214,    CDR-L2 as depicted in SEQ ID NO: 215 and CDR-L3 as depicted in SEQ    ID NO: 216, CDR-H1 as depicted in SEQ ID NO: 58, CDR-H2 as depicted    in SEQ ID NO: 59, CDR-H3 as depicted in SEQ ID NO: 60, CDR-L1 as    depicted in SEQ ID NO: 226, CDR-L2 as depicted in SEQ ID NO: 227 and    CDR-L3 as depicted in SEQ ID NO: 228, CDR-H1 as depicted in SEQ ID    NO: 64, CDR-H2 as depicted in SEQ ID NO: 65, CDR-H3 as depicted in    SEQ ID NO: 66, CDR-L1 as depicted in SEQ ID NO: 232, CDR-L2 as    depicted in SEQ ID NO: 233 and CDR-L3 as depicted in SEQ ID NO: 234,    CDR-H1 as depicted in SEQ ID NO: 70, CDR-H2 as depicted in SEQ ID    NO: 71, CDR-H3 as depicted in SEQ ID NO: 72, CDR-L1 as depicted in    SEQ ID NO: 238, CDR-L2 as depicted in SEQ ID NO: 239 and CDR-L3 as    depicted in SEQ ID NO: 240, CDR-H1 as depicted in SEQ ID NO: 160,    CDR-H2 as depicted in SEQ ID NO: 161, CDR-H3 as depicted in SEQ ID    NO: 162, CDR-L1 as depicted in SEQ ID NO: 328, CDR-L2 as depicted in    SEQ ID NO: 329 and CDR-L3 as depicted in SEQ ID NO: 330, CDR-H1 as    depicted in SEQ ID NO: 46, CDR-H2 as depicted in SEQ ID NO: 47,    CDR-H3 as depicted in SEQ ID NO: 48, CDR-L1 as depicted in SEQ ID    NO: 924, CDR-L2 as depicted in SEQ ID NO: 215 and CDR-L3 as depicted    in SEQ ID NO: 216, CDR-H1 as depicted in SEQ ID NO: 46, CDR-H2 as    depicted in SEQ ID NO: 47, CDR-H3 as depicted in SEQ ID NO: 902,    CDR-L1 as depicted in SEQ ID NO: 924, CDR-L2 as depicted in SEQ ID    NO: 215 and CDR-L3 as depicted in SEQ ID NO: 216, CDR-H1 as depicted    in SEQ ID NO: 46, CDR-H2 as depicted in SEQ ID NO: 47, CDR-H3 as    depicted in SEQ ID NO: 903, CDR-L1 as depicted in SEQ ID NO: 924,    CDR-L2 as depicted in SEQ ID NO: 215 and CDR-L3 as depicted in SEQ    ID NO: 216, CDR-H1 as depicted in SEQ ID NO: 46, CDR-H2 as depicted    in SEQ ID NO: 47, CDR-H3 as depicted in SEQ ID NO: 48, CDR-L1 as    depicted in SEQ ID NO: 925, CDR-L2 as depicted in SEQ ID NO: 215 and    CDR-L3 as depicted in SEQ ID NO: 216, CDR-H1 as depicted in SEQ ID    NO: 70, CDR-H2 as depicted in SEQ ID NO: 907, CDR-H3 as depicted in    SEQ ID NO: 72, CDR-L1 as depicted in SEQ ID NO: 238, CDR-L2 as    depicted in SEQ ID NO: 239 and CDR-L3 as depicted in SEQ ID NO: 240,    CDR-H1 as depicted in SEQ ID NO: 70, CDR-H2 as depicted in SEQ ID    NO: 907, CDR-H3 as depicted in SEQ ID NO: 908, CDR-L1 as depicted in    SEQ ID NO: 238, CDR-L2 as depicted in SEQ ID NO: 239 and CDR-L3 as    depicted in SEQ ID NO: 240, CDR-H1 as depicted in SEQ ID NO: 28,    CDR-H2 as depicted in SEQ ID NO: 901, CDR-H3 as depicted in SEQ ID    NO: 30, CDR-L1 as depicted in SEQ ID NO: 922, CDR-L2 as depicted in    SEQ ID NO: 197 and CDR-L3 as depicted in SEQ ID NO: 923, CDR-H1 as    depicted in SEQ ID NO: 58, CDR-H2 as depicted in SEQ ID NO: 905,    CDR-H3 as depicted in SEQ ID NO: 906, CDR-L1 as depicted in SEQ ID    NO: 226, CDR-L2 as depicted in SEQ ID NO: 227 and CDR-L3 as depicted    in SEQ ID NO: 228, CDR-H1 as depicted in SEQ ID NO: 58, CDR-H2 as    depicted in SEQ ID NO: 905, CDR-H3 as depicted in SEQ ID NO: 60,    CDR-L1 as depicted in SEQ ID NO: 226, CDR-L2 as depicted in SEQ ID    NO: 227 and CDR-L3 as depicted in SEQ ID NO: 228, CDR-H1 as depicted    in SEQ ID NO: 160, CDR-H2 as depicted in SEQ ID NO: 161, CDR-H3 as    depicted in SEQ ID NO: 162, CDR-L1 as depicted in SEQ ID NO: 939,    CDR-L2 as depicted in SEQ ID NO: 329 and CDR-L3 as depicted in SEQ    ID NO: 330, CDR-H1 as depicted in SEQ ID NO: 160, CDR-H2 as depicted    in SEQ ID NO: 921, CDR-H3 as depicted in SEQ ID NO: 162, CDR-L1 as    depicted in SEQ ID NO: 939, CDR-L2 as depicted in SEQ ID NO: 329 and    CDR-L3 as depicted in SEQ ID NO: 940, CDR-H1 as depicted in SEQ ID    NO: 160, CDR-H2 as depicted in SEQ ID NO: 161, CDR-H3 as depicted in    SEQ ID NO: 162, CDR-L1 as depicted in SEQ ID NO: 941, CDR-L2 as    depicted in SEQ ID NO: 329 and CDR-L3 as depicted in SEQ ID NO: 330,    CDR-H1 as depicted in SEQ ID NO: 28, CDR-H2 as depicted in SEQ ID    NO: 29, CDR-H3 as depicted in SEQ ID NO: 30, CDR-L1 as depicted in    SEQ ID NO: 196, CDR-L2 as depicted in SEQ ID NO: 197 and CDR-L3 as    depicted in SEQ ID NO: 923, CDR-H1 as depicted in SEQ ID NO: 28,    CDR-H2 as depicted in SEQ ID NO: 29, CDR-H3 as depicted in SEQ ID    NO: 30, CDR-L1 as depicted in SEQ ID NO: 922, CDR-L2 as depicted in    SEQ ID NO: 197 and CDR-L3 as depicted in SEQ ID NO: 923, CDR-H1 as    depicted in SEQ ID NO: 28, CDR-H2 as depicted in SEQ ID NO: 901,    CDR-H3 as depicted in SEQ ID NO: 30, CDR-L1 as depicted in SEQ ID    NO: 922, CDR-L2 as depicted in SEQ ID NO: 197 and CDR-L3 as depicted    in SEQ ID NO: 923,    -   CDR-H1 as depicted in SEQ ID NO: 28, CDR-H2 as depicted in SEQ        ID NO: 29, CDR-H3 as depicted in SEQ ID NO: 30, CDR-L1 as        depicted in SEQ ID NO: 939, CDR-L2 as depicted in SEQ ID NO: 329        and CDR-L3 as depicted in SEQ ID NO: 330,    -   CDR-H1 as depicted in SEQ ID NO: 970, CDR-H2 as depicted in SEQ        ID NO: 971, CDR-H3 as depicted in SEQ ID NO: 972, CDR-L1 as        depicted in SEQ ID NO: 973, CDR-L2 as depicted in SEQ ID NO: 974        and CDR-L3 as depicted in SEQ ID NO: 975,    -   CDR-H1 as depicted in SEQ ID NO: 1061, CDR-H2 as depicted in SEQ        ID NO: 1062, CDR-H3 as depicted in SEQ ID NO: 1063, CDR-L1 as        depicted in SEQ ID NO: 1064, CDR-L2 as depicted in SEQ ID NO:        1065 and CDR-L3 as depicted in SEQ ID NO: 1066,    -   CDR-H1 as depicted in SEQ ID NO: 1139, CDR-H2 as depicted in SEQ        ID NO: 1140, CDR-H3 as depicted in SEQ ID NO: 1141, CDR-L1 as        depicted in SEQ ID NO: 1142, CDR-L2 as depicted in SEQ ID NO:        1143 and CDR-L3 as depicted in SEQ ID NO: 1144,    -   CDR-H1 as depicted in SEQ ID NO: 1152, CDR-H2 as depicted in SEQ        ID NO: 1153, CDR-H3 as depicted in SEQ ID NO: 1154, CDR-L1 as        depicted in SEQ ID NO: 1155, CDR-L2 as depicted in SEQ ID NO:        1156 and CDR-L3 as depicted in SEQ ID NO: 1157,    -   CDR-H1 as depicted in SEQ ID NO: 1178, CDR-H2 as depicted in SEQ        ID NO: 1179, CDR-H3 as depicted in SEQ ID NO: 1180, CDR-L1 as        depicted in SEQ ID NO: 1181, CDR-L2 as depicted in SEQ ID NO:        1182 and CDR-L3 as depicted in SEQ ID NO: 1183,    -   CDR-H1 as depicted in SEQ ID NO: 1191, CDR-H2 as depicted in SEQ        ID NO: 1192, CDR-H3 as depicted in SEQ ID NO: 1193, CDR-L1 as        depicted in SEQ ID NO: 1194, CDR-L2 as depicted in SEQ ID NO:        1195 and CDR-L3 as depicted in SEQ ID NO: 1196,    -   CDR-H1 as depicted in SEQ ID NO: 1204, CDR-H2 as depicted in SEQ        ID NO: 1205, CDR-H3 as depicted in SEQ ID NO: 1206, CDR-L1 as        depicted in SEQ ID NO: 1207, CDR-L2 as depicted in SEQ ID NO:        1208 and CDR-L3 as depicted in SEQ ID NO: 1209,    -   CDR-H1 as depicted in SEQ ID NO: 1217, CDR-H2 as depicted in SEQ        ID NO: 1218, CDR-H3 as depicted in SEQ ID NO: 1219, CDR-L1 as        depicted in SEQ ID NO: 1220, CDR-L2 as depicted in SEQ ID NO:        1221 and CDR-L3 as depicted in SEQ ID NO: 1222,    -   CDR-H1 as depicted in SEQ ID NO: 1230, CDR-H2 as depicted in SEQ        ID NO: 1231, CDR-H3 as depicted in SEQ ID NO: 1232, CDR-L1 as        depicted in SEQ ID NO: 1233, CDR-L2 as depicted in SEQ ID NO:        1234 and CDR-L3 as depicted in SEQ ID NO: 1235,    -   CDR-H1 as depicted in SEQ ID NO: 1308, CDR-H2 as depicted in SEQ        ID NO: 1309, CDR-H3 as depicted in SEQ ID NO: 1310, CDR-L1 as        depicted in SEQ ID NO: 1311, CDR-L2 as depicted in SEQ ID NO:        1312 and CDR-L3 as depicted in SEQ ID NO: 1313,    -   CDR-H1 as depicted in SEQ ID NO: 1321, CDR-H2 as depicted in SEQ        ID NO: 1322, CDR-H3 as depicted in SEQ ID NO: 1323, CDR-L1 as        depicted in SEQ ID NO: 1324, CDR-L2 as depicted in SEQ ID NO:        1325 and CDR-L3 as depicted in SEQ ID NO: 1326,    -   CDR-H1 as depicted in SEQ ID NO: 1373, CDR-H2 as depicted in SEQ        ID NO: 1374, CDR-H3 as depicted in SEQ ID NO: 1375, CDR-L1 as        depicted in SEQ ID NO: 1376, CDR-L2 as depicted in SEQ ID NO:        1377 and CDR-L3 as depicted in SEQ ID NO: 1378,    -   CDR-H1 as depicted in SEQ ID NO: 1386, CDR-H2 as depicted in SEQ        ID NO: 1387, CDR-H3 as depicted in SEQ ID NO: 1388, CDR-L1 as        depicted in SEQ ID NO: 1389, CDR-L2 as depicted in SEQ ID NO:        1390 and CDR-L3 as depicted in SEQ ID NO: 1391,    -   CDR-H1 as depicted in SEQ ID NO: 1399, CDR-H2 as depicted in SEQ        ID NO: 1400, CDR-H3 as depicted in SEQ ID NO: 1401, CDR-L1 as        depicted in SEQ ID NO: 1402, CDR-L2 as depicted in SEQ ID NO:        1403 and CDR-L3 as depicted in SEQ ID NO: 1404,    -   CDR-H1 as depicted in SEQ ID NO: 1412, CDR-H2 as depicted in SEQ        ID NO: 1413, CDR-H3 as depicted in SEQ ID NO: 1414, CDR-L1 as        depicted in SEQ ID NO: 1415, CDR-L2 as depicted in SEQ ID NO:        1416 and CDR-L3 as depicted in SEQ ID NO: 1417,    -   CDR-H1 as depicted in SEQ ID NO: 1777, CDR-H2 as depicted in SEQ        ID NO: 1778, CDR-H3 as depicted in SEQ ID NO: 1779, CDR-L1 as        depicted in SEQ ID NO: 1780, CDR-L2 as depicted in SEQ ID NO:        1781 and CDR-L3 as depicted in SEQ ID NO: 1782,    -   CDR-H1 as depicted in SEQ ID NO: 1790, CDR-H2 as depicted in SEQ        ID NO: 1791, CDR-H3 as depicted in SEQ ID NO: 1792, CDR-L1 as        depicted in SEQ ID NO: 1793, CDR-L2 as depicted in SEQ ID NO:        1794 and CDR-L3 as depicted in SEQ ID NO: 1795,    -   CDR-H1 as depicted in SEQ ID NO: 1803, CDR-H2 as depicted in SEQ        ID NO: 1804, CDR-H3 as depicted in SEQ ID NO: 1805, CDR-L1 as        depicted in SEQ ID NO: 1806, CDR-L2 as depicted in SEQ ID NO:        1807 and CDR-L3 as depicted in SEQ ID NO: 1808,    -   CDR-H1 as depicted in SEQ ID NO: 1816, CDR-H2 as depicted in SEQ        ID NO: 1817, CDR-H3 as depicted in SEQ ID NO: 1818, CDR-L1 as        depicted in SEQ ID NO: 1819, CDR-L2 as depicted in SEQ ID NO:        1820 and CDR-L3 as depicted in SEQ ID NO: 1821,    -   CDR-H1 as depicted in SEQ ID NO: 1829, CDR-H2 as depicted in SEQ        ID NO: 1830, CDR-H3 as depicted in SEQ ID NO: 1831, CDR-L1 as        depicted in SEQ ID NO: 1832, CDR-L2 as depicted in SEQ ID NO:        1833 and CDR-L3 as depicted in SEQ ID NO: 1834,    -   CDR-H1 as depicted in SEQ ID NO: 1842, CDR-H2 as depicted in SEQ        ID NO: 1843, CDR-H3 as depicted in SEQ ID NO: 1844, CDR-L1 as        depicted in SEQ ID NO: 1845, CDR-L2 as depicted in SEQ ID NO:        1846 and CDR-L3 as depicted in SEQ ID NO: 1847,    -   CDR-H1 as depicted in SEQ ID NO: 1855, CDR-H2 as depicted in SEQ        ID NO: 1856, CDR-H3 as depicted in SEQ ID NO: 1857, CDR-L1 as        depicted in SEQ ID NO: 1858, CDR-L2 as depicted in SEQ ID NO:        1859 and CDR-L3 as depicted in SEQ ID NO: 1860,    -   CDR-H1 as depicted in SEQ ID NO: 1868, CDR-H2 as depicted in SEQ        ID NO: 1869, CDR-H3 as depicted in SEQ ID NO: 1870, CDR-L1 as        depicted in SEQ ID NO: 1871, CDR-L2 as depicted in SEQ ID NO:        1872 and CDR-L3 as depicted in SEQ ID NO: 1873,    -   CDR-H1 as depicted in SEQ ID NO: 1881, CDR-H2 as depicted in SEQ        ID NO: 1882, CDR-H3 as depicted in SEQ ID NO: 1883, CDR-L1 as        depicted in SEQ ID NO: 1884, CDR-L2 as depicted in SEQ ID NO:        1885 and CDR-L3 as depicted in SEQ ID NO: 1886,    -   CDR-H1 as depicted in SEQ ID NO: 2063, CDR-H2 as depicted in SEQ        ID NO: 2064, CDR-H3 as depicted in SEQ ID NO: 2065, CDR-L1 as        depicted in SEQ ID NO: 2066, CDR-L2 as depicted in SEQ ID NO:        2067 and CDR-L3 as depicted in SEQ ID NO: 2068,    -   CDR-H1 as depicted in SEQ ID NO: 2076, CDR-H2 as depicted in SEQ        ID NO: 2077, CDR-H3 as depicted in SEQ ID NO: 2078, CDR-L1 as        depicted in SEQ ID NO: 2079, CDR-L2 as depicted in SEQ ID NO:        2080 and CDR-L3 as depicted in SEQ ID NO: 2081,    -   CDR-H1 as depicted in SEQ ID NO: 2089, CDR-H2 as depicted in SEQ        ID NO: 2090, CDR-H3 as depicted in SEQ ID NO: 2091, CDR-L1 as        depicted in SEQ ID NO: 2092, CDR-L2 as depicted in SEQ ID NO:        2093 and CDR-L3 as depicted in SEQ ID NO: 2094,    -   CDR-H1 as depicted in SEQ ID NO: 2102, CDR-H2 as depicted in SEQ        ID NO: 2103, CDR-H3 as depicted in SEQ ID NO: 2104, CDR-L1 as        depicted in SEQ ID NO: 2105, CDR-L2 as depicted in SEQ ID NO:        2106 and CDR-L3 as depicted in SEQ ID NO: 2107,    -   CDR-H1 as depicted in SEQ ID NO: 2115, CDR-H2 as depicted in SEQ        ID NO: 2116, CDR-H3 as depicted in SEQ ID NO: 2117, CDR-L1 as        depicted in SEQ ID NO: 2118, CDR-L2 as depicted in SEQ ID NO:        2119 and CDR-L3 as depicted in SEQ ID NO: 2120,    -   CDR-H1 as depicted in SEQ ID NO: 2128, CDR-H2 as depicted in SEQ        ID NO: 2129, CDR-H3 as depicted in SEQ ID NO: 2130, CDR-L1 as        depicted in SEQ ID NO: 2131, CDR-L2 as depicted in SEQ ID NO:        2132 and CDR-L3 as depicted in SEQ ID NO: 2133,    -   CDR-H1 as depicted in SEQ ID NO: 2141, CDR-H2 as depicted in SEQ        ID NO: 2142, CDR-H3 as depicted in SEQ ID NO: 2143, CDR-L1 as        depicted in SEQ ID NO: 2144, CDR-L2 as depicted in SEQ ID NO:        2145 and CDR-L3 as depicted in SEQ ID NO: 2146,    -   CDR-H1 as depicted in SEQ ID NO: 2154, CDR-H2 as depicted in SEQ        ID NO: 2155, CDR-H3 as depicted in SEQ ID NO: 2156, CDR-L1 as        depicted in SEQ ID NO: 2157, CDR-L2 as depicted in SEQ ID NO:        2158 and CDR-L3 as depicted in SEQ ID NO: 2159,    -   CDR-H1 as depicted in SEQ ID NO: 2180, CDR-H2 as depicted in SEQ        ID NO: 2181, CDR-H3 as depicted in SEQ ID NO: 2182, CDR-L1 as        depicted in SEQ ID NO: 2183, CDR-L2 as depicted in SEQ ID NO:        2184 and CDR-L3 as depicted in SEQ ID NO: 2185,    -   CDR-H1 as depicted in SEQ ID NO: 2193, CDR-H2 as depicted in SEQ        ID NO: 2194, CDR-H3 as depicted in SEQ ID NO: 2195, CDR-L1 as        depicted in SEQ ID NO: 2196, CDR-L2 as depicted in SEQ ID NO:        2197 and CDR-L3 as depicted in SEQ ID NO: 2198, and    -   CDR-H1 as depicted in SEQ ID NO: 2206, CDR-H2 as depicted in SEQ        ID NO: 2207, CDR-H3 as depicted in SEQ ID NO: 2208, CDR-L1 as        depicted in SEQ ID NO: 2209, CDR-L2 as depicted in SEQ ID NO:        2210 and CDR-L3 as depicted in SEQ ID NO: 2211    -   which all characterize binding domains for CDH19 grouped into        bin 4; and-   (e) CDR-H1 as depicted in SEQ ID NO: 76, CDR-H2 as depicted in SEQ    ID NO: 77, CDR-H3 as depicted in SEQ ID NO: 78, CDR-L1 as depicted    in SEQ ID NO: 244, CDR-L2 as depicted in SEQ ID NO: 245 and CDR-L3    as depicted in SEQ ID NO: 246, CDR-H1 as depicted in SEQ ID NO: 88,    CDR-H2 as depicted in SEQ ID NO: 89, CDR-H3 as depicted in SEQ ID    NO: 90, CDR-L1 as depicted in SEQ ID NO: 256, CDR-L2 as depicted in    SEQ ID NO: 257 and CDR-L3 as depicted in SEQ ID NO: 258, CDR-H1 as    depicted in SEQ ID NO: 106, CDR-H2 as depicted in SEQ ID NO: 107,    CDR-H3 as depicted in SEQ ID NO: 108, CDR-L1 as depicted in SEQ ID    NO: 274, CDR-L2 as depicted in SEQ ID NO: 275 and CDR-L3 as depicted    in SEQ ID NO: 276, CDR-H1 as depicted in SEQ ID NO: 112, CDR-H2 as    depicted in SEQ ID NO: 113, CDR-H3 as depicted in SEQ ID NO: 114,    CDR-L1 as depicted in SEQ ID NO: 280, CDR-L2 as depicted in SEQ ID    NO: 281 and CDR-L3 as depicted in SEQ ID NO: 282, CDR-H1 as depicted    in SEQ ID NO: 106, CDR-H2 as depicted in SEQ ID NO: 107, CDR-H3 as    depicted in SEQ ID NO: 108, CDR-L1 as depicted in SEQ ID NO: 274,    CDR-L2 as depicted in SEQ ID NO: 275 and CDR-L3 as depicted in SEQ    ID NO: 276, CDR-H1 as depicted in SEQ ID NO: 983, CDR-H2 as depicted    in SEQ ID NO: 984, CDR-H3 as depicted in SEQ ID NO: 985, CDR-L1 as    depicted in SEQ ID NO: 986, CDR-L2 as depicted in SEQ ID NO: 987 and    CDR-L3 as depicted in SEQ ID NO: 988, CDR-H1 as depicted in SEQ ID    NO: 1582, CDR-H2 as depicted in SEQ ID NO: 1583, CDR-H3 as depicted    in SEQ ID NO: 1584, CDR-L1 as depicted in SEQ ID NO: 1585, CDR-L2 as    depicted in SEQ ID NO: 1586 and CDR-L3 as depicted in SEQ ID NO:    1587, and    -   CDR-H1 as depicted in SEQ ID NO: 1595, CDR-H2 as depicted in SEQ        ID NO: 1596, CDR-H3 as depicted in SEQ ID NO: 1597, CDR-L1 as        depicted in SEQ ID NO: 1598, CDR-L2 as depicted in SEQ ID NO:        1599 and CDR-L3 as depicted in SEQ ID NO: 1600,        which all characterize binding domains for CDH19 grouped into        bin 5.

In a further embodiment of the antibody construct of the invention thefirst binding domain comprises a VH region selected from the groupconsisting of VH regions

-   (a) as depicted in SEQ ID NO: 362, SEQ ID NO: 364, SEQ ID NO: 485,    SEQ ID NO: 486, SEQ ID NO: 487, SEQ ID NO: 492, SEQ ID NO: 493, SEQ    ID NO: 494, SEQ ID NO: 495, SEQ ID NO: 1133, SEQ ID NO: 1172, SEQ ID    NO: 1341, SEQ ID NO: 1354, SEQ ID NO: 1367, SEQ ID NO: 1432, SEQ ID    NO: 1445 and SEQ ID NO: 2174, grouped into bin 1;-   (b) as depicted in SEQ ID NO: 342, SEQ ID NO: 366, SEQ ID NO: 370,    SEQ ID NO: 344, SEQ ID NO: 372, SEQ ID NO: 368, SEQ ID NO: 496, SEQ    ID NO: 497, SEQ ID NO: 498, SEQ ID NO: 499, SEQ ID NO: 500, SEQ ID    NO: 508, SEQ ID NO: 509, SEQ ID NO:510, SEQ ID NO:511, SEQ ID    NO:512, SEQ ID NO:519, SEQ ID NO: 520, SEQ ID NO: 521, SEQ ID NO:    522, SEQ ID NO: 523, SEQ ID NO: 524, SEQ ID NO: 525, SEQ ID NO: 526,    SEQ ID NO: 527, SEQ ID NO: 528, SEQ ID NO: 529, SEQ ID NO: 530, SEQ    ID NO: 531, SEQ ID NO: 532, SEQ ID NO: 533, SEQ ID NO: 534, SEQ ID    NO: 535, SEQ ID NO: 536, SEQ ID NO: 537, SEQ ID NO: 538, SEQ ID NO:    1016, SEQ ID NO: 1029, SEQ ID NO: 1042, SEQ ID NO: 1081, SEQ ID NO:    1107, SEQ ID NO: 1120, SEQ ID NO: 1250, SEQ ID NO: 1263, SEQ ID NO:    1276, SEQ ID NO: 1289, SEQ ID NO: 1302, SEQ ID NO: 1654, SEQ ID NO:    1667, SEQ ID NO: 1901, SEQ ID NO: 1914, SEQ ID NO: 1940, SEQ ID NO:    1953, SEQ ID NO: 1966, SEQ ID NO: 1979, SEQ ID NO: 1992, SEQ ID NO:    2005, SEQ ID NO: 2018, SEQ ID NO: 2031, SEQ ID NO: 2044, and SEQ ID    NO: 2057,    -   grouped into bin 2;-   (c) as depicted in SEQ ID NO: 338, SEQ ID NO: 354, SEQ ID NO: 378,    SEQ ID NO: 356, SEQ ID NO: 476, SEQ ID NO: 477, SEQ ID NO: 478, SEQ    ID NO: 479, SEQ ID NO:480, SEQ ID NO:481, SEQ ID NO: 482, SEQ ID NO:    483, SEQ ID NO: 484, SEQ ID NO:501, SEQ ID NO:502, SEQ ID NO: 503,    SEQ ID NO:504, SEQ ID NO: 505, SEQ ID NO: 506, SEQ ID NO: 517, SEQ    ID NO: 518, SEQ ID NO: 1003, SEQ ID NO: 1055, SEQ ID NO: 1094, SEQ    ID NO: 1615, SEQ ID NO: 1628, SEQ ID NO: 1641, SEQ ID NO: 1680, SEQ    ID NO: 1693, SEQ ID NO: 1706, SEQ ID NO: 1719, SEQ ID NO: 1732, SEQ    ID NO: 1745, SEQ ID NO: 1758, SEQ ID NO: 1771, and SEQ ID NO: 1927,    -   grouped into bin 3;-   (d) as depicted in SEQ ID NO: 352, SEQ ID NO: 360, SEQ ID NO: 388,    SEQ ID NO: 386, SEQ ID NO: 340, SEQ ID NO: 346, SEQ ID NO: 374, SEQ    ID NO: 348, SEQ ID NO: 390, SEQ ID NO: 463, SEQ ID NO: 464, SEQ ID    NO: 465, SEQ ID NO: 466, SEQ ID NO: 467, SEQ ID NO: 468, SEQ ID NO:    469, SEQ ID NO: 470, SEQ ID NO: 471, SEQ ID NO: 472, SEQ ID NO: 473,    SEQ ID NO: 474, SEQ ID NO: 475, SEQ ID NO:488, SEQ ID NO:489, SEQ ID    NO:490, SEQ ID NO:491, SEQ ID NO: 513, SEQ ID NO: 514, SEQ ID NO:    515, SEQ ID NO: 516, SEQ ID NO: 540, SEQ ID NO: 541, SEQ ID NO: 542,    SEQ ID NO: 543, SEQ ID NO: 977, SEQ ID NO: 1068, SEQ ID NO: 1146,    SEQ ID NO: 1159, SEQ ID NO: 1185, SEQ ID NO: 1198, SEQ ID NO: 1211,    SEQ ID NO: 1224, SEQ ID NO: 1237, SEQ ID NO: 1315, SEQ ID NO: 1328,    SEQ ID NO: 1380, SEQ ID NO: 1393, SEQ ID NO: 1406, SEQ ID NO: 1419,    SEQ ID NO: 1469, SEQ ID NO: 1478, SEQ ID NO: 1485, SEQ ID NO: 1494,    SEQ ID NO: 1501, SEQ ID NO: 1508, SEQ ID NO: 1519, SEQ ID NO: 1526,    SEQ ID NO: 1533, SEQ ID NO: 1542, SEQ ID NO: 1549, SEQ ID NO: 1558,    SEQ ID NO: 1565, SEQ ID NO: 1784, SEQ ID NO: 1797, SEQ ID NO: 1810,    SEQ ID NO: 1823, SEQ ID NO: 1836, SEQ ID NO: 1849, SEQ ID NO: 1862,    SEQ ID NO: 1875, SEQ ID NO: 1888, SEQ ID NO: 2070, SEQ ID NO: 2083,    SEQ ID NO: 2096, SEQ ID NO: 2109, SEQ ID NO: 2122, SEQ ID NO: 2135,    SEQ ID NO: 2148, SEQ ID NO: 2161, SEQ ID NO: 2187, SEQ ID NO: 2200,    and SEQ ID NO: 2213,    -   grouped into bin 4; and-   (e) as depicted in SEQ ID NO: 376, SEQ ID NO: 392, SEQ ID NO: 358,    SEQ ID NO: 350, SEQ ID NO: 507, SEQ ID NO: 990, SEQ ID NO: 1589, and    SEQ ID NO: 1602, grouped into bin 5.

In another embodiment of the antibody construct of the invention thefirst binding domain comprises a VL region selected from the groupconsisting of VL regions

-   (a) as depicted in SEQ ID NO: 418, SEQ ID NO: 420, SEQ ID NO: 580,    SEQ ID NO: 581, SEQ ID NO: 582, SEQ ID NO: 587, SEQ ID NO: 588, SEQ    ID NO: 589, SEQ ID NO: 590, SEQ ID NO: 1135, SEQ ID NO: 1174, SEQ ID    NO: 1343, SEQ ID NO: 1356, SEQ ID NO: 1369, SEQ ID NO: 1434, SEQ ID    NO: 1447 and SEQ ID NO: 2176, grouped into bin 1;-   (b) as depicted in SEQ ID NO: 398, SEQ ID NO: 422, SEQ ID NO: 426,    SEQ ID NO: 400, SEQ ID NO:428, SEQ ID NO:424, SEQ ID NO: 591, SEQ ID    NO:592, SEQ ID NO: 593, SEQ ID NO: 594, SEQ ID NO: 595, SEQ ID NO:    603, SEQ ID NO: 604, SEQ ID NO: 605, SEQ ID NO: 606, SEQ ID NO: 607,    SEQ ID NO: 614, SEQ ID NO: 615, SEQ ID NO: 616, SEQ ID NO: 617, SEQ    ID NO: 618, SEQ ID NO: 619, SEQ ID NO: 620, SEQ ID NO: 621, SEQ ID    NO: 622, SEQ ID NO: 623, SEQ ID NO: 624, SEQ ID NO: 625, SEQ ID NO:    626, SEQ ID NO: 627, SEQ ID NO: 628, SEQ ID NO:629, SEQ ID NO:630,    SEQ ID NO: 631, SEQ ID NO:632, SEQ ID NO: 633, SEQ ID NO: 1018, SEQ    ID NO: 1031, SEQ ID NO: 1044, SEQ ID NO: 1083, SEQ ID NO: 1109, SEQ    ID NO: 1122, SEQ ID NO: 1252, SEQ ID NO: 1265, SEQ ID NO: 1278, SEQ    ID NO: 1291, SEQ ID NO: 1304, SEQ ID NO: 1656, SEQ ID NO: 1669, SEQ    ID NO: 1903, SEQ ID NO: 1916, SEQ ID NO: 1942, SEQ ID NO: 1955, SEQ    ID NO: 1968, SEQ ID NO: 1981, SEQ ID NO: 1994, SEQ ID NO: 2007, SEQ    ID NO: 2020, SEQ ID NO: 2033, SEQ ID NO: 2046, and SEQ ID NO: 2059,    -   grouped into bin 2;-   (c) as depicted in SEQ ID NO: 394, SEQ ID NO: 410, SEQ ID NO: 434,    SEQ ID NO: 412, SEQ ID NO: 571, SEQ ID NO: 572, SEQ ID NO: 573, SEQ    ID NO: 574, SEQ ID NO: 575, SEQ ID NO: 576, SEQ ID NO: 577, SEQ ID    NO: 578, SEQ ID NO: 579, SEQ ID NO: 596, SEQ ID NO: 597, SEQ ID NO:    598, SEQ ID NO: 599, SEQ ID NO: 600, SEQ ID NO: 601, SEQ ID NO: 612,    SEQ ID NO: 613, SEQ ID NO: 1005, SEQ ID NO: 1057, SEQ ID NO: 1096,    SEQ ID NO: 1617, SEQ ID NO: 1630, SEQ ID NO: 1643, SEQ ID NO: 1682,    SEQ ID NO: 1695, SEQ ID NO: 1708, SEQ ID NO: 1721, SEQ ID NO: 1734,    SEQ ID NO: 1747, SEQ ID NO: 1760, SEQ ID NO: 1773, and SEQ ID NO:    1929,    -   grouped into bin 3;-   (d) as depicted in SEQ ID NO: 408, SEQ ID NO: 416, SEQ ID NO: 444,    SEQ ID NO: 442, SEQ ID NO: 396, SEQ ID NO: 402, SEQ ID NO: 430, SEQ    ID NO: 404, SEQ ID NO: 446, SEQ ID NO: 558, SEQ ID NO: 559, SEQ ID    NO: 560, SEQ ID NO: 561, SEQ ID NO: 562, SEQ ID NO: 563, SEQ ID NO:    564, SEQ ID NO: 565, SEQ ID NO: 566, SEQ ID NO: 567, SEQ ID NO: 568,    SEQ ID NO: 569, SEQ ID NO: 570, SEQ ID NO: 583, SEQ ID NO: 584, SEQ    ID NO: 585, SEQ ID NO: 586, SEQ ID NO:608, SEQ ID NO:609, SEQ ID    NO:610, SEQ ID NO:611, SEQ ID NO:635, SEQ ID NO: 636, SEQ ID NO:    637, SEQ ID NO: 638, SEQ ID NO: 979, SEQ ID NO: 1070, SEQ ID NO:    1148, SEQ ID NO: 1161, SEQ ID NO: 1187, SEQ ID NO: 1200, SEQ ID NO:    1213, SEQ ID NO: 1226, SEQ ID NO: 1239, SEQ ID NO: 1317, SEQ ID NO:    1330, SEQ ID NO: 1382, SEQ ID NO: 1395, SEQ ID NO: 1408, SEQ ID NO:    1421, SEQ ID NO: 1471, SEQ ID NO: 1480, SEQ ID NO: 1487, SEQ ID NO:    1496, SEQ ID NO: 1503, SEQ ID NO: 1510, SEQ ID NO: 1521, SEQ ID NO:    1528, SEQ ID NO: 1535, SEQ ID NO: 1544, SEQ ID NO: 1551, SEQ ID NO:    1560, SEQ ID NO: 1567, SEQ ID NO: 1786, SEQ ID NO: 1799, SEQ ID NO:    1812, SEQ ID NO: 1825, SEQ ID NO: 1838, SEQ ID NO: 1851, SEQ ID NO:    1864, SEQ ID NO: 1877, SEQ ID NO: 1890, SEQ ID NO: 2072, SEQ ID NO:    2085, SEQ ID NO: 2098, SEQ ID NO: 2111, SEQ ID NO: 2124, SEQ ID NO:    2137, SEQ ID NO: 2150, SEQ ID NO: 2163, SEQ ID NO: 2189, SEQ ID NO:    2202, and SEQ ID NO: 2215,    -   grouped into bin 4; and-   (e) as depicted in SEQ ID NO: 432, SEQ ID NO: 448, SEQ ID NO: 414,    SEQ ID NO: 406, SEQ ID NO: 602, SEQ ID NO: 992, SEQ ID NO: 1591, and    SEQ ID NO: 1604,    -   grouped into bin 5.

The invention further provides an embodiment of the antibody constructof the invention, wherein the first binding domain comprises a VH regionand a VL region selected from the group consisting of:

-   (1) pairs of a VH region and a VL region as depicted in SEQ ID NOs:    362+418, SEQ ID NOs: 364+420, SEQ ID NOs: 485+580, SEQ ID NOs:    486+581, SEQ ID NOs: 487+582, SEQ ID NOs: 492+587, SEQ ID NOs:    493+588, SEQ ID NOs: 494+589, SEQ ID NOs: 495+590, SEQ ID NOs:    1133+1135, SEQ ID NOs: 1172+1174, SEQ ID NOs: 1341+1343, SEQ ID NOs:    1354+1356, SEQ ID NOs: 1367+1369, SEQ ID NOs: 1432+1434, SEQ ID NOs:    1445+1447, and SEQ ID NOs: 2174+2176,    -   all pairs grouped into bin 1;-   (2) pairs of a VH region and a VL region as depicted in SEQ ID NOs:    342+398, SEQ ID NOs: 366+422, SEQ ID NOs: 370+426, SEQ ID NOs:    344+400, SEQ ID NOs: 372+428, SEQ ID NOs: 368+424, SEQ ID NOs:    496+591, SEQ ID NOs: 497+592, SEQ ID NOs: 498+593, SEQ ID NOs:    499+594, SEQ ID NOs: 500+595, SEQ ID NOs: 508+603, SEQ ID NOs:    509+604, SEQ ID NOs: 510+605, SEQ ID NOs: 511+606, SEQ ID NOs:    512+607, SEQ ID NOs: 519+614, SEQ ID NOs: 520+615, SEQ ID NOs:    521+616, SEQ ID NOs: 522+617, SEQ ID NOs: 523+618, SEQ ID NOs:    524+619, SEQ ID NOs: 525+620, SEQ ID NOs: 526+621, SEQ ID NOs:    527+622, SEQ ID NOs: 528+623, SEQ ID NOs: 529+624, SEQ ID NOs:    530+625, SEQ ID NOs: 531+626, SEQ ID NOs: 532+627, SEQ ID NOs:    533+628, SEQ ID NOs: 534+629, SEQ ID NOs: 535+630, SEQ ID NOs:    536+631, SEQ ID NOs: 537+632, SEQ ID NOs: 538+633, SEQ ID NOs:    1016+1018, SEQ ID NOs: 1029+1031, SEQ ID NOs: 1042+1044, SEQ ID NOs:    1081+1083, SEQ ID NOs: 1107+1109, SEQ ID NOs: 1120+1122, SEQ ID NOs:    1250+1252, SEQ ID NOs: 1263+1265, SEQ ID NOs: 1276+1278, SEQ ID NOs:    1289+1291, SEQ ID NOs: 1302+1304, SEQ ID NOs: 1654+1656, SEQ ID NOs:    1667+1669, SEQ ID NOs: 1901+1903, SEQ ID NOs: 1914+1916, SEQ ID NOs:    1940+1942, SEQ ID NOs: 1953+1955, SEQ ID NOs: 1966+1968, SEQ ID NOs:    1979+1981, SEQ ID NOs: 1992+1994, SEQ ID NOs: 2005+2007, SEQ ID NOs:    2018+2020, SEQ ID NOs: 2031+2033, SEQ ID NOs: 2044+2046, and SEQ ID    NOs: 2057+2059, all pairs grouped into bin 2;-   (3) pairs of a VH region and a VL region as depicted in SEQ ID NOs:    338+394, SEQ ID NOs: 354+410, SEQ ID NOs: 378+434, SEQ ID NOs:    356+412, SEQ ID NOs: 476+571, SEQ ID NOs: 477+572, SEQ ID NOs:    478+573, SEQ ID NOs: 479+574, SEQ ID NOs: 480+575, SEQ ID NOs:    481+576, SEQ ID NOs: 482+577, SEQ ID NOs: 483+578, SEQ ID NOs:    484+579, SEQ ID NOs: 501+596, SEQ ID NOs: 502+597, SEQ ID NOs:    503+598, SEQ ID NOs: 504+599, SEQ ID NOs: 505+600, SEQ ID NOs:    506+601, SEQ ID NOs: 517+612, SEQ ID NOs: 518+613, SEQ ID NOs:    1003+1005, SEQ ID NOs: 1055+1057, SEQ ID NOs: 1094+1096, SEQ ID NOs:    1615+1617, SEQ ID NOs: 1628+1630, SEQ ID NOs: 1641+1643, SEQ ID NOs:    1680+1682, SEQ ID NOs: 1693+1695, SEQ ID NOs: 1706+1708, SEQ ID NOs:    1719+1721, SEQ ID NOs: 1732+1734, SEQ ID NOs: 1745+1747, SEQ ID NOs:    1758+1760, SEQ ID NOs: 1771+1773, and SEQ ID NOs: 1927+1929,    -   all pairs grouped into bin 3;-   (4) pairs of a VH region and a VL region as depicted in SEQ ID NOs:    352+408, SEQ ID NOs: 360+416, SEQ ID NOs: 388+444, SEQ ID NOs:    386+442, SEQ ID NOs: 340+396, SEQ ID NOs: 346+402, SEQ ID NOs:    374+430, SEQ ID NOs: 348+404, SEQ ID NOs: 390+446, SEQ ID NOs:    463+558, SEQ ID NOs: 464+559, SEQ ID NOs: 465+560, SEQ ID NOs:    466+561, SEQ ID NOs: 467+562, SEQ ID NOs: 468+563, SEQ ID NOs:    469+564, SEQ ID NOs: 470+565, SEQ ID NOs: 471+566, SEQ ID NOs:    472+567, SEQ ID NOs: 473+568, SEQ ID NOs: 474+569, SEQ ID NOs:    475+570, SEQ ID NOs: 488+583, SEQ ID NOs: 489+584, SEQ ID NOs:    490+585, SEQ ID NOs: 491+586, SEQ ID NOs: 513+608, SEQ ID NOs:    514+609, SEQ ID NOs: 515+610, SEQ ID NOs: 516+611, SEQ ID NOs:    540+635, SEQ ID NOs: 541+636, SEQ ID NOs: 542+637, SEQ ID NOs:    543+638, SEQ ID NOs: 977+979, SEQ ID NOs: 1068+1070, SEQ ID NOs:    1146+1148, SEQ ID NOs: 1159+1161, SEQ ID NOs: 1185+1187, SEQ ID NOs:    1198+1200, SEQ ID NOs: 1211+1213, SEQ ID NOs: 1224+1226, SEQ ID NOs:    1237+1239, SEQ ID NOs: 1315+1317, SEQ ID NOs: 1328+1330, SEQ ID NOs:    1380+1382 SEQ ID NOs: 1393+1395, SEQ ID NOs: 1406+1408, SEQ ID NOs:    1419+1421, SEQ ID NOs: 1469+1471, SEQ ID NOs: 1478+1480, SEQ ID NOs:    1485+1487, SEQ ID NOs: 1494+1496, SEQ ID NOs: 1501+1503, SEQ ID NOs:    1508+1510, SEQ ID NOs: 1519+1521, SEQ ID NOs: 1526+1528, SEQ ID NOs:    1533+1535, SEQ ID NOs: 1542+1544, SEQ ID NOs: 1549+1551, SEQ ID NOs:    1558+1560, SEQ ID NOs: 1565+1567, SEQ ID NOs: 1784+1786, SEQ ID NOs:    1797+1799, SEQ ID NOs: 1810+1812, SEQ ID NOs: 1823+1825, SEQ ID NOs:    1836+1838, SEQ ID NOs: 1849+1851, SEQ ID NOs: 1862+1864, SEQ ID NOs:    1875+1877, SEQ ID NOs: 1888+1890, SEQ ID NOs: 2070+2072, SEQ ID NOs:    2083+2085, SEQ ID NOs: 2096+2098, SEQ ID NOs: 2109+2111, SEQ ID NOs:    2122+2124, SEQ ID NOs: 2135+2137, SEQ ID NOs: 2148+2150, SEQ ID NOs:    2161+2163, SEQ ID NOs: 2187+2189, SEQ ID NOs: 2200+2202, and SEQ ID    NOs: 2213+2215,    -   all pairs grouped into bin 4; and-   (5) pairs of a VH region and a VL region as depicted in SEQ ID NOs:    376+432, SEQ ID NOs: 392+448, SEQ ID NOs: 358+414, SEQ ID NOs:    350+406, SEQ ID NOs: 507+602, SEQ ID NOs: 990+992, SEQ ID NOs:    1589+1591, and SEQ ID NOs: 1602+1604,    -   all pairs grouped into bin 5.

In a further embodiment of the invention the antibody construct is in aformat selected from the group consisting of (scFv)₂, (single domainmAb)₂, scFv-single domain mAb, diabodies and oligomers thereof.

In a preferred embodiment the first binding domain comprises an aminoacid selected from the group consisting of

-   (a) as depicted in SEQ ID NO: 117, SEQ ID NO: 1137, SEQ ID NO: 1176,    SEQ ID NO: 1345, SEQ ID NO: 1358, SEQ ID NO: 1371, SEQ ID NO: 1436,    SEQ ID NO: 1449 and SEQ ID NO: 2178,    -   all binders grouped into bin 1;-   (b) as depicted in SEQ ID NO: 1020, SEQ ID NO: 1033, SEQ ID NO:    1046, SEQ ID NO: 1085, SEQ ID NO: 1111, SEQ ID NO: 1124, SEQ ID NO:    1254, SEQ ID NO: 1267, SEQ ID NO: 1280, SEQ ID NO: 1293, SEQ ID NO:    1306, SEQ ID NO: 1658, SEQ ID NO: 1671, SEQ ID NO: 1905, SEQ ID NO:    1918, SEQ ID NO: 1944, SEQ ID NO: 1957, SEQ ID NO: 1970, SEQ ID NO:    1983, SEQ ID NO: 1996, SEQ ID NO: 2009, SEQ ID NO: 2022, SEQ ID NO:    2035, SEQ ID NO: 2048, and SEQ ID NO: 2061,    -   all binders grouped into bin 2;-   (c) as depicted in SEQ ID NO: 1007, SEQ ID NO: 1059, SEQ ID NO:    1098, SEQ ID NO: 1619, SEQ ID NO: 1632, SEQ ID NO: 1645, SEQ ID NO:    1684, SEQ ID NO: 1697, SEQ ID NO: 1710, SEQ ID NO: 1723, SEQ ID NO:    1736, SEQ ID NO: 1749, SEQ ID NO: 1762, SEQ ID NO: 1775, and SEQ ID    NO: 1931,    -   all binders grouped into bin 3;-   (d) as depicted in SEQ ID NO: 981, SEQ ID NO: 1072, SEQ ID NO: 1150,    SEQ ID NO: 1163, SEQ ID NO: 1189, SEQ ID NO: 1202, SEQ ID NO: 1215,    SEQ ID NO: 1228, SEQ ID NO: 1241, SEQ ID NO: 1319, SEQ ID NO: 1332,    SEQ ID NO: 1384, SEQ ID NO: 1397, SEQ ID NO: 1410, SEQ ID NO: 1423,    SEQ ID NO: 1473, SEQ ID NO: 1482, SEQ ID NO: 1489, SEQ ID NO: 1498,    SEQ ID NO: 1505, SEQ ID NO: 1512, SEQ ID NO: 1523, SEQ ID NO: 1530,    SEQ ID NO: 1537, SEQ ID NO: 1546, SEQ ID NO: 1553, SEQ ID NO: 1562,    SEQ ID NO: 1569, SEQ ID NO: 1788, SEQ ID NO: 1801, SEQ ID NO: 1814,    SEQ ID NO: 1827, SEQ ID NO: 1840, SEQ ID NO: 1853, SEQ ID NO: 1866,    SEQ ID NO: 1879, SEQ ID NO: 1892, SEQ ID NO: 2074, SEQ ID NO: 2087,    SEQ ID NO: 2100, SEQ ID NO: 2113, SEQ ID NO: 2126, SEQ ID NO: 2139,    SEQ ID NO: 2152, SEQ ID NO: 2165, SEQ ID NO: 2191, SEQ ID NO: 2204,    and SEQ ID NO: 2217,    -   all binders grouped into bin 4; and-   (e) as depicted in SEQ ID NO: 994, SEQ ID NO: 1593, and SEQ ID NO:    1606, grouped into bin 5.

In one aspect of the invention, the second binding domain is capable ofbinding to to human CD3 and to macaque CD3, preferably to human CD3epsilon and to macaque CD3 epsilon. Additionally or alternatively, thesecond binding domain is capable of binding to Callithrix jacchus,Saguinus oedipus and/or Saimiri sciureus CD3 epsilon. According to theseembodiments, one or both binding domains of the antibody construct ofthe invention are preferably cross-species specific for members of themammalian order of primates. Cross-species specific CD3 binding domainsare, for example, described in WO 2008/119567. It is particularlypreferred for the antibody construct of the present invention that thesecond binding domain capable of binding to the T cell CD3 receptorcomplex comprises a VL region comprising CDR-L1, CDR-L2 and CDR-L3selected from:

-   (a) CDR-L1 as depicted in SEQ ID NO: 27 of WO 2008/119567, CDR-L2 as    depicted in SEQ ID NO: 28 of WO 2008/119567 and CDR-L3 as depicted    in SEQ ID NO: 29 of WO 2008/119567;-   (b) CDR-L1 as depicted in SEQ ID NO: 117 of WO 2008/119567, CDR-L2    as depicted in SEQ ID NO: 118 of WO 2008/119567 and CDR-L3 as    depicted in SEQ ID NO: 119 of WO 2008/119567; and-   (c) CDR-L1 as depicted in SEQ ID NO: 153 of WO 2008/119567, CDR-L2    as depicted in SEQ ID NO: 154 of WO 2008/119567 and CDR-L3 as    depicted in SEQ ID NO: 155 of WO 2008/119567.

In an alternatively preferred embodiment of the antibody construct ofthe present invention, the second binding domain capable of binding tothe T cell CD3 receptor complex comprises a VH region comprising CDR-H1, CDR-H2 and CDR-H3 selected from:

-   (a) CDR-H1 as depicted in SEQ ID NO: 12 of WO 2008/119567, CDR-H2 as    depicted in SEQ ID NO: 13 of WO 2008/119567 and CDR-H3 as depicted    in SEQ ID NO: 14 of WO 2008/119567;-   (b) CDR-H1 as depicted in SEQ ID NO: 30 of WO 2008/119567, CDR-H2 as    depicted in SEQ ID NO: 31 of WO 2008/119567 and CDR-H3 as depicted    in SEQ ID NO: 32 of WO 2008/119567;-   (c) CDR-H1 as depicted in SEQ ID NO: 48 of WO 2008/119567, CDR-H2 as    depicted in SEQ ID NO: 49 of WO 2008/119567 and CDR-H3 as depicted    in SEQ ID NO: 50 of WO 2008/119567;-   (d) CDR-H1 as depicted in SEQ ID NO: 66 of WO 2008/119567, CDR-H2 as    depicted in SEQ ID NO: 67 of WO 2008/119567 and CDR-H3 as depicted    in SEQ ID NO: 68 of WO 2008/119567;-   (e) CDR-H1 as depicted in SEQ ID NO: 84 of WO 2008/119567, CDR-H2 as    depicted in SEQ ID NO: 85 of WO 2008/119567 and CDR-H3 as depicted    in SEQ ID NO: 86 of WO 2008/119567;-   (f) CDR-H1 as depicted in SEQ ID NO: 102 of WO 2008/119567, CDR-H2    as depicted in SEQ ID NO: 103 of WO2008/119567 and CDR-H3 as    depicted in SEQ ID NO: 104 of WO 2008/119567;-   (g) CDR-H1 as depicted in SEQ ID NO: 120 of WO 2008/119567, CDR-H2    as depicted in SEQ ID NO: 121 of WO2008/119567 and CDR-H3 as    depicted in SEQ ID NO: 122 of WO 2008/119567;-   (h) CDR-H1 as depicted in SEQ ID NO: 138 of WO 2008/119567, CDR-H2    as depicted in SEQ ID NO: 139 of WO2008/119567 and CDR-H3 as    depicted in SEQ ID NO: 140 of WO 2008/119567;-   (i) CDR-H1 as depicted in SEQ ID NO: 156 of WO 2008/119567, CDR-H2    as depicted in SEQ ID NO: 157 of WO2008/119567 and CDR-H3 as    depicted in SEQ ID NO: 158 of WO 2008/119567; and-   (j) CDR-H1 as depicted in SEQ ID NO: 174 of WO 2008/119567, CDR-H2    as depicted in SEQ ID NO: 175 of WO2008/119567 and CDR-H3 as    depicted in SEQ ID NO: 176 of WO 2008/119567.

It is further preferred for the antibody construct of the presentinvention that the second binding domain capable of binding to the Tcell CD3 receptor complex comprises a VL region selected from the groupconsisting of a VL region as depicted in SEQ ID NO: 35, 39, 125, 129,161 or 165 of WO 2008/119567.

It is alternatively preferred that the second binding domain capable ofbinding to the T cell CD3 receptor complex comprises a VH regionselected from the group consisting of a VH region as depicted in SEQ IDNO: 15, 19, 33, 37, 51, 55, 69, 73, 87, 91, 105, 109, 123, 127, 141,145, 159, 163, 177 or 181 of WO 2008/119567.

More preferably, the antibody construct of the present invention ischaracterized by the second binding domain capable of binding to the Tcell CD3 receptor complex comprising a VL region and a VH regionselected from the group consisting of:

-   (a) a VL region as depicted in SEQ ID NO: 17 or 21 of WO 2008/119567    and a VH region as depicted in SEQ ID NO: 15 or 19 of WO    2008/119567;-   (b) a VL region as depicted in SEQ ID NO: 35 or 39 of WO 2008/119567    and a VH region as depicted in SEQ ID NO: 33 or 37 of WO    2008/119567;-   (c) a VL region as depicted in SEQ ID NO: 53 or 57 of WO 2008/119567    and a VH region as depicted in SEQ ID NO: 51 or 55 of WO    2008/119567;-   (d) a VL region as depicted in SEQ ID NO: 71 or 75 of WO 2008/119567    and a VH region as depicted in SEQ ID NO: 69 or 73 of WO    2008/119567;-   (e) a VL region as depicted in SEQ ID NO: 89 or 93 of WO 2008/119567    and a VH region as depicted in SEQ ID NO: 87 or 91 of WO    2008/119567;-   (f) a VL region as depicted in SEQ ID NO: 107 or 111 of WO    2008/119567 and a VH region as depicted in SEQ ID NO: 105 or 109 of    WO 2008/119567;-   (g) a VL region as depicted in SEQ ID NO: 125 or 129 of WO    2008/119567 and a VH region as depicted in SEQ ID NO: 123 or 127 of    WO 2008/119567;-   (h) a VL region as depicted in SEQ ID NO: 143 or 147 of WO    2008/119567 and a VH region as depicted in SEQ ID NO: 141 or 145 of    WO 2008/119567;-   (i) a VL region as depicted in SEQ ID NO: 161 or 165 of WO    2008/119567 and a VH region as depicted in SEQ ID NO: 159 or 163 of    WO 2008/119567; and-   (j) a VL region as depicted in SEQ ID NO: 179 or 183 of WO    2008/119567 and a VH region as depicted in SEQ ID NO: 177 or 181 of    WO 2008/119567.

According to a preferred embodiment of the antibody construct of thepresent invention, in particular the second binding domain capable ofbinding to the T cell CD3 receptor complex, the pairs of VH-regions andVL-regions are in the format of a single chain antibody (scFv). The VHand VL regions are arranged in the order VH-VL or VL-VH. It is preferredthat the VH-region is positioned N-terminally to a linker sequence. TheVL-region is positioned C-terminally of the linker sequence.

A preferred embodiment of the above described antibody construct of thepresent invention is characterized by the second binding domain capableof binding to the T cell CD3 receptor complex comprising an amino acidsequence selected from the group consisting of SEQ ID NOs: 23, 25, 41,43, 59, 61, 77, 79, 95, 97, 113, 115, 131, 133, 149, 151, 167, 169, 185or 187 of WO 2008/119567.

In a preferred embodiment the antibody construct of the invention has anamino acid sequence selected from the group consisting of

-   (a) as depicted in SEQ ID NO: 1138, SEQ ID NO: 1177, SEQ ID NO:    1346, SEQ ID NO: 1359, SEQ ID NO: 1372, SEQ ID NO: 1437, SEQ ID NO:    1450 and SEQ ID NO: 2179;-   (b) as depicted in SEQ ID NO: 1021, SEQ ID NO: 1034, SEQ ID NO:    1047, SEQ ID NO: 1086, SEQ ID NO: 1112, SEQ ID NO: 1125, SEQ ID NO:    1255, SEQ ID NO: 1268, SEQ ID NO: 1281, SEQ ID NO: 1294, SEQ ID NO:    1307, SEQ ID NO: 1659, SEQ ID NO: 1672, SEQ ID NO: 1906, SEQ ID NO:    1919, SEQ ID NO: 1945, SEQ ID NO: 1958, SEQ ID NO: 1971, SEQ ID NO:    1984, SEQ ID NO: 1997, SEQ ID NO: 2010, SEQ ID NO: 2023, SEQ ID NO:    2036, SEQ ID NO: 2049, and SEQ ID NO: 2062;-   (c) as depicted in SEQ ID NO: 1008, SEQ ID NO: 1060, SEQ ID NO:    1099, SEQ ID NO: 1620, SEQ ID NO: 1633, SEQ ID NO: 1646, SEQ ID NO:    1685, SEQ ID NO: 1698, SEQ ID NO: 1711, SEQ ID NO: 1724, SEQ ID NO:    1737, SEQ ID NO: 1750, SEQ ID NO: 1763, SEQ ID NO: 1776, and SEQ ID    NO: 1932;-   (d) as depicted in SEQ ID NO: 982, SEQ ID NO: 1073, SEQ ID NO: 1151,    SEQ ID NO: 1164, SEQ ID NO: 1190, SEQ ID NO: 1203, SEQ ID NO: 1216,    SEQ ID NO: 1229, SEQ ID NO: 1242, SEQ ID NO: 1320, SEQ ID NO: 1333,    SEQ ID NO: 1385, SEQ ID NO: 1398, SEQ ID NO: 1411, SEQ ID NO: 1424,    SEQ ID NO: 1474, SEQ ID NO: 1475, SEQ ID NO: 1476, SEQ ID NO: 1483,    SEQ ID NO: 1490, SEQ ID NO: 1491, SEQ ID NO: 1492, SEQ ID NO: 1499,    SEQ ID NO: 1506, SEQ ID NO: 1513, SEQ ID NO: 1514, SEQ ID NO: 1515,    SEQ ID NO: 1516, SEQ ID NO: 1517, SEQ ID NO: 1524, SEQ ID NO: 1531,    SEQ ID NO: 1538, SEQ ID NO: 1539, SEQ ID NO: 1540, SEQ ID NO: 1547,    SEQ ID NO: 1554, SEQ ID NO: 1555, SEQ ID NO: 1556, SEQ ID NO: 1563,    SEQ ID NO: 1570, SEQ ID NO: 1571, SEQ ID NO: 1572, SEQ ID NO: 1573,    SEQ ID NO: 1574, SEQ ID NO: 1575, SEQ ID NO: 1576, SEQ ID NO: 1577,    SEQ ID NO: 1578, SEQ ID NO: 1579, SEQ ID NO: 1580, SEQ ID NO: 1581,    SEQ ID NO: 1789, SEQ ID NO: 1802, SEQ ID NO: 1815, SEQ ID NO: 1828,    SEQ ID NO: 1841, SEQ ID NO: 1854, SEQ ID NO: 1867, SEQ ID NO: 1880,    SEQ ID NO: 1893, SEQ ID NO: 2075, SEQ ID NO: 2088, SEQ ID NO:2101,    SEQ ID NO:2114, SEQ ID NO: 2127, SEQ ID NO: 2140, SEQ ID NO: 2153,    SEQ ID NO: 2166, SEQ ID NO: 2192, SEQ ID NO: 2205, and SEQ ID NO:    2218 to 2228; and-   (e) as depicted in SEQ ID NO: 995, SEQ ID NO: 1594, and SEQ ID NO:    1607.

The invention further provides a nucleic acid sequence encoding anantibody construct of the invention.

Furthermore, the invention provides a vector comprising a nucleic acidsequence of the invention. Moreover, the invention provides a host celltransformed or transfected with the nucleic acid sequence of theinvention.

In a further embodiment the invention provides a process for theproduction of a antibody construct of the invention, said processcomprising culturing a host cell of the invention under conditionsallowing the expression of the antibody construct of the invention andrecovering the produced antibody construct from the culture.

Moreover, the invention provides a pharmaceutical composition comprisingan antibody construct of the invention or produced according to theprocess of the invention

The formulations described herein are useful as pharmaceuticalcompositions in the treatment, amelioration and/or prevention of thepathological medical condition as described herein in a patient in needthereof. The term “treatment” refers to both therapeutic treatment andprophylactic or preventative measures. Treatment includes theapplication or administration of the formulation to the body, anisolated tissue, or cell from a patient who has a disease/disorder, asymptom of a disease/disorder, or a predisposition toward adisease/disorder, with the purpose to cure, heal, alleviate, relieve,alter, remedy, ameliorate, improve, or affect the disease, the symptomof the disease, or the predisposition toward the disease.

Those “in need of treatment” include those already with the disorder, aswell as those in which the disorder is to be prevented. The term“disease” is any condition that would benefit from treatment with theprotein formulation described herein. This includes chronic and acutedisorders or diseases including those pathological conditions thatpredispose the mammal to the disease in question. Non-limiting examplesof diseases/disorders to be treated herein include proliferativedisease, a tumorous disease, or an immunological disorder.

In some embodiments, the invention provides a pharmaceutical compositioncomprising a therapeutically effective amount of one or a plurality ofthe antibody construct of the invention together with a pharmaceuticallyeffective diluents, carrier, solubilizer, emulsifier, preservative,and/or adjuvant. Pharmaceutical compositions of the invention include,but are not limited to, liquid, frozen, and lyophilized compositions.

Preferably, formulation materials are nontoxic to recipients at thedosages and concentrations employed. In specific embodiments,pharmaceutical compositions comprising a therapeutically effectiveamount of an antibody construct of the invention.

In certain embodiments, the pharmaceutical composition may containformulation materials for modifying, maintaining or preserving, forexample, the pH, osmolarity, viscosity, clarity, color, isotonicity,odor, sterility, stability, rate of dissolution or release, adsorptionor penetration of the composition. In such embodiments, suitableformulation materials include, but are not limited to, amino acids (suchas glycine, glutamine, asparagine, arginine, proline, or lysine);antimicrobials; antioxidants (such as ascorbic acid, sodium sulfite orsodium hydrogen-sulfite); buffers (such as borate, bicarbonate,Tris-HCl, citrates, phosphates or other organic acids); bulking agents(such as mannitol or glycine); chelating agents (such as ethylenediaminetetraacetic acid (EDTA)); complexing agents (such as caffeine,polyvinylpyrrolidone, beta-cyclodextrin orhydroxypropyl-beta-cyclodextrin); fillers; monosaccharides;disaccharides; and other carbohydrates (such as glucose, mannose ordextrins); proteins (such as serum albumin, gelatin or immunoglobulins);coloring, flavoring and diluting agents; emulsifying agents; hydrophilicpolymers (such as polyvinylpyrrolidone); low molecular weightpolypeptides; salt-forming counterions (such as sodium); preservatives(such as benzalkonium chloride, benzoic acid, salicylic acid,thimerosal, phenethyl alcohol, methylparaben, propylparaben,chlorhexidine, sorbic acid or hydrogen peroxide); solvents (such asglycerin, propylene glycol or polyethylene glycol); sugar alcohols (suchas mannitol or sorbitol); suspending agents; surfactants or wettingagents (such as pluronics, PEG, sorbitan esters, polysorbates such aspolysorbate 20, polysorbate, triton, tromethamine, lecithin,cholesterol, tyloxapal); stability enhancing agents (such as sucrose orsorbitol); tonicity enhancing agents (such as alkali metal halides,preferably sodium or potassium chloride, mannitol sorbitol); deliveryvehicles; diluents; excipients and/or pharmaceutical adjuvants. See,REMINGTON'S PHARMACEUTICAL SCIENCES, 18″ Edition, (A. R. Genrmo, ed.),1990, Mack Publishing Company.

In certain embodiments, the optimal pharmaceutical composition will bedetermined by one skilled in the art depending upon, for example, theintended route of administration, delivery format and desired dosage.See, for example, REMINGTON'S PHARMACEUTICAL SCIENCES, supra. In certainembodiments, such compositions may influence the physical state,stability, rate of in vivo release and rate of in vivo clearance of theantigen binding proteins of the invention. In certain embodiments, theprimary vehicle or carrier in a pharmaceutical composition may be eitheraqueous or non-aqueous in nature. For example, a suitable vehicle orcarrier may be water for injection, physiological saline solution orartificial cerebrospinal fluid, possibly supplemented with othermaterials common in compositions for parenteral administration. Neutralbuffered saline or saline mixed with serum albumin are further exemplaryvehicles. In specific embodiments, pharmaceutical compositions compriseTris buffer of about pH 7.0-8.5, or acetate buffer of about pH 4.0-5.5,and may further include sorbitol or a suitable substitute therefore. Incertain embodiments of the invention, human antibody or antigen bindingfragment thereof of the invention or the antibody construct of theinvention compositions may be prepared for storage by mixing theselected composition having the desired degree of purity with optionalformulation agents (REMINGTON'S PHARMACEUTICAL SCIENCES, supra) in theform of a lyophilized cake or an aqueous solution. Further, in certainembodiments, the human antibody or antigen binding fragment thereof ofthe invention or the antibody construct of the invention may beformulated as a lyophilizate using appropriate excipients such assucrose. The pharmaceutical compositions of the invention can beselected for parenteral delivery.

Alternatively, the compositions may be selected for inhalation or fordelivery through the digestive tract, such as orally. Preparation ofsuch pharmaceutically acceptable compositions is within the skill of theart. The formulation components are present preferably in concentrationsthat are acceptable to the site of administration. In certainembodiments, buffers are used to maintain the composition atphysiological pH or at a slightly lower pH, typically within a pH rangeof from about 5 to about 8.

When parenteral administration is contemplated, the therapeuticcompositions for use in this invention may be provided in the form of apyrogen-free, parenterally acceptable aqueous solution comprising thedesired human antibody or antigen binding fragment thereof of theinvention or the antibody construct of the invention in apharmaceutically acceptable vehicle. A particularly suitable vehicle forparenteral injection is sterile distilled water in which the antibodyconstruct of the invention is formulated as a sterile, isotonicsolution, properly preserved. In certain embodiments, the preparationcan involve the formulation of the desired molecule with an agent, suchas injectable microspheres, bio-erodible particles, polymeric compounds(such as polylactic acid or polyglycolic acid), beads or liposomes, thatmay provide controlled or sustained release of the product which can bedelivered via depot injection. In certain embodiments, hyaluronic acidmay also be used, having the effect of promoting sustained duration inthe circulation. In certain embodiments, implantable drug deliverydevices may be used to introduce the desired antigen binding protein.

Additional pharmaceutical compositions will be evident to those skilledin the art, including formulations involving h the antibody construct ofthe invention in sustained- or controlled-delivery formulations.Techniques for formulating a variety of other sustained- orcontrolled-delivery means, such as liposome carriers, bio-erodiblemicroparticles or porous beads and depot injections, are also known tothose skilled in the art. See, for example, International PatentApplication No. PCT/US93/00829, which is incorporated by reference anddescribes controlled release of porous polymeric microparticles fordelivery of pharmaceutical compositions. Sustained-release preparationsmay include semipermeable polymer matrices in the form of shapedarticles, e.g., films, or microcapsules. Sustained release matrices mayinclude polyesters, hydrogels, polylactides (as disclosed in U.S. Pat.No. 3,773,919 and European Patent Application Publication No. EP 058481,each of which is incorporated by reference), copolymers of L-glutamicacid and gamma ethyl-L-glutamate (Sidman et al., 1983, Biopolymers2:547-556), poly (2-hydroxyethyl-methacrylate) (Langer et al., 1981, J.Biomed. Mater. Res. 15:167-277 and Langer, 1982, Chem. Tech. 12:98-105),ethylene vinyl acetate (Langer et al., 1981, supra) orpoly-D(−)-3-hydroxybutyric acid (European Patent Application PublicationNo. EP 133,988). Sustained release compositions may also includeliposomes that can be prepared by any of several methods known in theart. See, e.g., Eppstein et al., 1985, Proc. Natl. Acad. Sci. U.S.A.82:3688-3692; European Patent Application Publication Nos. EP 036,676;EP 088,046 and EP 143,949, incorporated by reference.

Pharmaceutical compositions used for in vivo administration aretypically provided as sterile preparations. Sterilization can beaccomplished by filtration through sterile filtration membranes. Whenthe composition is lyophilized, sterilization using this method may beconducted either prior to or following lyophilization andreconstitution. Compositions for parenteral administration can be storedin lyophilized form or in a solution. Parenteral compositions generallyare placed into a container having a sterile access port, for example,an intravenous solution bag or vial having a stopper pierceable by ahypodermic injection needle.

Aspects of the invention includes self-buffering antibody construct ofthe invention formulations, which can be used as pharmaceuticalcompositions, as described in international patent application WO06138181A2 (PCT/US2006/022599), which is incorporated by reference inits entirety herein.

As discussed above, certain embodiments provide antibody construct ofthe invention protein compositions, particularly pharmaceuticalcompositions of the invention, that comprise, in addition to theantibody construct of the invention, one or more excipients such asthose illustratively described in this section and elsewhere herein.Excipients can be used in the invention in this regard for a widevariety of purposes, such as adjusting physical, chemical, or biologicalproperties of formulations, such as adjustment of viscosity, and orprocesses of the invention to improve effectiveness and or to stabilizesuch formulations and processes against degradation and spoilage due to,for instance, stresses that occur during manufacturing, shipping,storage, pre-use preparation, administration, and thereafter.

A variety of expositions are available on protein stabilization andformulation materials and methods useful in this regard, such as Arakawaet al., “Solvent interactions in pharmaceutical formulations,” PharmRes. 8(3): 285-91 (1991); Kendrick et al., “Physical stabilization ofproteins in aqueous solution,” in: RATIONAL DESIGN OF STABLE PROTEINFORMULATIONS: THEORY AND PRACTICE, Carpenter and Manning, eds.Pharmaceutical Biotechnology. 13: 61-84 (2002), and Randolph et al.,“Surfactant-protein interactions,” Pharm Biotechnol. 13: 159-75 (2002),each of which is herein incorporated by reference in its entirety,particularly in parts pertinent to excipients and processes of the samefor self-buffering protein formulations in accordance with the currentinvention, especially as to protein pharmaceutical products andprocesses for veterinary and/or human medical uses.

Salts may be used in accordance with certain embodiments of theinvention to, for example, adjust the ionic strength and/or theisotonicity of a formulation and/or to improve the solubility and/orphysical stability of a protein or other ingredient of a composition inaccordance with the invention.

As is well known, ions can stabilize the native state of proteins bybinding to charged residues on the protein's surface and by shieldingcharged and polar groups in the protein and reducing the strength oftheir electrostatic interactions, attractive, and repulsiveinteractions. Ions also can stabilize the denatured state of a proteinby binding to, in particular, the denatured peptide linkages (—CONH) ofthe protein. Furthermore, ionic interaction with charged and polargroups in a protein also can reduce intermolecular electrostaticinteractions and, thereby, prevent or reduce protein aggregation andinsolubility.

Ionic species differ significantly in their effects on proteins. Anumber of categorical rankings of ions and their effects on proteinshave been developed that can be used in formulating pharmaceuticalcompositions in accordance with the invention. One example is theHofmeister series, which ranks ionic and polar non-ionic solutes bytheir effect on the conformational stability of proteins in solution.Stabilizing solutes are referred to as “kosmotropic.” Destabilizingsolutes are referred to as “chaotropic.” Kosmotropes commonly are usedat high concentrations (e.g., >1 molar ammonium sulfate) to precipitateproteins from solution (“salting-out”). Chaotropes commonly are used todenture and/or to solubilize proteins (“salting-in”). The relativeeffectiveness of ions to “salt-in” and “salt-out” defines their positionin the Hofmeister series.

Free amino acids can be used in the antibody construct of the inventionformulations in accordance with various embodiments of the invention asbulking agents, stabilizers, and antioxidants, as well as other standarduses. Lysine, proline, serine, and alanine can be used for stabilizingproteins in a formulation. Glycine is useful in lyophilization to ensurecorrect cake structure and properties. Arginine may be useful to inhibitprotein aggregation, in both liquid and lyophilized formulations.Methionine is useful as an antioxidant.

Polyols include sugars, e.g., mannitol, sucrose, and sorbitol andpolyhydric alcohols such as, for instance, glycerol and propyleneglycol, and, for purposes of discussion herein, polyethylene glycol(PEG) and related substances. Polyols are kosmotropic. They are usefulstabilizing agents in both liquid and lyophilized formulations toprotect proteins from physical and chemical degradation processes.Polyols also are useful for adjusting the tonicity of formulations.

Among polyols useful in select embodiments of the invention is mannitol,commonly used to ensure structural stability of the cake in lyophilizedformulations. It ensures structural stability to the cake. It isgenerally used with a lyoprotectant, e.g., sucrose. Sorbitol and sucroseare among preferred agents for adjusting tonicity and as stabilizers toprotect against freeze-thaw stresses during transport or the preparationof bulks during the manufacturing process. Reducing sugars (whichcontain free aldehyde or ketone groups), such as glucose and lactose,can glycate surface lysine and arginine residues. Therefore, theygenerally are not among preferred polyols for use in accordance with theinvention. In addition, sugars that form such reactive species, such assucrose, which is hydrolyzed to fructose and glucose under acidicconditions, and consequently engenders glycation, also is not amongpreferred polyols of the invention in this regard. PEG is useful tostabilize proteins and as a cryoprotectant and can be used in theinvention in this regard.

Embodiments of the antibody construct of the invention formulationsfurther comprise surfactants. Protein molecules may be susceptible toadsorption on surfaces and to denaturation and consequent aggregation atair-liquid, solid-liquid, and liquid-liquid interfaces. These effectsgenerally scale inversely with protein concentration. These deleteriousinteractions generally scale inversely with protein concentration andtypically are exacerbated by physical agitation, such as that generatedduring the shipping and handling of a product.

Surfactants routinely are used to prevent, minimize, or reduce surfaceadsorption. Useful surfactants in the invention in this regard includepolysorbate 20, polysorbate 80, other fatty acid esters of sorbitanpolyethoxylates, and poloxamer 188.

Surfactants also are commonly used to control protein conformationalstability. The use of surfactants in this regard is protein-specificsince, any given surfactant typically will stabilize some proteins anddestabilize others.

Polysorbates are susceptible to oxidative degradation and often, assupplied, contain sufficient quantities of peroxides to cause oxidationof protein residue side-chains, especially methionine. Consequently,polysorbates should be used carefully, and when used, should be employedat their lowest effective concentration. In this regard, polysorbatesexemplify the general rule that excipients should be used in theirlowest effective concentrations.

Embodiments of the antibody construct of the invention formulationsfurther comprise one or more antioxidants. To some extent deleteriousoxidation of proteins can be prevented in pharmaceutical formulations bymaintaining proper levels of ambient oxygen and temperature and byavoiding exposure to light. Antioxidant excipients can be used as wellto prevent oxidative degradation of proteins. Among useful antioxidantsin this regard are reducing agents, oxygen/free-radical scavengers, andchelating agents. Antioxidants for use in therapeutic proteinformulations in accordance with the invention preferably arewater-soluble and maintain their activity throughout the shelf life of aproduct. EDTA is a preferred antioxidant in accordance with theinvention in this regard.

Antioxidants can damage proteins. For instance, reducing agents, such asglutathione in particular, can disrupt intramolecular disulfidelinkages. Thus, antioxidants for use in the invention are selected to,among other things, eliminate or sufficiently reduce the possibility ofthemselves damaging proteins in the formulation.

Formulations in accordance with the invention may include metal ionsthat are protein co-factors and that are necessary to form proteincoordination complexes, such as zinc necessary to form certain insulinsuspensions. Metal ions also can inhibit some processes that degradeproteins. However, metal ions also catalyze physical and chemicalprocesses that degrade proteins.

Magnesium ions (10-120 mM) can be used to inhibit isomerization ofaspartic acid to isoaspartic acid. Ca⁺² ions (up to 100 mM) can increasethe stability of human deoxyribonuclease. Mg⁺², Mn⁺², and Zn⁺², however,can destabilize rhDNase. Similarly, Ca⁺² and Sr⁺² can stabilize FactorVIII, it can be destabilized by Mg⁺², Mn⁺² and Zn⁺², Cu⁺² and Fe⁺², andits aggregation can be increased by Al⁺³ ions.

Embodiments of the antibody construct of the invention formulationsfurther comprise one or more preservatives. Preservatives are necessarywhen developing multi-dose parenteral formulations that involve morethan one extraction from the same container. Their primary function isto inhibit microbial growth and ensure product sterility throughout theshelf-life or term of use of the drug product. Commonly usedpreservatives include benzyl alcohol, phenol and m-cresol. Althoughpreservatives have a long history of use with small-moleculeparenterals, the development of protein formulations that includespreservatives can be challenging. Preservatives almost always have adestabilizing effect (aggregation) on proteins, and this has become amajor factor in limiting their use in multi-dose protein formulations.To date, most protein drugs have been formulated for single-use only.However, when multi-dose formulations are possible, they have the addedadvantage of enabling patient convenience, and increased marketability.A good example is that of human growth hormone (hGH) where thedevelopment of preserved formulations has led to commercialization ofmore convenient, multi-use injection pen presentations. At least foursuch pen devices containing preserved formulations of hGH are currentlyavailable on the market. Norditropin (liquid, Novo Nordisk), Nutropin AQ(liquid, Genentech) & Genotropin (lyophilized—dual chamber cartridge,Pharmacia & Upjohn) contain phenol while Somatrope (Eli Lilly) isformulated with m-cresol. Several aspects need to be considered duringthe formulation and development of preserved dosage forms. The effectivepreservative concentration in the drug product must be optimized. Thisrequires testing a given preservative in the dosage form withconcentration ranges that confer anti-microbial effectiveness withoutcompromising protein stability.

As might be expected, development of liquid formulations containingpreservatives are more challenging than lyophilized formulations.Freeze-dried products can be lyophilized without the preservative andreconstituted with a preservative containing diluent at the time of use.This shortens the time for which a preservative is in contact with theprotein, significantly minimizing the associated stability risks. Withliquid formulations, preservative effectiveness and stability should bemaintained over the entire product shelf-life (about 18 to 24 months).An important point to note is that preservative effectiveness should bedemonstrated in the final formulation containing the active drug and allexcipient components.

The antibody construct of the invention generally will be designed forspecific routes and methods of administration, for specificadministration dosages and frequencies of administration, for specifictreatments of specific diseases, with ranges of bio-availability andpersistence, among other things. Formulations thus may be designed inaccordance with the invention for delivery by any suitable route,including but not limited to orally, aurally, opthalmically, rectally,and vaginally, and by parenteral routes, including intravenous andintraarterial injection, intramuscular injection, and subcutaneousinjection.

Once the pharmaceutical composition has been formulated, it may bestored in sterile vials as a solution, suspension, gel, emulsion, solid,crystal, or as a dehydrated or lyophilized powder. Such formulations maybe stored either in a ready-to-use form or in a form (e.g., lyophilized)that is reconstituted prior to administration. The invention alsoprovides kits for producing a single-dose administration unit. The kitsof the invention may each contain both a first container having a driedprotein and a second container having an aqueous formulation. In certainembodiments of this invention, kits containing single andmulti-chambered pre-filled syringes (e.g., liquid syringes andlyosyringes) are provided. The therapeutically effective amount of anantibody construct of the invention protein-containing pharmaceuticalcomposition to be employed will depend, for example, upon thetherapeutic context and objectives. One skilled in the art willappreciate that the appropriate dosage levels for treatment will varydepending, in part, upon the molecule delivered, the indication forwhich the antibody construct of the invention is being used, the routeof administration, and the size (body weight, body surface or organsize) and/or condition (the age and general health) of the patient. Incertain embodiments, the clinician may titer the dosage and modify theroute of administration to obtain the optimal therapeutic effect. Atypical dosage may range from about 0.1 pg/kg to up to about 30 mg/kg ormore, depending on the factors mentioned above. In specific embodiments,the dosage may range from 1.0 pg/kg up to about 20 mg/kg, optionallyfrom 10 pg/kg up to about 10 mg/kg or from 100 pg/kg up to about 5mg/kg.

A therapeutic effective amount of an antibody construct of the inventionpreferably results in a decrease in severity of disease symptoms, inincrease in frequency or duration of disease symptom-free periods or aprevention of impairment or disability due to the disease affliction.For treating CDH19-expressing tumors, a therapeutically effective amountof the antibody construct of the invention, e.g. an anti-CDH19/CD3antibody construct, preferably inhibits cell growth or tumor growth byat least about 20%, at least about 40%, at least about 50%, at leastabout 60%, at least about 70%, at least about 80%, or at least about 90%relative to untreated patients. The ability of a compound to inhibittumor growth may be evaluated in an animal model predictive of efficacyin human tumors.

Pharmaceutical compositions may be administered using a medical device.Examples of medical devices for administering pharmaceuticalcompositions are described in U.S. Pat. Nos. 4,475,196; 4,439,196;4,447,224; 4,447, 233; 4,486,194; 4,487,603; 4,596,556; 4,790,824;4,941,880; 5,064,413; 5,312,335; 5,312,335; 5,383,851; and 5,399,163,all incorporated by reference herein.

In one embodiment the invention provides the antibody construct of theinvention or produced according to the process of the invention for usein the prevention, treatment or amelioration of a melanoma disease ormetastatic melanoma disease.

The invention also provides a method for the treatment or ameliorationof a melanoma disease or metastatic melanoma disease, comprising thestep of administering to a subject in need thereof the antibodyconstruct of the invention or produced according to the process of theinvention.

In a preferred embodiment method of use of the invention the melanomadisease or metastatic melanoma disease is selected from the groupconsisting of superficial spreading melanoma, lentigo maligna, lentigomaligna melanoma, acral lentiginous melanoma and nodular melanoma.

In a further embodiment, the invention provides a kit comprising anantibody construct of the invention, or produced according to theprocess of the invention, a vector of the invention, and/or a host cellof the invention.

It should be understood that the inventions herein are not limited toparticular methodology, protocols, or reagents, as such can vary. Thediscussion and examples provided herein are presented for the purpose ofdescribing particular embodiments only and are not intended to limit thescope of the present invention, which is defined solely by the claims.

All publications and patents cited throughout the text of thisspecification (including all patents, patent applications, scientificpublications, manufacturer's specifications, instructions, etc.),whether supra or infra, are hereby incorporated by reference in theirentirety. Nothing herein is to be construed as an admission that theinvention is not entitled to antedate such disclosure by virtue of priorinvention. To the extent the material incorporated by referencecontradicts or is inconsistent with this specification, thespecification will supersede any such material.

EXAMPLES

The following examples are provided for the purpose of illustratingspecific embodiments or features of the present invention. Theseexamples should not be construed as to limit the scope of thisinvention. The examples are included for purposes of illustration, andthe present invention is limited only by the claims.

Example 1—Fully Human Monoclonal Antibodies Against CDH19 1.1Immunization:

Fully human antibodies to Cadherin-19 (CDH19) were generated usingXENOMOUSE® technology, transgenic mice engineered to express diverserepertoires of fully human IgGK and IgGA antibodies of the correspondingisotype. (U.S. Pat. Nos. 6,114,598; 6,162,963; 6,833,268; 7,049,426;7,064,244, which are incorporated herein by reference in their entirety;Green et al., 1994, Nature Genetics 7:13-21; Mendez et al., 1997, NatureGenetics 15:146-156; Green and Jakobovitis, 1998, J. Ex. Med.188:483-495; Kellermann and Green, Current Opinion in Biotechnology 13,593-597, 2002).

Mice were immunized with multiple forms of Cadherin-19 immunogen,including: (1) full length human and cynomologous (“cyno”) monkeycadherin-19, (2) secreted Cadherin-19 ecto-domain (amino acids 1-596),and (3) a truncated membrane bound form of human cadherin-19 (aminoacids 1-624). Mice were immunized over a period of 8 to 10 weeks with arange of 16-18 boosts.

Sera were collected at approximately 5 and 9 weeks after the firstinjection and specific titers were determined by FACs staining ofrecombinant Cadherin-19 receptor transiently expressed on CHO-S cells. Atotal of 37 animals were identified with specific immune responses,these animals were pooled into 3 groups and advanced to antibodygeneration.

1.2 Preparation of Monoclonal Antibodies

Animals exhibiting suitable titers were identified, and lymphocytes wereobtained from draining lymph nodes and, if necessary, pooled for eachcohort. Lymphocytes were dissociated from lymphoid tissue by grinding ina suitable medium (for example, Dulbecco's Modified Eagle Medium (DMEM);obtainable from Invitrogen, Carlsbad, Calif.) to release the cells fromthe tissues, and suspended in DMEM. B cells were selected and/orexpanded using standard methods, and fused with suitable fusion partnerusing techniques that were known in the art.

After several days of culture, the hybridoma supernatants were collectedand subjected to screening assays as detailed in the examples below,including confirmation of binding to human and cynomologous monkey aswell as the ability to kill cell lines in secondary antibody-drugconjugate Bioassays. Hybridoma lines that were identified to have thebinding and functional properties of interest were then further selectedand subjected to standard cloning and subcloning techniques. Clonallines were expanded in vitro, and the secreted human antibodies obtainedfor analysis and V gene sequencing was performed.

1.3 Selection of Cadherin-19 Receptor Specific Binding Antibodies byFMAT

After 14 days of culture, hybridoma supernatants were screened forCDH19-specific monoclonal antibodies by Fluorometric Microvolume AssayTechnology (FMAT) (Applied Biosystems, Foster City, Calif.). Thesupernatants were screened against adherent CHO cells transientlytransfected with human Cadherin-19 and counter screened against CHOcells transiently transfected with the same expression plasmid that didnot contain the Cadherin-19 gene.

After multiple screening campaigns, a panel of 1570 anti-Cadherin-19binding hybridoma lines were identified and advanced to furthercharacterization assays.

Example 2—Assessment of Fully Human Monoclonal Antibodies Against CDH192.1 Additional Binding Characterization by Flow Cytometry (FACs)

FACS binding assays were performed to evaluate the binding of theanti-Cadherin-19 receptor specific antibodies to endogenous Cadherin-19receptor expressed on the CHL-1 tumor cell lines. In addition,cross-reactive binding to murine and cynomologous monkey Cadherin-19orthologues was also evaluated by FACs using recombinant forms of thevarious receptors transiently expressed on 293T cells.

FACs assays were performed by incubating hybridoma supernatants with10,000 to 25,000 cells in PBS/2% Fetal bovine serum/2 mM CalciumChloride at 4° C. for one hour followed by two washes with PBS/2% Fetalbovine serum/2 mM Calcium Chloride. Cells were then treated withflorochrome-labeled secondary antibodies at 4° C. followed by one wash.The cells were resuspended in 50 μl of PBS/2% FBS and antibody bindingwas analyzed using a FACSCalibur™ instrument.

2.2 Antibody Drug Conjugate Screening of Fully Human Antibodies Derivedfrom XenoMouse® Hybridomas

Cell killing through antibody drug conjugates requires the delivery ofthe conjugate into a cell through internalization and the catabolism ofthe drug-conjugate into a form that it is toxic to the cell. To identifyantibodies with these properties, CDH19-positive cell lines (Colo-699 orCHL-1) were seeded at low cell densities and allowed to adhere overnightin a 384 well plate. XENOMOUSE® hybridoma samples containing fully humananti-CDH19 antibodies were then added to these cells in the presence ofa high concentration of a goat anti-human Fc monovalent Fab conjugatedwith DM1 (DM1-Fab) at a relatively low drug-antibody ratio (DAR) (1.3).The cells were incubated for 96 hours at 37° C. and 5% CO₂ in thepresence of the antibody samples and the DM1-Fab. At the end of thistime, the cell viability was assessed using the CellTiter-Glo®Luminescent Cell Viability reagent (Promega) according to manufacturer'srecommendations.

An example of the cell viability data with the Colo-699 cells is shownin FIG. 1 and FIG. 2. The antibodies capable of delivering the DM1-Fabto the cells and inhibiting the cell growth read out with a lowerluminescent signal (RLU). The top antibodies of interest from thisscreen are observed in the lower left corner of FIG. 1 and are denotedas open circles. These antibodies were taken forward into a cellviability assay on CHL-1 cells. The average cell viability data from theCHL-1 assay is plotted against the average cell viability data from theColo-699 assay (FIG. 2). The antibodies that had activity on both theColo-699 and the CHL-1 cells are denoted as open circles on theleft-hand side of the FIG. 2.

This assay was run concurrently with the FACs antibody binding assayabove (2.2), and the results from these two studies were used to selectthe antibodies for further characterization. In total, 1570 antibodieswere run through these cell based viability assays and approximately 44antibodies were selected on the bases of in vitro cell killing and/orantibody binding for sub-cloning, V gene sequencing and expressed inrecombinant form for further characterization assays as described below.

These 44 antibodies were again assayed as in Example 2 and 19 antibodieswere selected that contained unique sequences. Of these 19 antibodies,18 antibodies were analyzed and their properties characterized in Table2 below. The data in this table was generated using FACs binding onrecombinant human and cynomologous CDH-19, +/−Calcium (Ca⁺²⁾ bindingdata on 293/CDH-19 transfectants, binding to endogenous CDH-19 on CHL-1and Colo699 tumor cells and competition with the antibody designated as4A9 in the table. These experiments provided the furthercharacterizations for the grouping of these antibodies into 5 groups orbins.

TABLE 2 Binning of Lead panel using Antibody Binding Information LMR BinSequence/ Clone ID Ab ID ID Bin Characteristics 1 13589 4A9 HighEndogenous binding, Calcium 13591 4F7 insensitive, sequence clustered,moderate cyno complete 4A9 competitor 2 13885 19B5 High Endogenousbinding, Calcium 13880 25F8 insensitive, sequence clustered, Good 1388226D1 cyno, partial 4A9 competitor 13881 26F12 = 27B3 13878 16H2 = 20D3 =23E7 13879 22D1 3 13877 22G10 High Endogenous binding, moderate 29313874 17H8 = 23B6 = 28D10 binding, Calcium insensitive, 2 sequence 1388325G10 clusters, moderate cyno, partial 13875 16C1 4A9 competitor, 22G10best binder in bin. 4 13590 4B10 Low Endogenous and recombinant 135864F3 binding, Calcium sensitive, sequence 13592 4A2 diverse group,comparable cyno, No 4A9 13884 23A10 competition 13588 2G6 5 13876 16A4Best endogenous binder, moderate recombinant binder, calciuminsensitive, very weak cyno, No 4A9 competition.

Of these 18 antibodies. 8 antibodies were selected for further analysisof their epitope binding as described below. At least one representativeantibody from each bin was selected for further analysis.

Example 3—Epitope Prediction Epitope Prediction by 4A9 AntibodyCompetition and by Human/Mouse Cadherin-19 Chimeras

A 4A9 binding competition method was developed to identify antibodiesthat compete with 4A9 binding. In 96-well V-bottom plates (Sarstedt#82.1583.001), 50,000 transiently transfected 293T cells were incubatedwith 5 ug/ml of purified anti-CDH19 antibodies for 1 hr at 4° C.followed by one wash with PBS/2% FBS. 25 μl of 5 μg/ml Alexa647-labelled4A9 was then added to each well and the plates incubated for 1 hour at4° C. Cells were then washed two times and the amount of cell associatedAlexa647-labelled 4A9 was quantitated by flow cytometry.

The experiments included negative controls consisting of PBS/2% FBSonly. The average signal observed in these negative control experimentswas adopted as the maximum possible signal for the assay. Antibodieswere compared to this maximum signal and a percent inhibition wascalculated for each well (% Inhibition=(1-(FL4 Geomean with theanti-CDH19 antibodies/Maximum FL4 Geomean signal)).

Domain binding was determined by flow cytometry as above on 293T cellstransiently transfected with plasmids consisting of single or dual humanCDH19 cadherin repeat domain replacements into the mouse Cadherinl9backbone cloned into the pTT5 expression vector immediately preceded bynative human or murine CDH19 leader sequences and a Flag tag (SEQ ID NO:968). The experiment included assaying the anti-CDH19 antibodies againstmouse Cadherin19 to determine suitability for binning on thesehuman/mouse chimeras. The data from these experiments are presented inthe Table below entitled as follows:

TABLE 3 Calcium Sensitive Binding and Epitope Prediction Summary Hu HuHu Hu Mu Ca2+ Competes EC1- Hu EC1- Hu EC2- Hu EC4- Hu EC1- PredictedClone Sensitive with 4A9 5 EC1 2 EC2 3 EC3 5 EC5 5 Epitope ID Ab ID BinBinding (13589) A B C D E F G H I Region 4A9 13589 1 No Yes + + + − − −− − −  44-141 14056 1 No Yes + + + − − − − − − 14057 1 No Yes + + + − −− − − − 25F8 13880 2 No Yes + + + − − − − − − 14094 2 No Yes + + + − − −− − − 14096 2 No Yes + + + − − − − − − 26D1 13882 2 No Yes + + + − − − −− − 14088 2 No Yes + + + − − − − − − 17H8 13874 3 No Yes + + + − − − − −− 14045 3 No Yes + + + − − − − − − 14048 3 No Yes + + + − − − − − − 4A213592 4 Yes No + − − − + + − − − 250-364 14026 4 Yes No + − − − + + − −− 4B10 13590 4 Yes No + − − − + + − − − 14055 4 Yes No + − − − + + − − −14054 4 Yes No + − − − + + − − − 2G6 13588 4 Yes No + + + + + + + + +un- 14304 4 Yes No + + + + + + + + + assignable 14039 4 YesNo + + + + + + + + + 16A4 13876 5 No No + + + − − − − − − Unassigned14071 5 No No + + + − − − − − − complex epitope Ratanti-FLAG + + + + + + + + + Legend Table 3 Human and/or murine chimeraconstructs A = huCDH19(44-772) (see SEQ ID NO: 944) B =huCDH19(44-141)::muCDH19(140-770) (see SEQ ID NO: 952) C =huCDH19(44-249)::muCDH19(248-770) (see SEQ ID NO: 954) D =muCDH19(44-139)::huCDH19(142-249)::muCDH19(248-770) (see SEQ ID NO: 956)E = muCDH19(44-139)::huCDH19(142-364)::muCDH19(363-770) (see SEQ ID NO:958) F = muCDH19(44-247)::huCDH19(250-364)::muCDH19(363-770) (see SEQ IDNO: 960) G = muCDH19(44-362)::huCDH19(365-772) (see SEQ ID NO: 962) H =muCDH19(44-461)::huCDH19(464-772) (see SEQ ID NO: 964) I =muCDH19(44-770) (see SEQ ID NO: 966)

Epitope Prediction by Human/Chicken Cadherin-19 Chimeras

Domain binding was determined by flow cytometry on 293T cellstransiently transfected with plasmids consisting of single human CDH19cadherin repeat domain replacements into the chicken Cadherinl9 backbonecloned into the pTT5 expression vector immediately preceded by nativehuman or chicken CDH19 leader sequences and a Flag tag. The experimentincluded assaying a subset of anti-CDH19 antibodies against chickenCadherin19 to determine suitability for binning on these human/chickenchimeras.

The following binding assay was completed in presence of 2 mM CaCl2). In96-well V-bottom plates (Costar 3897), 50,000 transiently transfected293T cells were incubated with 5 ug/ml of purified anti-CDH19 antibodiesfor 1 hr at 4° C. followed by two washes with PBS/2% FBS. 50 μl of 5μg/ml Alexa647-labelled anti-human IgG secondary antibody (JacksonImmuno 109-605-098) and 2 ug/ml 7AAD (Sigma A9400) was then added toeach well and the plates incubated for 15 minutes at 4° C. Cells werethen washed one time and the amount of cell associated Alexa647-labelledAb was quantitated by flow cytometry. The experiments included mocktransfected controls. The data from these experiments are presented inthe Table below, n.d.=not determined.

TABLE 4 Antibody Bin C Epitope Prediction Summary Hu Ck Hu Hu Hu HuPredicted EC1-5 EC1-5 EC1 EC2 EC3 EC5 Epitope Clone ID Ab. ID Bin A J KL M O Region 4A9 13589 1 + − + − − −  44-141 26F12 13881 2 + − + − − −Bin A 25F8 14096 2 + − + − − − 26D1 13882 2 + − + − − − 17H8 13874 3 +− + − − − 16A4 14071 5 + − + − − − 4A2 13592 4 + − − − + − 250-364 481013590 4 + − − − + − Bin B 2G6 13588 4 + − − − + − 23A10 14077 4 + − −− + − Rat anti-FLAG + + + + + + control Positive Binding (+) NegativeBinding (−) Legend Table 4 Human and/or chicken chimera constructs A =huCDH19(44-772) (see SEQ ID NO: 944) J = ckCDH19(44-776) (see SEQ ID NO:1451) K = huCDH19(44-141)::ckCDH19(142-776) (see SEQ ID NO: 1452) L =ckCDH19(44-141)::huCDH19(142-249)::ckCDH19(250-776) (see SEQ ID NO:1453) M = ckCDH19(44-249)::huCDH19(250-364)::ckCDH19(365-776) (see SEQID NO: 1454) N = ckCDH19(44-364)::huCDH19(365-463)::ckCDH19(469-776)(see SEQ ID NO: 1455) O = ckCDH19(44-468)::huCDH19(464-772) (see SEQ IDNO: 1456)

Epitope Prediction by Macaque/Dog or Rat/Macaque Cadherin-19 Chimeras

Domain binding was determined by flow cytometry on 293T cellstransiently transfected with plasmids consisting of rhesus macaque CDH19cadherin repeat domain 1 or segments domain 1 (designated EC1a, EC1b,EC1c) replacements into the dog Cadherinl9 backbone, or rat CDH19cadherin repeat domain 2 replacement into the rhesus Cadherinl9 backbonecloned into the pTT5 expression vector immediately preceded by nativerhesus or canine CDH19 leader sequences and a Flag tag. The experimentincluded assaying a subset of anti-CDH19 antibodies against dog, rat andmacaque Cadherinl9 to determine suitability for binning on thesemacaque/dog and rat/rhesus chimeras.

The following binding assay was completed in presence of 2 mM CaCl2. In96-well V-bottom plates (Costar 3897), 50,000 transiently transfected293T cells were incubated with 5 ug/ml of purified anti-CDH19 antibodiesfor 1 hr at 4° C. followed by two washes with PBS/2% FBS. 50 μl of 5μg/ml Alexa647-labelled anti-human IgG secondary antibody (JacksonImmuno 109-605-098) and 2 ug/ml 7AAD (Sigma A9400) was then added toeach well and the plates incubated for 15 minutes at 4° C. Cells werethen washed one time and the amount of cell associated Alexa647-labelledAb was quantitated by flow cytometry. The experiments included mocktransfected controls. The data from these experiments are presented inthe Table below, n.d.=not determined.

TABLE 5 Antibody BinA Epitope prediction Summary Rh Ca rh rh rh ra RaPredicted Clone Ab. EC1-5 EC1-5 EC1 EC1a EC1b EC2 EC1-5 Epitope ID IDBin P Q R S T V W Region 4A9 13589 1 + − + − − − −  44-141 Bin A.1 26F1213881 2 + − + + + − −  44-141 25F8 14096 2 + − + + + − − Bin A.2 26D113882 2 + − + + + − − (44-114) 17H8 13874 3 + − + + − − −  44-141 16A414071 5 + − + + − n.d. + Bin A.3 (44-65) 4A2 13592 4 + − n.d. n.d. n.d.n.d. + 4B10 13590 4 + + n.d. n.d. n.d. n.d. + 250-364 2G6 13588 4 + +n.d. n.d. n.d. n.d. + Bin B 23A10 14077 4 + + n.d. n.d. n.d. n.d. + Ratanti-FLAG + + + + + + + Positive Binding (+) Negative Binding (−) NotDetermined (n.d.) Legend Table 5 Rhesus macaque, dog, and/or rat chimeraconstructs P = rhCDH19(44-772) (see SEQ ID NO: 1457) Q = caCDH19(44-770)(see SEQ ID NO: 1458) R = rhCDH19(44-141)::caCDH19(141-770) (see SEQ IDNO: 1459) S = rhCDH19(44-65)::caCDH19(65-770) (see SEQ ID NO: 1460) T =caCDH19(44-87)::rhCDH19(89-114)::caCDH19(115-770) (see SEQ ID NO: 1461)U = caCDH19(44-120)::rhCDH19(122-137)::caCDH19(137-770) (see SEQ ID NO:1462) V = rhCDH19(44-141)::raCDH19(140-247)::rhCDH19(250-772) (see SEQID NO: 1463) W = raCDH19(44-770) (see SEQ ID NO: 1464)

The data summarized in table 5 allowed for segregating the binder of BinA 44-141 into the following subgroups:

Bin A.1 44-141 Bin A.2 44-141 (44-114) Bin A.3 44-141 (44-65) EpitopePrediction by Rat/Mouse or Human/Mouse Cadherin-19 Chimeras

Domain binding was determined by flow cytometry on 293T cellstransiently transfected with plasmids consisting of rat CDH19 cadherinrepeat domain 3 substitutions (designated EC3a, EC3b) or human CDH19cadherin repeat domain 3 substitution (designated EC3c) into the mouseCadherinl9 backbone cloned into the pTT5 expression vector immediatelypreceded by native mouse CDH19 leader sequence and a Flag tag. Theexperiment included assaying a subset of anti-CDH19 antibodies againsthuman, rat and mouse Cadherinl9 to determine suitability for binning onthese rat/mouse and human/mouse chimeras.

The following binding assay was completed in presence of 2 mM CaCl2). In96-well V-bottom plates (Costar 3897), 50,000 transiently transfected293T cells were incubated with 5 ug/ml of purified anti-CDH19 antibodiesfor 1 hr at 4° C. followed by two washes with PBS/2% FBS. 50 μl of 5μg/ml Alexa647-labelled anti-human IgG secondary antibody (JacksonImmuno 109-605-098) and 2 ug/ml 7AAD (Sigma A9400) was then added toeach well and the plates incubated for 15 minutes at 4° C. Cells werethen washed one time and the amount of cell associated Alexa647-labelledAb was quantitated by flow cytometry. The experiments included mocktransfected controls. The data from these experiments are presented inthe Table below, n.d.=not determined.

TABLE 6 Antibody Bin B Epitope Prediction Summary Hu Mo Ra Ra Ra HuPredicted EC1-5 EC1-5 EC1-5 EC3c EC3b EC3a Epitope Clone ID Ab. ID Bin A1 W X Y Z Region 4A9 13589 1 + − − n.d. n.d. n.d.  44-141 26F12 138812 + − − n.d. n.d. n.d. Bin A 25F8 14096 2 + − − n.d. n.d. n.d. 26D113882 2 + − − n.d. n.d. n.d. 17H8 13874 3 + − − n.d. n.d. n.d. 16A414071 5 + − + n.d. n.d. n.d. 4A2 13592 4 + − + + − − 250-364 4B10 135904 + − + + − − (324-327) Bin B.2 2G6 13588 4 + + + + + + 250-364 23A1014077 4 + + + n.d. n.d. n.d. Bin B.1 Rat anti-FLAG + + + + + + controlPositive Binding (+) Negative Binding (−) Not Determined (n.d.) LegendTable 6 Rat/mouse or human/mouse chimera constructs A = huCDH19(44-772)(see SEQ ID NO: 944) I = muCDH19(44-770) (see SEQ ID NO: 966) W =raCDH19(44-770) (see SEQ ID NO: 1464) X =muCDH19(44-323)::raCDH19(324-327)::muCDH19(328-770) (see SEQ ID NO:1465) Y = muCDH19(44-770)::raCDH19(290,299,308) (see SEQ ID NO: 1466) Z= muCDH19(44-770)::huCDH19(271) (see SEQ ID NO: 1467)

The data summarized in table 6 allowed for segregating the binder of BinB 250-364 into the following subgroups:

Bin B.1 250-364

Bin B.2 250-364 (324-327)) by rodent numeration as referenced in table6, corresponding to residues (326-329) within human and macaque CDH19.

Example 4—Hotspot/Covariant Mutants

A total of 18 antibodies were analyzed for potential hotspots andcovariance violations. The designed variants (shown below) outline aminoacid substitutions capable of reducing and/or avoiding isomerization,deamidation, oxidation, covariance violations, and the like. The 80engineered variants together with the 15 parental antibodies, thustotaling 95 sequences, were taken forward to the cloning, expression,and purification processes. Site-directed mutagenesis was performed onthe engineered variants in a 96-well format. The parental antibodies andengineered variants were expressed by high throughput transienttransfection in HEK 293-6E cells, purified using a modified AKTAauto-sampler and assayed for activity and biophysical characteristics.The 3 parental antibodies that had either free (unpaired) Cys orN-glycosylation site were not taken forward in this process. Those werereplaced with the engineered version of the parental antibodies. Thedesigned variants outline amino acid substitutions capable of reducingand/or avoiding isomerization, deamidation, oxidation, covarianceviolations, immunogenicity and the like. It will be appreciated thatthese variant sequences are examples of engineered antibodies within themeaning of the present application but single point and/or multiplepoint mutations can be combined in any combinatorial manner in order toarrive at a final desired antigen binding molecule or antibody.

Example 5—CDH19 mRNA Expression Pattern

RNA was extracted from individual patient tissues representing tumor(>70% tumor content by cell count) or normal (0% tumor content by cellcount). Individual tissues were homogenized using TisssueLyzer (Qiagen,Valencia, Calif.) and total RNA extracted and purified by the mirVanatotal RNA extraction kit (Life Technologies, Foster City, Calif.). RNAquality and quantity checked by NanoDrop (NanoDrop, Wilmington, Del.)spectrophotometer readings and Bioanalyzer RNA profiling (AgilientTechnologies, Santa Clara, Calif.). RNA was DNAse treated with DNA-freekit (Life Technologies, Foster City, Calif.) and reverse transcribedaccording to manufacturer's specifications using random hexamers in theHigh Capacity cDNA Reverse Transcription Kit (Life Technologies, FosterCity, Calif.). Quantitative Real Time Polymerase Chain Reaction(qRT-PCR) was performed on cDNA using primers to CDH19, probesetHs00253534_m1, (Life Technologies, Foster City, Calif.) or thehousekeeping gene human ACTB (primers CCT GGC ACC CAG CAC AA; GCC GATCCA CAC GGA GTA CT; probe ATC AAG ATC ATT GCT CCT CCT GAG CG). 10 μLqRT-PCR reaction components; 1.0 ng/μL cDNA, 2×Universal PCR Master Mix(Life Technologies, Foster City, Calif.), gene expression assay (ACTB;75 nM primers, 150 nM probe. EPOR; 300 nM primers, 250 nM probe)Following the qRT-PCR amplification program: (1) activation at 50° C.for 2 min; (2) denaturation at 95° C. for 10 min; (3) amplification 40cycles at 95° C. for 15 s and 60° C. for 1 min with fluorescence captureat each step (ABI PRISM 7900HT Sequence Detection Systems, AppliedBiosystems). Threshold cycle values (C_(T)) were determined, usingSequence Detector software version 2.3 (Applied Biosystems) andtransformed to 2^(−ΔCT) for relative expression of CDH19 specifictranscript to ACTB. The results are shown in FIG. 3. Of 54 uniquemetastatic and primary melanoma samples, the majority can be seen tooverexpress CDH19 mRNA relative to the expression in samples from normaltissue.

Example 6—CDH19 Protein Expression

Expression of CDH19 protein was analyzed in human tumor samples by IHCand the results are shown in FIG. 4. Samples were fixed in 10% neutralbuffered formalin for 24 hours, dehydrated and paraffin embedded. 4 μmsections were cut. Sections were deparaffinized first and then heated inDIVA Decloaker solution (Biocare) for 40 minutes for antigen retrieval.Remaining IHC steps were performed at room temperature in a DAKOAutostainer. Sections were incubated for 10 minutes with Peroxidazed 1(Biocare) to block endogenous peroxidase, followed by incubation for 10minutes with background sniper (Biocare) to reduce nonspecificbackground. Section were incubated for 60 minutes with CDH19 antibody(Novo Biologicals, Catalog #H00028513-B01P) at 5 μg/ml, then incubatedfor 30 minutes with Envision+ HRP anti-mouse polymer (DAKO), followed byDAB+(DAKO) for 5 minutes. Sections were counterstained with hematoxylin(DAKO) approximately for 1 minute. CDH19 expression could be detected in62% of tumors examined (staining intensity ≥1+ in 101 of 162 samples).51% of the tumor samples demonstrated medium to high expression(staining intensity of 2+ to 3+ in 83 of 162 samples). CDH19 showeddense and distinct membrane staining in many samples, although in sometumors heterogeneity was noted.

Example 7—Selection of Model Cell Lines

Tumor cell lines were analyzed by flow cytometry and IHC to identifymodel systems with CDH19 expression similar to human tumors. Humananti-huCDH19 IgG4 antibody 4A2 was purified directly from hybridomaconditioned media. For flow cytometry, 2×10⁵ cells were incubated with200 nM of the CDH19 4A2 antibody that was conjugated to PE at a 1:1ratio. The incubation and subsequent wash steps were performed in thepresence of 1.2 mM calcium. A tube of QuantiBRITE PE lyophilized beadswith four levels of PE (BD, cat#340495) was simultaneously preparedaccording to the manufacturer's instructions. The beads were analyzed byflow cytometry to generate a standard curve. The PE median valuesobtained from the melanoma lines after FACS analysis were thencalibrated against the standard curve to calculate the antibodies boundper cell (ABC), which provides an estimate of the number of receptors oneach cell. IHC was performed as described in Example 6 and the resultsare provided in FIG. 5. The melanoma cell line CHL-1 expresses about10,000 CDH19 molecules on the cell surface, while Colo699 cells expressabout 5,000 receptors. Both cell lines represent tumors with medium tohigh expression levels based on IHC. Expression in A2058 is very low,while LOX cells do not express any detectable CDH19 protein.

Example 8 Bispecific Binding and Interspecies Cross-Reactivity

For confirmation of binding to human CDH19 and to human and macaque CD3,bispecific antibodies were tested by flow cytometry using indicated celllines. L1.2 transfected with human CDH19, the human melanoma cell linesCHL-1 and A2058 expressing native human CDH19, CD3-expressing human Tcell leukemia cell line HPB-ALL (DSMZ, Braunschweig, ACC483) and theCD3-expressing macaque T cell line 4119LnPx (Knappe A, et al., Blood,2000, 95, 3256-3261) were used as antigen positive cell lines. Moreover,untransfected L1.2 cells were used as negative control.

For flow cytometry 200,000 cells of the respective cell lines wereincubated for 30 min on ice with 50 μl of purified bispecific antibodyat a concentration of 5 μg/ml. The cells were washed twice in PBS/2% FCSand binding of the constructs was detected with a murine PentaHisantibody (Qiagen; diluted 1:20 in 50 μl PBS/2% FCS). After washing,bound PentaHis antibodies were detected with an Fc gamma-specificantibody (Dianova) conjugated to phycoerythrin, diluted 1:100 in PBS/2%FCS. Samples were measured by flow cytometry on a FACSCanto IIinstrument and analyzed by FACSDiva software (both from BectonDickinson).

The CDH19/CD3 bispecific antibodies stained L1.2 cells transfected withhuman CDH19, the human CDH19-expressing melanoma cell lines CHL-1 andA2058 as well as human and macaque T cells. Moreover, there was nostaining of untransfected L1.2 cells (see FIG. 6).

Example 9 Cytotoxic Activity

FACS-Based Cytotoxicity Assay with Unstimulated Human PBMC

Isolation of Effector Cells

Human peripheral blood mononuclear cells (PBMC) were prepared by Ficolldensity gradient centrifugation from enriched lymphocyte preparations(e.g. buffy coats), a side product of blood banks collecting blood fortransfusions. Buffy coats were supplied by a local blood bank and PBMCwere prepared on the same day of blood collection. After Ficoll densitycentrifugation and extensive washes with Dulbecco's PBS (Gibco),remaining erythrocytes were removed from PBMC via incubation witherythrocyte lysis buffer (155 mM NH₄Cl, 10 mM KHCO₃, 100 μM EDTA).Platelets were removed via the supernatant upon centrifugation of PBMCat 100×g. Remaining lymphocytes mainly encompass B and T lymphocytes, NKcells and monocytes. PBMC were kept in culture at 37° C./5% CO₂ in RPMImedium (Gibco) with 10% FCS (Gibco).

Depletion of CD14⁺ and CD56⁺ Cells

For depletion of CD14⁺ cells, human CD14 MicroBeads (Milteny Biotec,MACS, #130-050-201) were used, for depletion of NK cells human CD56MicroBeads (MACS, #130-050-401). PBMC were counted and centrifuged for10 min at room temperature with 300×g. The supernatant was discarded andthe cell pellet resuspended in MACS isolation buffer [80 μL/10⁷ cells;PBS (Invitrogen, #20012-043), 0.5% (v/v) FBS (Gibco, #10270-106), 2 mMEDTA (Sigma-Aldrich, #E-6511)]. CD14 MicroBeads and CD56 MicroBeads (20μL/10⁷ cells) were added and incubated for 15 min at 4-8° C. The cellswere washed with MACS isolation buffer (1-2 mL/10⁷ cells). Aftercentrifugation (see above), supernatant was discarded and cellsresuspended in MACS isolation buffer (500 μL/10⁸ cells). CD14/CD56negative cells were then isolated using LS Columns (Miltenyi Biotec,#130-042-401). PBMC w/o CD14+/CD56+ cells were cultured in RPMI completemedium i.e. RPMI1640 (Biochrom AG, #FG1215) supplemented with 10% FBS(Biochrom AG, #S0115), 1× non-essential amino acids (Biochrom AG,#K0293), 10 mM Hepes buffer (Biochrom AG, #L1613), 1 mM sodium pyruvate(Biochrom AG, #L0473) and 100 U/mL penicillin/streptomycin (Biochrom AG,#A2213) at 37° C. in an incubator until needed.

Target Cell Labeling

For the analysis of cell lysis in flow cytometry assays, the fluorescentmembrane dye DiOC₁₈ (DiO) (Molecular Probes, #V22886) was used to labelhuman CDH19− as target cells and distinguish them from effector cells.Briefly, cells were harvested, washed once with PBS and adjusted to 10⁶cell/mL in PBS containing 2% (v/v) FBS and the membrane dye DiO (5μL/10⁶ cells). After incubation for 3 min at 37° C., cells were washedtwice in complete RPMI medium and the cell number adjusted to 1.25×10⁵cells/mL. The vitality of cells was determined using 0.5% (v/v) isotonicEosinG solution (Roth, #45380).

Flow Cytometry Based Analysis

This assay was designed to quantify the lysis of human CDH19-transfectedCHO cells in the presence of serial dilutions of CDH19 bispecificantibodies.

Equal volumes of DiO-labeled target cells and effector cells (i.e., PBMCw/o CD14⁺ cells) were mixed, resulting in an E:T cell ratio of 10:1. 160μL of this suspension were transferred to each well of a 96-well plate.40 μL of serial dilutions of the CDH19 bispecific antibodies and anegative control bispecific (an CD3-based bispecific antibodyrecognizing an irrelevant target antigen) or RPMI complete medium as anadditional negative control were added. The bispecific antibody-mediatedcytotoxic reaction proceeded for 48 hours in a 7% CO₂ humidifiedincubator. Then cells were transferred to a new 96-well plate and lossof target cell membrane integrity was monitored by adding propidiumiodide (PI) at a final concentration of 1 μg/mL. PI is a membraneimpermeable dye that normally is excluded from viable cells, whereasdead cells take it up and become identifiable by fluorescent emission.

Samples were measured by flow cytometry on a FACSCanto II instrument andanalyzed by FACSDiva software (both from Becton Dickinson).

Target cells were identified as DiO-positive cells. PI-negative targetcells were classified as living target cells. Percentage of cytotoxicitywas calculated according to the following formula:

${{Cytotoxicity}\mspace{11mu}\lbrack\%\rbrack} = {\frac{n_{{dead}\mspace{14mu} {target}\mspace{14mu} {cells}}}{n_{{target}\mspace{14mu} {cells}}} \times 100}$n = number  of  events

Using GraphPad Prism 5 software (Graph Pad Software, San Diego), thepercentage of cytotoxicity was plotted against the correspondingbispecific antibody concentrations. Dose response curves were analyzedwith the four parametric logistic regression models for evaluation ofsigmoid dose response curves with fixed hill slope and EC50 values werecalculated. The results are shown in FIG. 7.

Example 10 In Vivo Tumor Growth Inhibition Experiments

5 million Colo699 or CHL-1 tumor cells were admixed with 2.5 millionfreshly isolated peripheral blood mononuclear cells (PBMC) and injectedsubcutaneously in the left flank of female athymic nude mice on Day 0.The same day, mice were treated intraperitoneally with either CDH19 BiTE2G6 or non-specific control BiTE (MEC14) at the indicated doses. Dosingcontinued daily for the first 10 days post-tumor inoculation.

Tumor volumes and body weights were measured twice per week usingcalipers and an analytical scale, respectively.

The results of experiments with Colo699 or CHL-1 tumor cells are shownin FIGS. 8 and 9.

Example 11 Cytotoxic Activity

Imaging-Based Cytotoxicity Assay with Unstimulated Human T-Cells

Effector Cells

Purified, naïve human T cells were obtained from AllCells LLC, Alameda,USA.

Image Based Analysis

This assay measures the T cell mediated lysis of melanoma cells. 3000A2058 cells (CDH19 positive) or 2500 LOX IMVI cells (CDH19 negative) arecombined with naïve human T cells in a 1:10 ratio in the wells of 384well plates. After addition of a serial dilution of CDH19 targeting BiTEmolecules as well as a negative control bispecific (a CD3-basedbispecific antibody recognizing an irrelevant target antigen), the cellsare incubated for 48 h at 37° C. Next, the samples are treated for 2 hwith 30 μM Hoechst 33342 to stain the nuclei of all cells and 2 μMpropidium iodide (PI) to identify dead cells.

Image acquisition and analysis is performed on a ThermoFisher ArrayScanwith a 10× objective. Data for two channels is collected, at 386 nm(Hoechst 33342) and at 549 nm (propidium iodide).

Live cells are identified as Hoechst positive, PI negative events, deadcells as Hoechst positive, PI positive.

Percentage of cytotoxicity is determined as described in example 7.Representative results are shown in FIG. 10.

Example 12 Domain Specificity and Biochemical Affinity Determination ofBi-Specific Binders Purification of CDH19 Sub-Domains LackingPost-Translational Modifications

A methionine initiation codon followed by nucleotide sequences encodingCDH19 sub-domain protein A=huCDH19(140-367 of SEQ ID NO:944),immediately preceding a G₄S linker and poly-Histidine tag was clonedinto a suitable pET vector; whereas, nucleotides sequences encodingsub-domain proteins B=huCDH19(44-367 of SEQ ID NO:944) andC=rhCDH19(44-367 of SEQ ID NO:1457) were cloned into the pET-SUMO vector(Life Technologies, Invitrogen) by methods known in the art. Each wasexpressed in E. coli, isolated from the soluble fraction and purified tohomogeneity by metal chelate affinity chromatography, followed by anionexchange, and size exclusion chromatography in HEPES buffered saline, 3mM CaCl2, pH 8. Sub-domain protein A retained its linker and C terminalpolyhistidine tag, but His-SUMO tags constituent to the N termini ofproteins B and C were removed by digestion with SUMO protease (LifeTechnologies, Invitrogen) prior to anion exchange. All proteins weredetermined to have their expected molecular weight by ESI LC/MS.Proteins used in binding experiments described below were randomlybiotinylated by typical methods known in the art.

Purification of CDH19 Sub-Domains with Post-Translational Modifications

CDH19 sub-domain proteins D=huCDH19(44-367 of SEQ ID NO:944), andE=rhCDH19(44-367 of SEQ ID NO:1457) were generated by cloning nucleotidesequences encoding respective amino acid residues 1-367 into thepSURETech235b vector (Selexis) each immediately preceded a G₄S linkerand poly-Histidine tag were cloned into the pSURETech235b vector(Selexis), transfected into CHO-S cells (Life Technologies, Invitrogen),and stable pools were generated following hygromycin selection bymethods known in the art. Stable pools were expanded and conditionedmedia was collected after 7 days culture in serum free media. CM wasexchanged by UF/DF with 5 diavolumes HEPES buffered saline plus CaCl₂using a 1 sq ft 10K PES Pellicon 2 membrane and purified to homogeneityas described above. CDH19 sub-domain proteins D and E retainedconstituent linker and C terminal polyhistidine tags. N terminalsequence of each protein was determined to be G44 as expected, while ESILC/MS of purified proteins as compared with same subjected to PNGase Fdigestion revealed the presence of both N- and O-linked glycans.Proteins used in binding experiments described below were randomlybiotinylated by methods well known in the art.

Methods for Binding Affinity Determination by Octet

The Octet RED384 biosensor was used to characterize kinetics andaffinity of protein-protein interactions. Minimally biotinylated CDH19domain target proteins A-E were bound to streptavidin tips in themachine while serial dilutions of analyte bi-specific binder proteinswere made in 96-well or 384-well plates. Empirical target loadingconditions were found from assay development to be 10-20 nM targetconcentration and loading for 600 seconds to give a 2 nm signal. Bindingexperiments were performed by setting up a plate with 6-point (Tables7-9) or 3-point (Table 10) 1:3 serial dilutions from 30 nM startingconcentrations of each analyte, with two reference wells per columnhaving buffer alone. Octet Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl,+/−1 mM CaCl₂, 0.13% Triton X-100 and 0.10 mg/ml BSA. Additionalbaseline and dissociation wells in the plate also contained bufferalone. The binding method was as follows: ForteBio Octet streptavidintips were (1) soaked in buffer for 10 minutes; (2) transferred to theplate baseline wells and incubated for 5 minutes; (3) transferred to thetarget loading wells and incubated for 10 minutes; (4) transferred tothe plate baseline wells and incubated for 5 minutes; (5) transferred tothe sample wells and incubated for 5 minutes (Table 9) or 20 minutes(Tables 7, 8, 10); (6) transferred to the dissociation wells andincubated for 8.3 minutes (Table 9) or 1.5 hr (Tables 7, 8, 10). Rawdata was processed in the following manner: (a) reference tip curveswere averaged and subtracted from sample curves; (b) the association anddissociation curves were isolated and aligned to the Y axis; (c) theassociation and dissociation interstep was aligned; (d) Savitzky-Golayfiltering was implemented to reduce the signal noise and (e) theresulting set of association and dissociation curves for eachsample-target interaction were fit globally with a single 1:1 bindingmodel to determine the measured values of the association (Ka) anddissociation (Kd) rate constants to calculate the equilibriumdissociation constant, KD.

TABLE 7 Domain Specificity and Biochemical Affinity of Bi-specificBinders to Isolated human CDH19 Protein Domains Lacking PostTranslational Modifications A = huCDH19(140-367) E coli B =huCDH19(44-367) E coli Predicted Bispecific KD ka kd KD ka kd EpitopeClone ID binder ID (nM) (M-1s-1) (s-1) (pM) (M-1s-1) (s-1) Region 2G665254 <0.03 3.37E+05 <1.0E−05 <0.04 2.31E+05 <1.0E−05 250-364 Bin B.126F12 65251 (−) (−) (−) 0.20 3.86E+05   7.56E−05  44-114 Bin A.2 (−)negative binding, 20 min association, 1.5 hr dissociation Legend Table 7Human CDH19 Protein domains lacking post translational modifications A =E coli expressed huCDH19(140-367 of SEQ ID NO: 944) B = E coli expressedhuCDH19(44-367 of SEQ ID NO: 944)

The data summarized in table 7 confirmed CDH19 epitope regionspecificity of bi-specific binders and allowed for their relativeaffinity ranking.

TABLE 8 Calcium Modulated Biochemical Affinity of Bi-specific Binders toIsolated Human and Macaque CDH19 Protein Domains Lacking PostTranslational Modifications B = huCDH19(44-367) E coli C =rhCDH19(44-367) E coli Clone ID, Bispecific KD ka kd KD ka kd EpitopeBin binder ID (nM) (M-1s-1) (s-1) (nM) (M-1s-1) (s-1) CaCl₂ 2G6, Bin B.165254 <0.06 1.66E+05 <1.0E−05 <0.03 2.97E+05 <1.0E−05 1 mM 26F12, BinA.2 65251 0.31 2.91E+05   9.0E−05 0.17 8.19E+05 1.36E−04 1 mM 2G6, BinB.1 65254 (−) (−) (−) (−) (−) (−) absent 26F12, Bin A.2 65251 2.561.21E+05 3.08E−04 1.16 4.68E+05 5.44E−04 absent (−) negative binding, 20min association, 1.5 hr dissociation Legend Table 8 CDH19 Proteindomains lacking post translational modifications B = E coli expressedhuCDH19(44-367 of SEQ ID NO: 944) C = E coli expressed rhCDH19(44-367 ofSEQ ID NO: 1457)

The data summarized in table 8 allowed determination of calciumsensitivity of bi-specific binders and for their relative affinityranking. Data further suggests conformational epitopes, with Bin B.1more dependent on CDH19/Ca2+ association than epitope Bin A.2

TABLE 9 Biochemical Affinity of Bi-specific Binders to Isolated Humanand Macaque CDH19 Protein Domains Lacking Post TranslationalModifications B = huCDH19(44-367) E coli C = rhCDH19(44-367) E coliBispecific KD ka kd KD ka kd Clone ID binder ID (nM) (M-1s-1) (s-1) (nM)(M-1s-1) (s-1) 2G6  65254 <0.3 3.11E+05 <1.0E−04 <0.3 3.69E+05 <1.0E−042G6.001  65254.001 <0.4 2.21E+05 <1.0E−04 <0.4 2.42E+05 <1.0E−04 2G6.003 65254.003 <0.5 1.80E+05 <1.0E−04 <0.5 1.91E+05 <1.0E−04 2G6.007 65254.007 0.57 2.95E+05 1.69E−04 0.55 3.53E+05 1.94E−04 4A2.002 65238.002 <0.2 5.48E+05 <1.0E−04 <0.1 9.13E+05 <1.0E−04 4810.002 65240.002 <0.2 5.02E+05 <1.0E−04 <0.1 7.48E+05 <1.0E−04 4810.003 65240.003 <0.2 3.87E+05 <1.0E−04 <0.2 5.06E+05 <1.0E−04 4810.005 65240.005 <0.2 4.41E+05 <1.0E−04 <0.2 6.00E+05 <1.0E−04 1985.1.002 65235.002 1.74 3.74E+05 6.49E−04 1.02 4.94E+05 5.02E−04 1985.1.003 65235.003 2.44 3.09E+05 7.54E−04 1.63 3.97E+05 6.45E−04 23A10.001 (B1) 65237.001 <0.4 2.55E+05 <1.0E−04 <0.3 3.16E+05 <1.0E−04 23A10.001 (B2)65237b.001 0.57 2.95E+05 1.69E−04 0.55 3.53E+05 1.94E−04 23A10.002 65237.002 <0.3 2.86E+05 <1.0E−04 <0.3 3.61E+05 <1.0E−04 26D1.1.003 65250.003 0.66 3.64E+05 2.41E−04 0.50 5.20E+05 2.62E−04 26D1.1.004 65250.004 1.08 3.39E+05 3.67E−04 0.65 4.66E+05 3.02E−04 26D1.1.005 65250.005 2.65 3.19E+05 8.44E−04 1.42 4.42E+05 6.25E−04 26F12.002 65251.002 0.97 3.25E+05 3.16E−04 1.70 4.33E+05 7.36E−04 26F12.004 65251.004 1.04 2.90E+05 3.00E−04 1.85 3.46E+05 6.38E−04 26F12.006 65251.006 3.96 4.10E+05 1.62E−03 5.39 5.95E+05 3.21E−03 26F12.008 65251.008 3.77 4.87E+05 1.84E−03 5.14 7.45E+05 3.83E−03 1 mM CaCl₂, 5min association, 8.3 min dissociation Legend Table 9 CDH19 Proteindomains lacking post translational modifications B = E coli expressedhuCDH19(44-367 of SEQ ID NO: 944) C = E coli expressed rhCDH19(44-367 ofSEQ ID NO: 1457)

The data summarized in table 9 allowed relative affinity ranking ofbi-specific binders to human and non-human primate CDH19 domains lackingglycosylation.

TABLE 10 Calcium Modulated Biochemical Affinity of Bi-specific Bindersto Isolated Glycosylated Human and Macaque CDH19 Protein Domains D =huCDH19(44-367) CHO E = rhCDH19(44-367) CHO Clone ID, Bispecific KD kakd KD ka kd Epitope Bin binder ID (nM) (M-1s-1) (s-1) (nM) (M-1s-1)(s-1) CaCl₂ 2G6, Bin B.1 65254 <0.041 2.44E+05 <1.0E−05 <0.031 3.19E+05<1.0E−05 1 mM 2G6.003, 65254.003 <0.099 1.01E+05 <1.0E−05 <0.09 1.10E+05<1.0E−05 1 mM Bin B.1 4B10.003, 65240.003 0.24 2.08E+05 4.91E−05 0.292.70E+05 7.88E−05 1 mM Bin B.2 19B5.1.003, 65235.003 1.01 4.02E+054.07E−04 0.27 7.12E+05 1.93E−04 1 mM Bin A.2 23A10.002, 65237.002 <0.0362.75E+05 <1.0E−05 <0.035 2.82E+05 <1.0E−05 1 mM Bin B.1 26D1.1.005,65250.005 0.97 3.13E+05 3.04E−04 0.37 4.64E+05 1.74E−04 1 mM Bin A.226F12, Bin 65251 0.28 5.28E+05 1.50E−04 0.22 8.72E+05 1.94E−04 1 mM A.226F12.006, 65251.006 1.24 4.92E+05 6.07E−04 1.13 6.94E+05 7.86E−04 1 mMBin A.2 2G6, Bin B.1 65254 (−) (−) (−) (−) (−) (−) absent 2G6.003,65254.003 (−) (−) (−) (−) (−) (−) absent Bin B.1 4B10.003, 65240.003 (−)(−) (−) (−) (−) (−) absent Bin B.2 19B5.1.003, 65235.003 3.49 2.90E+051.01E−03 3.28 2.65E+05 8.68E−04 absent Bin A.2 23A10.002, 65237.002 (−)(−) (−) (−) (−) (−) absent Bin B.1 26D1.1.005, Bin A.2 65250.005 0.864.12E+05 3.56E−04 2.58 3.26E+05 8.41E−04 absent 26F12, Bin 65251 1.912.66E+05 5.09E−04 1.09 5.38E+05 5.88E−04 absent A.2 26F12.006, 65251.0060.79 6.29E+05 4.95E−04 18.53 3.36E+05 6.22E−03 absent Bin A.2 (−)negative binding, 20 min association, 1.5 hr dissociation Legend Table10 Glycosylated CDH19 Protein domains D =CHO expressed huCDH19(44-367 ofSEQ ID NO: 944) E = CHO expressed rhCDH19(44-367 of SEQ ID NO: 1457)

The data summarized in table 10 allowed determination of calciumsensitivity of bi-specific binders and relative affinity ranking towardglycosylated human and non-human primate CDH19 domain proteins. Ascompared to data in Table 8, affinities are similar to those withdomains lacking post-translational modifications. Data further suggestsconformational epitopes, with epitope Bins B.1 and B.2 being moredependent on CDH19/Ca2+ association than epitope Bin A.2

Example 13 Bispecific Binding and Interspecies Cross-Reactivity:

For confirmation of binding to human CDH19 and to human CD3, bispecificantibodies were tested by flow cytometry using indicated cell lines.HEK293 transfected with human CDH19 (see example 14) and CD3-expressinghuman T cell leukemia cell line HPB-ALL (DSMZ, Braunschweig, ACC483)were used as antigen positive cell lines.

For flow cytometry 200,000 cells of the respective cell lines wereincubated for 30 min on ice with 100 μl of BiTE containing cell culturesupernatant. The cells were washed twice in PBS/2% FCS and binding ofthe constructs was detected with a murine anti-CD3scFv antibody (3E5.A5,Amgen; diluted to 2 μg/ml PBS/2% FCS). After washing, bound anti-CD3scFvantibodies were detected with an Fc gamma-specific antibody (Dianova)conjugated to phycoerythrin, diluted 1:100 in PBS/2% FCS. Samples weremeasured by flow cytometry on a FACSCanto II instrument and analyzed byFACSDiva software (both from Becton Dickinson).

The CDH19/CD3 bispecific antibodies stained HEK293 cells transfectedwith human CDH19 as well as human and macaque T cells (see FIG. 19).

Example 14 Cytotoxic Activity

Chromium Release Assay with Stimulated Human T Cells

Isolation of Effector Cells

A petri dish (145 mm diameter, Greiner bio-one GmbH, Kremsmünster) wascoated with a commercially available anti-CD3 specific antibody (OKT3,Orthoclone) in a final concentration of 1 μg/ml for 1 hour at 37° C.Unbound protein was removed by one washing step with PBS. 3-5×10⁷ humanPBMC were added to the precoated petri dish in 120 ml of RPMI 1640 withstabilized glutamine/10% FCS/IL-2 20 U/ml (Proleukin®, Chiron) andstimulated for 2 days. On the third day, the cells were collected andwashed once with RPMI 1640. IL-2 was added to a final concentration of20 U/ml and the cells were cultured again for one day in the same cellculture medium as above.

Depletion of CD4⁺ and CD56⁺ Cells

CD8⁺ cytotoxic T lymphocytes (CTLs) were enriched by depletion of CD4⁺ Tcells and CD56⁺ NK cells using Dynal-Beads according to themanufacturer's protocol.

⁵¹Cr Release Based Analysis

Human CDH19-transfected HEK293 target cells (production see example 14)were washed twice with PBS and labeled with 11.1 MBq ⁵¹Cr in a finalvolume of 50 μl supplemented RPMI for 60 minutes at 37° C. Subsequently,the labeled target cells were washed 3 times with 5 ml RPMI and thenused in the cytotoxicity assay. The assay was performed in a 96-wellplate in a total volume of 200 μl supplemented RPMI with an E:T ratio of10:1. A starting concentration of 0.1-1 μg/ml of purified bispecificantibody and threefold dilutions thereof were used. Incubation time forthe assay was 18 hours. Cytotoxicity was determined as relative valuesof released chromium in the supernatant relative to the difference ofmaximum lysis (addition of Triton-X) and spontaneous lysis (withouteffector cells). All measurements were carried out in quadruplicates.Measurement of chromium activity in the supernatants was performed in aWizard 3″ gamma counter (Perkin Elmer Life Sciences GmbH, Köln,Germany). Analysis of the results was carried out with Prism 6 forWindows (version 6.02, GraphPad Software Inc., San Diego, Calif., USA).EC50 values calculated by the analysis program from the sigmoidal doseresponse curves were used for comparison of cytotoxic activity (see FIG.20).

Example 15 Production and Purification of BiTE Antibodies

Standardized research scale production of CDH19 BiTE antibodies wasperformed in roller bottles. Harvested culture supernatant was subjectedafter filtration to two step BiTE antibody purification based either onimmobilized metal affinity chromatography (IMAC) capture and subsequentsize exclusion chromatography or Protein_A capture and subsequent sizeexclusion chromatography (SEC).

15.1 IMAC Capture Step of BiTE Antibodies

Äkta® Explorer Systems (GE Healthcare) controlled by Unicorn® Softwarewere used for chromatography. Immobilized metal affinity chromatography(IMAC) was performed using Fractogel EMD Chelate® (Merck, Darmstadt)which was loaded with ZnCl2 according to the protocol provided by themanufacturer. The column was equilibrated with buffer A (20 mM sodiumphosphate buffer, 0.1 M NaCl, 10 mM imidazole, pH 7.2) and the cellculture supernatant (1000 ml) applied to the column (10 ml packingvolume) at a flow rate of 4 ml/min. The column was washed with buffer Ato remove unbound sample. Bound protein was eluted using a two stepgradient of buffer B (20 mM sodium phosphate buffer, 0.1 M NaCl, 0.5 Mimidazole, pH 7.2) according to the following procedure:

Step 1: 10% buffer B in 5 column volumesStep 2: 100% buffer B in 5 column volumes

Eluted protein fractions from step 2 were pooled for furtherpurification and concentrated to 3 ml final volume using Vivaspin(Sartorius-Stedim, Göttingen-Germany) centrifugation units with PESmembrane and a molecular weight cut-off of 10 kDa. All chemicals were ofresearch grade and purchased from Merck (Darmstadt, Germany). FIG. 11

15.2 Protein_a Capture of BiTE Antibodies

Äkta® Explorer Systems (GE Life Sciences) controlled by Unicorn@Software were used for chromatography. Affinity columns which containinbeads with covalently bound Protein_A were used for the capture step.The column was equilibrated with equillibration buffer pH 7.4 and thecell culture supernatant applied. After washing the column with threecolumn volumes of equillibration buffer to wash out unbound sample thebound BiTE antibodies were eluted by application of an elution buffer atpH 3.0. Eluted solution was immediately neutralized in pH by aTrishydroxymethylamine Tris solution pH 8.0 already contained in thefractionation tubes in the fraction collector.

Eluted protein fractions from step 2 were pooled for furtherpurification and concentrated to 3 ml final volume using Vivaspin(Sartorius-Stedim, Göttingen-Germany) centrifugation units with PESmembrane and a molecular weight cut-off of 10 kDa. All chemicals were ofresearch grade and purchased from Merck (Darmstadt, Germany). FIG. 12

15.3 Size Exclusion Chromatography

Size exclusion chromatography was performed on a HiLoad 16/60 Superdex200 prep grade column (GE Healthcare) equilibrated with SEC buffer (20mM NaCl, 30 mM NaH2PO4, 100 mM L-Arginin, pH 7.0) at a flow rate of 1ml/min. BiTE antibody monomer and dimer fractions were pooled and a 24%trehalose stock solution was added to reach a final trehaloseconcentration of 4%. Eluted protein samples were subjected to reducingSDS-PAGE and Anti His TAG Western Blot for analysis.

Protein pools were measured at 280 nm in polycarbonate cuvettes with 1cm lightpath (Eppendorf, Hamburg-Germany) and protein concentration wascalculated on the base of the Vector NTI sequence analysis softwarecalculated factor for each protein.

BiTE monomer pools were adjusted to 250 μg/ml with additional BiTEformulation buffer (20 mM NaCl, 30 mM NaH2PO4, 100 mM L-Arginin, 4%Trehalose, pH 7.0). An amount of a minimum of 600 μg for each BiTE wastaken and transferred for immediate protein analytics as described inexample 16.

Remaining protein pools of BiTE antibody monomer and BiTE antibody dimerwere aliquoted in 15 and 50 μg protein aliquots and shock frozen inliquid nitrogen. Further storage until usage was done in a −80° C.freezer until analysis of biologic activity and affinity measurements.FIG. 13.

The purity of isolated BiTE antibody monomer was determined by SDS-PAGEto be >95%. As expected, purified monomeric BiTE antibody appeared asprotein bands in the molecular weight range of 54-56 kDa. FIG. 14

Example 16 Protein Properties

The freshly prepared BiTE monomer solution generated in example 15 wasapplied to the following analytical methods

-   -   High Performance Size Exclusion Chromatography (HP-SEC) of        initially monomeric CDH19 BiTE antibodies after one week of        incubation at 250 μg/ml and 37° C.    -   BiTE monomer conversion of BiTE monomer to dimer by three        freeze/thaw cycles followed by HP-SEC    -   High resolution analytical cation exchange    -   Hydrophobic interaction chromatography on a Sepharose Octyl FF        matrix.    -   Concentration to 2500 μg/ml followed by over night storage and        turbidity measurement    -   Aggregation temperature TA determination by heated Dynamic Light        Scattering measurement        16.1 BiTE Monomer Conversion into Dimer by Incubation for 7 Days

15 μg of the monomeric CDH19 BiTE antibody at a concentration of 250μg/ml were incubated at 37° C. for 7 days.

A high resolution SEC Column TSK Gel G3000 SWXL (Tosoh, Tokyo-Japan) wasconnected to an Äkta Purifier 10 FPLC (GE Lifesciences) equipped with anA905 Autosampler. Column equilibration and running buffer consisted of100 mM KH2PO4—200 mM Na2SO4 adjusted to pH 6.6. After 7 days ofincubation, the BiTE antibody solution (15 μg protein) was applied tothe equilibrated column and elution was carried out at a flow rate of0.75 ml/min at a maximum pressure of 7 MPa. The whole run was monitoredat 280, 254 and 210 nm optical absorbance. Analysis was done by peakintegration of the 210 nm signal recorded in the Äkta Unicorn softwarerun evaluation sheet. Dimer content was calculated by dividing the areaof the dimer peak by the total area of monomer plus dimer peak. FIG. 15

16.2. BiTE Monomer Conversion into Dimer by Three Freeze/Thaw Cycles

15 μg of monomeric BiTE antibody at 250 μg/ml were frozen at −80° C. for30 min followed by thawing for 30 min at room temperature. After threefreeze/thaw cycles the dimer content was determined by HP-SEC asdescribed in example 16.1. FIG. 16

CDH19 BiTE CH19 2G6 302×I2C SA21: 0.50% Dimer content

16.3 High Resolution Analytical Ion Exchange Chromatography

A 1 ml BioPro SP column manufactured by YMC (YMC Europe GmbH,Dinslaken-Germany) with sulphpropyl groups coupled to solid beads wasconnected to a Äkta Micro FPLC (GE Healthcare) device.

For column equilibration, sample dilution and washing a bufferconsisting of 20 mM sodium dihydrogen phosphate and 30 mM sodiumchloride adjusted with sodium hydroxide to a pH of 5.5 was used.

For elution a buffer consisting of 20 mM NaH2PO4 and 1000 mM NaCladjusted with sodium hydroxide to a pH of 5.5 was used.

50 μg of BiTE antibody monomer were diluted with dilution buffer to 50ml final volume. After column equilibration 40 ml of the diluted proteinsolution was applied to the column followed by a wash step.

Elution was carried out by a steadily increasing gradient with elutionbuffer from zero to 100% over a total volume corresponding to 200 columnvolumes. The whole run was monitored at 280 (blue line) and 254 nm (redline) optical absorption.

Percentage of Main Peak was calculated by dividing the peak area of themain peak by the Sum of Peak Area of all Detected Peaks Followed byMultiplication with a Factor of 100. FIG. 17

CDH19 BiTE CH19 2G6 302×I2C SA21: 89.3% Main Peak Percentage

16.4 Sepharose Octyl FF

Elution of monomeric BiTE antibodies was evaluated on a hydrophobicinteraction chromatography C8 Sepharose Octyl FF column (GE Healthcare)with 1 ml gel volume.

50 μg of BiTE antibody monomeric protein was filled up with buffer (10mM Citric acid—75 mM Lysine×HCl—4% Trehalose—pH 7.2) to a final volumeof 300 μl. The column was connected to an Äkta Purifier 10 system (GEHealthcare). A 500 μl sample loop was connected to the system. Thesystem and column were equilibrated with running buffer (10 mM Citricacid—75 mM Lysine×HCl—200 mM NaCl—pH 7.2).

The complete sample was injected into the sample loop and the content ofthe sample loop was applied to the column. After sample injection avolume of 10 ml running buffer was applied to the column at a flow rateof 0.2 ml/min while recording the optical absorption at 254 and 280 nmtogether with conductivity. FIG. 18

CDH19 BiTE CH19 2G6 302×I2C SA21: Rapid and complete elution

16.5 Concentration of BiTE monomer to 2500 μg/ml followed by over nightstorage and Turbidity Measurement

1000 μl of CDH19 BiTE monomer were concentrated in two Vivaspin 500centrifugation units with 10 kDa PES membrane (Sartorius-Stedim,Göttingen-Germany) to a final volume of 100 μl. This volume as storedover night at 5° C. in a cooling cabinet. Turbidity was measured threetimes at 340 nm optical wavelength absorption. Afterwards the mean valueof the three measurement values was calculated.

OD340 Turbidity of CDH19 BiTE CH19 2G6 302×I2C SA21: 0.034

16.6 Aggregation Temperature TA Determination by Heated Dynamic LightScattering Measurement

A volume of 40 μl monomeric BiTE antibody at 250 μg/ml was transferredinto the inner core of a disposable plastic cuvette. The deeper placedouter core was filled up with generic BiTE formulation buffer. The topof the cuvette was sealed with a rubber top to avoid liquid loss byevaporation in the process of sample heating.

The cuvette was placed in a Nanostar Dynamic Light Scattering device(Wyatt) and heated from 40° C. to 70° C. at a heating increment of 0.5°C./min

Aggregation status was permanently monitored and recorded in the wholeheating process. Evaluation was executed with the software packagesupplied by the device manufacturer.

Aggregation temperature of CDH19 BiTE CH19 2G6 302×I2C SA21: 52.4° C.

16.7 PEGylation of BiTE Antibodies with CysLoop

Monomeric BiTE antibody containing an c-terminal CysLoop (see formethodical details WO 2006/008096) was dialyzed against a Tris/NaClbuffer pH 7.4 and reduced by the addition of the reduction agentTris(2-carboxyethyl)phosphine TCEP (Perbio Pierce) to create two reducedcysteins of the now opened CysLoop.

TCEP was removed by dialysis. PEG Maleimid capable of covalent bindingto reduced cystein was added in molar excess and incubated for 3 hoursat room temperature.

A Sepharose SP column cation exchange column (GE Healthcare) wasconnected to an Äkta FPLC system and equillibrated with binding buffer(low molar Phosphat/NaCl buffer of pH 5.0)

The protein solution was diluted with binding buffer adjusted to pH 5.0to enable binding of the BiTE protein to the cation exchange column.Unbound PEG was removed in the wash step with further binding puffer pH5.0 over 10 column volumes. Bound protein was eluted by a linearincreasing percentage of elution buffer 20 mM phosphate 1 M NaCl.

PEGylated BiTE antibody eluted at lower molarity of the elution buffercompared to the unmodified BiTE antibody.

Sequence Table:

TABLE Ia HEAVY CHAIN CDRs Ab Type CDR 1 CDR 2 CDR 3 1D10 NAAGCTATGGCATGCAC GTTATATGGTATGATGGAAGT AGGGCCGGTATAATAGGAAC 2C12AATAAATACTATGCAGACTCC TACAGGCTACTACTACGGTA GTGAAGGGC TGGACGTCSEQ ID NO: 1 SEQ ID NO: 2 SEQ ID NO: 3 AA SYGMH VIWYDGSNKYYADSVKGRAGIIGTTGYYYGMDV SEQ ID NO: 4 SEQ ID NO: 5 SEQ ID NO: 6 1F10 NAAGTGGTGGTTACTACT TACATCTATTACAGTGGGAGC GATGGAAGCAGTGGCTGGTA GGAGCACCTACTACAACCCGTCCCTC CTTCCAGCAC ACGAGT SEQ ID NO: 7 SEQ ID NO: 8SEQ ID NO: 9 AA SGGYYWS YIYYSGSTYYNPSLTS DGSSGWYFQH SEQ ID NO: 10SEQ ID NO: 11 SEQ ID NO: 12 2C12_LC#1 NA AGCTATGGCATGCACGTTATATGGTATGATGGAAGT AGGGCCGGTATAATAGGAAC AATAAATACTATGCAGACTCCTACAGGCTACTACTACGGTA GTGAAGGGC TGGACGTC SEQ ID NO: 13 SEQ ID NO: 14SEQ ID NO: 15 AA SYGMH VIWYDGSNKYYADSVKG RAGIIGTTGYYYGMDV SEQ ID NO: 16SEQ ID NO: 17 SEQ ID NO: 18 2G6_LC#1 NA AGCTATGGCATGCACTTTATATGGTATGATGGAAGT AGGGCCGGTATAATAGGAAC AATAAATACTATGCAGACTCCTATAGGCTACTACTACGGTA GTGAAGGAC TGGACGTC SEQ ID NO: 19 SEQ ID NO: 20SEQ ID NO: 21 AA SYGMH FIWYDGSNKYYADSVKD RAGIIGTIGYYYGMDV SEQ ID NO: 22SEQ ID NO: 23 SEQ ID NO: 24 2G6 NA AGCTATGGCATGCAC TTTATATGGTATGATGGAAGTAGGGCCGGTATAATAGGAAC AATAAATACTATGCAGACTCC TATAGGCTACTACTACGGTAGTGAAGGAC TGGACGTC SEQ ID NO: 25 SEQ ID NO: 26 SEQ ID NO: 27 AA SYGMHFIWYDGSNKYYADSVKD RAGIIGTIGYYYGMDV SEQ ID NO: 28 SEQ ID NO: 29SEQ ID NO: 30 2H12 NA AGCTATGGCATGCAC GTTATATGGTATGATGGAAGTAGGGCCGGTATAATAGGAAC AATAAATACTATACAGACTCC TACAGGCTACTACTACGGTAGTGAAGGGC TGGACGTC SEQ ID NO: 31 SEQ ID NO: 32 SEQ ID NO: 33 AA SYGMHVIWYDGSNKYYTDSVKG RAGIIGTTGYYYGMDV SEQ ID NO: 34 SEQ ID NO: 35SEQ ID NO: 36 2H12_LC#2 NA AGCTATGGCATGCAC GTTATATGGTATGATGGAAGTAGGGCCGGTATAATAGGAAC AATAAATACTATACAGACTCC TACAGGCTACTACTACGGTAGTGAAGGGC TGGACGTC SEQ ID NO: 37 SEQ ID NO: 38 SEQ ID NO: 39 AA SYGMHVIWYDGSNKYYTDSVKG RAGIIGTTGYYYGMDV SEQ ID NO: 40 SEQ ID NO: 41SEQ ID NO: 42 4A2 NA AGTAGTGGTTACTACT TACATCTATTACACTGGGAGCGATGGAAGCAGTGGCTGGTA 5B4 GGAGC GCCTACTACAACCCGTCCCTC CTTCCAGTAT 5C5AAGAGT SEQ ID NO: 43 SEQ ID NO: 44 SEQ ID NO: 45 AA SSGYYWSYIYYTGSAYYNPSLKS DGSSGWYFQY SEQ ID NO: 46 SEQ ID NO: 47 SEQ ID NO: 484A9 NA GGTTACTACTGGAGC TATTTCTCTTACAGTGGGAGC AACTGGGCCTTCCACTTTGAACCAACTACAACCCCTCCCTC CTTC AAGAGT SEQ ID NO: 49 SEQ ID NO: 50SEQ ID NO: 51 AA GYYWS YFSYSGSTNYNPSLKS NWAFHFDF SEQ ID NO: 52SEQ ID NO: 53 SEQ ID NO: 54 4B10 NA AGCTATGACATGCACGTTATATCATATGATGGAACT GAACGATATTTTGACTGGTC 4C2 AATGAATACTATGCAGACTCCTTTTGACTAC GTGAAGGGC SEQ ID NO: 55 SEQ ID NO: 56 SEQ ID NO: 57 AA SYDMHVISYDGTNEYYADSVKG ERYFDWSFDY SEQ ID NO: 58 SEQ ID NO: 59 SEQ ID NO: 604D2 NA AGTTATGACATGCAC GTTATATCATATGATGGAACT GAACGATATTTTGACTGGTCAATGAATACTATGCAGACTCC TTTTGACTAC GTGAAGGGC SEQ ID NO: 61 SEQ ID NO: 62SEQ ID NO: 63 AA SYDMH VISYDGTNEYYADSVKG ERYFDWSFDY SEQ ID NO: 64SEQ ID NO: 65 SEQ ID NO: 66 4D3 NA AGCTATGACATGGAC GTTATATGGTATGATGGAAGTGAAACTGGGGAGGgCTGGTA 4F3 AATAAAtacTATGCAGACTCC CTTCGAtctc GTGAGGGGCSEQ ID NO: 67 SEQ ID NO: 68 SEQ ID NO: 69 AA SYDMD VIWYDGSNKYYADSVRGETGEGWYFDL SEQ ID NO: 70 SEQ ID NO: 71 SEQ ID NO: 72 4E10 NAAGCTATGACATGCAC GTTATATGGTATGATGGAAGT GAGTATAGGTACAGCTGGTAAATAAATACTATGCAGACTCC CTTTGACTAC GTGAAGGGC SEQ ID NO: 73 SEQ ID NO: 74SEQ ID NO: 75 AA SYDMH VIWYDGSNKYYADSVKG EYRYSWYFDY SEQ ID NO: 76SEQ ID NO: 77 SEQ ID NO: 78 4F7 NA AGTTACTCCTGGAGC TATATCTATTACAGTGGGAGCAACTGGGCCTTCCACTTTGA ACCAACTACAACCCCTCCCTC CTAC AAGAGT SEQ ID NO: 79SEQ ID NO: 80 SEQ ID NO: 81 AA SYSWS YIYYSGSTNYNPSLKS NWAFHFDYSEQ ID NO: 82 SEQ ID NO: 83 SEQ ID NO: 84 5E3 NA AGCTATAGCATGCACTCCATTAGTAGTAGTAGTAGT GGGGAAACTGGAACTAACTA TACATATACTACGCAGACTCACTACTACTACGGTATGGACG GTGAAGGGC TC SEQ ID NO: 85 SEQ ID NO: 86SEQ ID NO: 87 AA SYSMH SISSSSSYIYYADSVKG GETGTNYYYYGMDV SEQ ID NO: 88SEQ ID NO: 89 SEQ ID NO: 90 17H8 NA AGTTACTACTGGAGCTATATCTATTACATTGGGAGC GATTCCCGGTATAGAAGTGG 23B6 ACCAACTACAACCCCTCCCTCCTGGTACGATGCTTTTGATA 28D10 AAGAGT TC SEQ ID NO: 91 SEQ ID NO: 92SEQ ID NO: 93 AA SYYWS YIYYIGSTNYNPSLKS DSRYRSGWYDAFDI SEQ ID NO: 94SEQ ID NO: 95 SEQ ID NO: 96 16C1 NA GGTTACTACTGGAGCTATATCTATTACATTGGGAGC GATGGGAGCAGTGGCTGGTA ACCAACTACAACCCCTCCCTCCCGGTGGTTCGACCCC AAGAGT SEQ ID NO: 97 SEQ ID NO: 98 SEQ ID NO: 99 AAGYYWS YIYYIGSTNYNPSLKS DGSSGWYRWFDP SEQ ID NO: 100 SEQ ID NO: 101SEQ ID NO: 102 16A4 NA AGTTACTACTGGAGC TATATCTATTACAGTGGGAGCGATCAAAGGCGGATAGCAGC ACCAATTACAACCCCTCCCTC AGCTGGTACCCACTTCTACG AAGAGTGTATGGACGTC SEQ ID NO: 103 SEQ ID NO: 104 SEQ ID NO: 105 AA SYYWSYIYYSGSTNYNPSLKS DQRRIAAAGTHFYGMDV SEQ ID NO: 106 SEQ ID NO: 107SEQ ID NO: 108 16E2 NA AGCTATGGCATGCAC GTGATATGGTATGATGGAAGTGACGGGTGGGAGCTGTCCTT 17E10 AATAAATACTATGCAGACTCC TGACTAC 20B12 GTGAAGGGCSEQ ID NO: 109 SEQ ID NO: 110 SEQ ID NO: 111 AA SYGMH VIWYDGSNKYYADSVKGDGWELSFDY SEQ ID NO: 112 SEQ ID NO: 113 SEQ ID NO: 114 22G10 NAAGTTATGCCATGAAC ACTATTAGTGGTGGTGGTGCT GGGGGAATGGGGGGATACTAAACACATACTACGCAGACTCC CTACGGTATGGACGTC GTGAAGGGC SEQ ID NO: 115SEQ ID NO: 116 SEQ ID NO: 117 AA SYAMN TISGGGANTYYADSVKG GGMGGYYYGMDVSEQ ID NO: 118 SEQ ID NO: 119 SEQ ID NO: 120 16H2 NA AGCTACTTTATTCACATAATCAACCCTATTAGTGTT GGGGGGATACAGCTATGGTT 20D3 AGCACAAGCTACGCACAGAAGACATTTTGACTAC 23E7 TTCCAGGGC SEQ ID NO: 121 SEQ ID NO: 122SEQ ID NO: 123 AA SYFIH IINPISVSTSYAQKFQG GGIQLWLHFDY SEQ ID NO: 124SEQ ID NO: 125 SEQ ID NO: 126 22D1 NA AGCTACTTTATTCACATAATCAACCCTATTAGTGTT GGGGGGATACAGCTATGGTT AGCACAAGCTACGCACAGAAGACATTTGGACTAC TTCCAGGGC SEQ ID NO: 127 SEQ ID NO: 128 SEQ ID NO: 129 AASYFIH IINPISVSTSYAQKFQG GGIQLWLHLDY SEQ ID NO: 130 SEQ ID NO: 131SEQ ID NO: 132 25F8 NA AGCTACTATATTCAC ATAATCAACCCCAGTGGTGGTGGGGGAATACAGCTATGGTT AGCACAAGGTACGCACAGAAG ACATTttGACTAC TTCCAGGGCSEQ ID NO: 133 SEQ ID NO: 134 SEQ ID NO: 135 AA SYYIH IINPSGGSTRYAQKFQGGGIQLWLHFDY SEQ ID NO: 136 SEQ ID NO: 137 SEQ ID NO: 138 26F12 NAAACTACTATATGTCC ATAATCAACCCTAGTGGTGGT GGGGGGATACAACTATGGTT 27B3GACTCAACCTACGCACAGAAG ACATTTTGACTAC TTCCAGGGC SEQ ID NO: 139SEQ ID NO: 140 SEQ ID NO: 141 AA NYYMS IINPSGGDSTYAQKFQG GGIQLWLHFDYSEQ ID NO: 142 SEQ ID NO: 143 SEQ ID NO: 144 26D1 NA AGCTACTATATGTCCATAATCCACCCTAGTGGTGGT GGGGGGATAAAACTATGGTT GACACAACCTACGCACAGAAGACATTTTGACTAT TTCCAGGGC SEQ ID NO: 145 SEQ ID NO: 146 SEQ ID NO: 147 AASYYMS IIHPSGGDTTYAQKFQG GGIKLWLHFDY SEQ ID NO: 148 SEQ ID NO: 149SEQ ID NO: 150 25G10 NA GGTTACTACTGGAGC TATATCTATTACATTGGGAGCGATGGGAGCAGTGGCTGGTA ACCAACTACAACCCCTCCCTC CCGGTGGTTCGACCCC AAGAGTSEQ ID NO: 151 SEQ ID NO: 152 SEQ ID NO: 153 AA GYYWS YIYYIGSTNYNPSLKSDGSSGWYRWFDP SEQ ID NO: 154 SEQ ID NO: 155 SEQ ID NO: 156 23A10 NACGCTATGGCATACAC GTTATATGGTATGATGGAAGT AGGGCCGGTATACCTGGAACAATAAATACTATGCAGACTCC TACGGGCTACTACTATGGTA GTGAAGGGC TGGACGTCSEQ ID NO: 157 SEQ ID NO: 158 SEQ ID NO: 159 AA RYGIH VIWYDGSNKYYADSVKGRAGIPGTTGYYYGMDV SEQ ID NO: 160 SEQ ID NO: 161 SEQ ID NO: 162 19B5 NAAGCTACTTTATTCAC ATTATCAACCCTATTAGTGTT GGGGGGATACAGCTATGGTTAGCACAAGCTACGCACAGAAG ACATTTGGACTAC TTCCAGGGC SEQ ID NO: 163SEQ ID NO: 164 SEQ ID NO: 165 AA SYFIH IINPISVSTSYAQKFQG GGIQLWLHLDYSEQ ID NO: 166 SEQ ID NO: 167 SEQ ID NO: 168

TABLE Ib LIGHT CHAIN CDRs Ab Type CDR 1 CDR 2 CDR 3 1D10 NATCTGGAGATAGATTGG CAAGATACCAAGCGGCCCTCA CAGGCGTGGGACAGCAGCAC 2C12GGGAAAAATATACTTG TGTGGTA C SEQ ID NO: 169 SEQ ID NO: 170 SEQ ID NO: 171AA SGDRLGEKYTC QDTKRPS QAWDSSTVV SEQ ID NO: 172 SEQ ID NO: 173SEQ ID NO: 174 1F10 NA AGGGCCAGTCGGAGTA GGTCCATCCAGCAGGGCCACTCAGCAGTATGGTAGCTCATT TTAGCAGCAGCTACTT CACT AGCC SEQ ID NO: 175SEQ ID NO: 176 SEQ ID NO: 177 AA RASRSISSSYLA GPSSRAT QQYGSSFTSEQ ID NO: 178 SEQ ID NO: 179 SEQ ID NO: 180 2012_LC#1 NAAGGtCTAGTCAAAGcc AAGGTTTCTAACTGGGactct ATGCAAGGTATAGTGTGGCCtcgtaTACAGTGATGG GTGCAGT AAACAcctACTTGAAT SEQ ID NO: 181 SEQ ID NO: 182SEQ ID NO: 183 AA RSSQSLVYSDGNTYLN KVSNWDS MQGIVWPCS SEQ ID NO: 184SEQ ID NO: 185 SEQ ID NO: 186 2G6_LC#1 NA AGGTCTAGTCAAAGCCCAGGTTTCTAACTGGGACTCT ATGCAAGATACACTGTGGCC TCGTATACAGTGATGG GTGCAGTAAACACCTACTTGAAT SEQ ID NO: 187 SEQ ID NO: 188 SEQ ID NO: 189 AARSSQSLVYSDGNTYLN QVSNWDS MQDTLWPCS SEQ ID NO: 190 SEQ ID NO: 191SEQ ID NO: 192 2G6 NA TCTGGAGATAGGTTGG CAAGATACCAAGCGGCCCTCACAGGCGTGGGACAGCAGCAC GGGAAAAATATACTTG TGTGGTA C SEQ ID NO: 193SEQ ID NO: 194 SEQ ID NO: 195 AA SGDRLGEKYTC QDTKRPS QAWDSSTVVSEQ ID NO: 196 SEQ ID NO: 197 SEQ ID NO: 198 2H12 NA TCTGGAGATAGATTGGCAAGATACCAAGCGGCCCTCA CAGGCGTGGGACAGCAGCAC GGGAAAAATATACTTG TGTGGTA CSEQ ID NO: 199 SEQ ID NO: 200 SEQ ID NO: 201 AA SGDRLGEKYTC QDTKRPSQAWDSSTVV SEQ ID NO: 202 SEQ ID NO: 203 SEQ ID NO: 204 2H12_LC#2 NAAGGTCTAGTCAAAGCC AAGGTTTCTAACTGGGACTCT ATGCAAGATACACTGTGGCCTCGTATACAGTGATGG GTGCAGT AAACACCTACTTGAAT SEQ ID NO: 205 SEQ ID NO: 206SEQ ID NO: 207 AA RSSQSLVYSDGNTYLN KVSNWDS MQDTLWPCS SEQ ID NO: 208SEQ ID NO: 209 SEQ ID NO: 210 4A2 NA AGGgcCAGTCGGAATAGGTCCATCCAGCAGGGccaCT CAGCAGTATGGtagctCATT 5B4 TTAGCAGCAGCTACtt CACT 5C5aGCC SEQ ID NO: 211 SEQ ID NO: 212 SEQ ID NO: 213 AA RASRNISSSYLAGPSSRAT QQYGSSFT SEQ ID NO: 214 SEQ ID NO: 215 SEQ ID NO: 216 4A9 NAACTGGGAGCAGCTCCA GGTAACAACAATCGGCCCTCA CAGTCCTATGACAGCagACTACATCGGGACAGGTTA GAGTGGTTGGGTG TGCTGTACAC SEQ ID NO: 217 SEQ ID NO: 218SEQ ID NO: 219 AA TGSSSNIGTGYAVH GNNNRPS QSYDSRLSGWV SEQ ID NO: 220SEQ ID NO: 221 SEQ ID NO: 222 4B10 NA AGGGCCAGTCAGAGTGGGTGCATCCAGCAGGGCCACT CAGCAGTACAGTAACTCgtg 4C2 TTAGCAACACCTACTT GACGAGCC SEQ ID NO: 223 SEQ ID NO: 224 SEQ ID NO: 225 AA RASQSVSNTYLAGASSRAT QQYSNSWT SEQ ID NO: 226 SEQ ID NO: 227 SEQ ID NO: 228 4D2 NAAGGGCCAGTCAGAGTG GGTGCATCCAGCAGGGCCGCT CagcagTATAGTAacTcgtgTTAGCAACACCTACTT GACG AGCC SEQ ID NO: 229 SEQ ID NO: 230 SEQ ID NO: 231AA RASQSVSNTYLA GASSRAA QQYSNSWT SEQ ID NO: 232 SEQ ID NO: 233SEQ ID NO: 234 4D3 NA AGGGCCAGTCAGAGTG GGTGCATCCAGCAGGGCCACTCAGCAGTATGGTAGCTCGTG 4F3 TTAGCAGCAGCTACTT GACG AGCC SEQ ID NO: 235SEQ ID NO: 236 SEQ ID NO: 237 AA RASQSVSSSYLA GASSRAT QQYGSSWTSEQ ID NO: 238 SEQ ID NO: 239 SEQ ID NO: 240 4E10 NA AGGGCCAGTCAGAGTGGGTGCATCCAGCAGGGTCACT CAGCAATATAGTAACTCGTG TTGGCAGCAGCTACTT GACG AGCCSEQ ID NO: 241 SEQ ID NO: 242 SEQ ID NO: 243 AA RASQSVGSSYLA GASSRVTQQYSNSWT SEQ ID NO: 244 SEQ ID NO: 245 SEQ ID NO: 246 4F7 NAACTGGGAGCAGCTCCA GGTAACAGCAATCGGCCCTCA CAGTCCTATGACAGCAGTCTATATCGGGACAGGTTA GAGTGGTTGGGTG TGATGTACAC SEQ ID NO: 247 SEQ ID NO: 248SEQ ID NO: 249 AA TGSSSNIGTGYDVH GNSNRPS QSYDSSLSGWV SEQ ID NO: 250SEQ ID NO: 251 SEQ ID NO: 252 5E3 NA TCTGGAGATAAATTGGCAAGATAGCAAGCGGCCCTCA CAGGCGTGGGACAGCAGCAC GGGATGAATATGCTTG TGTGGTA CSEQ ID NO: 253 SEQ ID NO: 254 SEQ ID NO: 255 AA SGDKLGDEYAC QDSKRPSQAWDSSTVV SEQ ID NO: 256 SEQ ID NO: 257 SEQ ID NO: 258 17H8 NAAGGGCCAGTCAGAGTG GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAAATCACC 23B6TTGCCGGCAGCTACCT GATCACC 28D10 AGCC SEQ ID NO: 259 SEQ ID NO: 260SEQ ID NO: 261 AA RASQSVAGSYLA GASSRAT QQYGKSPIT SEQ ID NO: 262SEQ ID NO: 263 SEQ ID NO: 264 16C1 NA AGGGCCAGCCAGAGTGGGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAACTCACC TTAGCAGCAGCTACTT GCTCACT AGCCSEQ ID NO: 265 SEQ ID NO: 266 SEQ ID NO: 267 AA RASQSVSSSYLA GASSRATQQYGNSPLT SEQ ID NO: 268 SEQ ID NO: 269 SEQ ID NO: 270 16A4 NAAGGGCCAGTCAGAGTG GGTACATCCAGCAGGGCCACT CAGCAGTACGGTAGCTCACCTTAGCAGCAGTTATTT TTTCACT AGCC SEQ ID NO: 271 SEQ ID NO: 272SEQ ID NO: 273 AA RASQSVSSSYLA GTSSRAT QQYGSSPFT SEQ ID NO: 274SEQ ID NO: 275 SEQ ID NO: ***276 16E2 NA CGGGCGAGTCAGGGCAGCTGCATCCAGTTTGCAAAGT CAACACTATTTTACTTACCC 17E10 TTAGCAATTATTTAGCTCGGACG 20B12 C SEQ ID NO: 277 SEQ ID NO: 278 SEQ ID NO: 279 AARASQGISNYLA AASSLQS QHYFTYPRT SEQ ID NO: 280 SEQ ID NO: 281SEQ ID NO: 282 22G10 NA AGGGCCAGTCAGAGTA GGTGCATTTACCAGGGCCACTCAGCAGTATAATTACTGGCC TTAGCAGCAACTTAGC GCTCACT C SEQ ID NO: 283SEQ ID NO: 284 SEQ ID NO: 285 AA RASQSISSNLA GAFTRAT QQYNYWPLTSEQ ID NO: 286 SEQ ID NO: 287 SEQ ID NO: 288 16H2 NA TCTGGAAGCAGCTCCAACTAATAATCAGCGGCCCTCA GCAACATGGGATGACAGCCT 20D3 ACATCGGAAGTAATTTGAATGGTTGGGTG 23E7 TGTAAAC SEQ ID NO: 289 SEQ ID NO: 290 SEQ ID NO: 291AA SGSSSNIGSNFVN TNNQRPS ATWDDSLNGWV SEQ ID NO: 292 SEQ ID NO: 293SEQ ID NO: 294 22D1 NA TCTGGAAGCAGCTCCA ACTAATAATCAGCGGCCCTCAGCAACATGGGATGACAGTAT ACATCGGAAGCAATTT GAATGGTTGGGTG TGTAAACSEQ ID NO: 295 SEQ ID NO: 296 SEQ ID NO: 297 AA SGSSSNIGSNEVN TNNQRPSATWDDSMNGWV SEQ ID NO: 298 SEQ ID NO: 299 SEQ ID NO: 300 25F8 NATCTGGAAGCAGCTCCA ACTAATAATCAGCGGCCCTCA GCAGCATGGGATGACAGCCTACATCGGAAGGAATTT GAATGGTTGGGTG TGTAAAC SEQ ID NO: 301 SEQ ID NO: 302SEQ ID NO: 303 AA SGSSSNIGRNEVN TNNQRPS AAWDDSLNGWV SEQ ID NO: 304SEQ ID NO: 305 SEQ ID NO: 306 26F12 NA TCTGGAAGCCGCTCCAACTAATTATCAGCGGCCCTCA GCAGTATGGGATGACAGCCT 27B3 ACATCGGAAGTAATTTGAATGGTTGGGTG TGTAAAC SEQ ID NO: 307 SEQ ID NO: 308 SEQ ID NO: 309 AASGSRSNIGSNEVN TNYQRPS AVWDDSLNGWV SEQ ID NO: 310 SEQ ID NO: 311SEQ ID NO: 312 26D1 NA TCTGGAAGCCGCTCCA ACTAATAATCAGCGGCCCTCAGCAGTATGGGATGACAGCCT ACATCGGAAGTAATTT GAATGGTTGGGTG TGTAAACSEQ ID NO: 313 SEQ ID NO: 314 SEQ ID NO: 315 AA SGSRSNIGSNEVN TNNQRPSAVWDDSLNGWV SEQ ID NO: 316 SEQ ID NO: 317 SEQ ID NO: 318 25G10 NAAGGGCCAGTCAGAGTG GGTGCATCCAGCAGGGCCACT CAGCAGTATGGTAACTCACCTTAGCAGCAGCTACTT GCTCACT AGCC SEQ ID NO: 319 SEQ ID NO: 320SEQ ID NO: 321 AA RASQSVSSSYLA GASSRAT QQYGNSPLT SEQ ID NO: 322SEQ ID NO: 323 SEQ ID NO: 324 23A10 NA TCTGGAGATAGATTGGCAAGATAATAAGTGGCCCTCA CAGGCGTGGGACAGCAGcac GGGAGAAATATGTTTG TGTGGTA CSEQ ID NO: 325 SEQ ID NO: 326 SEQ ID NO: 327 AA SGDRLGEKYVC QDNKWPSQAWDSSTVV SEQ ID NO: 328 SEQ ID NO: 329 SEQ ID NO: 330 19B5 NATCTGGAAGCAGGTCCA ACTAATAATCAGCGGCCCTCA GCAACATGGGATGACAGTATACATCGGAAGCAATTT GAATGGTTGGGTG TGTAAAC SEQ ID NO: 331 SEQ ID NO: 332SEQ ID NO: 333 AA SGSRSNIGSNEVN TNNQRPS ATWDDSMNGWV SEQ ID NO: 334SEQ ID NO: 335 SEQ ID NO: 336

Anti-CDH19 Variable Region Amino Acid Sequences and PolynucleotideSequences

TABLE IIaHeavy Chain Variable Region Polynucleotide and Amino acid Sequences SEQID NO. DESIGNATION SOURCE TYPE SEQUENCE 337 17H8 artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACGTGCACTGTCTCTGGTGGCTCCAT23B6CAATAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACATTGGGAGCACCA28D10ACTACAACCCCTCCCTCAAGAGTCGCGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCCTGTATTACTGTGCGAGAGATTCCCGGTATAGAAGTGGCTGGTACGATGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTCTCTTCA 338 17H8 artificial aaQVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVT23B6 AADTALYYCARDSRYRSGWYDAFDIWGQGTMVTVSS 28D10 339 4A2 artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCAT5B4CAGCAGTAGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACACTGGGA5C5GCGCCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGATGGAAGCAGTGGCTGGTACTTCCAGTATTGGGGCCAGGGCACCCTGGTCACCGTCTCCTCA 340 4A2 artificial aaQVQLQESGPGLVKPSQTLSLTCTVSGGSISSSGYYWSWIRQHPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSS5B4 VTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSS 5C5 341 16H2 artificial ntCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGTTTCTGGATACACCTT20D3CACCAGCTACTTTATTCACTGGGTGCGCCAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTATTAGTGTTAGCA23E7CAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTTCATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGCGAGGGGGGATACAGCTATGGTTACATTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 342 16H2 artificial aaQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSL20D3 RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS 23E7 343 26F12 artificial ntCAGGTGCAGTTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTAGATACACCTT27B3CACCAACTACTATATGTCCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTGACTCAACCTACGCACAGAAGTTCCAGGGCAGACTCACCATGACCGGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGGGGGATACAACTATGGTTACATTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 344 26F12 artificial aaQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSL27B3 RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS 345 4B10 artificial ntCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTT4C2CAGTAGCTATGACATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAACTAATGAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACACTTCCAAGAACACGCTGTATTTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTATATTACTGTGCGAGAGAACGATATTTTGACTGGTCTTTTGACTACTGGGGCCAGGGAACCCTGGTCAGTGTCTCCTCA 346 4B10 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSL4C2 RAEDTAVYYCARERYFDWSFDYWGQGTLVSVSS 347 4D3 artificial ntCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCTCCTT4F3CAGTAGCTATGACATGGACTGGGTCCGCCAGACTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAGGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTTTCTGCAAATGAACAGCCTGAGAGTCGAGGACACGGCTGTGTATTACTGTGCGAGAGAAACTGGGGAGGGCTGGTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACTGTCTCCTCA 348 4D3 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFSFSSYDMDWVRQTPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSL4F3 RVEDTAVYYCARETGEGWYFDLWGRGTLVTVSS 349 16E2 artificial ntCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCATCTT17E10CAGTAGCTATGGCATGCACTGGGTCCGCCAGACTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTGATATGGTATGATGGAAGTAATA20B12AATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACATTTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGTCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGGTGGGAGCTGTCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 350 16E2 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFIFSSYGMHWVRQTPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDISKNTLYLQMNSL17E10 RVEDTAVYYCARDGWELSFDYWGQGTLVTVSS 20B12 351 1D10 artificial ntCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTT2C12CAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGTCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGCGCGAGAAGGGCCGGTATAATAGGAACTACAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCA 352 1D10 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVSVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSL2C2 RAEDTAVYYCARRAGIIGTTGYYYGMDVWGQGTTVTVSS 353 1601 artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACTTGTACTGTCTCTGGTGGCTCCATCAGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACATTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAATAGACACGTCCAAGAACCAGTTCTCCCTGACGCTGAGCTCTTTGACCGCTGCGGACACGGCCGTGTATTTCTGTGCGAGAGATGGGAGCAGTGGCTGGTACCGGTGGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 354 16C1 artificial aaQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSIDTSKNQFSLTLSSLTAADTAVYFCARDGSSGWYRWFDPWGQGTLVTVSS 355 25G10 artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACATTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGATGGGAGCAGTGGCTGGTACCGGTGGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 356 25G10 artificial aaQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYRWFDPWGQGTLVTVSS 357 16A4 artificial ntCAGGTGCAGCTGCAGGAGTCgGGCCCAGGACTGGCGAAgccttcGGAGACcctgtccctcacctgCACTGTCTCTGGTGACTCCATCACTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAATTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGATCAAAGGCGGATAGCAGCAGCTGGTACCCACTTCTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCA 358 16A4 artificial aaQVQLQESGPGLAKPSETLSLTCTVSGDSITSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDQRRIAAAGTHFYGMDVWGQGTTVTVSS 359 1F10 artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCACGAGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGATGGAAGCAGTGGCTGGTACTTCCAGCACTGGGGCCAGGGCACCCTGGTCACCGTCTCCTCA 360 1F10 artificial aaQVQLQESGPGLVKPSQTLSLTCTVSGGSISSGGYYWSWIRQHPGKGLEWIGYIYYSGSTYYNPSLTSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYFQHWGQGTLVTVSS 361 4A9 artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGAAAGGGACTGGAGTGGTTTGCATATTTCTCTTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCTTATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGGAACTGGGCCTTCCACTTTGACTTCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 362 4A9 artificial aaQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWFAYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDFWGQGTLVTVSS 363 4F7 artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTCCTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGGAACTGGGCCTTCCACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 364 4F7 artificial aaQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDYWGQGTLVTVSS 365 22D1 artificial ntCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAGGGTTTCCTGCAAGGTTTCTGGATACACCTTCACCAGCTACTTTATTCACTGGGTACGCCAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTATTAGTGTTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTTCATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGCGAGGGGGGATACAGCTATGGTTACATTTGGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 366 22D1 artificial aaQVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS 367 19B5 artificial ntCAGGTGCAGTTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGTTTCTGGATACACCTTCACCAGCTACTTTATTCACTGGGTGCGCCAGGCCCCTGGACAAGGGCTTGAATGGATGGGAATTATCAACCCTATTAGTGTTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTTCATGGAGCTGAGCAGcCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGCGAGGGGGGATACAGCTATGGTTACATTTGGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 368 19B5 artificial aaQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS 369 25F8 artificial ntCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATTCACTGGGTGCGCCAGGCCCCTGGACAAGGACTTGAGTGGATGGGAATAATCAACCCCAGTGGTGGTAGCACAAGGTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTTCATGGAGCTGAGCagcctGAGATCTGAGGACACGGCCGTGTATTACTGTGCGCGAGGGGGAATACAGCTATGGTTACATTttGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 370 25F8 artificial aaQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS 371 26D1 artificial ntCAGGTGCAGTTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGTAAGGCATCTAGATACACCTTCACCAGCTACTATATGTCCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCCACCCTAGTGGTGGTGACACAACCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCGGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGGGGGATAAAACTATGGTTACATTTTGACTATTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 372 26D1 artificial aaQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSS 373 4D2 artificial ntCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGTTATGACATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAACTAATGAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACACTTCCAAGAACACGCTGTATTTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTATATTACTGTGCGAGAGAACGATATTTTGACTGGTCTTTTGACTACTGGGGCCAGGGAACCCTGGTCAGTGTCTCCTCA 374 4D2 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCARERYFDWSFDYWGQGTLVSVSS 375 4E10 artificial ntCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGACATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCACGAACACGCTGCATCTGCAAATGAACAGCCCGAGAGCCGAGGACACGGCTGTGTACTACTGTGCGAGAGAGTATAGGTACAGCTGGTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 376 4E10 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSTNTLHLQMNSPRAEDTAVYYCAREYRYSWYFDYWGQGTLVTVSS 377 22G10 artificial ntGAGGTGCAACTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGTTATGCCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAACTATTAGTGGTGGTGGTGCTAACACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGTGACAATTCCAAGAGCACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGCGGACACGGCCGTATATCACTGTGCGAAAGGGGGAATGGGGGGATACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCA 378 22G10 artificial aaEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISSDNSKSTLYLQMNSLRAADTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSS 379 2012_LC#1 artificial ntCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGTCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGCGCGAGAAGGGCCGGTATAATAGGAACTACAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCA 380 2012_LC#1 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVSVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTTGYYYGMDVWGQGTTVTVSS 381 2H12_LC#2 artificial ntCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATACAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTACAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCA 382 2H12_LC#2 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNKYYTDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTTGYYYGMDVWGQGTTVTVSS 383 2G6_LC#1 artificial ntCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAAAAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCA 384 2G6_LC#1 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS 385 2H12 artificial ntCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATACAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTACAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCA 386 2H12 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAVIWYDGSNKYYTDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTTGYYYGMDVWGQGTTVTVSS 387 2G6 artificial ntCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAAAAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCA 388 2G6 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGRITSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS 389 23A10 artificial ntCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTCGCTATGGCATACACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCTAATGAACAGCCTGAGAGCCGAGGACTCGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATACCTGGAACTACGGGCTACTACTATGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCA 390 23A10 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGRITSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLLMNSLRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSS 391 5E3 artificial ntGAGGTGCAGTTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGGGGAAACTGGAACTAACTACTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCA 392 5E3 artificial aaEVQLVESGGGLVKPGGSLRLSCAASGFTESSYSMHWVRQAPGKGLEWVSSISSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARGETGTNYYYYGMDVWGQGTTVTVSS

TABLE IIBLight Chain Variable Region Polynucleotide and Amino acid Sequences SEQID NO. DESIGNATION SOURCE TYPE SEQUENCE 393 17H8 artificial ntGACATTGTATTGACGCAGtctCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGT23B6TGCCGGCAGCTACCTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTCTGGTGCATCCAGCAGGGCCACTG28D10GCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAAATCACCGATCACCTTCGGCCAAGGGACACGACTGGAGATGAAAGGA394 17H8 artificial aaDIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLISGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAV23B6 YYCQQYGKSPITFGQGTRLEMKG 28D10 395 4A2 artificial ntGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCTTGCAGGGCCAGTCGGAATAT5B4TAGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTCCATCCAGCAGGGCCACTG5C5GCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTACAGTGTATTACTGTCAGCAGTATGGTAGCTCATTCACTTTCGGCCCTGGGACCAAAGTGGATATCAAACGA 3964A2 artificial aaEIVLTQSPGTLSLSPGERATLSCRASRNISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFTV5B4 YYCQQYGSSFTEGPGTKVDIKR 5C5 397 16H2 artificial ntCAGTCTGCGCTGACTCAGCCACCCTCAGCGACTGGGACCCCCGGGCAGAGGGTCACCATCTCTTGTTCTGGAAGCAGCTCCAACAT20D3CGGAAGTAATTTTGTAAACTGGTACAAACAACTCCCAGGAACGGCCCCCAAAGTCCTCATCTATACTAATAATCAGCGGCCCTCAG23E7GGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGTCTGATTATTACTGTGCAACATGGGATGACAGCCTGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTAGGT398 16H2 artificial aaQSALTQPPSATGTPGQRVTISCSGSSSNIGSNEVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESD20D3 YYCATWDDSLNGWVFGGGTKLTVLG 23E7 399 26F12 artificial ntCAGTCTGTGCTGACTCAGTCACCCTCAGCGTCTGGGACCCCCGGGCAGAAGGTCACCATCTCTTGTTCTGGAAGCCGCTCCAACAT27B3CGGAAGTAATTTTGTAAACTGGTACCAGCAGCTCCCAGGAACGGCCCCCAAACTCCTCATCTATACTAATTATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGGCTGATTATTACTGTGCAGTATGGGATGACAGCCTGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTAGGT400 26F12 artificial aaQSVLTQSPSASGTPGQKVTISCSGSRSNIGSNEVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD27B3 YYCAVWDDSLNGWVFGGGTKLTVLG 401 4B10 artificial ntGAAATTGTATTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGT4C2TAGCAACACCTACTTAGCCTGGTACCATCAGAGACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATCCAGCAGGGCCACTGGCATCCCAGACAGATTCAGTGGCAGTGGGTCTGGGACAGACTTCGCTCTCACCATCAGCAGTCTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTACAGTAACTCgtgGACGTTCGGCCAAGGGACCAAGGTGGAAATCAaacGA 4024B10 artificial aaEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYHQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFALTISSLEPEDFAV4C2 YYCQQYSNSWTFGQGTKVEIKR 403 4D3 artificial ntGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGT4F3TAGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATCCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAACCTGAGGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAACGA 4044D3 artificial aaEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAV4F3 YYCQQYGSSWTFGQGTKVEIKR 405 16E2 artificial ntGACATCCAGATGACCCAGTCTCCATCCTCACTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGTCGGGCGAGTCAGGGCAT17E10TAGCAATTATTTAGCCTGGTTACAGCAGAAACCAGGGAAAGCCCCTAAGTCCCTGATCTATGCTGCATCCAGTTTGCAAAGTGGGG20B12TCCCATCAAAGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATTTTGCAACTTATTACTGCCAACACTATTTTACTTACCCTCGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAACGA 40616E2 artificial aaDIQMTQSPSSLSASVGDRVTITCRASQGISNYLAWLQQKPGKAPKSLIYAASSLQSGVPSKFSGSGSGTDFTLTISSLQPEDFATY17E10 YCQHYFTYPRTFGQGTKVEIKR 20B12 407 1D10 artificial ntTCCTATGCGCTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCCTCACCTGCTCTGGAGATAGATTGGGGGA2C12AAAATATACTTGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCACCTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGACAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTAGGT 408 1D10artificial aaSYALTQPPSVSVSPGQTASLTCSGDRLGEKYTCWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSTSGNTATLTISGTQAMDEADYY2C12 CQAWDSSTVVFGGGTKLTVLG 409 16C1 artificial ntGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGCCAGAGTGTTAGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTTTGGTGCATCCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCGGACTGGAGCCTGAAGATTTTGCAGTGTATCACTGTCAGCAGTATGGTAACTCACCGCTCACTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGA410 16C1 artificial aaEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISGLEPEDFAVYHCQQYGNSPLTFGGGTKVEIKR 411 25G10 artificial ntGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTAGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTTTGGTGCATCCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGactTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATCACTGTCAGCAGTATGGTAACTCACCGCTCACTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGA412 25G10 artificial aaEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYHCQQYGNSPLTFGGGTKVEIKR 413 16A4 artificial ntGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCtCTCCTGCAGGGCCAGTCAGAGTGTTAGCAGCAGTTATTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTACATCCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTATTGTCAGCAGTACGGTAGCTCACCTTTCACTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGA414 16A4 artificial aaEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGTSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPFTFGGGTKVEIKR 415 1F10 artificial ntGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCGGAGTATTAGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTCCATCCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCATTCACTTTCGGCCCTGGGACCAAAGTGGATATCAAACGA 4161F10 artificial aaEIVLTQSPGTLSLSPGERATLSCRASRSISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGPGTKVDIKR 417 4A9 artificial ntCAGTCTGTGCTGACGCAGCCGCCCTCAGTGTCTGGGGCCCCAGGACAGAGGGTCACCATCTCCTGCACTGGGAGCAGCTCCAACATCGGGACAGGTTATGCTGTACACTGGTACCAGCAGTTTCCAGGAACAGCCCCCAAACTCCTCATCTATGGTAACAACAATCGGCCCTCAGGGGTTCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCACTGGGCTCCAGGCTGAGGATGAGGCTGATTATTACTGCCAGTCCTATGACAGCAGACTGAGTGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTAGGT418 4A9 artificial aaQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQFPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSRLSGWVFGGGTKLTVLG 419 4F7 artificial ntCAGTCTGTgcTGACGCAGCCGCCCTCAGTGTCTGGGGCCCCAGGGCAGAGGGTCACCATCTCCTGCACTGGGAGCAGCTCCAATATCGGGACAGGTTATGATGTACACTGGTATCAGCAGcttcCAGGAACAGCCCCCAAACTCCTCATCCATGGTAACAGCAATCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCACTGGGCTCCAGGCTGAGGATGAGGCTGATTATTACTGCCAGTCCTATGACAGCAGTCTGAGTGGTTGGGTGTTCGGCGGAGGGACCAGGTTGACCGTCCTAGGT420 4F7 artificial aaQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIHGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVLG 421 22D1 artificial ntCAGTCTGCGCTGACTCAGCCACCCTCAGCGACTGGGACCCCCGGGCAGAGGGTCACCATCTCTTGTTCTGGAAGCAGCTCCAACATCGGAAGCAATTTTGTAAACTGGTACAAGCAGCTCCCAGGAACGGCCCCCAAAGTCCTCATCTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGTCTGATTATTACTGTGCAACATGGGATGACAGTATGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTAGGT422 22D1 artificial aaQSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSMNGWVFGGGTKLTVLG 423 19B5 artificial ntCAGTCTGCGCTGACTCAGCCACCCTCAACGACTGGGACCCCCGGGCAGAGGGTCACCATCTCTTGTTCTGGAAGCAGGTCCAACATCGGAAGCAATTTTGTAAACTGGTACAAGCAGCTCCCAGGAACGGCCCCCAAAGTCCTCATCTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGTCTGATTATTACTGCGCAACATGGGATGACAGTATGAATGGTTGGGTGTTCGGCGGAGGGACCAAACTGACCGTCCTAGGT424 19B5 artificial aaQSALTQPPSTTGTPGQRVTISCSGSRSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSMNGWVFGGGTKLTVLG 425 25F8 artificial ntCAGTCTGCGCTGactCAGCCACCCTCAGCGACTGGGACCCCCGGGCAGAGGGTCACCATCTCTTGTTCTGGAAGCAGCTCCAACATCGGAAGGAATTTTGTAAACTGGTATAAGCAGCTCCCAGGAACGGCCCCCAAAGTCCTCATTTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGTCTGATTATTACTGTGCAGCATGGGATGACAGCCTGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTAGGT426 25F8 artificial aaQSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCAAWDDSLNGWVFGGGTKLTVLG 427 26D1 artificial ntCACTCTGTGCTGACTCAGTCACCCTCAGCGTCTGGGACCCCCGGACAGAGGGTCACCATCTCTTGTTCTGGAAGCCGCTCCAACATCGGAAGTAATTTTGTAAACTGGTACCAGCAGCTCCCAGGAACGGCCCCCAAACTCCTCATCTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGGCTGATTATTACTGTGCAGTATGGGATGACAGCCTGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTAGGT428 26D1 artificial aaHSVLTQSPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLG 429 4D2 artificial ntGAAATTGTATTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTAGCAACACCTACTTAGCCTGGTACCATCAGAGACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATCCAGCAGGGCCGCTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATAGTAACTCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAACGA 4304D2 artificial aaEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYHQRPGQAPRLLIYGASSRAAGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYSNSWTFGQGTKVEIKR 431 4E10 artificial ntGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTGGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATCCAGCAGGGTCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGATTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAATATAGTAACTCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAACGA 4324E10 artificial aaEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGASSRVTGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYSNSWTFGQGTKVEIKR 433 22G10 artificial ntGAAATAGTGATGACGCAGTCTCCAGTCACCCTGTCTCTGTCTCTAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTATTAGCAGCAACTTAGCCTGGTTCCAGCAGAAACCTGGCCAGGCTCCCAGACTCCTCATCTATGGTGCATTTACCAGGGCCACTGGTATCCCAGCCAGGGTCAGTGGCAGTGGGTCTGGGACAGAGTTCACTCTCACCATCAGCAGCCTGCAGTCTGAAGATTTTGCAGTTTATTACTGTCAGCAGTATAATTACTGGCCGCTCACTTTCGGCGGAGGGACCAAGGTGGAGATCAAGCGA 43422G10 artificial aaEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKR 435 2C12_LC#1 artificial ntGATGTTGTGATGactCAGtCTccActctccctgcCCGTCACCCTTGGACAGCCGGcctCCAtctcctgCAGGtCTAGTCAAAGcctcgtaTACAGTGATGGAAACAcctACTTGAATTGGTTTCAGCAGAGGCCAGGCCAATCTCCAAGGcgcctaATTTATAAGGTTTCTAACTGGGactctGGGGtCCCAGACAGATTCAGCgGCAGTGGGTCAGGCActGATTTCACactGAAAAtCAGCAGGGTGGaggctgaGGATGTTGGGGTTTATTactgCATGCAAGGTATAGTGTGGCCGTGCAGTTTTGGCCAGGGGACCAAGCTGGAGATCAAaCgA436 2C12_LC#1 artificial aaDVVMTQSPLSLPVTLGQPASISCRSSQSLVYSDGNTYLNWFQQRPGQSPRRLIYKVSNWDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQGIVWPCSFGQGTKLEIKR 437 2H12_LC#2 artificial ntGATGTTGTGATGACTCAGTCTCCACTCTCCCTGCCCGTCACCCTTGGACAGCCGGCCTCCATCTCCTGCAGGTCTAGTCAAAGCCTCGTATACAGTGATGGAAACACCTACTTGAATTGGTTTCAGCAGAGGCCAGGCCAATCTCCAAGGCGCCTAATTTATAAGGTTTCTAACTGGGACTCTGGGGTCCCAGACAGAATCAGCGGCAGTGGGTCAGGCACCGATTTCACACTGAAAATCAGCAGGGTGGAGGCTGAGGATGTTGGGGTTTATTACTGCATGCAAGATACACTGTGGCCGTGCAGTTTTGGCCAGGGGACCAAGCTGGAGATCAAACGA438 2H12_LC#2 artificial aaDVVMTQSPLSLPVTLGQPASISCRSSQSLVYSDGNTYLNWFQQRPGQSPRRLIYKVSNWDSGVPDRISGSGSGTDFTLKISRVEAEDVGVYYCMQDTLWPCSFGQGTKLEIKR 439 2G6_LC#1 artificial ntGaTGTTGTGATGACTCagtctccACTCTCCCTGCCCGTCACCCttggacaGCCGGCCTccaTCTCCTGCAGGTCTAGTCAAAGCCTCGTATACAGTGATGGAAACACCTACTTGAATTGGTTTCAGCAGAGGCCAGGCCAATCTCCACGGCGCCTAATTTATCAGGTTTCTAACTGGGACTCTGGGGTCCCAGACAGATTCAGCGGCAGTGGGTCAGGCACTGATTTCACACTGAAAATCAGCAGGGTGGAGGCTGAGGATGTTGGGATTTATTACTGCATGCAAGATACACTGTGGCCGTGCAGTTTTGGCCAGGGGACCAAGCTGGAGATCAAACGA440 2G6_LC#1 artificial aaDVVMTQSPLSLPVTLGQPASISCRSSQSLVYSDGNTYLNWFQQRPGQSPRRLIYQVSNWDSGVPDRFSGSGSGTDFTLKISRVEAEDVGIYYCMQDTLWPCSFGQGTKLEIKR 441 2H12 artificial ntTCCTATGAGCTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGATTGGGGGAAAAATATACTTGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGCCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGACAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCtAGGT 442 2H12artificial aaSYELTQPPSVSVSPGQTASITCSGDRLGEKYTCWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQPMDEADYYCQAWDSSTVVFGGGTKLTVLG 443 2G6 artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTTGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGACAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTAGGT 444 2G6artificial aaSYELTQPPSVSVSPGQTASITCSGDRLGEKYTCWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLG 445 23A10 artificial ntTCCTATGAGCTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGATTGGGGGAGAAATATGTTTGCTGGTATCAGCAGAAGCCAGGCCAGTCCCCTATACTGGTCATCTATCAAGATAATAAGTGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGGAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGACAGCAGCACTGTGGTATTCGGCGGGGGGACCAAGCTGACCGTCCTAGGT 44623A10 artificial aaSYELTQPPSVSVSPGQTASITCSGDRLGEKYVCWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLG 447 5E3 artificial ntTCCTATGAGCTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAAATTGGGGGATGAATATGCTTGCTGGTATCAGCAGAAGCCAGGCCAGTCCCCTGTGCTGGTCATCTATCAAGATAGCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGGAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGACAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTAGGT 448 5E3artificial aaSYELTQPPSVSVSPGQTASITCSGDKLGDEYACWYQQKPGQSPVLVIYQDSKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLG

TABLE 11cHeavy Chain Variable Region Polynucleotide and Amino acid Sequences 13586_HC [hu anti-<huCDH19>4F3 VH]QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYDMDWVRQTPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLRVEDTAVYYCARETGEGWYFDLWGRGTLVTVSS SEQ ID NO: 44913589_HC [hu anti-<huCDH19>4A9 VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWFAYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDFWGQGTLVTVSS SEQ ID NO: 45013590_HC [hu anti-<huCDH19>4B10 VH]QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCARERYFDWSFDYWGQGTLVSVSS SEQ ID NO: 45113874_HC [hu anti-<huCDH19>17H8.2 VH]QVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTALYYCARDSRYRSGWYDAFDIWGQGTMVTVSS SEQ ID NO: 45213875_HC [hu anti-<huCDH19>16C1.1 VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSIDTSKNQFSLTLSSLTAADTAVYFCARDGSSGWYRWFDPWGQGTLVTVSS SEQ ID NO: 45313876_HC [hu anti-<huCDH19>16A4.1 VH]QVQLQESGPGLAKPSETLSLTCTVSGDSITSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDQRRIAAAGTHFYGMDVWGQGTTVTVSS SEQ ID NO: 45413877_HC [hu anti-<huCDH19>22G10.1 VH]EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISSDNSKSTLYLQMNSLRAADTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSS SEQ ID NO: 45513878_HC [hu anti-<huCDH19>20D3.1 VH]QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS SEQ ID NO: 45613879_HC [hu anti-<huCDH19>22D1.1 VH]QVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS SEQ ID NO: 45713880_HC [hu anti-<huCDH19>25F8.1 VH]QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS SEQ ID NO: 45813881_HC [hu anti-<huCDH19>26F12.1 VH]QVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS SEQ ID NO: 45913882_HC [hu anti-<huCDH19>26D1.1 VH]QVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSS SEQ ID NO: 46013883_HC [hu anti-<huCDH19>25G10.1 VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYRWFDPWGQGTLVTVSS SEQ ID NO: 46113885_HC [hu anti-<huCDH19>19B5.1 VH]QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS SEQ ID NO: 46214022_HC [hu anti-<huCDH19>4A2 VH]QVQLQESGPGLVKPSQTLSLTCTVSGGSISSSGYYWSWIRQHPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSVTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSS SEQ ID NO: 46314024_HC [hu anti-<huCDH19>4A2 (1-472)(Q17E, H47P) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSS SEQ ID NO: 46414025_HC [hu anti-<huCDH19>4A2 VH]QVQLQESGPGLVKPSQTLSLTCTVSGGSISSSGYYWSWIRQHPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSS SEQ ID NO: 46514026_HC [hu anti-<huCDH19>4A2 (1-472)(Q17E, H47P) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSS SEQ ID NO: 46614027_HC [hu anti-<huCDH19>4A2 (1-472)(Q17E, H47P, D111E) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAREGSSGWYFQYWGQGTLVTVSS SEQ ID NO: 46714028_HC [hu anti-<huCDH19>4A2 (1-472)(Q17E, H47P, D111E, W134Y) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAREGSSGYYFQYWGQGTLVTVSS SEQ ID NO: 46814029_HC [hu anti-<huCDH19>4A2 VH]QVQLQESGPGLVKPSQTLSLTCTVSGGSISSSGYYWSWIRQHPGKGLEWIGYIYYTGSAYYNPSLKSRV TISVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSS  SEQ ID NO: 469 14030_HC [hu anti-<huCDH19>4F3 (1-471)(R17G) VH]QVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQTPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLRVEDTAVYYCARETGEGWYFDLWGRGTLVTVSS SEQ ID NO: 47014031_HC [hu anti-<huCDH19>4F3 (1-471)(R17G, T47A) VH]QVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLRVEDTAVYYCARETGEGWYFDLWGRGTLVTVSS SEQ ID NO: 47114032_HC [hu anti-<huCDH19>4F3 (1-471)(R17G, T47A, R141Q) VH]QVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLRVEDTAVYYCARETGEGWYFDLWGQGTLVTVSS SEQ ID NO: 47214033_HC [hu anti-<huCDH19>4F3 (1-471)(R17G, T47A, D61E, D72E, R141Q) VH]QVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYEGSNKYYAESVRGRFTISRDNSKNTLFLQMNSLRVEDTAVYYCARETGEGWYFDLWGQGTLVTVSS SEQ ID NO: 47314034_HC [hu anti-<huCDH19>4F3 (1-471)(R17G, T47A, D61E, D72E, W134Y, R141Q) VH]QVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYEGSNKYYAESVRGRFTISRDNSKNTLFLQMNSLRVEDTAVYYCARETGEGYYFDLWGQGTLVTVSS SEQ ID NO: 47414039_HC [hu anti-<huCDH19>2G6 (1-477)(R17G, D61E, D72E, K94N) VH]QVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSSEQ ID NO: 475 14040_HC [hu anti-<huCDH19>16C1.1 VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSIDTSKNQFSLTLSSLTAADTAVYFCARDGSSGWYRWFDPWGQGTLVTVSS SEQ ID NO: 47614041_HC [hu anti-<huCDH19>16C1.1 (1-469)(T92K) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSIDTSKNQFSLKLSSLTAADTAVYFCARDGSSGWYRWFDPWGQGTLVTVSS SEQ ID NO: 47714042_HC [hu anti-<huCDH19>16C1.1 (1-469)(T92K, D109E) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSIDTSKNQFSLKLSSLTAADTAVYFCAREGSSGWYRWFDPWGQGTLVTVSS SEQ ID NO: 47814043_HC [hu anti-<huCDH19>16C1.1 (1-469)(T92K, W132Y, W135Y) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSIDTSKNQFSLKLSSLTAADTAVYFCARDGSSGYYRYFDPWGQGTLVTVSS SEQ ID NO: 47914044_HC [hu anti-<huCDH19>16C1.1 (1-469)(T92K) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSIDTSKNQFSLKLSSLTAADTAVYFCARDGSSGWYRWFDPWGQGTLVTVSS SEQ ID NO: 48014045_HC [hu anti-<huCDH19>17H8.2 VH]QVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTALYYCARDSRYRSGWYDAFDIWGQGTMVTVSS SEQ ID NO: 48114046_HC [hu anti-<huCDH19>17H8.2 (1-471)(D109E) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTALYYCARESRYRSGWYDAFDIWGQGTMVTVSS SEQ ID NO: 48214047_HC [hu anti-<huCDH19>17H8.2 (1-471)(D109E, W132Y) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTALYYCARESRYRSGYYDAFDIWGQGTMVTVSS SEQ ID NO: 48314048_HC [hu anti-<huCDH19>17H8.2 (1-471)(D109E) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTALYYCARESRYRSGWYDAFDIWGQGTMVTVSS SEQ ID NO: 48414049_HC [hu anti-<huCDH19>4F7 VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDYWGQGTLVTVSS SEQ ID NO: 48514050_HC [hu anti-<huCDH19>4F7 VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDYWGQGTLVTVSS SEQ ID NO: 48614051_HC [hu anti-<huCDH19>4F7 (1-468)(W113Y) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTAADTAVYYCARNYAFHFDYWGQGTLVTVSS SEQ ID NO: 48714052_HC [hu anti-<huCDH19>4B10 (1-471)(R17G, D61E, D72E, W134Y) VH]QVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYEGTNEYYAESVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCARERYFDYSFDYWGQGTLVSVSS SEQ ID NO: 48814053_HC [hu anti-<huCDH19>4B10 VH]QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCARERYFDWSFDYWGQGTLVSVSS SEQ ID NO: 48914054_HC [hu anti-<huCDH19>4B10 (1-471)(R17G) VH]QVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCARERYFDWSFDYWGQGTLVSVSS SEQ ID NO: 49014055_HC [hu anti-<huCDH19>4B10 (1-471)(R17G, D61E, D72E) VH]QVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYEGTNEYYAESVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCARERYFDWSFDYWGQGTLVSVSS SEQ ID NO: 49114056_HC [hu anti-<huCDH19>4A9 VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWFAYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDFWGQGTLVTVSS SEQ ID NO: 49214057_HC [hu anti-<huCDH19>4A9 (1-468)(F55I, A56G) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDFWGQGTLVTVSS SEQ ID NO: 49314058_HC [hu anti-<huCDH19>4A9 (1-468)(F55I, A56G) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDFWGQGTLVTVSS SEQ ID NO: 494 14059_HC [hu anti-<huCDH19>4A9 (1-468)(F55I, A56G, W113Y) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTAADTAVYYCARNYAFHFDFWGQGTLVTVSS SEQ ID NO: 49514060_HC [hu anti-<huCDH19>20D3.1 VH]QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS SEQ ID NO: 49614061_HC [hu anti-<huCDH19>20D3.1 VH]QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS SEQ ID NO: 49714062_HC [hu anti-<huCDH19>20D3.1 (1-469)(W133Y) VH]QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLYLHFDYWGQGTLVTVSS SEQ ID NO: 49814063_HC [hu anti-<huCDH19>20D3.1 (1-469)(W133Y) VH]QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLYLHFDYWGQGTLVTVSS SEQ ID NO: 49914064_HC [hu anti-<huCDH19>20D3.1 (1-469)(W133Y) VH]QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLYLHFDYWGQGTLVTVSS SEQ ID NO: 50014065_HC [hu anti-<huCDH19>22G10.1 (1-470)(S82R, A99E) VH]EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSLRAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSS SEQ ID NO: 50114066_HC [hu anti-<huCDH19>22G10.1 (1-470)(A99E, H105Y) VH]EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISSDNSKSTLYLQMNSLRAEDTAVYYCAKGGMGGYYYGMDVWGQGTTVTVSS SEQ ID NO: 50214067_HC [hu anti-<huCDH19>22G10.1 (1-470)(A99E) VH]EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISSDNSKSTLYLQMNSLRAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSS SEQ ID NO: 50314068_HC [hu anti-<huCDH19>22G10.1 (1-470)(A99E) VH]EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISSDNSKSTLYLQMNSLRAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSS SEQ ID NO: 50414069_HC [hu anti-<huCDH19>22G10.1 (1-470)(D72E, A99E) VH]EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYAESVKGRFTISSDNSKSTLYLQMNSLRAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSS SEQ ID NO: 50514070_HC [hu anti-<huCDH19>22G10.1 (1-470)(H105Y) VH]EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISSDNSKSTLYLQMNSLRAADTAVYYCAKGGMGGYYYGMDVWGQGTTVTVSS SEQ ID NO: 50614071_HC [hu anti-<huCDH19>16A4.1 (1-474)(T144L) VH]QVQLQESGPGLAKPSETLSLTCTVSGDSITSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDQRRIAAAGTHFYGMDVWGQGTLVTVSS SEQ ID NO: 50714072_HC [hu anti-<huCDH19>19B5.1 VH]QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS SEQ ID NO: 50814073_HC [hu anti-<huCDH19>19B5.1 (1-469)(W133Y) VH]QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLYLHLDYWGQGTLVTVSS SEQ ID NO: 509 14074_HC [hu anti-<huCDH19>19B5.1 VH]QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS SEQ ID NO: 51014075_HC [hu anti-<huCDH19>19B5.1 VH]QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS SEQ ID NO: 51114076_HC [hu anti-<huCDH19>19B5.1 (1-469)(W133Y) VH]QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLYLHLDYWGQGTLVTVSS SEQ ID NO: 51214077_HC [hu anti-<huCDH19>23A10.3 (1-474)(L92Q) VH]QVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSSEQ ID NO: 51314078_HC [hu anti-<huCDH19>23A10.3 (1-474)(R17G, L92Q) VH]QVQLVESGGGVVQPGGSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSSEQ ID NO: 51414079_HC [hu anti-<huCDH19>23A10.3 (1-474)(R17G, D61E, D72E, L92Q) VH]QVQLVESGGGVVQPGGSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYEGSNKYYAESVKGRFTISRDNSKNTLYLQMNSLRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSSEQ ID NO: 515 14080_HC [hu anti-<huCDH19>23A10.3 VH]QVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLLMNSLRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSSEQ ID NO: 516 14081_HC [hu anti-<huCDH19>25G10.1 VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYRWFDPWGQGTLVTVSS SEQ ID NO: 51714082_HC [hu anti-<huCDH19>25G10.1 (1-469)(D109E, W132Y, W135Y) VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSVDTSKNQFSLKLSSVTAADTAVYYCAREGSSGYYRYFDPWGQGTLVTVSS SEQ ID NO: 51814083_HC [hu anti-<huCDH19>26D1.1 VH]QVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSS SEQ ID NO: 51914084_HC [hu anti-<huCDH19>26D1.1 VH]QVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSS SEQ ID NO: 52014085_HC [hu anti-<huCDH19>26D1.1 VH]QVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSS SEQ ID NO: 52114086_HC [hu anti-<huCDH19>26D1.1 VH]QVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSS SEQ ID NO: 52214087_HC [hu anti-<huCDH19>26D1.1 (1-469)(W133Y) VH]QVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIKLYLHFDYWGQGTLVTVSS SEQ ID NO: 52314088_HC [hu anti-<huCDH19>26D1.1 (1-469)(R27G, G82R) VH]QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSS SEQ ID NO: 52414089_HC [hu anti-<huCDH19>26F12.1 VH]QVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS SEQ ID NO: 52514090_HC [hu anti-<huCDH19>26F12.1 VH]QVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS SEQ ID NO: 52614091_HC [hu anti-<huCDH19>26F12.1 (1-469)(W133Y) VH]QVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIQLYLHFDYWGQGTLVTVSS SEQ ID NO: 52714092_HC [hu anti-<huCDH19>26F12.1 (1-469)(W133Y) VH]QVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIQLYLHFDYWGQGTLVTVSS SEQ ID NO: 52814093_HC [hu anti-<huCDH19>25F8.1 VH]QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS SEQ ID NO: 52914094_HC [hu anti-<huCDH19>25F8.1 VH]QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS SEQ ID NO: 53014095_HC [hu anti-<huCDH19>25F8.1 (1-469)(F90Y) VH]QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS SEQ ID NO: 53114096_HC [hu anti-<huCDH19>25F8.1 (1-469)(F90Y) VH]QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS SEQ ID NO: 53214097_HC [hu anti-<huCDH19>25F8.1 (1-469)(F90Y, W133Y) VH]QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGGIQLYLHFDYWGQGTLVTVSS SEQ ID NO: 53314098_HC [hu anti-<huCDH19>22D1.1 VH]QVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS SEQ ID NO: 53414099_HC [hu anti-<huCDH19>22D1.1 VH]QVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS SEQ ID NO: 53514100_HC [hu anti-<huCDH19>22D1.1 (1-469)(W133Y) VH]QVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLYLHLDYWGQGTLVTVSS SEQ ID NO: 53614101_HC [hu anti-<huCDH19>22D1.1 (1-469)(W133Y) VH]QVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLYLHLDYWGQGTLVTVSS SEQ ID NO: 53714102_HC [hu anti-<huCDH19>22D1.1 (1-469)(F90Y) VH]QVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS SEQ ID NO: 53813591_HC [hu anti-<huCDH19>4F7 VH]QVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDYWGQGTLVTVSS SEQ ID NO: 53914301_HC [hu anti-<huCDH19>2G6 VH]QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSSEQ ID NO: 540 14302_HC [hu anti-<huCDH19>2G6 (1-477)(R17G, K94N) VH]QVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSSEQ ID NO: 541 14303_HC [hu anti-<huCDH19>2G6 (1-477)(D61E, D72E) VH]QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMKSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSSEQ ID NO: 542 14304_HC [hu anti-<huCDH19>2G6 (1-477)(R17G) VH]QVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSSEQ ID NO: 543

TABLE IId Light Chain Variable Region Amino acid Sequences13586_LC [hu anti-<huCDH19>4F3 VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIKR SEQ ID NO: 54413589_LC [hu anti-<huCDH19>4A9 VL]QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQFPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSRLSGWVFGGGTKLTVLG SEQ ID NO: 54513590_LC [hu anti-<huCDH19>4B10 VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYHQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFALTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKR SEQ ID NO: 54613874_LC [hu anti-<huCDH19>17H8.2 VL]DIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLISGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKG SEQ ID NO: 54713875_LC [hu anti-<huCDH19>16C1.1 VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISGLEPEDFAVYHCQQYGNSPLTFGGGTKVEIKR SEQ ID NO: 54813876_LC [hu anti-<huCDH19>16A4.1 VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGTSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPFTFGGGTKVEIKR SEQ ID NO: 54913877_LC [hu anti-<huCDH19>22G10.1 VL]EIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKR SEQ ID NO: 55213878_LC [hu anti-<huCDH19>20D3.1 VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSLNGWVFGGGTKLTVLG SEQ ID NO: 55413879_LC [hu anti-<huCDH19>22D1.1 VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSMNGWVFGGGTKLTVLG SEQ ID NO: 55513880_LC [hu anti-<huCDH19>25F8.1 VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCAAWDDSLNGWVFGGGTKLTVLG SEQ ID NO: 55613881_LC [hu anti-<huCDH19>26F12.1 VL]QSVLTQSPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLG SEQ ID NO: 55713882_LC [hu anti-<huCDH19>26D1.1 VL]HSVLTQSPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLG SEQ ID NO: 55513883_LC [hu anti-<huCDH19>25G10.1 VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYHCQQYGNSPLTFGGGTKVEIKR SEQ ID NO: 55613885_LC [hu anti-<huCDH19>19B5.1 VL]QSALTQPPSTTGTPGQRVTISCSGSRSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSMNGWVFGGGTKLTVLG SEQ ID NO: 55714022_LC [hu anti-<huCDH19>4A2 (1-236)(N30Q) VL]EIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFTVYYCQQYGSSFTFGPGTKVDIKR SEQ ID NO: 55814024_LC [hu anti-<huCDH19>4A2 (1-236)(N30Q, T102A, P141Q) VL]EIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGQGTKVDIKR SEQ ID NO: 55914025_LC [hu anti-<huCDH19>4A2 (1-236)(N30Q, T102A) VL]EIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGPGTKVDIKR SEQ ID NO: 56014026_LC [hu anti-<huCDH19>4A2 (1-236)(N30Q, T102A) VL]EIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGPGTKVDIKR SEQ ID NO: 56114027_LC [hu anti-<huCDH19>4A2 (1-236)(N30Q, T102A, P141Q) VL]EIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGQGTKVDIKR SEQ ID NO: 56214028_LC [hu anti-<huCDH19>4A2 (1-236)(N30Q, T102A, P141Q) VL]EIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGQGTKVDIKR SEQ ID NO: 56314029_LC [hu anti-<huCDH19>4A2 (1-236)(R29Q, N30S) VL]EIVLTQSPGTLSLSPGERATLSCRASQSISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFTVYYCQQYGSSFTFGPGTKVDIKR SEQ ID NO: 56414030_LC [hu anti-<huCDH19>4F3 VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIKR SEQ ID NO: 56514031_LC [hu anti-<huCDH19>4F3 VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIKR SEQ ID NO: 56614032_LC [hu anti-<huCDH19>4F3 VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIKR SEQ ID NO: 56714033_LC [hu anti-<huCDH19>4F3 VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIKR SEQ ID NO: 56814034_LC [hu anti-<huCDH19>4F3 VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIKR SEQ ID NO: 56914039_LC [hu anti-<huCDH19>2G6 (1-234)(C42S, D110E) VL]SYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLG SEQ ID NO: 57014040_LC [hu anti-<huCDH19>16C1.1 (1-235)(H105Y) VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISGLEPEDFAVYYCQQYGNSPLTFGGGTKVEIKR SEQ ID NO: 57114041_LC [hu anti-<huCDH19>16C1.1 (1-235)(H105Y) VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISGLEPEDFAVYYCQQYGNSPLTFGGGTKVEIKR SEQ ID NO: 57214042_LC [hu anti-<huCDH19>16C1.1 (1-235)(H105Y) VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISGLEPEDFAVYYCQQYGNSPLTFGGGTKVEIKR SEQ ID NO: 57314043_LC [hu anti-<huCDH19>16C1.1 (1-235)(H105Y) VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISGLEPEDFAVYYCQQYGNSPLTFGGGTKVEIKR SEQ ID NO: 57414044_LC [hu anti-<huCDH19>16C1.1 (1-235)(G95R, H105Y, G141Q) VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGNSPLTFGQGTKVEIKR SEQ ID NO: 57514045_LC [hu anti-<huCDH19>17118.2 (1-235)(G149R) VL]DIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLISGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKR SEQ ID NO: 57614046_LC [hu anti-<huCDH19>17118.2 (1-235)(G149R) VL]DIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLISGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKR SEQ ID NO: 57714047_LC [hu anti-<huCDH19>17118.2 (1-235)(G149R) VL]DIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLISGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKR SEQ ID NO: 57814048_LC [hu anti-<huCDH19>17118.2 (1-235)(S57Y, G149R) VL]DIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKR SEQ ID NO: 57914049_LC [hu anti-<huCDH19>4F7 (1-239)(H57Y) VL]QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVLG SEQ ID NO: 58014050_LC [hu anti-<huCDH19>4F7 (1-239)(H57Y, D110E) VL]QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYESSLSGWVFGGGTRLTVLG SEQ ID NO: 58114051_LC [hu anti-<huCDH19>4F7 (1-239)(D110E) VL]QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIHGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYESSLSGWVFGGGTRLTVLG SEQ ID NO: 58214052_LC [hu anti-<huCDH19>4B10 (1-236)(H45Q, A90T) VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKR SEQ ID NO: 58314053_LC [hu anti-<huCDH19>4B10 (1-236)(H45Q, A90T) VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKR SEQ ID NO: 58414054_LC [hu anti-<huCDH19>4B10 (1-236)(H45Q, A90T) VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKR SEQ ID NO: 58514055_LC [hu anti-<huCDH19>4B10 (1-236)(H45Q, A90T) VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKR SEQ ID NO: 58614056_LC [hu anti-<huCDH19>4A9 (1-239)(F47L) VL]QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSRLSGWVFGGGTKLTVLG SEQ ID NO: 58714057_LC [hu anti-<huCDH19>4A9 (1-239)(F47L) VL]QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSRLSGWVFGGGTKLTVLG SEQ ID NO: 58814058_LC [hu anti-<huCDH19>4A9 (1-239)(F47L, D110E) VL]QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYESRLSGWVFGGGTKLTVLG SEQ ID NO: 58914059_LC [hu anti-<huCDH19>4A9 (1-239)(F47L, D110E) VL]QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYESRLSGWVFGGGTKLTVLG SEQ ID NO: 59014060_LC [hu anti-<huCDH19>20D3.1 (1-235)(S102A) VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSLNGWVFGGGTKLTVLG SEQ ID NO: 59114061_LC [hu anti-<huCDH19>20D3.1 (1-235)(K45Q, S102A) VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSLNGWVFGGGTKLTVLG SEQ ID NO: 59214062_LC [hu anti-<huCDH19>20D3.1 (1-235)(K45Q, S102A) VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSLNGWVFGGGTKLTVLG SEQ ID NO: 59314063_LC [hu anti-<huCDH19>20D3.1 (1-235)(K45Q, S102A, D111E, N1350) VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDESLQGWVFGGGTKLTVLG SEQ ID NO: 59414064_LC [hu anti-<huCDH19>20D3.1 (1-235)(W109Y) VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATYDDSLNGWVFGGGTKLTVLG SEQ ID NO: 59514065_LC [hu anti-<huCDH19>22G10.1 VL]EIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKR SEQ ID NO: 59614066_LC [hu anti-<huCDH19>22G10.1 VL]EIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKR SEQ ID NO: 59714067_LC [hu anti-<huCDH19>22G10.1 (1-234)(Q97E, S98P) VL]EIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKR SEQ ID NO: 59814068_LC [hu anti-<huCDH19>22G10.1 (1-234)(V78F, Q97E, S98P) VL]EIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKR SEQ ID NO: 59914069_LC [hu anti-<huCDH19>22G10.1 (1-234)(V78F, Q97E, S98P) VL]EIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKR SEQ ID NO: 60014070_LC [hu anti-<huCDH19>22G10.1 VL]EIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKR SEQ ID NO: 60114071_LC [hu anti-<huCDH19>16A4.1 (1-235)(G141Q) VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGTSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPFTFGQGTKVEIKR SEQ ID NO: 60214072_LC [hu anti-<huCDH19>19B5.1 (1-235)(K45Q, S102A) VL]QSALTQPPSTTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSMNGWVFGGGTKLTVLG SEQ ID NO: 60314073_LC [hu anti-<huCDH19>19B5.1 (1-235)(K45Q, S102A) VL]QSALTQPPSTTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSMNGWVFGGGTKLTVLG SEQ ID NO: 60414074_LC [hu anti-<huCDH19>19B5.1 (1-235)(T11V, K45Q, S102A) VL]QSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSMNGWVFGGGTKLTVLG SEQ ID NO: 60514075_LC [hu anti-<huCDH19>19B5.1 (1-235)(T11V, K45Q, S102A, D111E, N135Q) VL]QSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDESMQGWVFGGGTKLTVLG SEQ ID NO: 60614076_LC [hu anti-<huCDH19>19B5.1 (1-235)(T11V, K45Q, S102A, W109Y, D111E, N135Q)VL]QSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATYDESMQGWVFGGGTKLTVLG SEQ ID NO: 60714077_LC [hu anti-<huCDH19>23A10.3 (1-231)(C42S) VL]SYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLG SEQ ID NO: 60814078_LC [hu anti-<huCDH19>23A10.3 (1-231)(C42S) VL]SYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLG SEQ ID NO: 60914079_LC [hu anti-<huCDH19>23A10.3 (1-231)(C42S, D110E) VL]SYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLG SEQ ID NO: 61014080_LC [hu anti-<huCDH19>23A10.3 (1-231)(C42Y) VL]SYELTQPPSVSVSPGQTASITCSGDRLGEKYVYWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLG SEQ ID NO: 61114081_LC [hu anti-<huCDH19>25G10.1 (1-235)(H105Y) VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGNSPLTFGGGTKVEIKR SEQ ID NO: 61214082_LC [hu anti-<huCDH19>25G10.1 (1-235)(H105Y) VL]EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGNSPLTFGGGTKVEIKR SEQ ID NO: 61314083_LC [hu anti-<huCDH19>26D1.1 (1-235)(S7P) VL]HSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLG SEQ ID NO: 61414084_LC [hu anti-<huCDH19>26D1.1 (1-235)(H1Q, S7P) VL]QSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLG SEQ ID NO: 61514085_LC [hu anti-<huCDH19>26D1.1 (1-235)(H1Q, S7P, W109Y) VL]QSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDDSLNGWVFGGGTKLTVLG SEQ ID NO: 61614086_LC [hu anti-<huCDH19>26D1.1 (1-235)(H1Q, S7P, W109Y, D111E, N135Q) VL]QSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDESLQGWVFGGGTKLTVLG SEQ ID NO: 61714087_LC [hu anti-<huCDH19>26D1.1 (1-235)(H1Q, S7P, W109Y, D111E, N135Q) VL]QSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDESLQGWVFGGGTKLTVLG SEQ ID NO: 61814088_LC [hu anti-<huCDH19>26D1.1 (1-235)(H1Q, S7P) VL]QSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLG SEQ ID NO: 61914089_LC [hu anti-<huCDH19>26F12.1 (1-235)(S7P) VL]QSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLG SEQ ID NO: 62014090_LC [hu anti-<huCDH19>26F12.1 (1-235)(S7P, D111E) VL]QSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDESLNGWVFGGGTKLTVLG SEQ ID NO: 62114091_LC [hu anti-<huCDH19>26F12.1 (1-235)(S7P, D111E) VL]QSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDESLNGWVFGGGTKLTVLG SEQ ID NO: 62214092_LC [hu anti-<huCDH19>26F12.1 (1-235)(S7P, W109Y, D111E, N135Q) VL]QSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDESLQGWVFGGGTKLTVLG SEQ ID NO: 62314093_LC [hu anti-<huCDH19>25F8.1 (1-235)(K45Q) VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCAAWDDSLNGWVFGGGTKLTVLG SEQ ID NO: 62414094_LC [hu anti-<huCDH19>25F8.1 (1-235)(K45Q, S102A) VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLNGWVFGGGTKLTVLG SEQ ID NO: 62514095_LC [hu anti-<huCDH19>25F8.1 (1-235)(K45Q, S102A) VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLNGWVFGGGTKLTVLG SEQ ID NO: 62614096_LC [hu anti-<huCDH19>25F8.1 (1-235)(K45Q, S102A, D111E) VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDESLNGWVFGGGTKLTVLG SEQ ID NO: 62714097_LC [hu anti-<huCDH19>25F8.1 (1-235)(K45Q, S102A, D111E, N135Q) VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDESLQGWVFGGGTKLTVLG SEQ ID NO: 62814098_LC [hu anti-<huCDH19>22D1.1 (1-235)(K45Q, S102A) VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSMNGWVFGGGTKLTVLG SEQ ID NO: 62914099_LC [hu anti-<huCDH19>22D1.1 (1-235)(K45Q, S102A, D111E, N1350) VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDESMQGWVFGGGTKLTVLG SEQ ID NO: 63014100_LC [hu anti-<huCDH19>22D1.1 (1-235)(K45Q, S102A, W109Y, D111E, N1350) VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATYDESMQGWVFGGGTKLTVLG SEQ ID NO: 63114101_LC [hu anti-<huCDH19>22D1.1 (1-235)(K45Q, S102A, W109Y) VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATYDDSMNGWVFGGGTKLTVLG SEQ ID NO: 63214102_LC [hu anti-<huCDH19>22D1.1 (1-235)(K45Q, S102A) VL]QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSMNGWVFGGGTKLTVLG SEQ ID NO: 63313591_LC [hu anti-<huCDH19>4F7 VL]QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIHGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVLG SEQ ID NO: 63414301_LC [hu anti-<huCDH19>2G6 (1-234)(D110E) VL]SYELTQPPSVSVSPGQTASITCSGDRLGEKYTCWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLG SEQ ID NO: 63514302_LC [hu anti-<huCDH19>2G6 (1-234)(C42S, D110E) VL]SYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLG SEQ ID NO: 63614303_LC [hu anti-<huCDH19>2G6 (1-234)(C42S, D110E) VL]SYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLG SEQ ID NO: 63714304_LC [hu anti-<huCDH19>23A10.3 (1-231)(C42S) VL]SYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLG SEQ ID NO: 638

Anti-CDH19 Variable and Constant Region Polynucleotide and Amino AcidSequences

TABLE IIIa:Heavy Chain Variable and Contant Region Polynucleotide and Amino acidSequences 2G6CAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAAAAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGCCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 639QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 640 4A2CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACACTGGGAGCGCCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGATGGAAGCAGTGGCTGGTACTTCCAGTATTGGGGCCAGGGCACCCTGGTCACCGTCTCTAGTGCCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 641QVQLQESGPGLVKPSQTLSLTCTVSGGSISSSGYYWSWIRQHPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 642 4A9CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGAAAGGGACTGGAGTGGTTTGCATATTTCTCTTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCTTATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGGAACTGGGCCTTCCACTTTGACTTCTGGGGCCAGGGAACCCTGGTCACCGTCTCTAGTGCCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 643QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWFAYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 644 4B10CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGACATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAACTAATGAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACACTTCCAAGAACACGCTGTATTTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTATATTACTGTGCGAGAGAACGATATTTTGACTGGTCTTTTGACTACTGGGGCCAGGGAACCCTGGTCAGCGTCTCTAGTGCCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 645QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCARERYFDWSFDYWGQGTLVSVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 646 4F3CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCTCCTTCAGTAGCTATGACATGGACTGGGTCCGCCAGACTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAGGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTTTCTGCAAATGAACAGCCTGAGAGTCGAGGACACGGCTGTGTATTACTGTGCGAGAGAAACTGGGGAGGGCTGGTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCTAGTGCCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 647QVQLVESGGGVVQPGRSLRLSCAASGFSFSSYDMDWVRQTPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLRVEDTAVYYCARETGEGWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 648 4F7CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTCCTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGGAACTGGGCCTTCCACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCTAGTGCCTCCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 649QVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 650 16A4CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGCGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGACTCCATCACTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGCGGGAGCACCAATTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGATCAAAGGCGGATAGCAGCAGCTGGTACCCACTTCTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACTGTCTCCTCAGCTTCCACCAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGGGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 651QVQLQESGPGLAKPSETLSLTCTVSGDSITSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDQRRIAAAGTHFYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 652 16C1CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACTTGTACTGTCTCTGGTGGCTCCATCAGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACATTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAATAGACACGTCCAAGAACCAGTTCTCCCTGACGCTGAGCTCTTTGACCGCTGCGGACACGGCCGTGTATTTCTGTGCGAGAGATGGGAGCAGTGGCTGGTACCGGTGGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTTCCACCAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGGGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 653QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSIDTSKNQFSLTLSSLTAADTAVYFCARDGSSGWYRWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 654 17H8CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACGTGCACTGTCTCTGGTGGCTCCATCAATAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACATTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGCGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCCTGTATTACTGTGCGAGAGATTCCCGGTATAGAAGTGGCTGGTACGATGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTCTCTTCAGCTTCCACCAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGGGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 655QVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTALYYCARDSRYRSGWYDAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 656 19B5CAGGTGCAGTTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGTTTCTGGATACACCTTCACCAGCTACTTTATTCACTGGGTGCGCCAGGCCCCTGGACAAGGGCTTGAATGGATGGGAATTATCAACCCTATTAGTGTTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTTCATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGCGAGGGGGGATACAGCTATGGTTACATTTGGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTTCCACCAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGGGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 657QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 658 20D3CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGTTTCTGGATACACCTTCACCAGCTACTTTATTCACTGGGTGCGCCAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTATTAGTGTTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTTCATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGCGAGGGGGGATACAGCTATGGTTACATTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTTCCACCAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGGGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 659QVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 660 22D1CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAGGGTTTCCTGCAAGGTTTCTGGATACACCTTCACCAGCTACTTTATTCACTGGGTACGCCAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTATTAGTGTTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTTCATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGCGAGGGGGGATACAGCTATGGTTACATTTGGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTTCCACCAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGGGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 661QVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 662 22G10GAGGTGCAACTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGTTATGCCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAACTATTAGTGGTGGTGGTGCTAACACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGTGACAATTCCAAGAGCACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGCGGACACGGCCGTATATCACTGTGCGAAAGGGGGAATGGGGGGATACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAGCTTCCACCAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGGGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 663EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISSDNSKSTLYLQMNSLRAADTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 664 23A10CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTCGCTATGGCATACACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCTAATGAACAGCCTGAGAGCCGAGGACTCGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATACCTGGAACTACGGGCTACTACTATGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAGCTTCCACCAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGGGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 665QVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLLMNSLRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 666 25F8CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATTCACTGGGTGCGCCAGGCCCCTGGACAAGGACTTGAGTGGATGGGAATAATCAACCCCAGTGGTGGTAGCACAAGGTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTTCATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGCGAGGGGGAATACAGCTATGGTTACATTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTTCCACCAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGGGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 667QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 668 25G10CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACATTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGATGGGAGCAGTGGCTGGTACCGGTGGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTTCCACCAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGGGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 669QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYRWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG SEQ ID NO: 670 26D1CAGGTGCAGTTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGTAAGGCATCTAGATACACCTTCACCAGCTACTATATGTCCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCCACCCTAGTGGTGGTGACACAACCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCGGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGGGGGATAAAACTATGGTTACATTTTGACTATTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTTCCACCAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGGGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 671QVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 672 26F12CAGGTGCAGTTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTAGATACACCTTCACCAACTACTATATGTCCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTGACTCAACCTACGCACAGAAGTTCCAGGGCAGACTCACCATGACCGGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGGGGGATACAACTATGGTTACATTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTTCCACCAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGGGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAAAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA SEQ ID NO: 673QVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 674 TABLE IIIb:Light Chain Variable and Contant Region Polynucleotide and Amino acidSequences 2G6TCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTTGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGACAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTAGGTCAGCCCAAGGCCAACCCCACTGTCACTCTGTTCCCGCCCTCCTCTGAGGAGCTCCAAGCCAACAAGGCCACACTAGTGTGTCTGATCAGTGACTTCTACCCGGGAGCTGTGACAGTGGCCTGGAAGGCAGATGGCAGCCCCGTCAAGGCGGGAGTGGAGACCACCAAACCCTCCAAACAGAGCAACAACAAGTACGCGGCCAGCAGCTACCTGAGCCTGACGCCCGAGCAGTGGAAGTCCCACAGAAGCTACAGCTGCCAGGTCACGCATGAAGGGAGCACCGTGGAGAAGACAGTGGCCCCTACAGAATGTTCATGA SEQ ID NO: 675SYELTQPPSVSVSPGQTASITCSGDRLGEKYTCWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 676 4A2GAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCGGAATATTAGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTCCATCCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTACAGTGTATTACTGTCAGCAGTATGGTAGCTCATTCACTTTCGGCCCTGGGACCAAAGTGGATATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTGA SEQ ID NO: 677EIVLTQSPGTLSLSPGERATLSCRASRNISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFTVYYCQQYGSSFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GECSEQ ID NO: 678 4A9CAGTCTGTGCTGACGCAGCCGCCCTCAGTGTCTGGGGCCCCAGGACAGAGGGTCACCATCTCCTGCACTGGGAGCAGCTCCAACATCGGGACAGGTTATGCTGTACACTGGTACCAGCAGTTTCCAGGAACAGCCCCCAAACTCCTCATCTATGGTAACAACAATCGGCCCTCAGGGGTTCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCACTGGGCTCCAGGCTGAGGATGAGGCTGATTATTACTGCCAGTCCTATGACAGCAGACTGAGTGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTAGGTCAGCCCAAGGCCAACCCCACTGTCACTCTGTTCCCGCCCTCCTCTGAGGAGCTCCAAGCCAACAAGGCCACACTAGTGTGTCTGATCAGTGACTTCTACCCGGGAGCTGTGACAGTGGCCTGGAAGGCAGATGGCAGCCCCGTCAAGGCGGGAGTGGAGACCACCAAACCCTCCAAACAGAGCAACAACAAGTACGCGGCCAGCAGCTACCTGAGCCTGACGCCCGAGCAGTGGAAGTCCCACAGAAGCTACAGCTGCCAGGTCACGCATGAAGGGAGCACCGTGGAGAAGACAGTGGCCCCTACAGAATGTTCATGASEQ ID NO: 679QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQFPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSRLSGWVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 680 4B10GAAATTGTATTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTAGCAACACCTACTTAGCCTGGTACCATCAGAGACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATCCAGCAGGGCCACTGGCATCCCAGACAGATTCAGTGGCAGTGGGTCTGGGACAGACTTCGCTCTCACCATCAGCAGTCTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTACAGTAACTCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAACGAACTGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTGA SEQ ID NO: 681EIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYHQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFALTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 682 4F3GAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTAGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATCCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAACCTGAGGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTGA SEQ ID NO: 683EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 684 4F7CAGTCTGTGCTGACGCAGCCGCCCTCAGTGTCTGGGGCCCCAGGGCAGAGGGTCACCATCTCCTGCACTGGGAGCAGCTCCAATATCGGGACAGGTTATGATGTACACTGGTATCAGCAGCTTCCAGGAACAGCCCCCAAACTCCTCATCCATGGTAACAGCAATCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCACTGGGCTCCAGGCTGAGGATGAGGCTGATTATTACTGCCAGTCCTATGACAGCAGTCTGAGTGGTTGGGTGTTCGGCGGAGGGACCAGGTTGACCGTCCTAGGTCAGCCCAAGGCCAACCCCACTGTCACTCTGTTCCCGCCCTCCTCTGAGGAGCTCCAAGCCAACAAGGCCACACTAGTGTGTCTGATCAGTGACTTCTACCCGGGAGCTGTGACAGTGGCCTGGAAGGCAGATGGCAGCCCCGTCAAGGCGGGAGTGGAGACCACCAAACCCTCCAAACAGAGCAACAACAAGTACGCGGCCAGCAGCTACCTGAGCCTGACGCCCGAGCAGTGGAAGTCCCACAGAAGCTACAGCTGCCAGGTCACGCATGAAGGGAGCACCGTGGAGAAGACAGTGGCCCCTACAGAATGTTCATGASEQ ID NO: 685QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIHGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 686 16A4GAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTAGCAGCAGTTATTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTACATCCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTATTGTCAGCAGTACGGTAGCTCACCTTTCACTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGAACTGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGTACCGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTGA SEQ ID NO: 687EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGTSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 688 16C1GAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGCCAGAGTGTTAGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTTTGGTGCATCCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCGGACTGGAGCCTGAAGATTTTGCAGTGTATCACTGTCAGCAGTATGGTAACTCACCGCTCACTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGAACTGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGTACCGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTGA SEQ ID NO: 689EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISGLEPEDFAVYHCQQYGNSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 690 17H8GACATTGTATTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTGCCGGCAGCTACCTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTCTGGTGCATCCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAAATCACCGATCACCTTCGGCCAAGGGACACGACTGGAGATGAAAGGAACTGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGTACCGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTGA SEQ ID NO: 691DIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLISGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKGTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 692 19B5CAGTCTGCGCTGACTCAGCCACCCTCAACGACTGGGACCCCCGGGCAGAGGGTCACCATCTCTTGTTCTGGAAGCAGGTCCAACATCGGAAGCAATTTTGTAAACTGGTACAAGCAGCTCCCAGGAACGGCCCCCAAAGTCCTCATCTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGTCTGATTATTACTGCGCAACATGGGATGACAGTATGAATGGTTGGGTGTTCGGCGGAGGGACCAAACTGACCGTCCTAGGTCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCCACCCTCCTCTGAGGAGCTTCAAGCCAACAAGGCCACACTGGTGTGTCTCATAAGTGACTTCTACCCGGGAGCCGTGACAGTGGCCTGGAAGGCAGATAGCAGCCCCGTCAAGGCGGGAGTGGAGACCACCACACCCTCCAAACAAAGCAACAACAAGTACGCGGCCAGCAGCTATCTGAGCCTGACGCCTGAGCAGTGGAAGTCCCACAGAAGCTACAGCTGCCAGGTCACGCATGAAGGGAGCACCGTGGAGAAGACAGTGGCCCCTACAGAATGTTCATGASEQ ID NO: 693QSALTQPPSTTGTPGQRVTISCSGSRSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSMNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 694 20D3CAGTCTGCGCTGACTCAGCCACCCTCAGCGACTGGGACCCCCGGGCAGAGGGTCACCATCTCTTGTTCTGGAAGCAGCTCCAACATCGGAAGCAATTTTGTAAACTGGTACAAGCAGCTCCCAGGAACGGCCCCCAAAGTCCTCATCTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGTCTGATTATTACTGTGCAACATGGGATGACAGCCTGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTAGGTCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCCACCCTCCTCTGAGGAGCTTCAAGCCAACAAGGCCACACTGGTGTGTCTCATAAGTGACTTCTACCCGGGAGCCGTGACAGTGGCCTGGAAGGCAGATAGCAGCCCCGTCAAGGCGGGAGTGGAGACCACCACACCCTCCAAACAAAGCAACAACAAGTACGCGGCCAGCAGCTATCTGAGCCTGACGCCTGAGCAGTGGAAGTCCCACAGAAGCTACAGCTGCCAGGTCACGCATGAAGGGAGCACCGTGGAGAAGACAGTGGCCCCTACAGAATGTTCATGASEQ ID NO: 695QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 696 22D1CAGTCTGCGCTGACTCAGCCACCCTCAGCGACTGGGACCCCCGGGCAGAGGGTCACCATCTCTTGTTCTGGAAGCAGCTCCAACATCGGAAGCAATTTTGTAAACTGGTACAAGCAGCTCCCAGGAACGGCCCCCAAAGTCCTCATCTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGTCTGATTATTACTGTGCAACATGGGATGACAGTATGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTAGGTCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCCACCCTCCTCTGAGGAGCTTCAAGCCAACAAGGCCACACTGGTGTGTCTCATAAGTGACTTCTACCCGGGAGCCGTGACAGTGGCCTGGAAGGCAGATAGCAGCCCCGTCAAGGCGGGAGTGGAGACCACCACACCCTCCAAACAAAGCAACAACAAGTACGCGGCCAGCAGCTATCTGAGCCTGACGCCTGAGCAGTGGAAGTCCCACAGAAGCTACAGCTGCCAGGTCACGCATGAAGGGAGCACCGTGGAGAAGACAGTGGCCCCTACAGAATGTTCATGASEQ ID NO: 697QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSMNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 698 22G10GAAATAGTGATGACGCAGTCTCCAGTCACCCTGTCTCTGTCTCTAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTATTAGCAGCAACTTAGCCTGGTTCCAGCAGAAACCTGGCCAGGCTCCCAGACTCCTCATCTATGGTGCATTTACCAGGGCCACTGGTATCCCAGCCAGGGTCAGTGGCAGTGGGTCTGGGACAGAGTTCACTCTCACCATCAGCAGCCTGCAGTCTGAAGATTTTGCAGTTTATTACTGTCAGCAGTATAATTACTGGCCGCTCACTTTCGGCGGAGGGACCAAGGTGGAGATCAAGCGAACTGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGTACCGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTGA SEQ ID NO: 699EIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 700 23A10TCCTATGAGCTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGATTGGGGGAGAAATATGTTTGCTGGTATCAGCAGAAGCCAGGCCAGTCCCCTATACTGGTCATCTATCAAGATAATAAGTGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGGAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGACAGCAGCACTGTGGTATTCGGCGGGGGGACCAAGCTGACCGTCCTAGGTCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCCACCCTCCTCTGAGGAGCTTCAAGCCAACAAGGCCACACTGGTGTGTCTCATAAGTGACTTCTACCCGGGAGCCGTGACAGTGGCCTGGAAGGCAGATAGCAGCCCCGTCAAGGCGGGAGTGGAGACCACCACACCCTCCAAACAAAGCAACAACAAGTACGCGGCCAGCAGCTATCTGAGCCTGACGCCTGAGCAGTGGAAGTCCCACAGAAGCTACAGCTGCCAGGTCACGCATGAAGGGAGCACCGTGGAGAAGACAGTGGCCCCTACAGAATGTTCATGA SEQ ID NO: 701SYELTQPPSVSVSPGQTASITCSGDRLGEKYVCWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 702 25F8CAGTCTGCGCTGACTCAGCCACCCTCAGCGACTGGGACCCCCGGGCAGAGGGTCACCATCTCTTGTTCTGGAAGCAGCTCCAACATCGGAAGGAATTTTGTAAACTGGTATAAGCAGCTCCCAGGAACGGCCCCCAAAGTCCTCATTTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGTCTGATTATTACTGTGCAGCATGGGATGACAGCCTGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTAGGTCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCCACCCTCCTCTGAGGAGCTTCAAGCCAACAAGGCCACACTGGTGTGTCTCATAAGTGACTTCTACCCGGGAGCCGTGACAGTGGCCTGGAAGGCAGATAGCAGCCCCGTCAAGGCGGGAGTGGAGACCACCACACCCTCCAAACAAAGCAACAACAAGTACGCGGCCAGCAGCTATCTGAGCCTGACGCCTGAGCAGTGGAAGTCCCACAGAAGCTACAGCTGCCAGGTCACGCATGAAGGGAGCACCGTGGAGAAGACAGTGGCCCCTACAGAATGTTCATGASEQ ID NO: 703QSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCAAWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 704 25G10GAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTAGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTTTGGTGCATCCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATCACTGTCAGCAGTATGGTAACTCACCGCTCACTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGAACTGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGTACCGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTGA SEQ ID NO: 705EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYHCQQYGNSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 706 26D1CACTCTGTGCTGACTCAGTCACCCTCAGCGTCTGGGACCCCCGGACAGAGGGTCACCATCTCTTGTTCTGGAAGCCGCTCCAACATCGGAAGTAATTTTGTAAACTGGTACCAGCAGCTCCCAGGAACGGCCCCCAAACTCCTCATCTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGGCTGATTATTACTGTGCAGTATGGGATGACAGCCTGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTAGGTCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCCACCCTCCTCTGAGGAGCTTCAAGCCAACAAGGCCACACTGGTGTGTCTCATAAGTGACTTCTACCCGGGAGCCGTGACAGTGGCCTGGAAGGCAGATAGCAGCCCCGTCAAGGCGGGAGTGGAGACCACCACACCCTCCAAACAAAGCAACAACAAGTACGCGGCCAGCAGCTATCTGAGCCTGACGCCTGAGCAGTGGAAGTCCCACAGAAGCTACAGCTGCCAGGTCACGCATGAAGGGAGCACCGTGGAGAAGACAGTGGCCCCTACAGAATGTTCATGA SEQ ID NO: 707HSVLTQSPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 708 26F12CAGTCTGTGCTGACTCAGTCACCCTCAGCGTCTGGGACCCCCGGGCAGAAGGTCACCATCTCTTGTTCTGGAAGCCGCTCCAACATCGGAAGTAATTTTGTAAACTGGTACCAGCAGCTCCCAGGAACGGCCCCCAAACTCCTCATCTATACTAATTATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGGCTGATTATTACTGTGCAGTATGGGATGACAGCCTGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTAGGTCAGCCCAAGGCTGCCCCCTCGGTCACTCTGTTCCCACCCTCCTCTGAGGAGCTTCAAGCCAACAAGGCCACACTGGTGTGTCTCATAAGTGACTTCTACCCGGGAGCCGTGACAGTGGCCTGGAAGGCAGATAGCAGCCCCGTCAAGGCGGGAGTGGAGACCACCACACCCTCCAAACAAAGCAACAACAAGTACGCGGCCAGCAGCTATCTGAGCCTGACGCCTGAGCAGTGGAAGTCCCACAGAAGCTACAGCTGCCAGGTCACGCATGAAGGGAGCACCGTGGAGAAGACAGTGGCCCCTACAGAATGTTCATGA SEQ ID NO: 709QSVLTQSPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 710 TABLE IIIc:Heavy Chain Variable and Contant Region Polynucleotide and Aminoacid Sequences 13586_HC [hu anti-<huCDH19>4F3 VH]::huIgG1zQVQLVESGGGVVQPGRSLRLSCAASGFSFSSYDMDWVRQTPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLRVEDTAVYYCARETGEGWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 71113589_HC [hu anti-<huCDH19>4A9 VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWFAYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 71213590_HC [hu anti-<huCDH19>4B10 VH]::huIgG1zQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCARERYFDWSFDYWGQGTLVSVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 71313874_HC [hu anti-<huCDH19>17H8.2 VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTALYYCARDSRYRSGWYDAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 71413875_HC [hu anti-<huCDH19>16C1.1 VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSIDTSKNQFSLTLSSLTAADTAVYFCARDGSSGWYRWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 71513876_HC [hu anti-<huCDH19>16A4.1 VH]::huIgG1zQVQLQESGPGLAKPSETLSLTCTVSGDSITSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDQRRIAAAGTHFYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 71613877_HC [hu anti-<huCDH19>22G10.1 VH]::huIgG1zEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISSDNSKSTLYLQMNSLRAADTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 71713878_HC [hu anti-<huCDH19>20D3.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 7181387911C [hu anti-<huCDH19>22D1.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 71913880_HC [hu anti-<huCDH19>25F8.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 72013881_HC [hu anti-<huCDH19>26F12.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 72113882_HC [hu anti-<huCDH19>26D1.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 72213883_HC [hu anti-<huCDH19>25G10.1 VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYRWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 72313885_HC [hu anti-<huCDH19>19B5.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 72414022_HC [hu anti-<huCDH19>4A2 VH]::huIgG1zQVQLQESGPGLVKPSQTLSLTCTVSGGSISSSGYYWSWIRQHPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 72514024_HC [hu anti-<huCDH19>4A2 (1-472)(Q17E, H47P) VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 72614025_HC [hu anti-<huCDH19>4A2 VH]::huIgG1zQVQLQESGPGLVKPSQTLSLTCTVSGGSISSSGYYWSWIRQHPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 72714026_HC [hu anti-<huCDH19>4A2 (1-472)(Q17E, H47P) VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 72814027_HC [hu anti-<huCDH19>4A2 (1-472)(Q17E, H47P, D111E) VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAREGSSGWYFQYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 72914028_HC [hu anti-<huCDH19>4A2 (1-472)(Q17E, H47P, D111E, W134Y)VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAREGSSGYYFQYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 73014029_HC [hu anti-<huCDH19>4A2 VH]::huIgG1zQVQLQESGPGLVKPSQTLSLTCTVSGGSISSSGYYWSWIRQHPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 73114030_HC [hu anti-<huCDH19>4F3 (1-471)(R17G) VH]::huIgG1zQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQTPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLRVEDTAVYYCARETGEGWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 73214031_HC [hu anti-<huCDH19>4F3 (1-471)(R17G, T47A) VH]::huIgG1zQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLRVEDTAVYYCARETGEGWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 73314032_HC [hu anti-<huCDH19>4F3 (1-471)(R17G, T47A, R141Q) VH]::huIgG1zQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLRVEDTAVYYCARETGEGWYFDLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 73414033_HC [hu anti-<huCDH19>4F3 (1-471)(R17G, T47A, D61E, D72E, R141Q)VH]::huIgG1zQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYEGSNKYYAESVRGRFTISRDNSKNTLFLQMNSLRVEDTAVYYCARETGEGWYFDLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 73514034_HC [hu anti-<huCDH19>4F3 (1-471)(R17G, T47A, D61E, D72E, W134Y,R1410) VH]::huIgG1zQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYEGSNKYYAESVRGRFTISRDNSKNTLFLQMNSLRVEDTAVYYCARETGEGYYFDLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 73614039_HC [hu anti-<huCDH19>2G6 (1-477)(R17G, D61E, D72E, K94N)VH]::huIgG1zQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 73714040_HC [hu anti-<huCDH19>16C1.1 VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSIDTSKNQFSLTLSSLTAADTAVYFCARDGSSGWYRWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 73814041_HC [hu anti-<huCDH19>16C1.1 (1-469)(T92K) VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSIDTSKNQFSLKLSSLTAADTAVYFCARDGSSGWYRWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 73914042_HC [hu anti-<huCDH19>16C1.1 (1-469)(T92K, D109E) VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSIDTSKNQFSLKLSSLTAADTAVYFCAREGSSGWYRWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 74014043_HC [hu anti-<huCDH19>16C1.1 (1-469)(T92K, W132Y, W135Y) VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSIDTSKNQFSLKLSSLTAADTAVYFCARDGSSGYYRYFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 74114044_HC [hu anti-<huCDH19>16C1.1 (1-469)(T92K) VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSIDTSKNQFSLKLSSLTAADTAVYFCARDGSSGWYRWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 74214045_HC [hu anti-<huCDH19>17H8.2 VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTALYYCARDSRYRSGWYDAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 74314046_HC [hu anti-<huCDH19>17H8.2 (1-471)(D109E) VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTALYYCARESRYRSGWYDAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 74414047_HC [hu anti-<huCDH19>17H8.2 (1-471)(D109E, W132Y) VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTALYYCARESRYRSGYYDAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 74514048_HC [hu anti-<huCDH19>17H8.2 (1-471)(D109E) VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTALYYCARESRYRSGWYDAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 74614049_HC [hu anti-<huCDH19>4F7 VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 74714050_HC [hu anti-<huCDH19>4F7 VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 74814051_HC [hu anti-<huCDH19>4F7 (1-468)(W113Y) VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTAADTAVYYCARNYAFHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 74914052_HC [hu anti-<huCDH19>4B10 (1-471)(R17G, D61E, D72E, W134Y)VH]::huIgG1zQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYEGTNEYYAESVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCARERYFDYSFDYWGQGTLVSVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 75014053_HC [hu anti-<huCDH19>4B10 VH]::huIgG1zQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCARERYFDWSFDYWGQGTLVSVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 75114054_HC [hu anti-<huCDH19>4B10 (1-471)(R17G) VH]::huIgG1zQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCARERYFDWSFDYWGQGTLVSVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 75214055_HC [hu anti-<huCDH19>4B10 (1-471)(R17G, D61E, D72E) VH]::huIgG1zQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYEGTNEYYAESVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCARERYFDWSFDYWGQGTLVSVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 75314056_HC [hu anti-<huCDH19>4A9 VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWFAYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 75414057_HC [hu anti-<huCDH19>4A9 (1-468)(F55I, A56G) VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 75514058_HC [hu anti-<huCDH19>4A9 (1-468)(F55I, A56G) VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 75614059_HC [hu anti-<huCDH19>4A9 (1-468)(F55I, A56G, W113Y) VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTAADTAVYYCARNYAFHFDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 75714060_HC [hu anti-<huCDH19>20D3.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 75814061_HC [hu anti-<huCDH19>20D3.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 75914062_HC [hu anti-<huCDH19>20D3.1 (1-469)(W133Y) VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLYLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 76014063_HC [hu anti-<huCDH19>20D3.1 (1-469)(W133Y) VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLYLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 76114064_HC [hu anti-<huCDH19>20D3.1 (1-469)(W133Y) VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLYLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 76214065_HC [hu anti-<huCDH19>22G10.1 (1-470)(S82R, A99E) VH]::huIgG1zEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSLRAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 76314066_HC [hu anti-<huCDH19>22G10.1 (1-470)(A99E, H105Y) VH]::huIgG1zEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISSDNSKSTLYLQMNSLRAEDTAVYYCAKGGMGGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 76414067_HC [hu anti-<huCDH19>22G10.1 (1-470)(A99E) VH]::huIgG1zEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISSDNSKSTLYLQMNSLRAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 76514068_HC [hu anti-<huCDH19>22G10.1 (1-470)(A99E) VH]::huIgG1zEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISSDNSKSTLYLQMNSLRAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 76614069_HC [hu anti-<huCDH19>22G10.1 (1-470)(D72E, A99E) VH]::huIgG1zEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYAESVKGRFTISSDNSKSTLYLQMNSLRAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 76714070_HC [hu anti-<huCDH19>22G10.1 (1-470)(H105Y) VH]::huIgG1zEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISSDNSKSTLYLQMNSLRAADTAVYYCAKGGMGGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 76814071_HC [hu anti-<huCDH19>16A4.1 (1-474)(T144L) VH]::huIgG1zQVQLQESGPGLAKPSETLSLTCTVSGDSITSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDQRRIAAAGTHFYGMDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 76914072_HC [hu anti-<huCDH19>19B5.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 77014073_HC [hu anti-<huCDH19>19B5.1 (1-469)(W133Y) VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLYLHLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 77114074_HC [hu anti-<huCDH19>19B5.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 77214075_HC [hu anti-<huCDH19>19B5.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 77314076_HC [hu anti-<huCDH19>19B5.1 (1-469)(W133Y) VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLYLHLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 77414077_HC [hu anti-<huCDH19>23A10.3 (1-474)(L92Q) VH]::huIgG1zQVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 77514078_HC [hu anti-<huCDH19>23A10.3 (1-474)(R17G, L92Q) VH]::huIgG1zQVQLVESGGGVVQPGGSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 77614079_HC [hu anti-<huCDH19>23A10.3 (1-474)(R17G, D61E, D72E, L92Q)VH]::huIgG1zQVQLVESGGGVVQPGGSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYEGSNKYYAESVKGRFTISRDNSKNTLYLQMNSLRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 77714080_HC [hu anti-<huCDH19>23A10.3 VH]::huIgG1zQVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLLMNSLRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 77814081_HC [hu anti-<huCDH19>25G10.1 VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSVDTSKNQFSLKLSSVTAADTAVYYCARDGSSGWYRWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 77914082_HC [hu anti-<huCDH19>25G10.1 (1-469)(D109E, W132Y, W135Y)VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSVDTSKNQFSLKLSSVTAADTAVYYCAREGSSGYYRYFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 78014083_HC [hu anti-<huCDH19>26D1.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 78114084_HC [hu anti-<huCDH19>26D1.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 78214085_HC [hu anti-<huCDH19>26D1.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 78314086_HC [hu anti-<huCDH19>26D1.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 78414087_HC [hu anti-<huCDH19>26D1.1 (1-469)(W133Y) VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIKLYLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 78514088_HC [hu anti-<huCDH19>26D1.1 (1-469)(R27G, G82R) VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 78614089_HC [hu anti-<huCDH19>26F12.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 78714090_HC [hu anti-<huCDH19>26F12.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 78814091_HC [hu anti-<huCDH19>26F12.1 (1-469)(W133Y) VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIQLYLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 78914092_HC [hu anti-<huCDH19>26F12.1 (1-469)(W133Y) VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSLRSEDTAVYYCARGGIQLYLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 79014093_HC [hu anti-<huCDH19>25F8.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 79114094_HC [hu anti-<huCDH19>25F8.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 79214095_HC [hu anti-<huCDH19>25F8.1 (1-469)(F90Y) VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 79314096_HC [hu anti-<huCDH19>25F8.1 (1-469)(F90Y) VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 79414097_HC [hu anti-<huCDH19>25F8.1 (1-469)(F90Y, W133Y) VH]::huIgG1zQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGGIQLYLHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 79514098_HC [hu anti-<huCDH19>22D1.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 79614099_HC [hu anti-<huCDH19>22D1.1 VH]::huIgG1zQVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 79714100_HC [hu anti-<huCDH19>22D1.1 (1-469)(W133Y) VH]::huIgG1zQVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLYLHLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 79814101_HC [hu anti-<huCDH19>22D1.1 (1-469)(W133Y) VH]::huIgG1zQVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLRSEDTAVYYCARGGIQLYLHLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 79914102_HC [hu anti-<huCDH19>22D1.1 (1-469)(F90Y) VH]::huIgG1zQVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 80013591_HC [hu anti-<huCDH19>4F7 VH]::huIgG1zQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTAADTAVYYCARNWAFHFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 80114301_HC [hu anti-<huCDH19>2G6 VH]::huIgG1zQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 80214302_HC [hu anti-<huCDH19>2G6 (1-477)(R17G, K94N) VH]::huIgG1zQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 80314303_HC [hu anti-<huCDH19>2G6 (1-477)(D61E, D72E) VH]::huIgG1zQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMKSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 80414304_HC [hu anti-<huCDH19>2G6 (1-477)(R17G) VH]::huIgG1zQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK SEQ ID NO: 805

TABLE IIIdLight Chain Variable and Contant Region Polynucleotide and Aminoacid Sequences 13586_LC [hu anti-<huCDH19>4F3 VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 806 13589_LC [hu anti-<huCDH19>4A9 VL]::huLLC-C1QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQFPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSRLSGWVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 807 13590_LC [hu anti-<huCDH19>4B10 VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYHQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFALTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 808 13874_LC [hu anti-<huCDH19>17H8.2 VL]::huKLCDIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLISGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKGTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 809 13875_LC [hu anti-<huCDH19>16C1.1 VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISGLEPEDFAVYHCQQYGNSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 810 13876_LC [hu anti-<huCDH19>16A4.1 VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGTSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 811 13877_LC [hu anti-<huCDH19>22G10.1 VL]::huKLCEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 812 13878_LC [hu anti-<huCDH19>20D3.1 VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 813 13879_LC [hu anti-<huCDH19>22D1.1 VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSMNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 814 13880_LC [hu anti-<huCDH19>25F8.1 VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCAAWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 81513881_LC [hu anti-<huCDH19>26F12.1 VL]::huLLC-C2QSVLTQSPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 816 13882_LC [hu anti-<huCDH19>26D1.1 VL]::huLLC-C2HSVLTQSPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 817 13883_LC [hu anti-<huCDH19>25G10.1 VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYHCQQYGNSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 818 13885_LC [hu anti-<huCDH19>19B5.1 VL]::huLLC-C2QSALTQPPSTTGTPGQRVTISCSGSRSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSMNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 81914022_LC [hu anti-<huCDH19>4A2 (1-236)(N30Q) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFTVYYCQQYGSSFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GECSEQ ID NO: 82014024_LC [hu anti-<huCDH19>4A2 (1-236)(N30Q, T102A, P141Q) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGQGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GECSEQ ID NO: 82114025_LC [hu anti-<huCDH19>4A2 (1-236)(N30Q, T102A) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GECSEQ ID NO: 82214026_LC [hu anti-<huCDH19>4A2 (1-236)(N30Q, T102A) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GECSEQ ID NO: 82314027_LC [hu anti-<huCDH19>4A2 (1-236)(N30Q, T102A, P141Q) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGQGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GECSEQ ID NO: 82414028_LC [hu anti-<huCDH19>4A2 (1-236)(N30Q, T102A, P141Q) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGQGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GECSEQ ID NO: 82514029_LC [hu anti-<huCDH19>4A2 (1-236)(R29Q, N30S) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFTVYYCQQYGSSFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR GECSEQ ID NO: 826 14030_LC [hu anti-<huCDH19>4F3 VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 827 14031_LC [hu anti-<huCDH19>4F3 VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 828 14032_LC [hu anti-<huCDH19>4F3 VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 829 14033_LC [hu anti-<huCDH19>4F3 VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 830 14034_LC [hu anti-<huCDH19>4F3 VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 83114039_LC [hu anti-<huCDH19>2G6 (1-234)(C42S, D110E) VL]::huLLC-C1SYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 83214040_LC [hu anti-<huCDH19>16C1.1 (1-235)(H105Y) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISGLEPEDFAVYYCQQYGNSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 83314041_LC [hu anti-<huCDH19>16C1.1 (1-235)(H105Y) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISGLEPEDFAVYYCQQYGNSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 83414042_LC [hu anti-<huCDH19>16C1.1 (1-235)(H105Y) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISGLEPEDFAVYYCQQYGNSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 83514043_LC [hu anti-<huCDH19>16C1.1 (1-235)(H105Y) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISGLEPEDFAVYYCQQYGNSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 83614044_LC [hu anti-<huCDH19>16C1.1 (1-235)(G95R, H105Y, G141Q) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGNSPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 83714045_LC [hu anti-<huCDH19>17H8.2 (1-235)(G149R) VL]::huKLCDIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLISGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 83814046_LC [hu anti-<huCDH19>17H8.2 (1-235)(G149R) VL]::huKLCDIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLISGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 83914047_LC [hu anti-<huCDH19>17H8.2 (1-235)(G149R) VL]::huKLCDIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLISGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 84014048_LC [hu anti-<huCDH19>17H8.2 (1-235)(S57Y, G149R) VL]::huKLCDIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 84114049_LC [hu anti-<huCDH19>4F7 (1-239)(H57Y) VL]::huLLC-C2QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 84214050_LC [hu anti-<huCDH19>4F7 (1-239)(H57Y, D110E) VL]::huLLC-C2QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYESSLSGWVFGGGTRLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 84314051_LC [hu anti-<huCDH19>4F7 (1-239)(D110E) VL]::huLLC-C2QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIHGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYESSLSGWVFGGGTRLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 84414052_LC [hu anti-<huCDH19>4B10 (1-236)(H45Q, A90T) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 84514053_LC [hu anti-<huCDH19>4B10 (1-236)(H45Q, A90T) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 84614054_LC [hu anti-<huCDH19>4B10 (1-236)(H45Q, A90T) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 84714055_LC [hu anti-<huCDH19>4B10 (1-236)(H45Q, A90T) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 84814056_LC [hu anti-<huCDH19>4A9 (1-239)(F47L) VL]::huLLC-C1QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSRLSGWVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 84914057_LC [hu anti-<huCDH19>4A9 (1-239)(F47L) VL]::huLLC-C1QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSRLSGWVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 85014058_LC [hu anti-<huCDH19>4A9 (1-239)(F47L, D110E) VL]::huLLC-C1QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYESRLSGWVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 85114059_LC [hu anti-<huCDH19>4A9 (1-239)(F47L, D110E) VL]::huLLC-C1QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYESRLSGWVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 85214060_LC [hu anti-<huCDH19>20D3.1 (1-235)(S102A) VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 85314061_LC [hu anti-<huCDH19>20D3.1 (1-235)(K45Q, S102A) VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 85414062_LC [hu anti-<huCDH19>20D3.1 (1-235)(K450, S102A) VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 85514063_LC [hu anti-<huCDH19>20D3.1 (1-235)(K45Q, S102A, D111E, N1350) VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDESLQGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 85614064_LC [hu anti-<huCDH19>20D3.1 (1-235)(W109Y) VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATYDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 857 14065_LC [hu anti-<huCDH19>22G10.1 VL]::huKLCEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 858 14066_LC [hu anti-<huCDH19>22G10.1 VL]::huKLCEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 85914067_LC [hu anti-<huCDH19>22G10.1 (1-234)(Q97E, S98P) VL]::huKLCEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 86014068_LC [hu anti-<huCDH19>22G10.1 (1-234)(V78F, Q97E, S98P) VL]::huKLCEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 86114069_LC [hu anti-<huCDH19>22G10.1 (1-234)(V78F, Q97E, S98P) VL]::huKLCEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 862 14070_LC [hu anti-<huCDH19>22G10.1 VL]::huKLCEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 86314071_LC [hu anti-<huCDH19>16A4.1 (1-235)(G141Q) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGTSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPFTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 86414072_LC [hu anti-<huCDH19>19B5.1 (1-235)(K45Q, S102A) VL]::huLLC-C2QSALTQPPSTTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSMNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 86514073_LC [hu anti-<huCDH19>19B5.1 (1-235)(K45Q, S102A) VL]::huLLC-C2QSALTQPPSTTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSMNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 86614074_LC [hu anti-<huCDH19>19B5.1 (1-235)(T11V, K45Q, S102A) VL]::huLLC-C2QSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSMNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 86714075_LC [hu anti-<huCDH19>19B5.1 (1-235)(T11V, K45Q, S102A, D111E, N135Q) VL]::huLLC-C2QSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDESMQGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 86814076_LC [hu anti-<huCDH19>19B5.1 (1-235)(T11V, K45Q, S102A, W109Y, D111E,N135Q) VL]::huLLC-C2QSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATYDESMQGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 86914077_LC [hu anti-<huCDH19>23A10.3 (1-231)(C42S) VL]::huLLC-C2SYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 87014078_LC [hu anti-<huCDH19>23A10.3 (1-231)(C42S) VL]::huLLC-C2SYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 87114079_LC [hu anti-<huCDH19>23A10.3 (1-231)(C42S, D110E) VL]::huLLC-C2SYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 87214080_LC [hu anti-<huCDH19>23A10.3 (1-231)(C42Y) VL]::huLLC-C2SYELTQPPSVSVSPGQTASITCSGDRLGEKYVYWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 87314081_LC [hu anti-<huCDH19>25G10.1 (1-235)(H105Y) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGNSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 87414082_LC [hu anti-<huCDH19>25G10.1 (1-235)(H105Y) VL]::huKLCEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGNSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC SEQ ID NO: 87514083_LC [hu anti-<huCDH19>26D1.1 (1-235)(S7P) VL]::huLLC-C2HSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 87614084_LC [hu anti-<huCDH19>26D1.1 (1-235)(H1Q, S7P) VL]::huLLC-C2QSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 87714085_LC [hu anti-<huCDH19>26D1.1 (1-235)(H1Q, S7P, W109Y) VL]::huLLC-C2QSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 87814086_LC [hu anti-<huCDH19>26D1.1 (1-235)(H1Q, S7P, W109Y, D111E, N135Q) VL]::huLLC-C2QSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDESLQGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 87914087_LC [hu anti-<huCDH19>26D1.1 (1-235)(H1Q, S7P, W109Y, D111E, N135Q) VL]::huLLC-C2QSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDESLQGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 88014088_LC [hu anti-<huCDH19>26D1.1 (1-235)(H1Q, S7P) VL]::huLLC-C2QSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 88114089_LC [hu anti-<huCDH19>26F12.1 (1-235)(S7P) VL]::huLLC-C2QSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 88214090_LC [hu anti-<huCDH19>26F12.1 (1-235)(S7P, D111E) VL]::huLLC-C2QSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDESLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 88314091_LC [hu anti-<huCDH19>26F12.1 (1-235)(S7P, D111E) VL]::huLLC-C2QSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDESLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 88414092_LC [hu anti-<huCDH19>26F12.1 (1-235)(S7P, W109Y, D111E, N135Q) VL]::huLLC-C2QSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDESLQGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 88514093_LC [hu anti-<huCDH19>25F8.1 (1-235)(K45Q) VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCAAWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 88614094_LC [hu anti-<huCDH19>25F8.1 (1-235)(K45Q, S102A) VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 88714095_LC [hu anti-<huCDH19>25F8.1 (1-235)(K45Q, S102A) VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 88814096_LC [hu anti-<huCDH19>25F8.1 (1-235)(K45Q, S102A, D111E) VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDESLNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 88914097_LC [hu anti-<huCDH19>25F8.1 (1-235)(K45Q, S102A, D111E, N135Q) VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDESLQGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 89014098_LC [hu anti-<huCDH19>22D1.1 (1-235)(K45Q, S102A) VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSMNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 89114099_LC [hu anti-<huCDH19>22D1.1 (1-235)(K45Q, S102A, D111E, N135Q) VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDESMQGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 89214100_LC [hu anti-<huCDH19>22D1.1 (1-235)(K45Q, S102A, W109Y, D111E, N135Q) VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATYDESMQGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 89314101_LC [hu anti-<huCDH19>22D1.1 (1-235)(K45Q, S102A, W109Y ) VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATYDDSMNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 89414102_LC [hu anti-<huCDH19>22D1.1 (1-235)(K45Q, S102A) VL]::huLLC-C2QSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSMNGWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 895 13591_LC [hu anti-<huCDH19>4F7 VL]::huLLC-C1QSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIHGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 89614301_LC [hu anti-<huCDH19>2G6 (1-234)(D110E) VL]::huLLC-C1SYELTQPPSVSVSPGQTASITCSGDRLGEKYTCWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 89714302_LC [hu anti-<huCDH19>2G6 (1-234)(C42S, D110E) VL]::huLLC-C1SYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 89814303_LC [hu anti-<huCDH19>2G6 (1-234)(C42S, D110E) VL]::huLLC-C1SYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKETVEGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 89914304_LC [hu anti-<huCDH19>23A10.3 (1-231)(C42S) VL]::huLLC-C2SYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKETVEGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS SEQ ID NO: 900

TABLE IVa HEAVY CHAIN CDRs Ab Type CDR 1 CDR 2 CDR 3 14039 AA SYGMHFIWYEGSNKYYAESVKD RAGIIGTIGYYYGMDV 14303 SEQ ID NO: 28 SEQ ID NO: 901SEQ ID NO: 30 14027 AA SSGYYWS YIYYTGSAYYNPSLKS EGSSGWYFQY SEQ ID NO: 46SEQ ID NO: 47 SEQ ID NO: 902 14028 AA SSGYYWS YIYYTGSAYYNPSLKSEGSSGYYFQY SEQ ID NO: 46 SEQ ID NO: 47 SEQ ID NO: 903 14059 AA GYYWSYFSYSGSTNYNPSLKS NYAFHFDF SEQ ID NO: 52 SEQ ID NO: 53 SEQ ID NO: 90414052 AA SYDMH VISYEGTNEYYAESVKG ERYFDYSFDY SEQ ID NO: 58 SEQ ID NO: 905SEQ ID NO: 906 14055 AA SYDMH VISYEGTNEYYAESVKG ERYFDWSFDY SEQ ID NO: 58SEQ ID NO: 905 SEQ ID NO: 60 14033 AA SYDMD VIWYEGSNKYYAESVRG ETGEGWYFDLSEQ ID NO: 70 SEQ ID NO: 907 SEQ ID NO: 72 14034 AA SYDMDVIWYEGSNKYYAESVRG ETGEGYYFDL SEQ ID NO: 70 SEQ ID NO: 907 SEQ ID NO: 90814051 AA SYSWS YIYYSGSTNYNPSLKS NYAFHFDY SEQ ID NO: 82 SEQ ID NO: 83SEQ ID NO: 909 14046 AA SYYWS YIYYIGSTNYNPSLKS ESRYRSGWYDAFDI 14048SEQ ID NO: 94 SEQ ID NO: 95 SEQ ID NO: 910 14047 AA SYYWSYIYYIGSTNYNPSLKS ESRYRSGYYDAFDI SEQ ID NO: 94 SEQ ID NO: 95SEQ ID NO: 911 14042 AA GYYWS YIYYIGSTNYNPSLKS EGSSGWYRWFDPSEQ ID NO: 100 SEQ ID NO: 101 SEQ ID NO: 912 14043 AA GYYWSYIYYIGSTNYNPSLKS DGSSGYYRYFDP SEQ ID NO: 100 SEQ ID NO: 101SEQ ID NO: 913 14069 AA SYAMN TISGGGANTYYAESVKG GGMGGYYYGMDVSEQ ID NO: 118 SEQ ID NO: 914 SEQ ID NO: 120 14062 AA SYFIHIINPISVSTSYAQKFQG GGIQLYLHFDY 14063 SEQ ID NO: 124 SEQ ID NO: 125SEQ ID NO: 915 14064 14100 AA SYFIH IINPISVSTSYAQKFQG GGIQLYLHLDY 14101SEQ ID NO: 130 SEQ ID NO: 131 SEQ ID NO: 916 14097 AA SYYIHIINPSGGSTRYAQKFQG GGIQLYLHFDY SEQ ID NO: 136 SEQ ID NO: 137SEQ ID NO: 917 14091 AA NYYMS IINPSGGDSTYAQKFQG GGIQLYLHFDY 14092SEQ ID NO: 142 SEQ ID NO: 143 SEQ ID NO: 918 14087 AA SYYMSIIHPSGGDTTYAQKFQG GGIKLYLHFDY SEQ ID NO: 148 SEQ ID NO: 149SEQ ID NO: 919 14082 AA GYYWS YIYYIGSTNYNPSLKS EGSSGYYRYFDPSEQ ID NO: 154 SEQ ID NO: 155 SEQ ID NO: 920 14079 AA RYGIHVIWYEGSNKYYAESVKG RAGIPGTTGYYYGMDV SEQ ID NO: 160 SEQ ID NO: 921SEQ ID NO: 162 14073 AA SYFIH IINPISVSTSYAQKFQG GGIQLYLHLDY 14076SEQ ID NO: 1 SEQ ID NO: 2 SEQ ID NO: 3 AA SYGMH VIWYDGSNKYYADSVKGRAGIIGTTGYYYGMDV SEQ ID NO: 4 SEQ ID NO: 5 SEQ ID NO: 6

TABLE IVb LIGHT CHAIN CDRs Ab Type CDR 1 CDR 2 CDR 3 14039 AASGDRLGEKYTS QDTKRPS QAWESSTVV 14302 SEQ ID NO: 922 SEQ ID NO: 197SEQ ID NO: 923 14303 14301 AA SGDRLGEKYTC QDTKRPS QAWESSTVVSEQ ID NO: 196 SEQ ID NO: 197 SEQ ID NO: 923 14022 AA RASRQISSSYLAGPSSRAT QQYGSSFT 14024 SEQ ID NO: 924 SEQ ID NO: 215 SEQ ID NO: 21614025 14026 14027 14028 14029 AA RASQSISSSYLA GPSSRAT QQYGSSFTSEQ ID NO: 925 SEQ ID NO: 215 SEQ ID NO: 216 14058 AA TGSSSNIGTGYAVHGNNNRPS QSYESRLSGWV 14059 SEQ ID NO: 220 SEQ ID NO: 221 SEQ ID NO: 92614050 AA TGSSSNIGTGYDVH GNSNRPS QSYESSLSGWV 14051 SEQ ID NO: 250SEQ ID NO: 251 SEQ ID NO: 927 14063 AA SGSSSNIGSNFVN TNNQRPS ATWDESLQGWVSEQ ID NO: 292 SEQ ID NO: 293 SEQ ID NO: 928 14064 AA SGSSSNIGSNFVNTNNQRPS ATYDDSLNGWV SEQ ID NO: 292 SEQ ID NO: 293 SEQ ID NO: 929 14099AA SGSSSNIGSNFVN TNNQRPS ATWDESMQGWV SEQ ID NO: 298 SEQ ID NO: 299SEQ ID NO: 930 14100 AA SGSSSNIGSNFVN TNNQRPS ATYDESMQGWV SEQ ID NO: 298SEQ ID NO: 299 SEQ ID NO: 931 14101 AA SGSSSNIGSNFVN TNNQRPS ATYDDSMNGWVSEQ ID NO: 298 SEQ ID NO: 299 SEQ ID NO: 932 14096 AA SGSSSNIGRNEVNTNNQRPS AAWDESLNGWV SEQ ID NO: 304 SEQ ID NO: 305 SEQ ID NO: 933 14097AA SGSSSNIGRNEVN TNNQRPS AAWDESLQGWV SEQ ID NO: 304 SEQ ID NO: 305SEQ ID NO: 934 14090 AA SGSRSNIGSNEVN TNYQRPS AVWDESLNGWV 14091SEQ ID NO: 310 SEQ ID NO: 311 SEQ ID NO: 935 14092 AA SGSRSNIGSNEVNTNYQRPS AVYDESLQGWV SEQ ID NO: 310 SEQ ID NO: 311 SEQ ID NO: 936 14085AA SGSRSNIGSNEVN TNNQRPS AVYDDSLNGWV SEQ ID NO: 316 SEQ ID NO: 317SEQ ID NO: 937 14086 AA SGSRSNIGSNEVN TNNQRPS AVYDESLQGWV 14087SEQ ID NO: 316 SEQ ID NO: 317 SEQ ID NO: 938 14077 AA SGDRLGEKYVSQDNKWPS QAWDSSTVV 14078 SEQ ID NO: 939 SEQ ID NO: 329 SEQ ID NO: 33014304 14079 AA SGDRLGEKYVS QDNKWPS QAWESSTVV SEQ ID NO: 939SEQ ID NO: 329 SEQ ID NO: 940 14080 AA SGDRLGEKYVY QDNKWPS QAWDSSTVVSEQ ID NO: 941 SEQ ID NO: 329 SEQ ID NO: 330 14075 AA SGSRSNIGSNEVNTNNQRPS ATWDESMQGWV SEQ ID NO: 334 SEQ ID NO: 335 SEQ ID NO: 942 14076AA SGSRSNIGSNEVN TNNQRPS ATYDESMQGWV SEQ ID NO: 334 SEQ ID NO: 335SEQ ID NO: 943

Human and Cynomologous Monkey Cadherin-19 Sequences

TABLE V SEQ ID NO. DESIGNATION SOURCE TYPE SEQUENCE 944 Human Human aaMNCYLLLRFMLGIPLLWPCLGATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGACadherin-19GSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEEVIKVSDINDNEPKELDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLELLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNINDNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHEYFNLSVEDTNNSSETIIDNQDNTAVILTNRTGENLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGSAVQSNN945 Human Human ntatgaactgttatttactgctgcgttttatgttgggaattcctctcctatggccttgtcttggagcaacagaaaactctcaaacaaaCadherin-19gaaagtcaagcagccagtgcgatctcatttgagagtgaagcgtggctgggtgtggaaccaattttttgtaccagaggaaatgaatacgactagtcatcacatcggccagctaagatctgatttagacaatggaaacaattctttccagtacaagcttttgggagctggagctggaagtacttttatcattgatgaaagaacaggtgacatatatgccatacagaagcttgatagagaggagcgatccctctacatcttaagagcccaggtaatagacatcgctactggaagggctgtggaacctgagtctgagtttgtcatcaaagtttcggatatcaatgacaatgaaccaaaattcctagatgaaccttatgaggccattgtaccagagatgtctccagaaggaacattagttatccaggtgacagcaagtgatgctgacgatccctcaagtggtaataatgctcgtctcctctacagcttacttcaaggccagccatatttttctgttgaaccaacaacaggagtcataagaatatcttctaaaatggatagagaactgcaagatgagtattgggtaatcattcaagccaaggacatgattggtcagccaggagcgttgtctggaacaacaagtgtattaattaaactttcagatgttaatgacaataagcctatatttaaagaaagtttataccgcttgactgtctctgaatctgcacccactgggacttctataggaacaatcatggcatatgataatgacataggagagaatgcagaaatggattacagcattgaagaggatgattcgcaaacatttgacattattactaatcatgaaactcaagaaggaatagttatattaaaaaagaaagtggattttgagcaccagaaccactacggtattagagcaaaagttaaaaaccatcatgttcctgagcagctcatgaagtaccacactgaggcttccaccactttcattaagatccaggtggaagatgttgatgagcctcctcttttcctccttccatattatgtatttgaagtttttgaagaaaccccacagggatcatttgtaggcgtggtgtctgccacagacccagacaataggaaatctcctatcaggtattctattactaggagcaaagtgttcaatatcaatgataatggtacaatcactacaagtaactcactggatcgtgaaatcagtgcttggtacaacctaagtattacagccacagaaaaatacaatatagaacagatctcttcgatcccactgtatgtgcaagttcttaacatcaatgatcatgctcctgagttctctcaatactatgagacttatgtttgtgaaaatgcaggctctggtcaggtaattcagactatcagtgcagtggatagagatgaatccatagaagagcaccatttttactttaatctatctgtagaagacactaacaattcaagttttacaatcatagataatcaagataacacagctgtcattttgactaatagaactggttttaaccttcaagaagaacctgtcttctacatctccatcttaattgccgacaatggaatcccgtcacttacaagtacaaacacccttaccatccatgtctgtgactgtggtgacagtgggagcacacagacctgccagtaccaggagcttgtgctttccatgggattcaagacagaagtcatcattgctattctcatttgcattatgatcatatttgggtttatttttttgactttgggtttaaaacaacggagaaaacagattctatttcctgagaaaagtgaagatttcagagagaatatattccaatatgatgatgaagggggtggagaagaagatacagaggcctttgatatagcagagctgaggagtagtaccataatgcgggaacgcaagactcggaaaaccacaagcgctgagatcaggagcctatacaggcagtctttgcaagttggccccgacagtgccatattcaggaaattcattctggaaaagctcgaagaagctaatactgatccgtgtgcccctccttttgattccctccagacctacgcttttgagggaacagggtcattagctggatccctgagctccttagaatcagcagtctctgatcaggatgaaagctatgattaccttaatgagttgggacctcgctttaaaagattagcatgcatgtttggttctgcagtgcagtcaaataattag946 Cyno Macaca aaMNCYLLLPFMLGIPLLWPCLGATENSQTKKVQQPVGSHLRVKRGWVWNQFFVPEEMNTTSHHVGRLRSDLDNGNNSFQYKLLGAGACadherin-19 fascicularisGSTFIIDERTGDIYAIEKLDREERSLYILRAQVIDITTGRAVEPESEFVIKVSDINDNEPKELDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTEDIITNHETQEGIVILKKKVNFEHQNHYGIRAKVKNHHVDEQLMKYHTEASTTFIKIQVEDVDEPPLELLPYYIFEIFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNIDDNGTITTTNSLDREISAWYNLSITATEKYNIEQISSIPVYVQVLNINDHAPEFSQYYESYVCENAGSGQVIQTISAVDRDESIEEHHEYFNLSVEDTNSSSETIIDNQDNTAVILTNRTGFNLQEEPIFYISILIADNGIPSLTSTNTLTIHVCDCDDSGSTQTCQYQELMLSMGFKTEVITAILICIMVIEGFIFLTLGLKQRRKQILFPEKSEDFRENIFRYDDEGGGEEDTEAFDVAALRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEADTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGSAVQSNN947 Cyno Macaca ntATGAATTGTTATTTACTGCTGCCTTTTATGTTGGGAATTCCTCTCCTATGGCCTTGTCTTGGAGCAACAGAAAACTCTCAAACAAACadherin-19 fascicularisGAAAGTCCAGCAGCCAGTAGGATCTCATCTGAGAGTGAAGCGTGGCTGGGTGTGGAACCAATTTTTTGTACCAGAGGAAATGAATACGACTAGTCATCACGTTGGCCGGCTAAGATCTGATTTAGACAATGGAAACAATTCTTTCCAGTACAAGCTTTTGGGAGCTGGAGCTGGAAGTACTTTTATCATTGATGAAAGAACAGGTGACATATATGCCATAGAGAAGCTTGATAGAGAGGAGCGATCCCTCTACATCTTAAGAGCCCAGGTAATAGACATCACTACTGGAAGGGCTGTGGAACCTGAGTCTGAGTTTGTCATCAAAGTTTCGGATATCAATGACAATGAACCAAAATTCCTAGATGAACCTTATGAGGCCATTGTACCAGAGATGTCTCCAGAAGGAACATTAGTCATCCAGGTGACAGCAAGTGATGCTGATGACCCTTCAAGTGGTAATAATGCTCGTCTCCTCTACAGCTTATTACAAGGCCAGCCATATTTTTCTGTTGAACCAACAACAGGAGTCATAAGAATATCTTCTAAAATGGATAGAGAACTGCAAGATGAGTATTGGGTAATCATTCAAGCCAAGGACATGATTGGTCAGCCAGGAGCGTTGTCTGGAACAACGAGTGTATTAATTAAACTTTCAGATGTTAATGACAATAAGCCTATATTTAAAGAAAGTTTATACCGCCTGACGGTCTCTGAATCTGCACCCACTGGGACTTCTATAGGAACAATCATGGCATATGATAATGACATAGGAGAGAATGCAGAAATGGATTACAGCATTGAAGAGGATGATTCACAGACATTTGACATTATTACTAATCATGAAACTCAAGAAGGAATAGTTATATTAAAAAAGAAAGTGAATTTTGAGCACCAGAACCACTATGGTATTAGAGCAAAAGTTAAAAACCATCATGTTGATGAGCAGCTCATGAAATACCACACTGAAGCTTCCACCACTTTCATTAAGATCCAGGTGGAAGATGTTGATGAGCCTCCTCTTTTCCTCCTTCCGTATTACATATTTGAAATTTTTGAAGAAACCCCACAAGGATCATTTGTAGGCGTGGTGTCTGCCACAGACCCAGACAATAGGAAATCTCCTATCAGGTATTCTATTACTAGGAGCAAAGTGTTCAATATCGATGATAATGGTACAATCACTACAACTAACTCACTGGATCGGGAAATCAGTGCTTGGTACAACCTAAGTATTACAGCCACAGAAAAATACAATATAGAGCAGATCTCTTCGATCCCAGTGTATGTGCAAGTTCTTAATATCAATGATCATGCTCCTGAGTTCTCTCAATACTATGAGAGTTATGTTTGTGAAAATGCAGGCTCTGGTCAGGTAATTCAGACTATCAGTGCAGTGGATAGAGATGAATCCATAGAAGAGCACCATTTTTACTTTAATCTATCTGTAGAAGACACTAACTCTTCAAGTTTTACAATCATAGACAATCAAGATAACACAGCTGTCATTTTGACTAATAGAACTGGTTTTAACCTTCAAGAAGAGCCCATCTTCTACATCTCCATCTTAATTGCCGACAATGGAATCCCGTCACTTACAAGTACAAACACCCTTACCATCCATGTCTGTGACTGTGATGACAGTGGGAGCACACAGACCTGCCAGTACCAGGAGCTTATGCTTTCCATGGGATTCAAGACAGAAGTCATCATTGCTATTCTCATTTGCATTATGGTAATATTTGGGTTTATTTTTTTGACTTTGGGTTTAAAACAACGGAGAAAACAGATTCTATTTCCTGAGAAAAGTGAAGATTTCAGAGAGAATATATTCCGATATGATGACGAAGGGGGTGGAGAAGAAGATACAGAGGCCTTTGACGTAGCAGCGCTGAGGAGTAGCACCATAATGCGGGAACGCAAGACTCGGAAAACCACCAGCGCTGAGATCAGGAGCCTATACAGGCAGTCTTTGCAAGTTGGCCCCGACAGTGCCATATTCAGGAAGTTCATCCTGGAAAAGCTCGAAGAAGCTGATACTGATCCGTGTGCCCCTCCTTTTGATTCCCTCCAGACCTACGCTTTTGAGGGAACAGGGTCATTAGCTGGATCCCTGAGCTCCTTAGAATCAGCTGTCTCTGATCAGGATGAAAGCTATGATTACCTTAACGAGTTGGGACCTCGCTTTAAAAGATTAGCATGCATGTTTGGTTCTGCAGTGCAGTCAAATAATTAG948 secreted Human aaMNCYLLLRFMLGIPLLWPCLGATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGACadherin-19GSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEEVIKVSDINDNEPKELDEPYEAIVPEMSPEGTLVIQVTAecto-domainSDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKE(amino acidsSLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQ1-596)LMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNINDNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHEYFNLSVEDTNNSSETIIDNQDNTAVILTNRTGENLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTE949 secreted Human ntatgaactgttatttactgctgcgttttatgttgggaattcctctcctatggccttgtcttggagcaacagaaaactctcaaacaaaCadherin-19gaaagtcaagcagccagtgcgatctcatttgagagtgaagcgtggctgggtgtggaaccaattttttgtaccagaggaaatgaataecto-domaincgactagtcatcacatcggccagctaagatctgatttagacaatggaaacaattctttccagtacaagcttttgggagctggagct(amino acidsggaagtacttttatcattgatgaaagaacaggtgacatatatgccatacagaagcttgatagagaggagcgatccctctacatctt1-596)aagagcccaggtaatagacatcgctactggaagggctgtggaacctgagtctgagtttgtcatcaaagtttcggatatcaatgacaatgaaccaaaattcctagatgaaccttatgaggccattgtaccagagatgtctccagaaggaacattagttatccaggtgacagcaagtgatgctgacgatccctcaagtggtaataatgctcgtctcctctacagcttacttcaaggccagccatatttttctgttgaaccaacaacaggagtcataagaatatcttctaaaatggatagagaactgcaagatgagtattgggtaatcattcaagccaaggacatgattggtcagccaggagcgttgtctggaacaacaagtgtattaattaaactttcagatgttaatgacaataagcctatatttaaagaaagtttataccgcttgactgtctctgaatctgcacccactgggacttctataggaacaatcatggcatatgataatgacataggagagaatgcagaaatggattacagcattgaagaggatgattcgcaaacatttgacattattactaatcatgaaactcaagaaggaatagttatattaaaaaagaaagtggattttgagcaccagaaccactacggtattagagcaaaagttaaaaaccatcatgttcctgagcagctcatgaagtaccacactgaggcttccaccactttcattaagatccaggtggaagatgttgatgagcctcctcttttcctccttccatattatgtatttgaagtttttgaagaaaccccacagggatcatttgtaggcgtggtgtctgccacagacccagacaataggaaatctcctatcaggtattctattactaggagcaaagtgttcaatatcaatgataatggtacaatcactacaagtaactcactggatcgtgaaatcagtgcttggtacaacctaagtattacagccacagaaaaatacaatatagaacagatctcttcgatcccactgtatgtgcaagttcttaacatcaatgatcatgctcctgagttctctcaatactatgagacttatgtttgtgaaaatgcaggctctggtcaggtaattcagactatcagtgcagtggatagagatgaatccatagaagagcaccatttttactttaatctatctgtagaagacactaacaattcaagttttacaatcatagataatcaagataacacagctgtcattttgactaatagaactggttttaaccttcaagaagaacctgtcttctacatctccatcttaattgccgacaatggaatcccgtcacttacaagtacaaacacccttaccatccatgtctgtgactgtggtgacagtgggagcacacagacctgccagtaccaggagcttgtgctttccatgggattcaagacagaa 950truncated Human aaMNCYLLLRFMLGIPLLWPCLGATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAmembraneGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEEVIKVSDINDNEPKELDEPYEAIVPEMSPEGTLVIQVTAbound form ofSDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKEhumanSLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQcadherin-19LMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNINDNGTITTSNSLDR(amino acidsEISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHEYFNLSVEDTNN1-624)SSETIIDNQDNTAVILTNRTGENLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQ 951 truncated Humanl ntatgaactgttatttactgctgcgttttatgttgggaattcctctcctatggccttgtcttggagcaacagaaaactctcaaacaaamembranegaaagtcaagcagccagtgcgatctcatttgagagtgaagcgtggctgggtgtggaaccaattttttgtaccagaggaaatgaatabound form ofcgactagtcatcacatcggccagctaagatctgatttagacaatggaaacaattctttccagtacaagcttttgggagctggagcthumanggaagtacttttatcattgatgaaagaacaggtgacatatatgccatacagaagcttgatagagaggagcgatccctctacatcttcadherin-19aagagcccaggtaatagacatcgctactggaagggctgtggaacctgagtctgagtttgtcatcaaagtttcggatatcaatgaca(amino acidsatgaaccaaaattcctagatgaaccttatgaggccattgtaccagagatgtctccagaaggaacattagttatccaggtgacagca1-624)agtgatgctgacgatccctcaagtggtaataatgctcgtctcctctacagcttacttcaaggccagccatatttttctgttgaaccaacaacaggagtcataagaatatcttctaaaatggatagagaactgcaagatgagtattgggtaatcattcaagccaaggacatgattggtcagccaggagcgttgtctggaacaacaagtgtattaattaaactttcagatgttaatgacaataagcctatatttaaagaaagtttataccgcttgactgtctctgaatctgcacccactgggacttctataggaacaatcatggcatatgataatgacataggagagaatgcagaaatggattacagcattgaagaggatgattcgcaaacatttgacattattactaatcatgaaactcaagaaggaatagttatattaaaaaagaaagtggattttgagcaccagaaccactacggtattagagcaaaagttaaaaaccatcatgttcctgagcagctcatgaagtaccacactgaggcttccaccactttcattaagatccaggtggaagatgttgatgagcctcctcttttcctccttccatattatgtatttgaagtttttgaagaaaccccacagggatcatttgtaggcgtggtgtctgccacagacccagacaataggaaatctcctatcaggtattctattactaggagcaaagtgttcaatatcaatgataatggtacaatcactacaagtaactcactggatcgtgaaatcagtgcttggtacaacctaagtattacagccacagaaaaatacaatatagaacagatctcttcgatcccactgtatgtgcaagttcttaacatcaatgatcatgctcctgagttctctcaatactatgagacttatgtttgtgaaaatgcaggctctggtcaggtaattcagactatcagtgcagtggatagagatgaatccatagaagagcaccatttttactttaatctatctgtagaagacactaacaattcaagttttacaatcatagataatcaagataacacagctgtcattttgactaatagaactggttttaaccttcaagaagaacctgtcttctacatctccatcttaattgccgacaatggaatcccgtcacttacaagtacaaacacccttaccatccatgtctgtgactgtggtgacagtgggagcacacagacctgccagtaccaggagcttgtgctttccatgggattcaagacagaagtcatcattgctattctcatttgcattatgatcatatttgggtttatttttttgactttgggtttaaaacaacggagaaaacag 952C137897 artificial aaGWVWNQFFVPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEhuCDH19PESEEVIKVSDINDNEPRELDEPYEAIVPEMSPEGTEVIKVTANDADDPSTGYHARILYNLERGQPYFSVEPTTGVIRISSKMDRE(44-141)LQDTYCVIIQAKDMLGQPGALSGTTTVSIKLSDINDNKPIFKESFYRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSIEDDDSKmuCDH19IFDIIIDNDTQEGIVILKKKVDFEQQSYYGIRAKVKNCHVDEELAPAHVNASTTYIKVQVEDEDEPPVFLLPYYILEIPEGKPYGT(140-770)IVGTVSATDPDRRQSPMRYYLTGSKMFDINDNGTIITTNMLDREVSAWYNLTVTATETYNVQQISSAHVYVQVFNINDNAPEFSQFYETYVCENAESGEIVQIISAIDRDESIEDHHEYENHSLEDTNNSSFMLTDNQDNTAVILSNRTGENLKEEPVEYMIILIADNGIPSLTSTNTLTIQVCDCGDSRNTETCANKGLLFIMGFRTEAIIAIMICVMVIFGEFFLILALKQRRKETLFPEKTEDFRENIFCYDDEGGGEEDSEAFDIVELRQSTVMRERKPQRSKSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFGSAVQPNN 953 C137897 artificial ntggctgggtgtggaaccaattttttgtaccagaggaaatgaatacgactagtcatcacatcggccagctaagatctgatttagacaahuCDH19tggaaacaattctttccagtacaagcttttgggagctggagctggaagtacttttatcattgatgaaagaacaggtgacatatatg(44-141)ccatacagaagcttgatagagaggagcgatccctctacatcttaagagcccaggtaatagacatcgctactggaagggctgtggaamuCDH19cctgagtctgagtttgtcatcaaagtttcggatatcaatgacaatgaacccagattcctagatgaaccatatgaggccattgtacc(140-770)tgagatgtctccagaaggaacatttgtcatcaaggtgacagccaatgacgcagatgatccttcaactggctatcatgctcgcatcctatacaacttagaacgaggtcaaccatacttttctgttgagccaacaacaggagtcataaggatatcttctaagatggatagagagttgcaagatacatactgtgtaattattcaagccaaggacatgctcggtcagcctggagccttgtctggaacaacaaccgtatcaattaagctgtcagatattaatgacaacaagccaatattcaaagaaagtttctaccgcttcactatatctgaatctgcacccattggaacatcaatagggaaaattatggcatatgatgatgacataggggagaatgcagagatggagtacagcattgaagatgatgattcaaaaatatttgacataatcattgacaatgacacccaagaagggatagttatacttaaaaagaaagttgattttgagcagcagagctattatggcattagagctaaggttaaaaactgccatgtggatgaagagcttgcacctgcccatgttaacgcttccacaacctacattaaagttcaagtagaagatgaagatgaacctcctgttttcctcttaccatattacatacttgaaattcctgaaggaaaaccatatggaacaattgtggggacggtttctgccacagacccagatcgaagacaatctcctatgagatattatctcactggaagcaaaatgtttgatatcaatgacaatggaacaataatcaccactaacatgcttgacagagaggtcagtgcttggtacaacttgactgtcacagctactgaaacatacaatgtacaacagatctcttcagcccatgtttatgtacaagtctttaacattaacgacaatgctccagagttctctcaattctatgagacttatgtttgtgaaaatgctgaatctggtgagatagttcagatcatcagtgcaattgatagagatgagtccatagaagatcaccatttttactttaatcactctctggaagacacaaacaactcaagttttatgctaacagacaatcaagataacacagctgtaattctgagtaatagaactggtttcaatcttaaagaagagcctgtcttctacatgatcatcttgattgctgataacgggatcccatctctcacaagcacaaacactctcactatccaagtctgtgactgtggagacagtagaaacacagaaacttgtgctaacaagggacttctctttatcatgggattcagaacagaggcaataattgccatcatgatatgtgttatggtaatatttgggtttttctttttgattcttgctctgaaacagcgaagaaaggagactctatttccagagaagactgaagactttagggagaatatattttgctatgatgatgaaggcggcggggaagaagactcggaagcctttgacatcgtagagctgagacaaagtacagtaatgagagaaagaaagcctcagagaagcaagagtgcggagatcaggagcttgtacaggcagtccctgcaggtgggcccagacagtgccatatttcgaaaatttatcctagagaagcttgaagaagccaacacagacccatgtgctcccccctttgattcactacagacgtttgcctatgagggaacagggtcatcagctggctctctgagctccttggcatccagagacactgatcaggaggatgacttcgactaccttaatgacctgggacctcgttttaaaagattagcaagcatgtttggctctgcagtacaacccaacaattag 954 C137896 artificial aaGWVWNQFFVPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEhuCDH19PESEEVIKVSDINDNEPKELDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRE(44-249)LQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESFYRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSIEDDDSKmuCDH19IFDIIIDNDTQEGIVILKKKVDFEQQSYYGIRAKVKNCHVDEELAPAHVNASTTYIKVQVEDEDEPPVFLLPYYILEIPEGKPYGT(248-770)IVGTVSATDPDRRQSPMRYYLTGSKMFDINDNGTIITTNMLDREVSAWYNLTVTATETYNVQQISSAHVYVQVFNINDNAPEFSQFYETYVCENAESGEIVQIISAIDRDESIEDHHEYENHSLEDTNNSSFMLTDNQDNTAVILSNRTGENLKEEPVEYMIILIADNGIPSLTSTNTLTIQVCDCGDSRNTETCANKGLLFIMGFRTEAIIAIMICVMVIFGEFFLILALKQRRKETLFPEKTEDFRENIFCYDDEGGGEEDSEAFDIVELRQSTVMRERKPQRSKSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFGSAVQPNN 955 C137896 artificial ntggctgggtgtggaaccaattttttgtaccagaggaaatgaatacgactagtcatcacatcggccagctaagatctgatttagacaahuCDH19tggaaacaattctttccagtacaagcttttgggagctggagctggaagtacttttatcattgatgaaagaacaggtgacatatatg(44-249)ccatacagaagcttgatagagaggagcgatccctctacatcttaagagcccaggtaatagacatcgctactggaagggctgtggaamuCDH19cctgagtctgagtttgtcatcaaagtttcggatatcaatgacaatgaaccaaaattcctagatgaaccttatgaggccattgtacc(248-770)agagatgtctccagaaggaacattagttatccaggtgacagcaagtgatgctgacgatccctcaagtggtaataatgctcgtctcctctacagcttacttcaaggccagccatatttttctgttgaaccaacaacaggagtcataagaatatcttctaaaatggatagagaactgcaagatgagtattgggtaatcattcaagccaaggacatgattggtcagccaggagcgttgtctggaacaacaagtgtattaattaaactttcagatgttaatgacaacaagccaatattcaaagaaagtttctaccgcttcactatatctgaatctgcacccattggaacatcaatagggaaaattatggcatatgatgatgacataggggagaatgcagagatggagtacagcattgaagatgatgattcaaaaatatttgacataatcattgacaatgacacccaagaagggatagttatacttaaaaagaaagttgattttgagcagcagagctattatggcattagagctaaggttaaaaactgccatgtggatgaagagcttgcacctgcccatgttaacgcttccacaacctacattaaagttcaagtagaagatgaagatgaacctcctgttttcctcttaccatattacatacttgaaattcctgaaggaaaaccatatggaacaattgtggggacggtttctgccacagacccagatcgaagacaatctcctatgagatattatctcactggaagcaaaatgtttgatatcaatgacaatggaacaataatcaccactaacatgcttgacagagaggtcagtgcttggtacaacttgactgtcacagctactgaaacatacaatgtacaacagatctcttcagcccatgtttatgtacaagtctttaacattaacgacaatgctccagagttctctcaattctatgagacttatgtttgtgaaaatgctgaatctggtgagatagttcagatcatcagtgcaattgatagagatgagtccatagaagatcaccatttttactttaatcactctctggaagacacaaacaactcaagttttatgctaacagacaatcaagataacacagctgtaattctgagtaatagaactggtttcaatcttaaagaagagcctgtcttctacatgatcatcttgattgctgataacgggatcccatctctcacaagcacaaacactctcactatccaagtctgtgactgtggagacagtagaaacacagaaacttgtgctaacaagggacttctctttatcatgggattcagaacagaggcaataattgccatcatgatatgtgttatggtaatatttgggtttttctttttgattcttgctctgaaacagcgaagaaaggagactctatttccagagaagactgaagactttagggagaatatattttgctatgatgatgaaggcggcggggaagaagactcggaagcctttgacatcgtagagctgagacaaagtacagtaatgagagaaagaaagcctcagagaagcaagagtgcggagatcaggagcttgtacaggcagtccctgcaggtgggcccagacagtgccatatttcgaaaatttatcctagagaagcttgaagaagccaacacagacccatgtgctcccccctttgattcactacagacgtttgcctatgagggaacagggtcatcagctggctctctgagctccttggcatccagagacactgatcaggaggatgacttcgactaccttaatgacctgggacctcgttttaaaagattagcaagcatgtttggctctgcagtacaacccaacaattag 956 C137913 artificial aaAWVWRPFVVLEEMDDIQCVGKLRSDLDNGNNSFQYKLLGIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTIGKAVETEmuCDH19SEEVIRVLDINDNEPKELDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQ(44-139)DEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESFYRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSIEDDDSKIFhuCDH19DIIIDNDTQEGIVILKKKVDFEQQSYYGIRAKVKNCHVDEELAPAHVNASTTYIKVQVEDEDEPPVFLLPYYILEIPEGKPYGTIV(142-249)GTVSATDPDRRQSPMRYYLTGSKMFDINDNGTIITTNMLDREVSAWYNLTVTATETYNVQQISSAHVYVQVFNINDNAPEFSQFYEmuCDH19TYVCENAESGEIVQIISAIDRDESIEDHHEYENHSLEDTNNSSFMLTDNQDNTAVILSNRTGENLKEEPVEYMIILIADNGIPSLT(248-770)STNTLTIQVCDCGDSRNTETCANKGLLFIMGFRTEAIIAIMICVMVIFGEFFLILALKQRRKETLFPEKTEDFRENIFCYDDEGGGEEDSEAFDIVELRQSTVMRERKPQRSKSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFGSAVQPNN 957 C137913 artificial ntgcctgggtgtggagaccatttgttgttctagaagaaatggatgatatacaatgtgttggaaagctaagatctgacttagacaatggmuCDH19aaacaactctttccagtacaagctactggggattggcgctggaagctttagcattaatgaaagaacaggtgaaatatgtgccatac(44-139)agaagcttgatagagaggaaaaatccctctacattctgagagcccaggtaatagacaccactattgggaaggctgtggaaactgaahuCDH19tccgagtttgtcatcagagttttggatatcaatgacaatgaaccaaaattcctagatgaaccttatgaggccattgtaccagagat(142-249)gtctccagaaggaacattagttatccaggtgacagcaagtgatgctgacgatccctcaagtggtaataatgctcgtctcctctacamuCDH19gcttacttcaaggccagccatatttttctgttgaaccaacaacaggagtcataagaatatcttctaaaatggatagagaactgcaa(248-770)gatgagtattgggtaatcattcaagccaaggacatgattggtcagccaggagcgttgtctggaacaacaagtgtattaattaaactttcagatgttaatgacaacaagccaatattcaaagaaagtttctaccgcttcactatatctgaatctgcacccattggaacatcaatagggaaaattatggcatatgatgatgacataggggagaatgcagagatggagtacagcattgaagatgatgattcaaaaatatttgacataatcattgacaatgacacccaagaagggatagttatacttaaaaagaaagttgattttgagcagcagagctattatggcattagagctaaggttaaaaactgccatgtggatgaagagcttgcacctgcccatgttaacgcttccacaacctacattaaagttcaagtagaagatgaagatgaacctcctgttttcctcttaccatattacatacttgaaattcctgaaggaaaaccatatggaacaattgtggggacggtttctgccacagacccagatcgaagacaatctcctatgagatattatctcactggaagcaaaatgtttgatatcaatgacaatggaacaataatcaccactaacatgcttgacagagaggtcagtgcttggtacaacttgactgtcacagctactgaaacatacaatgtacaacagatctcttcagcccatgtttatgtacaagtctttaacattaacgacaatgctccagagttctctcaattctatgagacttatgtttgtgaaaatgctgaatctggtgagatagttcagatcatcagtgcaattgatagagatgagtccatagaagatcaccatttttactttaatcactctctggaagacacaaacaactcaagttttatgctaacagacaatcaagataacacagctgtaattctgagtaatagaactggtttcaatcttaaagaagagcctgtcttctacatgatcatcttgattgctgataacgggatcccatctctcacaagcacaaacactctcactatccaagtctgtgactgtggagacagtagaaacacagaaacttgtgctaacaagggacttctctttatcatgggattcagaacagaggcaataattgccatcatgatatgtgttatggtaatatttgggtttttctttttgattcttgctctgaaacagcgaagaaaggagactctatttccagagaagactgaagactttagggagaatatattttgctatgatgatgaaggcggcggggaagaagactcggaagcctttgacatcgtagagctgagacaaagtacagtaatgagagaaagaaagcctcagagaagcaagagtgcggagatcaggagcttgtacaggcagtccctgcaggtgggcccagacagtgccatatttcgaaaatttatcctagagaagcttgaagaagccaacacagacccatgtgctcccccctttgattcactacagacgtttgcctatgagggaacagggtcatcagctggctctctgagctccttggcatccagagacactgatcaggaggatgacttcgactaccttaatgacctgggacctcgttttaaaagattagcaagcatgtttggctctgcagtacaacccaacaattag 958 C137847 artificial aaAWVWRPFVVLEEMDDIQCVGKLRSDLDNGNNSFQYKLLGIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTIGKAVETEmuCDH19SEEVIRVLDINDNEPKELDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQ(44-139)DEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFhuCDH19DIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPVFLLPYYILEIPEGKPYGTIV(142-364)GTVSATDPDRRQSPMRYYLTGSKMFDINDNGTIITTNMLDREVSAWYNLTVTATETYNVQQISSAHVYVQVFNINDNAPEFSQFYEmuCDH19TYVCENAESGEIVQIISAIDRDESIEDHHEYENHSLEDTNNSSFMLTDNQDNTAVILSNRTGENLKEEPVEYMIILIADNGIPSLT(363-770)STNTLTIQVCDCGDSRNTETCANKGLLFIMGFRTEAIIAIMICVMVIFGEFFLILALKQRRKETLFPEKTEDFRENIFCYDDEGGGEEDSEAFDIVELRQSTVMRERKPQRSKSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFGSAVQPNN 959 C137847 artificial ntgcctgggtgtggagaccatttgttgttctagaagaaatggatgatatacaatgtgttggaaagctaagatctgacttagacaatggmuCDH19aaacaactctttccagtacaagctactggggattggcgctggaagctttagcattaatgaaagaacaggtgaaatatgtgccatac(44-139)agaagcttgatagagaggaaaaatccctctacattctgagagcccaggtaatagacaccactattgggaaggctgtggaaactgaahuCDH19tccgagtttgtcatcagagttttggatatcaatgacaatgaaccaaaattcctagatgaaccttatgaggccattgtaccagagat(142-364)gtctccagaaggaacattagttatccaggtgacagcaagtgatgctgacgatccctcaagtggtaataatgctcgtctcctctacamuCDH19gcttacttcaaggccagccatatttttctgttgaaccaacaacaggagtcataagaatatcttctaaaatggatagagaactgcaa(363-770)gatgagtattgggtaatcattcaagccaaggacatgattggtcagccaggagcgttgtctggaacaacaagtgtattaattaaactttcagatgttaatgacaataagcctatatttaaagaaagtttataccgcttgactgtctctgaatctgcacccactgggacttctataggaacaatcatggcatatgataatgacataggagagaatgcagaaatggattacagcattgaagaggatgattcgcaaacatttgacattattactaatcatgaaactcaagaaggaatagttatattaaaaaagaaagtggattttgagcaccagaaccactacggtattagagcaaaagttaaaaaccatcatgttcctgagcagctcatgaagtaccacactgaggcttccaccactttcattaagatccaggtggaagatgttgatgaacctcctgttttcctcttaccatattacatacttgaaattcctgaaggaaaaccatatggaacaattgtggggacggtttctgccacagacccagatcgaagacaatctcctatgagatattatctcactggaagcaaaatgtttgatatcaatgacaatggaacaataatcaccactaacatgcttgacagagaggtcagtgcttggtacaacttgactgtcacagctactgaaacatacaatgtacaacagatctcttcagcccatgtttatgtacaagtctttaacattaacgacaatgctccagagttctctcaattctatgagacttatgtttgtgaaaatgctgaatctggtgagatagttcagatcatcagtgcaattgatagagatgagtccatagaagatcaccatttttactttaatcactctctggaagacacaaacaactcaagttttatgctaacagacaatcaagataacacagctgtaattctgagtaatagaactggtttcaatcttaaagaagagcctgtcttctacatgatcatcttgattgctgataacgggatcccatctctcacaagcacaaacactctcactatccaagtctgtgactgtggagacagtagaaacacagaaacttgtgctaacaagggacttctctttatcatgggattcagaacagaggcaataattgccatcatgatatgtgttatggtaatatttgggtttttctttttgattcttgctctgaaacagcgaagaaaggagactctatttccagagaagactgaagactttagggagaatatattttgctatgatgatgaaggcggcggggaagaagactcggaagcctttgacatcgtagagctgagacaaagtacagtaatgagagaaagaaagcctcagagaagcaagagtgcggagatcaggagcttgtacaggcagtccctgcaggtgggcccagacagtgccatatttcgaaaatttatcctagagaagcttgaagaagccaacacagacccatgtgctcccccctttgattcactacagacgtttgcctatgagggaacagggtcatcagctggctctctgagctccttggcatccagagacactgatcaggaggatgacttcgactaccttaatgacctgggacctcgttttaaaagattagcaagcatgtttggctctgcagtacaacccaacaattag 960 C137911 artificial aaAWVWRPFVVLEEMDDIQCVGKLRSDLDNGNNSFQYKLLGIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTIGKAVETEmuCDH19SEEVIRVLDINDNEPRELDEPYEAIVPEMSPEGTEVIKVTANDADDPSTGYHARILYNLERGQPYFSVEPTTGVIRISSKMDRELQ(44-247)DTYCVIIQAKDMLGQPGALSGTTTVSIKLSDINDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFhuCDH19DIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPVELLPYYILEIPEGKPYGTIV(250-364)GTVSATDPDRRQSPMRYYLTGSKMFDINDNGTIITTNMLDREVSAWYNLTVTATETYNVQQISSAHVYVQVFNINDNAPEFSQFYEmuCDH19TYVCENAESGEIVQIISAIDRDESIEDHHEYENHSLEDTNNSSFMLTDNQDNTAVILSNRTGENLKEEPVEYMIILIADNGIPSLT(363-770)STNTLTIQVCDCGDSRNTETCANKGLLFIMGERTEAIIAIMICVMVIFGEFFLILALKQRRKETLFPEKTEDFRENIFCYDDEGGGEEDSEAFDIVELRQSTVMRERKPQRSKSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFGSAVQPNN 961 C137911 artificial ntgcctgggtgtggagaccatttgttgttctagaagaaatggatgatatacaatgtgttggaaagctaagatctgacttagacaatggmuCDH19aaacaactctttccagtacaagctactggggattggcgctggaagctttagcattaatgaaagaacaggtgaaatatgtgccatac(44-247)agaagcttgatagagaggaaaaatccctctacattctgagagcccaggtaatagacaccactattgggaaggctgtggaaactgaahuCDH19tccgagtttgtcatcagagttttggatatcaatgacaatgaacccagattcctagatgaaccatatgaggccattgtacctgagat(250-364)gtctccagaaggaacatttgtcatcaaggtgacagccaatgacgcagatgatccttcaactggctatcatgctcgcatcctatacamuCDH19acttagaacgaggtcaaccatacttttctgttgagccaacaacaggagtcataaggatatcttctaagatggatagagagttgcaa(363-770)gatacatactgtgtaattattcaagccaaggacatgctcggtcagcctggagccttgtctggaacaacaaccgtatcaattaagctgtcagatattaatgacaataagcctatatttaaagaaagtttataccgcttgactgtctctgaatctgcacccactgggacttctataggaacaatcatggcatatgataatgacataggagagaatgcagaaatggattacagcattgaagaggatgattcgcaaacatttgacattattactaatcatgaaactcaagaaggaatagttatattaaaaaagaaagtggattttgagcaccagaaccactacggtattagagcaaaagttaaaaaccatcatgttcctgagcagctcatgaagtaccacactgaggcttccaccactttcattaagatccaggtggaagatgttgatgaacctcctgttttcctcttaccatattacatacttgaaattcctgaaggaaaaccatatggaacaattgtggggacggtttctgccacagacccagatcgaagacaatctcctatgagatattatctcactggaagcaaaatgtttgatatcaatgacaatggaacaataatcaccactaacatgcttgacagagaggtcagtgcttggtacaacttgactgtcacagctactgaaacatacaatgtacaacagatctcttcagcccatgtttatgtacaagtctttaacattaacgacaatgctccagagttctctcaattctatgagacttatgtttgtgaaaatgctgaatctggtgagatagttcagatcatcagtgcaattgatagagatgagtccatagaagatcaccatttttactttaatcactctctggaagacacaaacaactcaagttttatgctaacagacaatcaagataacacagctgtaattctgagtaatagaactggtttcaatcttaaagaagagcctgtcttctacatgatcatcttgattgctgataacgggatcccatctctcacaagcacaaacactctcactatccaagtctgtgactgtggagacagtagaaacacagaaacttgtgctaacaagggacttctctttatcatgggattcagaacagaggcaataattgccatcatgatatgtgttatggtaatatttgggtttttctttttgattcttgctctgaaacagcgaagaaaggagactctatttccagagaagactgaagactttagggagaatatattttgctatgatgatgaaggcggcggggaagaagactcggaagcctttgacatcgtagagctgagacaaagtacagtaatgagagaaagaaagcctcagagaagcaagagtgcggagatcaggagcttgtacaggcagtccctgcaggtgggcccagacagtgccatatttcgaaaatttatcctagagaagcttgaagaagccaacacagacccatgtgctcccccctttgattcactacagacgtttgcctatgagggaacagggtcatcagctggctctctgagctccttggcatccagagacactgatcaggaggatgacttcgactaccttaatgacctgggacctcgttttaaaagattagcaagcatgtttggctctgcagtacaacccaacaattag 962 C137917 artificial aaAWVWRPFVVLEEMDDIQCVGKLRSDLDNGNNSFQYKLLGIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTIGKAVETEmuCDH19SEEVIRVLDINDNEPRELDEPYEAIVPEMSPEGTEVIKVTANDADDPSTGYHARILYNLERGQPYFSVEPTTGVIRISSKMDRELQ(44-362)DTYCVIIQAKDMLGQPGALSGTTTVSIKLSDINDNKPIFKESFYRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSIEDDDSKIFhuCDH19DIIIDNDTQEGIVILKKKVDFEQQSYYGIRAKVKNCHVDEELAPAHVNASTTYIKVQVEDEDEPPLELLPYYVFEVFEETPQGSFV(365-772)GVVSATDPDNRKSPIRYSITRSKVFNINDNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESILIADNGIPSLTIEEHHEYFNLSVEDTNNSSETIIDNQDNTAVILTNRTGENLQEEPVFYISSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGIAILICIMIEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGSAVQSNN 963 C137917 artificial ntgcctgggtgtggagaccatttgttgttctagaagaaatggatgatatacaatgtgttggaaagctaagatctgacttagacaatggmuCDH19aaacaactctttccagtacaagctactggggattggcgctggaagctttagcattaatgaaagaacaggtgaaatatgtgccatac(44-362)agaagcttgatagagaggaaaaatccctctacattctgagagcccaggtaatagacaccactattgggaaggctgtggaaactgaahuCDH19tccgagtttgtcatcagagttttggatatcaatgacaatgaacccagattcctagatgaaccatatgaggccattgtacctgagat(365-772)gtctccagaaggaacatttgtcatcaaggtgacagccaatgacgcagatgatccttcaactggctatcatgctcgcatcctatacaacttagaacgaggtcaaccatacttttctgttgagccaacaacaggagtcataaggatatcttctaagatggatagagagttgcaagatacatactgtgtaattattcaagccaaggacatgctcggtcagcctggagccttgtctggaacaacaaccgtatcaattaagctgtcagatattaatgacaacaagccaatattcaaagaaagtttctaccgcttcactatatctgaatctgcacccattggaacatcaatagggaaaattatggcatatgatgatgacataggggagaatgcagagatggagtacagcattgaagatgatgattcaaaaatatttgacataatcattgacaatgacacccaagaagggatagttatacttaaaaagaaagttgattttgagcagcagagctattatggcattagagctaaggttaaaaactgccatgtggatgaagagcttgcacctgcccatgttaacgcttccacaacctacattaaagttcaagtagaagatgaagatgagcctcctcttttcctccttccatattatgtatttgaagtttttgaagaaaccccacagggatcatttgtaggcgtggtgtctgccacagacccagacaataggaaatctcctatcaggtattctattactaggagcaaagtgttcaatatcaatgataatggtacaatcactacaagtaactcactggatcgtgaaatcagtgcttggtacaacctaagtattacagccacagaaaaatacaatatagaacagatctcttcgatcccactgtatgtgcaagttcttaacatcaatgatcatgctcctgagttctctcaatactatgagacttatgtttgtgaaaatgcaggctctggtcaggtaattcagactatcagtgcagtggatagagatgaatccatagaagagcaccatttttactttaatctatctgtagaagacactaacaattcaagttttacaatcatagataatcaagataacacagctgtcattttgactaatagaactggttttaaccttcaagaagaacctgtcttctacatctccatcttaattgccgacaatggaatcccgtcacttacaagtacaaacacccttaccatccatgtctgtgactgtggtgacagtgggagcacacagacctgccagtaccaggagcttgtgctttccatgggattcaagacagaagtcatcattgctattctcatttgcattatgatcatatttgggtttatttttttgactttgggtttaaaacaacggagaaaacagattctatttcctgagaaaagtgaagatttcagagagaatatattccaatatgatgatgaagggggtggagaagaagatacagaggcctttgatatagcagagctgaggagtagtaccataatgcgggaacgcaagactcggaaaaccacaagcgctgagatcaggagcctatacaggcagtctttgcaagttggccccgacagtgccatattcaggaaattcattctggaaaagctcgaagaagctaatactgatccgtgtgcccctccttttgattccctccagacctacgcttttgagggaacagggtcattagctggatccctgagctccttagaatcagcagtctctgatcaggatgaaagctatgattaccttaatgagttgggacctcgctttaaaagattagcatgcatgtttggttctgcagtgcagtcaaataattag 964 C137915 artificial aaAWVWRPFVVLEEMDDIQCVGKLRSDLDNGNNSFQYKLLGIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTIGKAVETEmuCDH19SEEVIRVLDINDNEPRELDEPYEAIVPEMSPEGTEVIKVTANDADDPSTGYHARILYNLERGQPYFSVEPTTGVIRISSKMDRELQ(44-461)DTYCVIIQAKDMLGQPGALSGTTTVSIKLSDINDNKPIFKESFYRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSIEDDDSKIFhuCDH19DIIIDNDTQEGIVILKKKVDFEQQSYYGIRAKVKNCHVDEELAPAHVNASTTYIKVQVEDEDEPPVFLLPYYILEIPEGKPYGTIV(464-772)GTVSATDPDRRQSPMRYYLTGSKMFDINDNGTIITTNMLDREVSAWYNLTVTATETYNVQQISSAHVYVQVFNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHEYFNLSVEDTNNSSETIIDNQDNTAVILTNRTGENLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGSAVQSNN 965 C137915 artificial ntgcctgggtgtggagaccatttgttgttctagaagaaatggatgatatacaatgtgttggaaagctaagatctgacttagacaatggmuCDH19aaacaactctttccagtacaagctactggggattggcgctggaagctttagcattaatgaaagaacaggtgaaatatgtgccatac(44-461)agaagcttgatagagaggaaaaatccctctacattctgagagcccaggtaatagacaccactattgggaaggctgtggaaactgaahuCDH19tccgagtttgtcatcagagttttggatatcaatgacaatgaacccagattcctagatgaaccatatgaggccattgtacctgagat(464-772)gtctccagaaggaacatttgtcatcaaggtgacagccaatgacgcagatgatccttcaactggctatcatgctcgcatcctatacaacttagaacgaggtcaaccatacttttctgttgagccaacaacaggagtcataaggatatcttctaagatggatagagagttgcaagatacatactgtgtaattattcaagccaaggacatgctcggtcagcctggagccttgtctggaacaacaaccgtatcaattaagctgtcagatattaatgacaacaagccaatattcaaagaaagtttctaccgcttcactatatctgaatctgcacccattggaacatcaatagggaaaattatggcatatgatgatgacataggggagaatgcagagatggagtacagcattgaagatgatgattcaaaaatatttgacataatcattgacaatgacacccaagaagggatagttatacttaaaaagaaagttgattttgagcagcagagctattatggcattagagctaaggttaaaaactgccatgtggatgaagagcttgcacctgcccatgttaacgcttccacaacctacattaaagttcaagtagaagatgaagatgaacctcctgttttcctcttaccatattacatacttgaaattcctgaaggaaaaccatatggaacaattgtggggacggtttctgccacagacccagatcgaagacaatctcctatgagatattatctcactggaagcaaaatgtttgatatcaatgacaatggaacaataatcaccactaacatgcttgacagagaggtcagtgcttggtacaacttgactgtcacagctactgaaacatacaatgtacaacagatctcttcagcccatgtttatgtacaagtctttaacattaatgatcatgctcctgagttctctcaatactatgagacttatgtttgtgaaaatgcaggctctggtcaggtaattcagactatcagtgcagtggatagagatgaatccatagaagagcaccatttttactttaatctatctgtagaagacactaacaattcaagttttacaatcatagataatcaagataacacagctgtcattttgactaatagaactggttttaaccttcaagaagaacctgtcttctacatctccatcttaattgccgacaatggaatcccgtcacttacaagtacaaacacccttaccatccatgtctgtgactgtggtgacagtgggagcacacagacctgccagtaccaggagcttgtgctttccatgggattcaagacagaagtcatcattgctattctcatttgcattatgatcatatttgggtttatttttttgactttgggtttaaaacaacggagaaaacagattctatttcctgagaaaagtgaagatttcagagagaatatattccaatatgatgatgaagggggtggagaagaagatacagaggcctttgatatagcagagctgaggagtagtaccataatgcgggaacgcaagactcggaaaaccacaagcgctgagatcaggagcctatacaggcagtctttgcaagttggccccgacagtgccatattcaggaaattcattctggaaaagctcgaagaagctaatactgatccgtgtgcccctccttttgattccctccagacctacgcttttgagggaacagggtcattagctggatccctgagctccttagaatcagcagtctctgatcaggatgaaagctatgattaccttaatgagttgggacctcgctttaaaagattagcatgcatgtttggttctgcagtgcagtcaaataattag 966 C71144 artificial aaAWVWRPFVVLEEMDDIQCVGKLRSDLDNGNNSFQYKLLGIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTIGKAVETEmuCDH19SEEVIRVLDINDNEPRELDEPYEAIVPEMSPEGTEVIKVTANDADDPSTGYHARILYNLERGQPYFSVEPTTGVIRISSKMDRELQ(44-770)DTYCVIIQAKDMLGQPGALSGTTTVSIKLSDINDNKPIFKESFYRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSIEDDDSKIFDIIIDNDTQEGIVILKKKVDFEQQSYYGIRAKVKNCHVDEELAPAHVNASTTYIKVQVEDEDEPPVFLLPYYILEIPEGKPYGTIVGTVSATDPDRRQSPMRYYLTGSKMFDINDNGTIITTNMLDREVSAWYNLTVTATETYNVQQISSAHVYVQVFNINDNAPEFSQFYETYVCENAESGEIVQIISAIDRDESIEDHHEYENHSLEDTNNSSFMLTDNQDNTAVILSNRTGENLKEEPVEYMIILIADNGIPSLTSTNTLTIQVCDCGDSRNTETCANKGLLFIMGFRTEAIIAIMICVMVIFGEFFLILALKQRRKETLFPEKTEDFRENIFCYDDEGGGEEDSEAFDIVELRQSTVMRERKPQRSKSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFGSAVQPNN 967 C71144 artificial ntgcctgggtgtggagaccatttgttgttctagaagaaatggatgatatacaatgtgttggaaagctaagatctgacttagacaatggmuCDH19aaacaactctttccagtacaagctactggggattggcgctggaagctttagcattaatgaaagaacaggtgaaatatgtgccatac(44-770)agaagcttgatagagaggaaaaatccctctacattctgagagcccaggtaatagacaccactattgggaaggctgtggaaactgaatccgagtttgtcatcagagttttggatatcaatgacaatgaacccagattcctagatgaaccatatgaggccattgtacctgagatgtctccagaaggaacatttgtcatcaaggtgacagccaatgacgcagatgatccttcaactggctatcatgctcgcatcctatacaacttagaacgaggtcaaccatacttttctgttgagccaacaacaggagtcataaggatatcttctaagatggatagagagttgcaagatacatactgtgtaattattcaagccaaggacatgctcggtcagcctggagccttgtctggaacaacaaccgtatcaattaagctgtcagatattaatgacaacaagccaatattcaaagaaagtttctaccgcttcactatatctgaatctgcacccattggaacatcaatagggaaaattatggcatatgatgatgacataggggagaatgcagagatggagtacagcattgaagatgatgattcaaaaatatttgacataatcattgacaatgacacccaagaagggatagttatacttaaaaagaaagttgattttgagcagcagagctattatggcattagagctaaggttaaaaactgccatgtggatgaagagcttgcacctgcccatgttaacgcttccacaacctacattaaagttcaagtagaagatgaagatgaacctcctgttttcctcttaccatattacatacttgaaattcctgaaggaaaaccatatggaacaattgtggggacggtttctgccacagacccagatcgaagacaatctcctatgagatattatctcactggaagcaaaatgtttgatatcaatgacaatggaacaataatcaccactaacatgcttgacagagaggtcagtgcttggtacaacttgactgtcacagctactgaaacatacaatgtacaacagatctcttcagcccatgtttatgtacaagtctttaacattaacgacaatgctccagagttctctcaattctatgagacttatgtttgtgaaaatgctgaatctggtgagatagttcagatcatcagtgcaattgatagagatgagtccatagaagatcaccatttttactttaatcactctctggaagacacaaacaactcaagttttatgctaacagacaatcaagataacacagctgtaattctgagtaatagaactggtttcaatcttaaagaagagcctgtcttctacatgatcatcttgattgctgataacgggatcccatctctcacaagcacaaacactctcactatccaagtctgtgactgtggagacagtagaaacacagaaacttgtgctaacaagggacttctctttatcatgggattcagaacagaggcaataattgccatcatgatatgtgttatggtaatatttgggtttttctttttgattcttgctctgaaacagcgaagaaaggagactctatttccagagaagactgaagactttagggagaatatattttgctatgatgatgaaggcggcggggaagaagactcggaagcctttgacatcgtagagctgagacaaagtacagtaatgagagaaagaaagcctcagagaagcaagagtgcggagatcaggagcttgtacaggcagtccctgcaggtgggcccagacagtgccatatttcgaaaatttatcctagagaagcttgaagaagccaacacagacccatgtgctcccccctttgattcactacagacgtttgcctatgagggaacagggtcatcagctggctctctgagctccttggcatccagagacactgatcaggaggatgacttcgactaccttaatgacctgggacctcgttttaaaagattagcaagcatgtttggctctgcagtacaacccaacaattag 968 Flag Tag artificial aa DYKDDDDK969 Flag Tag artificial nt gactacaaagacgatgacgacaag

Bispecific Binding Molecules

TABLE VI SEQ ID NO. DESIGNATION SOURCE TYPE SEQUENCE  970 CDR-H1 ofartificial AA SYGMH CDH19 2G6  971 CDR-H2 of artificial AAFIWYDGSNKYYADSVKD CDH19 2G6  972 CDR-H3 of artificial AARAGIIGTIGYYYGMDV CDH19 2G6  973 CDR-L1 of artificial AA SGDRLGEKYTCCDH19 2G6  974 CDR-L2 of artificial AA QDTKRPS CDH19 2G6  975 CDR-L3 ofartificial AA QAWDSSTVV CDH19 2G6  976 VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCCGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT2G6CTCCAGCTACGGCATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCTTCATTTGGTACGACGGCTCCAACAAGTACTACGCCGACTCCGTGAAGGACCGGTTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTACCTGCAGATGAAGTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCATCGGCACCATCGGCTACTACTACGGCATGGACGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGC  977 VH of CDH19 artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSL2G6 RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS  978 VL of CDH19 artificialNTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGAGAA2G6GTACACCTGTTGGTATCAGCAGCGGCCTGGCCAGTCCCCCCTGCTGGTCATCTACCAGGACACCAAGCGGCCCTCCGGCATCCCTGAGCGGTTCTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCTGGGACTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG  979VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTCWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY2G6 CQAWDSSTVVFGGGTKLTVL  980 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCCGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19 2G6CTCCAGCTACGGCATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCTTCATTTGGTACGACGGCTCCAACAAGTACTACGCCGACTCCGTGAAGGACCGGTTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTACCTGCAGATGAAGTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCATCGGCACCATCGGCTACTACTACGGCATGGACGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGAGAAGTACACCTGTTGGTATCAGCAGCGGCCTGGCCAGTCCCCCCTGCTGGTCATCTACCAGGACACCAAGCGGCCCTCCGGCATCCCTGAGCGGTTCTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCTGGGACTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG  981 VH-VL ofartificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSLCDH19 2G6RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTCWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVL 982 CDH19 2G6 x artificialQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSLI2CRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTCWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH 983 CDR-H1 of artificial AA SYGMH CDH19 16E2.1  984 CDR-H2 ofartificial AA VIWYDGSNKYYADSVKG CDH19 16E2.1  985 CDR-H3 of artificialAA DGWELSFDY CDH19 16E2.1  986 CDR-L1 of artificial AA RASQGISNYLACDH19 16E2.1  987 CDR-L2 of artificial AA AASSLQS CDH19 16E2.1  988CDR-L3 of artificial AA QHYFTYPRT CDH19 16E2.1  989 VH of CDH19artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCCGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCATCTT16E2.1CTCCAGCTACGGCATGCACTGGGTCCGACAGACCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACAAGTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACATCTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGGGACGGCTGGGAGCTGTCCTTCGATTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC  990 VH of CDH19 artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFIFSSYGMHWVRQTPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDISKNTLYLQMNSL16E2.1 RVEDTAVYYCARDGWELSFDYWGQGTLVTVSS  991 VL of CDH19 artificial NTGACATCCAGATGACCCAGTCCCCCTCCAGCCTGTCCGCCTCCGTGGGCGACAGAGTGACCATCACCTGTCGGGCCTCCCAGGGCAT16E2.1CAGCAACTACCTGGCCTGGCTGCAGCAGAAGCCCGGCAAGGCCCCCAAGTCCCTGATCTACGCCGCCAGCTCCCTGCAGTCCGGCGTGCCCTCCAAGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCTCCAGCCTGCAGCCCGAGGACTTCGCCACCTACTACTGCCAGCACTACTTCACCTACCCCCGGACCTTCGGACAGGGCACCAAGGTGGAAATCAAG  992VL of CDH19 artificial AADIQMTQSPSSLSASVGDRVTITCRASQGISNYLAWLQQKPGKAPKSLIYAASSLQSGVPSKFSGSGSGTDFTLTISSLQPEDFATY16E2.1 YCQHYFTYPRTFGQGTKVEIK  993 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCCGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCATCTTCDH19 16E2.1CTCCAGCTACGGCATGCACTGGGTCCGACAGACCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACAAGTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACATCTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGGGACGGCTGGGAGCTGTCCTTCGATTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGACATCCAGATGACCCAGTCCCCCTCCAGCCTGTCCGCCTCCGTGGGCGACAGAGTGACCATCACCTGTCGGGCCTCCCAGGGCATCAGCAACTACCTGGCCTGGCTGCAGCAGAAGCCCGGCAAGGCCCCCAAGTCCCTGATCTACGCCGCCAGCTCCCTGCAGTCCGGCGTGCCCTCCAAGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCTCCAGCCTGCAGCCCGAGGACTTCGCCACCTACTACTGCCAGCACTACTTCACCTACCCCCGGACCTTCGGACAGGGCACCAAGGTGGAAATCAAG  994 VH-VL of artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFIFSSYGMHWVRQTPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDISKNTLYLQMNSLCDH19 16E2.1RVEDTAVYYCARDGWELSFDYWGQGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLAWLQQKPGKAPKSLIYAASSLQSGVPSKFSGSGSGTDFTLTISSLQPEDFATYYCQHYFTYPRTFGQGTKVEIK 995 CDH19 16E2.1 artificialQVQLVESGGGVVQPGRSLRLSCAASGFIFSSYGMHWVRQTPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDISKNTLYLQMNSLx I2CRVEDTAVYYCARDGWELSFDYWGQGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLAWLQQKPGKAPKSLIYAASSLQSGVPSKFSGSGSGTDFTLTISSLQPEDFATYYCQHYFTYPRTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH 996 CDR-H1 of artificial AA SYYWS CDH19 17H8.2  997 CDR-H2 ofartificial AA YIYYIGSTNYNPSLKS CDH19 17H8.2  998 CDR-H3 of artificial AADSRYRSGWYDAFDI CDH19 17H8.2  999 CDR-L1 of artificial AA RASQSVAGSYLACDH19 17H8.2 1000 CDR-L2 of artificial AA GASSRAT CDH19 17H8.2 1001CDR-L3 of artificial AA QQYGKSPIT CDH19 17H8.2 1002 VH of CDH19artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCAT17H8.2CAACTCCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACATCGGCTCCACCAACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCCTGTACTACTGCGCCAGAGACTCCCGGTACAGATCCGGGTGGTACGACGCCTTCGACATCTGGGGCCAGGGCACCATGGTCACCGTGTCCTCT 1003 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVT17H8.2 AADTALYYCARDSRYRSGWYDAFDIWGQGTMVTVSS 1004 VL of CDH19 artificialNTGATATCGTGCTGACCCAGTCCCCCGGCACCCTGTCTCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCTCAGTCCGT17H8.2GGCCGGCTCCTACCTGGCTTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTCCGGCGCCTCTTCTAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCCGTGTACTATTGCCAGCAGTACGGCAAGTCCCCCATCACCTTCGGCCAGGGAACCCGGCTGGAAATGAAG 1005VL of CDH19 artificial AADIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLISGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAV17H8.2 YYCQQYGKSPITFGQGTRLEMK 1006 VH-VL of artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCATCDH19 17H8.2CAACTCCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACATCGGCTCCACCAACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCCTGTACTACTGCGCCAGAGACTCCCGGTACAGATCCGGGTGGTACGACGCCTTCGACATCTGGGGCCAGGGCACCATGGTCACCGTGTCCTCTGGTGGCGGAGGCTCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCCGATATCGTGCTGACCCAGTCCCCCGGCACCCTGTCTCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCTCAGTCCGTGGCCGGCTCCTACCTGGCTTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTCCGGCGCCTCTTCTAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCCGTGTACTATTGCCAGCAGTACGGCAAGTCCCCCATCACCTTCGGCCAGGGAACCCGGCTGGAAATGAAG 1007 VH-VL of artificialAAQVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTCDH19 17H8.2AADTALYYCARDSRYRSGWYDAFDIWGQGTMVTVSSGGGGSGGGGSGGGGSDIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLISGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMK1008 CDH19 17H8.2 artificialQVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTx I2CAADTALYYCARDSRYRSGWYDAFDIWGQGTMVTVSSGGGGSGGGGSGGGGSDIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLISGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1009 CDR-H1 of artificial AA SYFIH CDH19 19B5.1 1010 CDR-H2 ofartificial AA IINPISVSTSYAQKFQG CDH19 19B5.1 1011 CDR-H3 of artificialAA GGIQLWLHLDY CDH19 19B5.1 1012 CDR-L1 of artificial AA SGSRSNIGSNFVNCDH19 19B5.1 1013 CDR-L2 of artificial AA TNNQRPS CDH19 19B5.1 1014CDR-L3 of artificial AA ATWDDSMNGWV CDH19 19B5.1 1015 VH of CDH19artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGTGTCCGGCTACACCTT19B5.1CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCACCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTTCATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACCTGGACTATTGGGGCCAGGGCACCCTGGTCACCGTGTCCTCT 1016 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSL19B5.1 RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS 1017 VL of CDH19 artificial NTCAGTCTGCCCTGACCCAGCCTCCCTCCACCACCGGCACACCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT19B5.1CGGCTCCAACTTCGTGAACTGGTACAAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGTCCGACTACTACTGTGCCACCTGGGACGACTCCATGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG1018 VL of CDH19 artificial AAQSALTQPPSTTGTPGQRVTISCSGSRSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESD19B5.1 YYCATWDDSMNGWVFGGGTKLTVL 1019 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGTGTCCGGCTACACCTTCDH19 19B5.1CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCACCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTTCATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACCTGGACTATTGGGGCCAGGGCACCCTGGTCACCGTGTCCTCTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTCAGTCTGCCCTGACCCAGCCTCCCTCCACCACCGGCACACCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTACAAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGTCCGACTACTACTGTGCCACCTGGGACGACTCCATGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG 1020 VH-VL of artificialAAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLCDH19 19B5.1RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSTTGTPGQRVTISCSGSRSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSMNGWVFGGGTKLTVL1021 CDH19 19B5.1 artificialQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLx I2CRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSTTGTPGQRVTISCSGSRSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSMNGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1022 CDR-H1 of artificial AA SYFIH CDH19 20D3.1 1023 CDR-H2 ofartificial AA IINPISVSTSYAQKFQG CDH19 20D3.1 1024 CDR-H3 of artificialAA GGIQLWLHFDY CDH19 20D3.1 1025 CDR-L1 of artificial AA SGSSSNIGSNEVNCDH19 20D3.1 1026 CDR-L2 of artificial AA TNNQRPS CDH19 20D3.1 1027CDR-L3 of artificial AA ATWDDSLNGWV CDH19 20D3.1 1028 VH of CDH19artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGTGTCCGGCTACACCTT20D3.1CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCACCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTTCATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1029 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSL20D3.1 RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS 1030 VL of CDH19 artificial NTCAGTCTGCCCTGACCCAGCCTCCTTCTGCCACCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCTCCTCCAACAT20D3.1CGGCTCCAACTTCGTGAACTGGTACAAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGTCCGACTACTACTGTGCCACCTGGGACGACTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG1031 VL of CDH19 artificial AAQSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESD20D3.1 YYCATWDDSLNGWVFGGGTKLTVL 1032 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGTGTCCGGCTACACCTTCDH19 20D3.1CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCACCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTTCATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCTCAGTCTGCCCTGACCCAGCCTCCTTCTGCCACCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCTCCTCCAACATCGGCTCCAACTTCGTGAACTGGTACAAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGTCCGACTACTACTGTGCCACCTGGGACGACTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG 1033 VH-VL of artificialAAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLCDH19 20D3.1RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSATGTPGQRVTISCSGSSSNIGSNEVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSLNGWVFGGGTKLTVL1034 CDH19 20D3.1 artificialQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLx I2CRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSATGTPGQRVTISCSGSSSNIGSNEVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSLNGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1035 CDR-H1 of artificial AA SYFIH CDH19 22D1.1 1036 CDR-H2 ofartificial AA IINPISVSTSYAQKFQG CDH19 22D1.1 1037 CDR-H3 of artificialAA GGIQLWLHLDY CDH19 22D1.1 1038 CDR-L1 of artificial AA SGSSSNIGSNFVNCDH19 22D1.1 1039 CDR-L2 of artificial AA TNNQRPS CDH19 22D1.1 1040CDR-L3 of artificial AA ATWDDSMNGWV CDH19 22D1.1 1041 VH of CDH19artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGCGGGTGTCCTGCAAGGTGTCCGGCTACACCTT22D1.1CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCACCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTTCATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACCTGGACTATTGGGGCCAGGGCACCCTGGTCACCGTGTCCTCT 1042 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSL22D1.1 RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS 1043 VL of CDH19 artificial NTCAGTCTGCCCTGACCCAGCCTCCTTCCGCTACCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCTCCTCCAACAT22D1.1CGGCTCCAACTTCGTGAACTGGTACAAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGTCCGACTACTACTGTGCCACCTGGGACGACTCCATGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG1044 VL of CDH19 artificial AAQSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESD22D1.1 YYCATWDDSMNGWVFGGGTKLTVL 1045 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGCGGGTGTCCTGCAAGGTGTCCGGCTACACCTTCDH19 22D1.1CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCACCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTTCATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACCTGGACTATTGGGGCCAGGGCACCCTGGTCACCGTGTCCTCTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTCAGTCTGCCCTGACCCAGCCTCCTTCCGCTACCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCTCCTCCAACATCGGCTCCAACTTCGTGAACTGGTACAAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGTCCGACTACTACTGTGCCACCTGGGACGACTCCATGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG 1046 VH-VL of artificialAAQVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLCDH19 22D1.1RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSMNGWVFGGGTKLTVL1047 CDH19 22D1.1 artificialQVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLx I2CRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSATGTPGQRVTISCSGSSSNIGSNEVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCATWDDSMNGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1048 CDR-H1 of artificial AA SYAMN CDH19 22G10.1 1049 CDR-H2 ofartificial AA TISGGGANTYYADSVKG CDH19 22G10.1 1050 CDR-H3 of artificialAA GGMGGYYYGMDV CDH19 22G10.1 1051 CDR-L1 of artificial AA RASQSISSNLACDH19 22G10.1 1052 CDR-L2 of artificial AA GAFTRAT CDH19 22G10.1 1053CDR-L3 of artificial AA QQYNYWPLT CDH19 22G10.1 1054 VH of CDH19artificial NTGAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT22G10.1CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACACCTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCTCCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGCCGACACCGCCGTGTACCACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGC 1055 VH of CDH19 artificial AAEVQLLESGGGLVQPGGSLRLSCAASGFTESSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISSDNSKSTLYLQMNSL22G10.1 RAADTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSS 1056 VL of CDH19 artificialNTGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCAT22G10.1CTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGAGTGTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGCAGTCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAG 1057VL of CDH19 artificial AAEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVY22G10.1 YCQQYNYWPLTFGGGTKVEIK 1058 VH-VL of artificial NTGAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACA22G10.1CCTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCTCCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGCCGACACCGCCGTGTACCACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGCGGTGGTGGTTCTGGCGGAGGCGGCTCCGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCATCTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGAGTGTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGCAGTCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAG 1059 VH-VL of artificial AAEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISSDNSKSTLYLQMNSLCDH19RAADTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWF22G10.1QQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIK1060 CDH19 artificialEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISSDNSKSTLYLQMNSL22G10.1 xRAADTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFI2CQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1061 CDR-H1 of artificial AA RYGIH CDH19 23A10.3 1062 CDR-H2 ofartificial AA VIWYDGSNKYYADSVKG CDH19 23A10.3 1063 CDR-H3 of artificialAA RAGIPGTTGYYYGMDV CDH19 23A10.3 1064 CDR-L1 of artificial AASGDRLGEKYVC CDH19 23A10.3 1065 CDR-L2 of artificial AA QDNKWPS CDH1923A10.3 1066 CDR-L3 of artificial AA QAWDSSTVV CDH19 23A10.3 1067VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCCGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTI23A10.3CTCCAGATACGGCATCCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACPAGTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTACCTGCTGATGAACTCCCTCCGGGCCGAGGACTCCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCCCCGGCACCACCGGCTACTACTACGGCATGGATGTGTCGGGCCAGGGCACCACCGTGACCGTGTCTAGC 1068 VH of CDH19 artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLLMNSL23A10.3 RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSS 1069 VL of CDH19artificial NTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGAGAP23A10.3ATACGTGTGCTGGTATCAGCAGAAGCCCGGCCAGTCCCCCATCCTGGTCATCTACCAGGACAACAAGTGGCCCTCCGGCATCCCTCAGCGGTTCTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCTGGGACTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG 1070VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYVCWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYY23A10.3 CQAWDSSTVVFGGGTKLTVL 1071 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCCGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTICDH19CTCCAGATACGGCATCCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACP23A10.3AGTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTACCTGCTGATGAACTCCCTCCGGGCCGAGGACTCCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCCCCGGCACCACCGGCTACTACTACGGCATGGATGTGTCGGGCCAGGGCACCACCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGAGAAATACGTCTGCTGGTATCAGCAGAAGCCCGGCCAGTCCCCCATCCTGGTCATCTACCAGGACAACAAGTGGCCCTCCGGCATCCCTGAGCGGTICTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCIGGGACTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG 1072 VH-VL ofartificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLLMNSLCDH19RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYV23A10.3CWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVL1073 CDH19 artificialQVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLLMNSL23A10.3 xRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYVI2CCWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTECTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1074 CDR-H1 of artificial AA SYYIH CDH19 25F8.1 1075 CDR-H2 ofartificial AA IINPSGGSTRYAQKFQG CDH19 25F8.1 1076 CDR-H3 of artificialAA GGIQLWLHFDY CDH19 25F8.1 1077 CDR-L1 of artificial AA SGSSSNIGRNFVNCDH19 25F8.1 1078 CDR-L2 of artificial AA TNNQRPS CDH19 25F8.1 1079CDR-L3 of artificial AA AAWDDSLNGWV CDH19 25F8.1 1080 VH of CDH19artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCGGCTACACCTT25F8.1CACCAGCTACTACATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCCGGCGGCTCCACCAGATACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTTCATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1081 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVFMELSSL25F8.1 RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS 1082 VL of CDH19 artificial NTCAGTCTGCCCTGACCCAGCCTCCTTCTGCCACCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCTCCTCCAACAT25F8.1CGGCCGGAACTTCGTGAACTGGTACAAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGTCCGACTACTACTGTGCCGCCTGGGACGACTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG1083 VL of CDH19 artificial AAQSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESD25F8.1 YYCAAWDDSLNGWVFGGGTKLTVL 1084 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCGGCTACACCTTCDH19 25F8.1CACCAGCTACTACATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCCGGCGGCTCCACCAGATACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTTCATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCTCAGTCTGCCCTGACCCAGCCTCCTTCTGCCACCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCTCCTCCAACATCGGCCGGAACTTCGTGAACTGGTACAAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGTCCGACTACTACTGTGCCGCCTGGGACGACTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG 1085 VH-VL of artificialAAQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVFMELSSLCDH19 25F8.1RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCAAWDDSLNGWVFGGGTKLTVL1086 CDH19 25F8.1 artificialQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVFMELSSLx I2CRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYKQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDESDYYCAAWDDSLNGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1087 CDR-H1 of artificial AA GYYWS CDH19 25G10.1 1088 CDR-H2 ofartificial AA YIYYIGSTNYNPSLKS CDH19 25G10.1 1089 CDR-H3 of artificialAA DGSSGWYRWFDP CDH19 25G10.1 1090 CDR-L1 of artificial AA RASQSVSSSYLACDH19 25G10.1 1091 CDR-L2 of artificial AA GASSRAT CDH19 25G10.1 1092CDR-L3 of artificial AA QQYGNSPLT CDH19 25G10.1 1093 VH of CDH19artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCAT25G10.1CTCCGGCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACATCGGCTCCACCAACTACAACCCCAGCCTGAAGTCCAGAGTGACCATGTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCAGAGATGGCTCCTCCGGCTGGTATCGTTGGTTCGACCCTTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1094 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSVDTSKNQFSLKLSSVT25G10.1 AADTAVYYCARDGSSGWYRWFDPWGQGTLVTVSS 1095 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGT25G10.1GTCCTCCTCCTACCTGGCTTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTTCGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCTCCCGGCTGGAACCCGAGGACTTCGCTGTGTACCACTGCCAGCAGTACGGCAACAGCCCCCTGACCTTCGGCGGAGGCACCAAGGTGGAAATCAAG 1096VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAV25G10.1 YHCQQYGNSPLTFGGGTKVEIK 1097 VH-VL of artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCATCDH19CTCCGGCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACATCGGCTCCACCA25G10.1ACTACAACCCCAGCCTGAAGTCCAGAGTGACCATGTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCAGAGATGGCTCCTCCGGCTGGTATCGTTGGTTCGACCCTTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGTGTCCTCCTCCTACCTGGCTTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTTCGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCTCCCGGCTGGAACCCGAGGACTTCGCTGTGTACCACTGCCAGCAGTACGGCAACAGCCCCCTGACCTTCGGCGGAGGCACCAAGGTGGAAATCAAG 1098 VH-VL of artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSVDTSKNQFSLKLSSVTCDH19AADTAVYYCARDGSSGWYRWFDPWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWY25G10.1QQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYHCQQYGNSPLTFGGGTKVEIK1099 CDH19 artificialQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSVDTSKNQFSLKLSSVT25G10.1 xAADTAVYYCARDGSSGWYRWFDPWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYI2CQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYHCQQYGNSPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1100 CDR-H1 of artificial AA SYYMS CDH19 26D1.1 1101 CDR-H2 ofartificial AA IIHPSGGDTTYAQKFQG CDH19 26D1.1 1102 CDR-H3 of artificialAA GGIKLWLHFDY CDH19 26D1.1 1103 CDR-L1 of artificial AA SGSRSNIGSNFVNCDH19 26D1.1 1104 CDR-L2 of artificial AA TNNQRPS CDH19 26D1.1 1105CDR-L3 of artificial AA AVWDDSLNGWV CDH19 26D1.1 1106 VH of CDH19artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCCGGTACACCTT26D1.1CACCAGCTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCCACCCCTCTGGCGGCGACACCACCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCGGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCAAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1107 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSL26D1.1 RSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSS 1108 VL of CDH19 artificial NTCATTCCGTGCTGACCCAGTCTCCTTCCGCCTCCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT26D1.1CGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTGGGACGACTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG1109 VL of CDH19 artificial AAHSVLTQSPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD26D1.1 YYCAVWDDSLNGWVFGGGTKLTVL 1110 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCCGGTACACCTTCDH19 26D1.1CACCAGCTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCCACCCCTCTGGCGGCGACACCACCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCGGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCAAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCCATTCCGTGCTGACCCAGTCTCCTTCCGCCTCCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTGGGACGACTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG 1111 VH-VL of artificialAAQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLCDH19 26D1.1RSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSHSVLTQSPSASGTPGQRVTISCSGSRSNIGSNEVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVL1112 CDH19 26D1.1 artificialQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLx I2CRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSHSVLTQSPSASGTPGQRVTISCSGSRSNIGSNEVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1113 CDR-H1 of artificial AA NYYMS CDH19 26F12.1 1114 CDR-H2 ofartificial AA IINPSGGDSTYAQKFQG CDH19 26F12.1 1115 CDR-H3 of artificialAA GGIQLWLHFDY CDH19 26F12.1 1116 CDR-L1 of artificial AA SGSRSNIGSNFVNCDH19 26F12.1 1117 CDR-L2 of artificial AA TNYQRPS CDH19 26F12.1 1118CDR-L3 of artificial AA AVWDDSLNGWV CDH19 26F12.1 1119 VH of CDH19artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCCGGTACACCTT26F12.1CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACTCCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCGGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1120 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSL26F12.1 RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS 1121 VL of CDH19 artificialNTCAGTCTGTGCTGACCCAGTCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT26F12.1CGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTGGGACGACTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG1122 VL of CDH19 artificial AAQSVLTQSPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD26F12.1 YYCAVWDDSLNGWVFGGGTKLTVL 1123 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCCGGTACACCTTCDH19CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACT26F12.1CCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCGGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCCAGTCTGTGCTGACCCAGTCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTGGGACGACTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG 1124 VH-VL of artificialAAQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSLCDH19RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQSPSASGTPGQKVTISCSGSRSNIGSNFVNWY26F12.1QQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVL1125 CDH19 artificialQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSL26F12.1 xRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQSPSASGTPGQKVTISCSGSRSNIGSNFVNWYI2CQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1126 CDR-H1 of artificial AA GYYWS CDH19 4A9 1127 CDR-H2 of artificialAA YFSYSGSTNYNPSLKS CDH19 4A9 1128 CDR-H3 of artificial AA NWAFHFDFCDH19 4A9 1129 CDR-L1 of artificial AA TGSSSNIGTGYAVH CDH19 4A9 1130CDR-L2 of artificial AA GNNNRPS CDH19 4A9 1131 CDR-L3 of artificial AAQSYDSRLSGWV CDH19 4A9 1132 VH of CDH19 artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCAT4A9CTCCGGCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGTTCGCCTACTTCTCCTACTCCGGCTCCACCAACTACAACCCCAGCCTGAAGTCCAGAGTGACCCTGTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCCGGAACTGGGCCTTCCACTTCGATTTCTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1133 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWFAYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVT4A9 AADTAVYYCARNWAFHFDFWGQGTLVTVSS 1134 VL of CDH19 artificial NTCAGTCTGTGCTGACCCAGCCTCCCTCTGTGTCTGGCGCCCCTGGCCAGAGAGTGACCATCTCCTGCACCGGCTCCTCCAGCAACAT4A9CGGCACCGGCTACGCCGTGCACTGGTATCAGCAGTTCCCCGGCACCGCCCCCAAGCTGCTGATCTACGGCAACAACAACCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCTATCACCGGCCTGCAGGCTGAGGACGAGGCCGACTACTACTGCCAGTCCTACGACTCCCGGCTGTCCGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG1135 VL of CDH19 artificial AAQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQFPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEA4A9 DYYCQSYDSRLSGWVFGGGTKLTVL 1136 VH-VL of artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCATCDH19 4A9CTCCGGCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGTTCGCCTACTTCTCCTACTCCGGCTCCACCAACTACAACCCCAGCCTGAAGTCCAGAGTGACCCTGTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCCGGAACTGGGCCTTCCACTTCGATTTCTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCCAGTCTGTGCTGACCCAGCCTCCCTCTGTGTCTGGCGCCCCTGGCCAGAGAGTGACCATCTCCTGCACCGGCTCCTCCAGCAACATCGGCACCGGCTACGCCGTGCACTGGTATCAGCAGTTCCCCGGCACCGCCCCCAAGCTGCTGATCTACGGCAACAACAACCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCTATCACCGGCCTGCAGGCTGAGGACGAGGCCGACTACTACTGCCAGTCCTACGACTCCCGGCTGTCCGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTG 1137 VH-VL of artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWFAYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTCDH19 4A9AADTAVYYCARNWAFHFDFWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQFPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSRLSGWVFGGGTKLTVL1138 CDH19 4A9 x artificialQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWFAYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTI2CAADTAVYYCARNWAFHFDFWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQFPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSRLSGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1139 CDR-H1 of artificial AA SYDMH CDH19 4B10 1140 CDR-H2 of artificialAA VISYDGTNEYYADSVKG CDH19 4B10 1141 CDR-H3 of artificial AA ERYFDWSFDYCDH19 4B10 1142 CDR-L1 of artificial AA RASQSVSNTYLA CDH19 4B10 1143CDR-L2 of artificial AA GASSRAT CDH19 4B10 1144 CDR-L3 of artificial AAQQYSNSWT CDH19 4B10 1145 VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCCGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT4B10CTCCAGCTACGACATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATCTCCTACGACGGCACCAACGAGTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACACCTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCGGTACTTCGACTGGTCCTTCGACTACTGGGGCCAGGGCACCCTGGTGTCCGTGTCTAGC 1146 VH of CDH19 artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSL4B10 RAEDTAVYYCARERYFDWSFDYWGQGTLVSVSS 1147 VL of CDH19 artificial NTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCGT4B10GTCCAACACCTACCTGGCCTGGTATCACCAGCGCCCTGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCTGGCACCGACTTCGCCCTGACCATCTCCAGCCTGGAACCCGAGGATTTCGCTGTGTACTATTGCCAGCAGTACTCCAACTCCTGGACCTTCGGACAGGGCACCAAGGTGGAAATCAAG 1148VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYHQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFALTISSLEPEDFAV4B10 YYCQQYSNSWTFGQGTKVEIK 1149 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCCGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19 4B10CTCCAGCTACGACATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATCTCCTACGACGGCACCAACGAGTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACACCTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCGGTACTTCGACTGGTCCTTCGACTACTGGGGCCAGGGCACCCTGGTGTCCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCGTGTCCAACACCTACCTGGCCTGGTATCACCAGCGCCCTGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCTGGCACCGACTTCGCCCTGACCATCTCCAGCCTGGAACCCGAGGATTTCGCTGTGTACTATTGCCAGCAGTACTCCAACTCCTGGACCTTCGGACAGGGCACCAAGGTGGAAATCAAG 1150 VH-VL of artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSLCDH19 4B10RAEDTAVYYCARERYFDWSFDYWGQGTLVSVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYHQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFALTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIK1151 CDH19 4B10 x artificialQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSLI2CRAEDTAVYYCARERYFDWSFDYWGQGTLVSVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYHQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFALTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1152 CDR-H1 of artificial AA SYDMD CDH19 4F3 1153 CDR-H2 of artificialAA VIWYDGSNKYYADSVRG CDH19 4F3 1154 CDR-H3 of artificial AA ETGEGWYFDLCDH19 4F3 1155 CDR-L1 of artificial AA RASQSVSSSYLA CDH19 4F3 1156CDR-L2 of artificial AA GASSRAT CDH19 4F3 1157 CDR-L3 of artificial AAQQYGSSWT CDH19 4F3 1158 VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCCGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTT4F3CTCCTCCTACGACATGGACTGGGTCCGACAGACCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACAAGTACTACGCCGACTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCAGAGGCACCCTGGTCACCGTGTCTAGC 1159 VH of CDH19 artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFSFSSYDMDWVRQTPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSL4F3 RVEDTAVYYCARETGEGWYFDLWGRGTLVTVSS 1160 VL of CDH19 artificial NTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGT4F3GTCCTCCTCCTACCTGGCCTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAG 1161VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAV4F3 YYCQQYGSSWTFGQGTKVEIK 1162 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCCGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTTCDH19 4F3CTCCTCCTACGACATGGACTGGGTCCGACAGACCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACAAGTACTACGCCGACTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCAGAGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGTGTCCTCCTCCTACCTGGCCTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAG 1163 VH-VL of artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFSFSSYDMDWVRQTPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLCDH19 4F3RVEDTAVYYCARETGEGWYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIK1164 CDH19 4F3 x artificialQVQLVESGGGVVQPGRSLRLSCAASGFSFSSYDMDWVRQTPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLI2CRVEDTAVYYCARETGEGWYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1165 CDR-H1 of artificial AA SYSWS CDH19 4F7 1166 CDR-H2 of artificialAA YIYYSGSTNYNPSLKS CDH19 4F7 1167 CDR-H3 of artificial AA NWAFHFDYCDH19 4F7 1168 CDR-L1 of artificial AA TGSSSNIGTGYDVH CDH19 4F7 1169CDR-L2 of artificial AA GNSNRPS CDH19 4F7 1170 CDR-L3 of artificial AAQSYDSSLSGWV CDH19 4F7 1171 VH of CDH19 artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCAT4F7CTCCTCCTACTCTTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACTCCGGCTCCACCAACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCCTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCCGGAACTGGGCCTTCCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1172 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVT4F7 AADTAVYYCARNWAFHFDYWGQGTLVTVSS 1173 VL of CDH19 artificial NTCAGTCTGTGCTGACCCAGCCTCCCTCTGTGTCTGGCGCCCCTGGCCAGCGCGTGACCATTTCCTGCACCGGCTCCTCCAGCAACAT4F7CGGCACCGGCTACGACGTGCACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCCACGGCAACTCCAACCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCTATCACCGGCCTGCAGGCTGAGGACGAGGCCGACTACTACTGCCAGTCCTACGACTCCTCCCTGTCCGGCTGGGTGTTCGGCGGAGGCACCAGACTGACCGTGCTG1174 VL of CDH19 artificial AAQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIHGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEA4F7 DYYCQSYDSSLSGWVFGGGTRLTVL 1175 VH-VL of artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCATCDH19 4F7CTCCTCCTACTCTTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACTCCGGCTCCACCAACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCCTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCCGGAACTGGGCCTTCCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCCAGTCTGTGCTGACCCAGCCTCCCTCTGTGTCTGGCGCCCCTGGCCAGCGCGTGACCATTTCCTGCACCGGCTCCTCCAGCAACATCGGCACCGGCTACGACGTGCACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCCACGGCAACTCCAACCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCTATCACCGGCCTGCAGGCTGAGGACGAGGCCGACTACTACTGCCAGTCCTACGACTCCTCCCTGTCCGGCTGGGTGTTCGGCGGAGGCACCAGACTGACCGTGCTG 1176 VH-VL of artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTCDH19 4F7AADTAVYYCARNWAFHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIHGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVL1177 CDH19 4F7 x artificialQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTI2CAADTAVYYCARNWAFHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIHGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1178 CDR-H1 of artificial AA SYGMH CDH19 14039 1179 CDR-H2 of artificialAA FIWYEGSNKYYAESVKD CDH19 14039 1180 CDR-H3 of artificial AARAGIIGTIGYYYGMDV CDH19 14039 1181 CDR-L1 of artificial AA SGDRLGEKYTSCDH19 14039 1182 CDR-L2 of artificial AA QDTKRPS CDH19 14039 1183CDR-L3 of artificial AA QAWESSTVV CDH19 14039 1184 VH of CDH19artificial NTCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTT14039CAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT 1185 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMNSL14039 RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS 1186 VL of CDH19artificial NTTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA14039AAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1187VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14039 CQAWESSTVVFGGGTKLTVL 1188 VH-VL of artificial NTCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCDH19 14039CAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1189 VH-VL ofartificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMNSLCDH19 14039RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVL1190 CDH19 14039 artificialQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMNSLx I2CRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1191 CDR-H1 of artificial AA SYGMH CDH19 14304 1192 CDR-H2 of artificialAA FIWYDGSNKYYADSVKD CDH19 14304 1193 CDR-H3 of artificial AARAGIIGTIGYYYGMDV CDH19 14304 1194 CDR-L1 of artificial AA SGDRLGEKYVSCDH19 14304 1195 CDR-L2 of artificial AA QDNKWPS CDH19 14304 1196CDR-L3 of artificial AA QAWDSSTVV CDH19 14304 1197 VH of CDH19artificial NTCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTT14304CAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAAAAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT 1198 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSL14304 RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS 1199 VL of CDH19artificial NTTCCTATGAGCTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGATTGGGGGA14304GAAATATGTTAGCTGGTATCAGCAGAAGCCAGGCCAGTCCCCTATACTGGTCATCTATCAAGATAATAAGTGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGGAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGACAGCAGCACTGTGGTATTCGGCGGGGGGACCAAGCTGACCGTCCTA 1200VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14304 CQAWDSSTVVFGGGTKLTVL 1201 VH-VL of artificial NTCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCDH19 14304CAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAAAAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTTCCTATGAGCTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGATTGGGGGAGAAATATGTTAGCTGGTATCAGCAGAAGCCAGGCCAGTCCCCTATACTGGTCATCTATCAAGATAATAAGTGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGGAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGACAGCAGCACTGTGGTATTCGGCGGGGGGACCAAGCTGACCGTCCTA 1202 VH-VL ofartificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSLCDH19 14304RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVL1203 CDH19 14304 artificialQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSLx I2CRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1204 CDR-H1 of artificial AA SYGMH CDH19 14301 1205 CDR-H2 of artificialAA FIWYDGSNKYYADSVKD CDH19 14301 1206 CDR-H3 of artificial AARAGIIGTIGYYYGMDV CDH19 14301 1207 CDR-L1 of artificial AA SGDRLGEKYTCCDH19 14301 1208 CDR-L2 of artificial AA QDTKRPS CDH19 14301 1209CDR-L3 of artificial AA QAWESSTVV CDH19 14301 1210 VH of CDH19artificial NTCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTT14301CAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAAAAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT 1211 VH of CDH19 artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSL14301 RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS 1212 VL of CDH19artificial NTTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA14301AAAATATACTTGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1213VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTCWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14301 CQAWESSTVVFGGGTKLTVL 1214 VH-VL of artificial NTCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCDH19 14301CAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAAAAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTTGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1215 VH-VL ofartificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSLCDH19 14301RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTCWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVL1216 CDH19 14301 artificialQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSLx I2CRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTCWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1217 CDR-H1 of artificial AA RYGIH CDH19 14079 1218 CDR-H2 of artificialAA VIWYEGSNKYYAESVKG CDH19 14079 1219 CDR-H3 of artificial AARAGIPGTTGYYYGMDV CDH19 14079 1220 CDR-L1 of artificial AA SGDRLGEKYVSCDH19 14079 1221 CDR-L2 of artificial AA QDNKWPS CDH19 14079 1222CDR-L3 of artificial AA QAWESSTVV CDH19 14079 1223 VH of CDH19artificial NTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTT14079CAGTCGCTATGGCATACACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACTCGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATACCTGGAACTACGGGCTACTACTATGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCA 1224 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYEGSNKYYAESVKGRFTISRDNSKNTLYLQMNSL14079 RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSS 1225 VL of CDH19artificial NTTCCTATGAGCTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGATTGGGGGA14079GAAATATGTTAGCTGGTATCAGCAGAAGCCAGGCCAGTCCCCTATACTGGTCATCTATCAAGATAATAAGTGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGGAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGGGGGACCAAGCTGACCGTCCTA 1226VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14079 CQAWESSTVVFGGGTKLTVL 1227 VH-VL of artificial NTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCDH19 14079CAGTCGCTATGGCATACACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACTCGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATACCTGGAACTACGGGCTACTACTATGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTTCCTATGAGCTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGATTGGGGGAGAAATATGTTAGCTGGTATCAGCAGAAGCCAGGCCAGTCCCCTATACTGGTCATCTATCAAGATAATAAGTGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGGAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGGGGGACCAAGCTGACCGTCCTA 1228 VH-VL ofartificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYEGSNKYYAESVKGRFTISRDNSKNTLYLQMNSLCDH19 14079RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVL1229 CDH19 14079 artificialQVQLVESGGGVVQPGGSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYEGSNKYYAESVKGRFTISRDNSKNTLYLQMNSLx I2CRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1230 CDR-H1 of artificial AA RYGIH CDH19 14077 1231 CDR-H2 of artificialAA VIWYDGSNKYYADSVKG CDH19 14077 1232 CDR-H3 of artificial AARAGIPGTTGYYYGMDV CDH19 14077 1233 CDR-L1 of artificial AA SGDRLGEKYVSCDH19 14077 1234 CDR-L2 of artificial AA QDNKWPS CDH19 14077 1235CDR-L3 of artificial AA QAWDSSTVV CDH19 14077 1236 VH of CDH19artificial NTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTT14077CAGTCGCTATGGCATACACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACTCGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATACCTGGAACTACGGGCTACTACTATGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCA 1237 VH of CDH19 artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSL14077 RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSS 1238 VL of CDH19artificial NTTCCTATGAGCTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGATTGGGGGA14077GAAATATGTTAGCTGGTATCAGCAGAAGCCAGGCCAGTCCCCTATACTGGTCATCTATCAAGATAATAAGTGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGGAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGACAGCAGCACTGTGGTATTCGGCGGGGGGACCAAGCTGACCGTCCTA 1239VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14077 CQAWDSSTVVFGGGTKLTVL 1240 VH-VL of artificial NTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCDH19 14077CAGTCGCTATGGCATACACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACTCGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATACCTGGAACTACGGGCTACTACTATGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTTCCTATGAGCTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGATTGGGGGAGAAATATGTTAGCTGGTATCAGCAGAAGCCAGGCCAGTCCCCTATACTGGTCATCTATCAAGATAATAAGTGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGGAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGACAGCAGCACTGTGGTATTCGGCGGGGGGACCAAGCTGACCGTCCTA 1241 VH-VL ofartificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLCDH19 14077RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVL1242 CDH19 14077 artificialQVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLx I2CRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1243 CDR-H1 of artificial AA SYYIH CDH19 14096 1244 CDR-H2 of artificialAA IINPSGGSTRYAQKFQG CDH19 14096 1245 CDR-H3 of artificial AAGGIQLWLHFDY CDH19 14096 1246 CDR-L1 of artificial AA SGSSSNIGRNFVNCDH19 14096 1247 CDR-L2 of artificial AA TNNQRPS CDH19 14096 1248CDR-L3 of artificial AA AAWDESLNGWV CDH19 14096 1249 VH of CDH19artificial NTCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTT14096CACCAGCTACTATATTCACTGGGTGCGCCAGGCCCCTGGACAAGGACTTGAGTGGATGGGAATAATCAACCCCAGTGGTGGTAGCACAAGGTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGCGAGGGGGAATACAGCTATGGTTACATTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 1250 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVYMELSSL14096 RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS 1251 VL of CDH19 artificial NTCAGTCTGCGCTGACTCAGCCACCCTCAGCGACTGGGACCCCCGGGCAGAGGGTCACCATCTCTTGTTCTGGAAGCAGCTCCAACAT14096CGGAAGGAATTTTGTAAACTGGTATCAGCAGCTCCCAGGAACGGCCCCCAAAGTCCTCATTTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGGCTGATTATTACTGTGCAGCATGGGATGAGAGCCTGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTA1252 VL of CDH19 artificial AAQSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDESLNGWVFGGGTKLTVL 1253 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCDH19 14096CACCAGCTACTATATTCACTGGGTGCGCCAGGCCCCTGGACAAGGACTTGAGTGGATGGGAATAATCAACCCCAGTGGTGGTAGCACAAGGTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGCGAGGGGGAATACAGCTATGGTTACATTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTCAGTCTGCGCTGACTCAGCCACCCTCAGCGACTGGGACCCCCGGGCAGAGGGTCACCATCTCTTGTTCTGGAAGCAGCTCCAACATCGGAAGGAATTTTGTAAACTGGTATCAGCAGCTCCCAGGAACGGCCCCCAAAGTCCTCATTTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGGCTGATTATTACTGTGCAGCATGGGATGAGAGCCTGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTA 1254 VH-VL of artificialAAQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVYMELSSLCDH19 14096RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDESLNGWVFGGGTKLTVL1255 CDH19 14096 artificialQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYIHWVRQAPGQGLEWMGIINPSGGSTRYAQKFQGRVTMTRDTSTSTVYMELSSLx I2CRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSATGTPGQRVTISCSGSSSNIGRNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDESLNGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1256 CDR-H1 of artificial AA SYYMS CDH19 14088 1257 CDR-H2 of artificialAA IIHPSGGDTTYAQKFQG CDH19 14088 1258 CDR-H3 of artificial AAGGIKLWLHFDY CDH19 14088 1259 CDR-L1 of artificial AA SGSRSNIGSNFVNCDH19 14088 1260 CDR-L2 of artificial AA TNNQRPS CDH19 14088 1261CDR-L3 of artificial AA AVWDDSLNGWV CDH19 14088 1262 VH of CDH19artificial NTCAGGTGCAGTTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGTAAGGCATCTGGATACACCTT14088CACCAGCTACTATATGTCCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCCACCCTAGTGGTGGTGACACAACCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGGGGGATAAAACTATGGTTACATTTTGACTATTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 1263 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTRDTSTSTVYMELSSL14088 RSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSS 1264 VL of CDH19 artificial NTCAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTGGGACCCCCGGACAGAGGGTCACCATCTCTTGTTCTGGAAGCCGCTCCAACAT14088CGGAAGTAATTTTGTAAACTGGTACCAGCAGCTCCCAGGAACGGCCCCCAAACTCCTCATCTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGGCTGATTATTACTGTGCAGTATGGGATGACAGCCTGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTA1265 VL of CDH19 artificial AAQSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD14088 YYCAVWDDSLNGWVFGGGTKLTVL 1266 VH-VL of artificial NTCAGGTGCAGTTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGTAAGGCATCTGGATACACCTTCDH19 14088CACCAGCTACTATATGTCCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCCACCCTAGTGGTGGTGACACAACCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGGGGGATAAAACTATGGTTACATTTTGACTATTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTCAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTGGGACCCCCGGACAGAGGGTCACCATCTCTTGTTCTGGAAGCCGCTCCAACATCGGAAGTAATTTTGTAAACTGGTACCAGCAGCTCCCAGGAACGGCCCCCAAACTCCTCATCTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGGCTGATTATTACTGTGCAGTATGGGATGACAGCCTGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTA 1267 VH-VL of artificialAAQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTRDTSTSTVYMELSSLCDH19 14088RSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVL1268 CDH19 14088 artificialQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTRDTSTSTVYMELSSLx I2CRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1269 CDR-H1 of artificial AA SYYMS CDH19 14085 1270 CDR-H2 of artificialAA IIHPSGGDTTYAQKFQG CDH19 14085 1271 CDR-H3 of artificial AAGGIKLWLHFDY CDH19 14085 1272 CDR-L1 of artificial AA SGSRSNIGSNFVNCDH19 14085 1273 CDR-L2 of artificial AA TNNQRPS CDH19 14085 1274CDR-L3 of artificial AA AVYDDSLNGWV CDH19 14085 1275 VH of CDH19artificial NTCAGGTGCAGTTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGTAAGGCATCTAGATACACCTT14085CACCAGCTACTATATGTCCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCCACCCTAGTGGTGGTGACACAACCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCGGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGGGGGATAAAACTATGGTTACATTTTGACTATTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 1276 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSL14085 RSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSS 1277 VL of CDH19 artificial NTCAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTGGGACCCCCGGACAGAGGGTCACCATCTCTTGTTCTGGAAGCCGCTCCAACAT14085CGGAAGTAATTTTGTAAACTGGTACCAGCAGCTCCCAGGAACGGCCCCCAAACTCCTCATCTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGGCTGATTATTACTGTGCAGTATACGATGACAGCCTGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTA1278 VL of CDH19 artificial AAQSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD14085 YYCAVYDDSLNGWVFGGGTKLTVL 1279 VH-VL of artificial NTCAGGTGCAGTTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGTAAGGCATCTAGATACACCTTCDH19 14085CACCAGCTACTATATGTCCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCCACCCTAGTGGTGGTGACACAACCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCGGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGGGGGATAAAACTATGGTTACATTTTGACTATTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTCAGTCTGTGCTGACTCAGCCACCCTCAGCGTCTGGGACCCCCGGACAGAGGGTCACCATCTCTTGTTCTGGAAGCCGCTCCAACATCGGAAGTAATTTTGTAAACTGGTACCAGCAGCTCCCAGGAACGGCCCCCAAACTCCTCATCTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGGCTGATTATTACTGTGCAGTATACGATGACAGCCTGAATGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTA 1280 VH-VL of artificialAAQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLCDH19 14085RSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDDSLNGWVFGGGTKLTVL1281 CDH19 14085 artificialQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLx I2CRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDDSLNGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1282 CDR-H1 of artificial AA SYFIH CDH19 14074 1283 CDR-H2 of artificialAA IINPISVSTSYAQKFQG CDH19 14074 1284 CDR-H3 of artificial AAGGIQLWLHLDY CDH19 14074 1285 CDR-L1 of artificial AA SGSRSNIGSNFVNCDH19 14074 1286 CDR-L2 of artificial AA TNNQRPS CDH19 14074 1287CDR-L3 of artificial AA ATWDDSMNGWV CDH19 14074 1288 VH of CDH19artificial NTCAGGTGCAGTTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGTTTCTGGATACACCTT14074CACCAGCTACTTTATTCACTGGGTGCGCCAGGCCCCTGGACAAGGGCTTGAATGGATGGGAATTATCAACCCTATTAGTGTTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTTCATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGCGAGGGGGGATACAGCTATGGTTACATTTGGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 1289 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSL14074 RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS 1290 VL of CDH19 artificial NTCAGTCTGCGCTGACTCAGCCACCCTCAGTGACTGGGACCCCCGGGCAGAGGGTCACCATCTCTTGTTCTGGAAGCAGGTCCAACAT14074CGGAAGCAATTTTGTAAACTGGTACCAGCAGCTCCCAGGAACGGCCCCCAAAGTCCTCATCTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGGCTGATTATTACTGCGCAACATGGGATGACAGTATGAATGGTTGGGTGTTCGGCGGAGGGACCAAACTGACCGTCCTA1291 VL of CDH19 artificial AAQSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD14074 YYCATWDDSMNGWVFGGGTKLTVL 1292 VH-VL of artificial NTCAGGTGCAGTTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGTTTCTGGATACACCTTCDH19 14074CACCAGCTACTTTATTCACTGGGTGCGCCAGGCCCCTGGACAAGGGCTTGAATGGATGGGAATTATCAACCCTATTAGTGTTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTTCATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGCGAGGGGGGATACAGCTATGGTTACATTTGGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTCAGTCTGCGCTGACTCAGCCACCCTCAGTGACTGGGACCCCCGGGCAGAGGGTCACCATCTCTTGTTCTGGAAGCAGGTCCAACATCGGAAGCAATTTTGTAAACTGGTACCAGCAGCTCCCAGGAACGGCCCCCAAAGTCCTCATCTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGGCTGATTATTACTGCGCAACATGGGATGACAGTATGAATGGTTGGGTGTTCGGCGGAGGGACCAAACTGACCGTCCTA 1293 VH-VL of artificialAAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLCDH19 14074RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSMNGWVFGGGTKLTVL1294 CDH19 14074 artificialQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLx I2CRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSMNGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1295 CDR-H1 of artificial AA SYFIH CDH19 14075 1296 CDR-H2 of artificialAA IINPISVSTSYAQKFQG CDH19 14075 1297 CDR-H3 of artificial AAGGIQLWLHLDY CDH19 14075 1298 CDR-L1 of artificial AA SGSRSNIGSNFVNCDH19 14075 1299 CDR-L2 of artificial AA TNNQRPS CDH19 14075 1300CDR-L3 of artificial AA ATWDESMQGWV CDH19 14075 1301 VH of CDH19artificial ntCAGGTGCAGTTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGTTTCTGGATACACCTT14075CACCAGCTACTTTATTCACTGGGTGCGCCAGGCCCCTGGACAAGGGCTTGAATGGATGGGAATTATCAACCCTATTAGTGTTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTTCATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGCGAGGGGGGATACAGCTATGGTTACATTTGGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA 1302 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSL14075 RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS 1303 VL of CDH19 artificial ntCAGTCTGCGCTGACTCAGCCACCCTCAGTGACTGGGACCCCCGGGCAGAGGGTCACCATCTCTTGTTCTGGAAGCAGGTCCAACAT14075CGGAAGCAATTTTGTAAACTGGTACCAGCAGCTCCCAGGAACGGCCCCCAAAGTCCTCATCTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGGCTGATTATTACTGCGCAACATGGGATGAGAGTATGCAGGGTTGGGTGTTCGGCGGAGGGACCAAACTGACCGTCCTA1304 VL of CDH19 artificial AAQSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD14075 YYCATWDESMQGWVFGGGTKLTVL 1305 VH-VL of artificial ntCAGGTGCAGTTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGTTTCTGGATACACCTTCDH19 14075CACCAGCTACTTTATTCACTGGGTGCGCCAGGCCCCTGGACAAGGGCTTGAATGGATGGGAATTATCAACCCTATTAGTGTTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTTCATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGCGAGGGGGGATACAGCTATGGTTACATTTGGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTCAGTCTGCGCTGACTCAGCCACCCTCAGTGACTGGGACCCCCGGGCAGAGGGTCACCATCTCTTGTTCTGGAAGCAGGTCCAACATCGGAAGCAATTTTGTAAACTGGTACCAGCAGCTCCCAGGAACGGCCCCCAAAGTCCTCATCTATACTAATAATCAGCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCAGTGGGCTCCAGTCTGAGGATGAGGCTGATTATTACTGCGCAACATGGGATGAGAGTATGCAGGGTTGGGTGTTCGGCGGAGGGACCAAACTGACCGTCCTA 1306 VH-VL of artificialAAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLCDH19 14075RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDESMQGWVFGGGTKLTVL1307 CDH19 14075 artificialQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLx I2CRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDESMQGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1308 CDR-H1 of artificial AA SSGYY CDH19 14024 1309 CDR-H2 of artificialAA YIYYTGSAYYNPSLKS CDH19 14024 1310 CDR-H3 of artificial AA DGSSGWYFQYCDH19 14024 1311 CDR-L1 of artificial AA RASRQISSSYLA CDH19 14024 1312CDR-L2 of artificial AA GPSSRAT CDH19 14024 1313 CDR-L3 of artificial AAQQYGSSFT CDH19 14024 1314 VH of CDH19 artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCAGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCAT14024CAGCAGTAGTGGTTACTACTGGAGCTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACACTGGGAGCGCCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGATGGAAGCAGTGGCTGGTACTTCCAGTATTGGGGCCAGGGCACCCTGGTCACCGTCTCTAGT 1315 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSS14024 VTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSS 1316 VL of CDH19 artificial ntGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCGGCAGAT14024TAGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTCCATCCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCATTCACTTTCGGCCAGGGGACCAAAGTGGATATCAAA 1317VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAV14024 YYCQQYGSSFTFGQGTKVDIK 1318 VH-VL of artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCAGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCDH19CAGCAGTAGTGGTTACTACTGGAGCTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACACTGGGAGCGCCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGATGGAAGCAGTGGCTGGTACTTCCAGTATTGGGGCCAGGGCACCCTGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCGGCAGATTAGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTCCATCCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCATTCACTTTCGGCCAGGGGACCAAAGTGGATATCAAA 1319 VH-VL of artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSCDH19 14024VTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGQGTKVDIK1320 CDH19 14024 artificialQVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSx I2CVTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGQGTKVDIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1321 CDR-H1 of artificial AA SYDMH CDH19 14054 1322 CDR-H2 of artificialAA VISYDGTNEYYADSVKG CDH19 14054 1323 CDR-H3 of artificial AA ERYFDWSFDYCDH19 14054 1324 CDR-L1 of artificial AA RASQSVSNTYLA CDH19 14054 1325CDR-L2 of artificial AA GASSRAT CDH19 14054 1326 CDR-L3 of artificial AAQQYSNSWT CDH19 14054 1327 VH of CDH19 artificial ntCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTT14054CAGTAGCTATGACATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAACTAATGAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACACTTCCAAGAACACGCTGTATTTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTATATTACTGTGCGAGAGAACGATATTTTGACTGGTCTTTTGACTACTGGGGCCAGGGAACCCTGGTCAGCGTCTCTAGT 1328 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSL14054 RAEDTAVYYCARERYFDWSFDYWGQGTLVSVSS 1329 VL of CDH19 artificial ntGAAATTGTATTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGT14054TAGCAACACCTACTTAGCCTGGTACCAGCAGAGACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATCCAGCAGGGCCACTGGCATCCCAGACAGATTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGTCTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTACAGTAACTCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAA 1330VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAV14054 YYCQQYSNSWTFGQGTKVEIK 1331 VH-VL of artificial ntCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCDH19 14054CAGTAGCTATGACATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAACTAATGAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACACTTCCAAGAACACGCTGTATTTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTATATTACTGTGCGAGAGAACGATATTTTGACTGGTCTTTTGACTACTGGGGCCAGGGAACCCTGGTCAGCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTGAAATTGTATTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTAGCAACACCTACTTAGCCTGGTACCAGCAGAGACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATCCAGCAGGGCCACTGGCATCCCAGACAGATTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGTCTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTACAGTAACTCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAA 1332 VH-VL of artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTESSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSLCDH19 14054RAEDTAVYYCARERYFDWSFDYWGQGTLVSVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIK1333 CDH19 14054 artificialQVQLVESGGGVVQPGGSLRLSCAASGFTESSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSLx I2CRAEDTAVYYCARERYFDWSFDYWGQGTLVSVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1334 CDR-H1 of artificial AA GYYWS CDH19 14056 1335 CDR-H2 of artificialAA YFSYSGSTNYNPSLKS CDH19 14056 1336 CDR-H3 of artificial AA NWAFHFDFCDH19 14056 1337 CDR-L1 of artificial AA TGSSSNIGTGYAVH CDH19 14056 1338CDR-L2 of artificial AA GNNNRPS CDH19 14056 1339 CDR-L3 of artificial AAQSYDSRLSGWV CDH19 14056 1340 VH of CDH19 artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCAT14056CAGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGAAAGGGACTGGAGTGGTTTGCATATTTCTCTTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCTTATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGGAACTGGGCCTTCCACTTTGACTTCTGGGGCCAGGGAACCCTGGTCACCGTCTCTAGT 1341 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWFAYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVT14056 AADTAVYYCARNWAFHFDFWGQGTLVTVSS 1342 VL of CDH19 artificial ntCAGTCTGTGCTGACGCAGCCGCCCTCAGTGTCTGGGGCCCCAGGACAGAGGGTCACCATCTCCTGCACTGGGAGCAGCTCCAACAT14056CGGGACAGGTTATGCTGTACACTGGTACCAGCAGCTTCCAGGAACAGCCCCCAAACTCCTCATCTATGGTAACAACAATCGGCCCTCAGGGGTTCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCACTGGGCTCCAGGCTGAGGATGAGGCTGATTATTACTGCCAGTCCTATGACAGCAGACTGAGTGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTA1343 VL of CDH19 artificial AAQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEA14056 DYYCQSYDSRLSGWVFGGGTKLTVL 1344 VH-VL of artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCDH19 14056CAGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGAAAGGGACTGGAGTGGTTTGCATATTTCTCTTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCTTATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGGAACTGGGCCTTCCACTTTGACTTCTGGGGCCAGGGAACCCTGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTCAGTCTGTGCTGACGCAGCCGCCCTCAGTGTCTGGGGCCCCAGGACAGAGGGTCACCATCTCCTGCACTGGGAGCAGCTCCAACATCGGGACAGGTTATGCTGTACACTGGTACCAGCAGCTTCCAGGAACAGCCCCCAAACTCCTCATCTATGGTAACAACAATCGGCCCTCAGGGGTTCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCACTGGGCTCCAGGCTGAGGATGAGGCTGATTATTACTGCCAGTCCTATGACAGCAGACTGAGTGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTA 1345 VH-VL of artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWFAYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTCDH19 14056AADTAVYYCARNWAFHFDFWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSRLSGWVFGGGTKLTVL1346 CDH19 14056 artificialQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWFAYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTx I2CAADTAVYYCARNWAFHFDFWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSRLSGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1347 CDR-H1 of artificial AA GYYWS CDH19 14057 1348 CDR-H2 of artificialAA YFSYSGSTNYNPSLKS CDH19 14057 1349 CDR-H3 of artificial AA NWAFHFDFCDH19 14057 1350 CDR-L1 of artificial AA TGSSSNIGTGYAVH CDH19 14057 1351CDR-L2 of artificial AA GNNNRPS CDH19 14057 1352 CDR-L3 of artificial AAQSYDSRLSGWV CDH19 14057 1353 VH of CDH19 artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCAT14057CAGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGAAAGGGACTGGAGTGGATTGGATATTTCTCTTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCTTATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGGAACTGGGCCTTCCACTTTGACTTCTGGGGCCAGGGAACCCTGGTCACCGTCTCTAGT 1354 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVT14057 AADTAVYYCARNWAFHFDFWGQGTLVTVSS 1355 VL of CDH19 artificial ntCAGTCTGTGCTGACGCAGCCGCCCTCAGTGTCTGGGGCCCCAGGACAGAGGGTCACCATCTCCTGCACTGGGAGCAGCTCCAACAT14057CGGGACAGGTTATGCTGTACACTGGTACCAGCAGCTTCCAGGAACAGCCCCCAAACTCCTCATCTATGGTAACAACAATCGGCCCTCAGGGGTTCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCACTGGGCTCCAGGCTGAGGATGAGGCTGATTATTACTGCCAGTCCTATGACAGCAGACTGAGTGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTA1356 VL of CDH19 artificial AAQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEA14057 DYYCQSYDSRLSGWVFGGGTKLTVL 1357 VH-VL of artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCDH19 14057CAGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGAAAGGGACTGGAGTGGATTGGATATTTCTCTTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCTTATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGGAACTGGGCCTTCCACTTTGACTTCTGGGGCCAGGGAACCCTGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTCAGTCTGTGCTGACGCAGCCGCCCTCAGTGTCTGGGGCCCCAGGACAGAGGGTCACCATCTCCTGCACTGGGAGCAGCTCCAACATCGGGACAGGTTATGCTGTACACTGGTACCAGCAGCTTCCAGGAACAGCCCCCAAACTCCTCATCTATGGTAACAACAATCGGCCCTCAGGGGTTCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCACTGGGCTCCAGGCTGAGGATGAGGCTGATTATTACTGCCAGTCCTATGACAGCAGACTGAGTGGTTGGGTGTTCGGCGGAGGGACCAAGCTGACCGTCCTA 1358 VH-VL of artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTCDH19 14057AADTAVYYCARNWAFHFDFWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSRLSGWVFGGGTKLTVL1359 CDH19 14057 artificial aaQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYFSYSGSTNYNPSLKSRVTLSVDTSKNQFSLKLSSVTx I2CAADTAVYYCARNWAFHFDFWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYAVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSRLSGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1360 CDR-H1 of artificial AA SYSWS CDH19 14049 1361 CDR-H2 of artificialAA YIYYSGSTNYNPSLKS CDH19 14049 1362 CDR-H3 of artificial AA NWAFHFDYCDH19 14049 1363 CDR-L1 of artificial AA TGSSSNIGTGYDVH CDH19 14049 1364CDR-L2 of artificial AA GNSNRPS CDH19 14049 1365 CDR-L3 of artificial AAQSYDSSLSGWV CDH19 14049 1366 VH of CDH19 artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCAT14049CAGTAGTTACTCCTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGGAACTGGGCCTTCCACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCTAGT 1367 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVT14049 AADTAVYYCARNWAFHFDYWGQGTLVTVSS 1368 VL of CDH19 artificial ntCAGTCTGTGCTGACGCAGCCGCCCTCAGTGTCTGGGGCCCCAGGGCAGAGGGTCACCATCTCCTGCACTGGGAGCAGCTCCAATAT14049CGGGACAGGTTATGATGTACACTGGTATCAGCAGCTTCCAGGAACAGCCCCCAAACTCCTCATCTATGGTAACAGCAATCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCACTGGGCTCCAGGCTGAGGATGAGGCTGATTATTACTGCCAGTCCTATGACAGCAGTCTGAGTGGTTGGGTGTTCGGCGGAGGGACCAGGTTGACCGTCCTA1369 VL of CDH19 artificial AAQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEA14049 DYYCQSYDSSLSGWVFGGGTRLTVL 1370 VH-VL of artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCDH19 14049CAGTAGTTACTCCTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGGAACTGGGCCTTCCACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTCAGTCTGTGCTGACGCAGCCGCCCTCAGTGTCTGGGGCCCCAGGGCAGAGGGTCACCATCTCCTGCACTGGGAGCAGCTCCAATATCGGGACAGGTTATGATGTACACTGGTATCAGCAGCTTCCAGGAACAGCCCCCAAACTCCTCATCTATGGTAACAGCAATCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCACTGGGCTCCAGGCTGAGGATGAGGCTGATTATTACTGCCAGTCCTATGACAGCAGTCTGAGTGGTTGGGTGTTCGGCGGAGGGACCAGGTTGACCGTCCTA 1371 VH-VL of artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTCDH19 14049AADTAVYYCARNWAFHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVL1372 CDH19 14049 artificial aaQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTx I2CAADTAVYYCARNWAFHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1373 CDR-H1 of artificial AA SYGMH CDH19 14302 1374 CDR-H2 of artificialAA FIWYDGSNKYYADSVKD CDH19 14302 1375 CDR-H3 of artificial AARAGIIGTIGYYYGMDV CDH19 14302 1376 CDR-L1 of artificial AA SGDRLGEKYTSCDH19 14302 1377 CDR-L2 of artificial AA QDTKRPS CDH19 14302 1378CDR-L3 of artificial AA QAWESSTVV CDH19 14302 1379 VH of CDH19artificial ntCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTT14302CAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT 1380 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSL14302 RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS 1381 VL of CDH19artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA14302AAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1382VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14302 CQAWESSTVVFGGGTKLTVL 1383 VH-VL of artificial ntCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCDH19 14302CAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1384 VH-VL ofartificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLCDH19 14302RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVL1385 CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLx I2CRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1386 CDR-H1 of artificial AA SYGMH CDH19 14303 1387 CDR-H2 of artificialAA FIWYEGSNKYYAESVKD CDH19 14303 1388 CDR-H3 of artificial AARAGIIGTIGYYYGMDV CDH19 14303 1389 CDR-L1 of artificial AA SGDRLGEKYTSCDH19 14303 1390 CDR-L2 of artificial AA QDTKRPS CDH19 14303 1391CDR-L3 of artificial AA QAWESSTVV CDH19 14303 1392 VH of CDH19artificial ntCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTT14303CAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAAAAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT 1393 VH of CDH19 artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMKSL14303 RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS 1394 VL of CDH19artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA14303AAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1395VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14303 CQAWESSTVVFGGGTKLTVL 1396 VH-VL of artificial ntCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCDH19 14303CAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAAAAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1397 VH-VL ofartificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMKSLCDH19 14303RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVL1398 CDH19 14303 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMKSLx I2CRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1399 CDR-H1 of artificial AA RYGIH CDH19 14078 1400 CDR-H2 of artificialAA VIWYDGSNKYYADSVKG CDH19 14078 1401 CDR-H3 of artificial AARAGIPGTTGYYYGMDV CDH19 14078 1402 CDR-L1 of artificial AA SGDRLGEKYVSCDH19 14078 1403 CDR-L2 of artificial AA QDNKWPS CDH19 14078 1404CDR-L3 of artificial AA QAWDSSTVV CDH19 14078 1405 VH of CDH19artificial ntCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTT14078CAGTCGCTATGGCATACACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACTCGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATACCTGGAACTACGGGCTACTACTATGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCA 1406 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSL14078 RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSS 1407 VL of CDH19artificial ntTCCTATGAGCTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGATTGGGGGA14078GAAATATGTTAGCTGGTATCAGCAGAAGCCAGGCCAGTCCCCTATACTGGTCATCTATCAAGATAATAAGTGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGGAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGACAGCAGCACTGTGGTATTCGGCGGGGGGACCAAGCTGACCGTCCTA 1408VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14078 CQAWDSSTVVFGGGTKLTVL 1409 VH-VL of artificial ntCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCDH19 14078CAGTCGCTATGGCATACACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACTCGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATACCTGGAACTACGGGCTACTACTATGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTTCCTATGAGCTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGATTGGGGGAGAAATATGTTAGCTGGTATCAGCAGAAGCCAGGCCAGTCCCCTATACTGGTCATCTATCAAGATAATAAGTGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGGAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGACAGCAGCACTGTGGTATTCGGCGGGGGGACCAAGCTGACCGTCCTA 1410 VH-VL ofartificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLCDH19 14078RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVL1411 CDH19 14078 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLx I2CRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1412 CDR-H1 of artificial AA RYGIH CDH19 14080 1413 CDR-H2 of artificialAA VIWYDGSNKYYADSVKG CDH19 14080 1414 CDR-H3 of artificial AARAGIPGTTGYYYGMDV CDH19 14080 1415 CDR-L1 of artificial AA SGDRLGEKYVYCDH19 14080 1416 CDR-L2 of artificial AA QDNKWPS CDH19 14080 1417CDR-L3 of artificial AA QAWDSSTVV CDH19 14080 1418 VH of CDH19artificial ntCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTT14080CAGTCGCTATGGCATACACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCTAATGAACAGCCTGAGAGCCGAGGACTCGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATACCTGGAACTACGGGCTACTACTATGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCA 1419 VH of CDH19 artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLLMNSL14080 RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSS 1420 VL of CDH19artificial ntTCCTATGAGCTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGATTGGGGGA14080GAAATATGTTTACTGGTATCAGCAGAAGCCAGGCCAGTCCCCTATACTGGTCATCTATCAAGATAATAAGTGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGGAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGACAGCAGCACTGTGGTATTCGGCGGGGGGACCAAGCTGACCGTCCTA 1421VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYVYWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14080 CQAWDSSTVVFGGGTKLTVL 1422 VH-VL of artificial ntCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCDH19 14080CAGTCGCTATGGCATACACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCTAATGAACAGCCTGAGAGCCGAGGACTCGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATACCTGGAACTACGGGCTACTACTATGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTTCCTATGAGCTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGATTGGGGGAGAAATATGTTTACTGGTATCAGCAGAAGCCAGGCCAGTCCCCTATACTGGTCATCTATCAAGATAATAAGTGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGGAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGACAGCAGCACTGTGGTATTCGGCGGGGGGACCAAGCTGACCGTCCTA 1423 VH-VL ofartificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLLMNSLCDH19 14080RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYVYWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVL1424 CDH19 14080 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLLMNSLx I2CRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYVYWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1425 CDR-H1 of artificial AA SYSWS CDH19 13591 1426 CDR-H2 of artificialAA YIYYSGSTNYNPSLKS CDH19 13591 1427 CDR-H3 of artificial AA NWAFHFDYCDH19 13591 1428 CDR-L1 of artificial AA TGSSSNIGTGYDVH CDH19 13591 1429CDR-L2 of artificial AA GNSNRPS CDH19 13591 1430 CDR-L3 of artificial AAQSYDSSLSGWV CDH19 13591 1431 VH of CDH19 artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCAT13591CAGTAGTTACTCCTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGGAACTGGGCCTTCCACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCTAGT 1432 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVT13591 AADTAVYYCARNWAFHFDYWGQGTLVTVSS 1433 VL of CDH19 artificial ntCAGTCTGTGCTGACGCAGCCGCCCTCAGTGTCTGGGGCCCCAGGGCAGAGGGTCACCATCTCCTGCACTGGGAGCAGCTCCAATAT13591CGGGACAGGTTATGATGTACACTGGTATCAGCAGCTTCCAGGAACAGCCCCCAAACTCCTCATCCATGGTAACAGCAATCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCACTGGGCTCCAGGCTGAGGATGAGGCTGATTATTACTGCCAGTCCTATGACAGCAGTCTGAGTGGTTGGGTGTTCGGCGGAGGGACCAGGTTGACCGTCCTA1434 VL of CDH19 artificial AAQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIHGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEA13591 DYYCQSYDSSLSGWVFGGGTRLTVL 1435 VH-VL of artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCDH19 1591CAGTAGTTACTCCTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGGAACTGGGCCTTCCACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTCAGTCTGTGCTGACGCAGCCGCCCTCAGTGTCTGGGGCCCCAGGGCAGAGGGTCACCATCTCCTGCACTGGGAGCAGCTCCAATATCGGGACAGGTTATGATGTACACTGGTATCAGCAGCTTCCAGGAACAGCCCCCAAACTCCTCATCCATGGTAACAGCAATCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCACTGGGCTCCAGGCTGAGGATGAGGCTGATTATTACTGCCAGTCCTATGACAGCAGTCTGAGTGGTTGGGTGTTCGGCGGAGGGACCAGGTTGACCGTCCTA 1436 VH-VL of artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTCDH19 13591AADTAVYYCARNWAFHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIHGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVL1437 CDH19 13591 artificial aaQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTx I2CAADTAVYYCARNWAFHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIHGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1438 CDR-H1 of artificial AA SYSWS CDH19 14299 1439 CDR-H2 of artificialAA YIYYSGSTNYNPSLKS CDH19 14299 1440 CDR-H3 of artificial AA NWAFHFDYCDH19 14299 1441 CDR-L1 of artificial AA TGSSSNIGTGYDVH CDH19 14299 1442CDR-L2 of artificial AA GNSNRPS CDH19 14299 1443 CDR-L3 of artificial AAQSYDSSLSGWV CDH19 14299 1444 VH of CDH19 artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCAT14299CAGTAGTTACTCCTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGGAACTGGGCCTTCCACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCTAGT 1445 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVT14299 AADTAVYYCARNWAFHFDYWGQGTLVTVSS 1446 VL of CDH19 artificial ntCAGTCTGTGCTGACGCAGCCGCCCTCAGTGTCTGGGGCCCCAGGGCAGAGGGTCACCATCTCCTGCACTGGGAGCAGCTCCAATAT14299CGGGACAGGTTATGATGTACACTGGTATCAGCAGCTTCCAGGAACAGCCCCCAAACTCCTCATCCATGGTAACAGCAATCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCACTGGGCTCCAGGCTGAGGATGAGGCTGATTATTACTGCCAGTCCTATGACAGCAGTCTGAGTGGTTGGGTGTTCGGCGGAGGGACCAGGTTGACCGTCCTA1447 VL of CDH19 artificial AAQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIHGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEA14299 DYYCQSYDSSLSGWVFGGGTRLTVL 1448 VH-VL of artificial ntCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCDH19 14299CAGTAGTTACTCCTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGGAACTGGGCCTTCCACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTCAGTCTGTGCTGACGCAGCCGCCCTCAGTGTCTGGGGCCCCAGGGCAGAGGGTCACCATCTCCTGCACTGGGAGCAGCTCCAATATCGGGACAGGTTATGATGTACACTGGTATCAGCAGCTTCCAGGAACAGCCCCCAAACTCCTCATCCATGGTAACAGCAATCGGCCCTCAGGGGTCCCTGACCGATTCTCTGGCTCCAAGTCTGGCACCTCAGCCTCCCTGGCCATCACTGGGCTCCAGGCTGAGGATGAGGCTGATTATTACTGCCAGTCCTATGACAGCAGTCTGAGTGGTTGGGTGTTCGGCGGAGGGACCAGGTTGACCGTCCTA 1449 VH-VL of artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTCDH19 14299AADTAVYYCARNWAFHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIHGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVL1450 CDH19 14299 artificial aaQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTx I2CAADTAVYYCARNWAFHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIHGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGWVFGGGTRLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1451 ckCDH19(1- artificial aaMNCSTELSLVLALVQLQLCSPTTQIFSAQKTDQSYTTIRRVKRDYKDDDDKGWVWEPLEVTEEETSTMPMYVGQLKSDLDKEDGSL43)::FLAG::QYILTGEGADSIFFINEHGKIYVRQKLDREKKSFYILRAQVINRKTRHPIEPDSEFIIKVRDINDHEPQFLDGPYVATVPEMSPEGckCDH19TSVTQVTATDGDDPSYGNNARLLYSLIQGQPYFSVEPKTGVIRMTSQMDRETKDQYLVVIQAKDMVGQAGAFSATATVTINLSDVN(44-776)DNPPKFQQRLYYLNVSEEAPVGTTVGRLLAEDSDIGENAAMNYFIEEDSSDVFGIITDRETQEGIIILKKRVDYESKRKHSVRVKAVNRYIDDRFLKEGPFEDITIVQISVVDADEPPVFTLESYVMEIAEGVVSGSLVGTVSARDLDNDDSSVRYSIVQGLHLKRLFSINEHNGTIITTEPLDREKASWHNITVTATETRNPEKISEANVYIQVLDVNDHAPEFSKYYETFVCENAVPGQLIQNISAVDKDDSAENHREYFSLAQATNSSHETVKDNQDNTAGIFTAGSGESRKEQFYFFLPILILDNGSPPLTSTNTLTVTVCDCDTEVNTLYCRYGAFLYSIGLSTEALVAVLACLLILLVFFLAIIGIRQQRKKTLFSEKVEEFRENIVRYDDEGGGEEDTEAFDISALRTRAVLRTHKPRKKITTEIHSLYRQSLQVGPDSAIFRQFISEKLEEANTDPSVPPYDSLQTYAFEGTGSLAGSLSSLGSNTSDVDQNYEYLVGWGPPFKQLAGMYTSQRSTRD 1452 huCDH19(1- artificial aaMNCYLLLRFMLGIPLLWPCLGATENSQTKKVKQPVRSHLRVKRDYKDDDDKGWVWNQFFVPEEMNTTSHHIGQLRSDLDNGNNSFQ43)::FLAG::huYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDHEPQFLDGPYVATVPEMSPEG(44-TSVTQVTATDGDDPSYGNNARLLYSLIQGQPYFSVEPKTGVIRMTSQMDRETKDQYLVVIQAKDMVGQAGAFSATATVTINLSDVN141)::ckCDH19DNPPKFQQRLYYLNVSEEAPVGTTVGRLLAEDSDIGENAAMNYFIEEDSSDVFGIITDRETQEGIIILKKRVDYESKRKHSVRVKA(142-776)VNRYIDDRFLKEGPFEDITIVQISVVDADEPPVFTLESYVMEIAEGVVSGSLVGTVSARDLDNDDSSVRYSIVQGLHLKRLFSINEHNGTIITTEPLDREKASWHNITVTATETRNPEKISEANVYIQVLDVNDHAPEFSKYYETFVCENAVPGQLIQNISAVDKDDSAENHREYFSLAQATNSSHETVKDNQDNTAGIFTAGSGESRKEQFYFFLPILILDNGSPPLTSTNTLTVTVCDCDTEVNTLYCRYGAFLYSIGLSTEALVAVLACLLILLVFFLAIIGIRQQRKKTLFSEKVEEFRENIVRYDDEGGGEEDTEAFDISALRTRAVLRTHKPRKKITTEIHSLYRQSLQVGPDSAIFRQFISEKLEEANTDPSVPPYDSLQTYAFEGTGSLAGSLSSLGSNTSDVDQNYEYLVGWGPPFKQLAGMYTSQRSTRD 1453 ckCDH19(1-43) artificial aaMNCSTELSLVLALVQLQLCSPTTQIFSAQKTDQSYTTIRRVKRDYKDDDDKGWVWEPLEVTEEETSTMPMYVGQLKSDLDKEDGSL::FLAG::QYILTGEGADSIFFINEHGKIYVRQKLDREKKSFYILRAQVINRKTRHPIEPDSEFIIKVRDINDNEPKFLDEPYEAIVPEMSPEGckCDH19(44-TLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVN141)::huCDH19DNPPKFQQRLYYLNVSEEAPVGTTVGRLLAEDSDIGENAAMNYFIEEDSSDVFGIITDRETQEGIIILKKRVDYESKRKHSVRVKA(142-VNRYIDDRFLKEGPFEDITIVQISVVDADEPPVFTLESYVMEIAEGVVSGSLVGTVSARDLDNDDSSVRYSIVQGLHLKRLFSINE249)::ckCDH19HNGTIITTEPLDREKASWHNITVTATETRNPEKISEANVYIQVLDVNDHAPEFSKYYETFVCENAVPGQLIQNISAVDKDDSAENH(250-776)REYFSLAQATNSSHETVKDNQDNTAGIFTAGSGESRKEQFYFFLPILILDNGSPPLTSTNTLTVTVCDCDTEVNTLYCRYGAFLYSIGLSTEALVAVLACLLILLVFFLAIIGIRQQRKKTLFSEKVEEFRENIVRYDDEGGGEEDTEAFDISALRTRAVLRTHKPRKKITTEIHSLYRQSLQVGPDSAIFRQFISEKLEEANTDPSVPPYDSLQTYAFEGTGSLAGSLSSLGSNTSDVDQNYEYLVGWGPPFKQLAGMYTSQRSTRD 1454 ckCDH19(1- artificial aaMNCSTELSLVLALVQLQLCSPTTQIFSAQKTDQSYTTIRRVKRDYKDDDDKGWVWEPLEVTEEETSTMPMYVGQLKSDLDKEDGSL43)::FLAG::QYILTGEGADSIFFINEHGKIYVRQKLDREKKSFYILRAQVINRKTRHPIEPDSEFIIKVRDINDHEPQFLDGPYVATVPEMSPEGckCDH19(44-TSVTQVTATDGDDPSYGNNARLLYSLIQGQPYFSVEPKTGVIRMTSQMDRETKDQYLVVIQAKDMVGQAGAFSATATVTINLSDVN249)::huCDH19DNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKV(250-KNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPVFTLESYVMEIAEGVVSGSLVGTVSARDLDNDDSSVRYSIVQGLHLKRLFSINE364)::ckCDH19HNGTIITTEPLDREKASWHNITVTATETRNPEKISEANVYIQVLDVNDHAPEFSKYYETFVCENAVPGQLIQNISAVDKDDSAENH(365-776)REYFSLAQATNSSHETVKDNQDNTAGIFTAGSGESRKEQFYFFLPILILDNGSPPLTSTNTLTVTVCDCDTEVNTLYCRYGAFLYSIGLSTEALVAVLACLLILLVFFLAIIGIRQQRKKTLFSEKVEEFRENIVRYDDEGGGEEDTEAFDISALRTRAVLRTHKPRKKITTEIHSLYRQSLQVGPDSAIFRQFISEKLEEANTDPSVPPYDSLQTYAFEGTGSLAGSLSSLGSNTSDVDQNYEYLVGWGPPFKQLAGMYTSQRSTRD 1455 ckCDH19(1- artificial aaMNCSTELSLVLALVQLQLCSPTTQIFSAQKTDQSYTTIRRVKRDYKDDDDKGWVWEPLEVTEEETSTMPMYVGQLKSDLDKEDGSL43)::FLAG::ckCQYILTGEGADSIFFINEHGKIYVRQKLDREKKSFYILRAQVINRKTRHPIEPDSEFIIKVRDINDHEPQFLDGPYVATVPEMSPEGDH19(44-TSVTQVTATDGDDPSYGNNARLLYSLIQGQPYFSVEPKTGVIRMTSQMDRETKDQYLVVIQAKDMVGQAGAFSATATVTINLSDVN364)::huCDH19DNPPKFQQRLYYLNVSEEAPVGTTVGRLLAEDSDIGENAAMNYFIEEDSSDVFGIITDRETQEGIIILKKRVDYESKRKHSVRVKA(365-VNRYIDDRFLKEGPFEDITIVQISVVDADEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNINDNGTI463)::ckCDH19TTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSKYYETFVCENAVPGQLIQNISAVDKDDSAENHRFYFS(469-776)LAQATNSSHETVKDNQDNTAGIFTAGSGESRKEQFYFFLPILILDNGSPPLTSTNTLTVTVCDCDTEVNTLYCRYGAFLYSIGLSTEALVAVLACLLILLVFFLAIIGIRQQRKKTLFSEKVEEFRENIVRYDDEGGGEEDTEAFDISALRTRAVLRTHKPRKKITTEIHSLYRQSLQVGPDSAIFRQFISEKLEEANTDPSVPPYDSLQTYAFEGTGSLAGSLSSLGSNTSDVDQNYEYLVGWGPPFKQLAGMYTSQRSTRD 1456 (1- artificial aaMNCSTELSLVLALVQLQLCSPTTQIFSAQKTDQSYTTIRRVKRDYKDDDDKGWVWEPLEVTEEETSTMPMYVGQLKSDLDKEDGSL43)::FLAG::QYILTGEGADSIFFINEHGKIYVRQKLDREKKSFYILRAQVINRKTRHPIEPDSEFIIKVRDINDHEPQFLDGPYVATVPEMSPEGckCDH19(44-TSVTQVTATDGDDPSYGNNARLLYSLIQGQPYFSVEPKTGVIRMTSQMDRETKDQYLVVIQAKDMVGQAGAFSATATVTINLSDVN468)::huCDH19DNPPKFQQRLYYLNVSEEAPVGTTVGRLLAEDSDIGENAAMNYFIEEDSSDVFGIITDRETQEGIIILKKRVDYESKRKHSVRVKA(464-772)VNRYIDDRFLKEGPFEDITIVQISVVDADEPPVFTLESYVMEIAEGVVSGSLVGTVSARDLDNDDSSVRYSIVQGLHLKRLFSINEHNGTIITTEPLDREKASWHNITVTATETRNPEKISEANVYIQVLDVNDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHEYFNLSVEDTNNSSETIIDNQDNTAVILTNRTGENLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGSAVQSNN 1457 rhCDH19(1- artificial aaMNCYLLLPFMLGIPLLWPCLGATENSQTKKVQQPVGSHLRVKRDYKDDDDKGWVWNQFFVPEEMNTTSHHVGRLRSDLDNGNNSFQ43)::FLAG::YKLLGAGAGSTFIIDERTGDIYAIEKLDREERSLYILRAQVIDITTGRAVEPESEFVIKVSDINDNEPKELDEPYEAIVPEMSPEGrhCDH19(44-772)TLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTEDIITNHETQEGIVILKKKVNFEHQNHYGIRAKVKNHHVDEQLMKYHTEASTTFIKIQVEDVDEPPLELLPYYIFEIFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNIDDNGTITTTNSLDREISAWYNLSITATEKYNIEQISSIPVYVQVLNINDHAPEFSQYYESYVCENAGSGQVIQTISAVDRDESIEEHHEYENLSVEDTNSSSETIIDNQDNTAVILTNRTGFNLQEEPIFYISILIADNGIPSLTSTNTLTIHVCDCDDSGSTQTCQYQELMLSMGFKTEVIIAILICIMVIEGFIFLTLGLKQRRKQILFPEKSEDFRENIFRYDDEGGGEEDTEAFDVAALRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEADTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGSAVQSNN 1458 caCDH19(1- artificial aaQFFVPEEMNKTDYHIGQLRSDLDNGNNSFQYKLLGAGAGSIFVIDERTGDIYAIQKLDREERSLYTLRAQVIDSTTGRAVEPESEF42)::FLAG::VIRVSDINDNEPKELDEPYEAIVPEMSPEGTLVIQVTATDADDPASGNNARLLYSLLQGQPYFSIEPTTGVIRISSKMDRELQDEYcaCDH19(43-770)WVIIQAKDMIGLPGALSGTTSVLIKLSDVNDNKPIFKERLYRLTVSESAPTGTSIGRIMAYDNDIGENAEMDYSIEDDSQTEDIITNNETQEGIVILKKKVDFEHQNHYLIRANVKNRHVAEHLMEYHVEASTTEVRVQVEDEDEPPVELLPYYLFEILEESPHGSFVGMVSATDPDQRKSPIRYSITRSKVFSIDDNGTIITTNPLDREISAWYNLSITATEKYNVQQISAVPVYVQVLNINDHAPEFSEYYDSYVCENAGSGQVIQTISAVDRDESVEDHHEYFNLSVEDTKNSSFIIIDNEDNTAVILTNRTGFSLQEEPVFYISVLIADNGIPSLTSTNTLTIHICDCDDYGSTQTCRDKDLLLSMGFRTEVILAILISIMIIFGFIFLILGLKQRRKPTLFPEKGEDFRENIFRYDDEGGGEEDTEAFDIVQLRSSTIMRERKTRKTAAAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLGSAVSDQDENYDYLNELGPRFKRLACMFGSAMQSNN 1459 rhCDH19(1- artificial aaMNCYLLLPFMLGIPLLWPCLGATENSQTKKVQQPVGSHLRVKRDYKDDDDKGWVWNQFFVPEEMNTTSHHVGRLRSDLDNGNNSFQ43):FLAG::YKLLGAGAGSTFIIDERTGDIYAIEKLDREERSLYILRAQVIDITTGRAVEPESEFVIKVSDINDNEPKELDEPYEAIVPEMSPEGrhCDH19(44-TLVIQVTATDADDPASGNNARLLYSLLQGQPYFSIEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGLPGALSGTTSVLIKLSDVN141)::caCDH19DNKPIFKERLYRLTVSESAPTGTSIGRIMAYDNDIGENAEMDYSIEDDSQTEDIITNNETQEGIVILKKKVDFEHQNHYLIRANVK(141-770)NRHVAEHLMEYHVEASTTEVRVQVEDEDEPPVELLPYYLFEILEESPHGSFVGMVSATDPDQRKSPIRYSITRSKVFSIDDNGTIITTNPLDREISAWYNLSITATEKYNVQQISAVPVYVQVLNINDHAPEFSEYYDSYVCENAGSGQVIQTISAVDRDESVEDHHEYFNLSVEDTKNSSFIIIDNEDNTAVILTNRTGESLQEEPVFYISVLIADNGIPSLTSTNTLTIHICDCDDYGSTQTCRDKDLLLSMGERTEVILAILISIMIIFGFIFLILGLKQRRKPTLFPEKGEDFRENIFRYDDEGGGEEDTEAFDIVQLRSSTIMRERKTRKTAAAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLGSAVSDQDENYDYLNELGPRFKRLACMFGSAMQSNN 1460 rhCDH19(1- artificial aaMNCYLLLPFMLGIPLLWPCLGATENSQTKKVQQPVGSHLRVKRDYKDDDDKGWVWNQFFVPEEMNTTSHHVGRLRSDLDNGNNSFQ43)::FLAG::rhCYKLLGAGAGSIFVIDERTGDIYAIQKLDREERSLYTLRAQVIDSTTGRAVEPESEEVIRVSDINDNEPKELDEPYEAIVPEMSPEGDH19(44-TLVIQVTATDADDPASGNNARLLYSLLQGQPYFSIEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGLPGALSGTTSVLIKLSDVN65)::caCDH19DNKPIFKERLYRLTVSESAPTGTSIGRIMAYDNDIGENAEMDYSIEDDSQTEDIITNNETQEGIVILKKKVDFEHQNHYLIRANVK(65-770)NRHVAEHLMEYHVEASTTEVRVQVEDEDEPPVELLPYYLFEILEESPHGSFVGMVSATDPDQRKSPIRYSITRSKVFSIDDNGTIITTNPLDREISAWYNLSITATEKYNVQQISAVPVYVQVLNINDHAPEFSEYYDSYVCENAGSGQVIQTISAVDRDESVEDHHEYFNLSVEDTKNSSFIIIDNEDNTAVILTNRTGESLQEEPVFYISVLIADNGIPSLTSTNTLTIHICDCDDYGSTQTCRDKDLLLSMGERTEVILAILISIMIIFGFIFLILGLKQRRKPTLFPEKGEDFRENIFRYDDEGGGEEDTEAFDIVQLRSSTIMRERKTRKTAAAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLGSAVSDQDENYDYLNELGPRFKRLACMFGSAMQSNN 1461 caCDH19(1- artificial aaMNYCELLPLMLGIPLIWPCFTASESSKTEVKHQAGSHLRVKRDYKDDDDKGWMWNQFFVPEEMNKTDYHIGQLRSDLDNGNNSFQY43)::FLAG::KLLGAGAGSTFIIDERTGDIYAIEKLDREERSLYILRAQVIDSTTGRAVEPESEEVIRVSDINDNEPKELDEPYEAIVPEMSPEGTcaCDH19(44-LVIQVTATDADDPASGNNARLLYSLLQGQPYFSIEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGLPGALSGTTSVLIKLSDVND87)::rhCDH19NKPIFKERLYRLTVSESAPTGTSIGRIMAYDNDIGENAEMDYSIEDDSQTFDIITNNETQEGIVILKKKVDFEHQNHYLIRANVKN(89-RHVAEHLMEYHVEASTTEVRVQVEDEDEPPVELLPYYLFEILEESPHGSFVGMVSATDPDQRKSPIRYSITRSKVFSIDDNGTIIT114)::caCDH19TNPLDREISAWYNLSITATEKYNVQQISAVPVYVQVLNINDHAPEFSEYYDSYVCENAGSGQVIQTISAVDRDESVEDHHEYFNLS(115-770)VEDTKNSSFIIIDNEDNTAVILTNRTGESLQEEPVFYISVLIADNGIPSLTSTNTLTIHICDCDDYGSTQTCRDKDLLLSMGERTEVILAILISIMIIFGFIFLILGLKQRRKPTLFPEKGEDFRENIFRYDDEGGGEEDTEAFDIVQLRSSTIMRERKTRKTAAAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLGSAVSDQDENYDYLNELGPRFKRLACMFGSAMQSNN 1462 caCDH19(1- artificial aaMNYCELLPLMLGIPLIWPCFTASESSKTEVKHQAGSHLRVKRDYKDDDDKGWMWNQFFVPEEMNKTDYHIGQLRSDLDNGNNSFQY43)::FLAG::KLLGAGAGSIFVIDERTGDIYAIQKLDREERSLYTLRAQVIDITTGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTcaCDH19(44-LVIQVTATDADDPASGNNARLLYSLLQGQPYFSIEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGLPGALSGTTSVLIKLSDVND120)::rhCDH19NKPIFKERLYRLTVSESAPTGTSIGRIMAYDNDIGENAEMDYSIEDDSQTFDIITNNETQEGIVILKKKVDFEHQNHYLIRANVKN(122-RHVAEHLMEYHVEASTTEVRVQVEDEDEPPVELLPYYLFEILEESPHGSFVGMVSATDPDQRKSPIRYSITRSKVFSIDDNGTIIT137)::caCDH19TNPLDREISAWYNLSITATEKYNVQQISAVPVYVQVLNINDHAPEFSEYYDSYVCENAGSGQVIQTISAVDRDESVEDHHEYFNLS(137-770)VEDTKNSSFIIIDNEDNTAVILTNRTGESLQEEPVFYISVLIADNGIPSLTSTNTLTIHICDCDDYGSTQTCRDKDLLLSMGERTEVILAILISIMIIFGFIFLILGLKQRRKPTLFPEKGEDFRENIFRYDDEGGGEEDTEAFDIVQLRSSTIMRERKTRKTAAAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLGSAVSDQDENYDYLNELGPRFKRLACMFGSAMQSNN 1463 rhCDH19(1- artificial aaMNCYLLLPFMLGIPLLWPCLGATENSQTKKVQQPVGSHLRVKRDYKDDDDKGWVWNQFFVPEEMNTTSHHVGRLRSDLDNGNNSFQ43)::FLAG::YKLLGAGAGSTFIIDERTGDIYAIEKLDREERSLYILRAQVIDITTGRAVEPESEFVIKVSDINDNEPRFLDEPYEAIVPEMSPEGrhCDH19(44-TFVIKVTANDADDPTSGYHARILYNLEQGQPYFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPGALSGTTTISIKLSDIN141)::raCDH19DNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVNFEHQNHYGIRAKV(140-KNHHVDEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYIFEIFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNIDDNGTI247)::rhCDH19TTTNSLDREISAWYNLSITATEKYNIEQISSIPVYVQVLNINDHAPEFSQYYESYVCENAGSGQVIQTISAVDRDESIEEHHEYEN(250-772)LSVEDTNSSSETIIDNQDNTAVILTNRTGFNLQEEPIFYISILIADNGIPSLTSTNTLTIHVCDCDDSGSTQTCQYQELMLSMGFKTEVIIAILICIMVIEGFIFLTLGLKQRRKQILFPEKSEDFRENIFRYDDEGGGEEDTEAFDVAALRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEADTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGSAVQSNN 1464 raCDH19(1- artificial aaMNHYFLKYWILMVPLIWPCLKVAETLKIEKAQRAVPSLGRAKRDYKDDDDKGWVWKQFVVPEEMDTIQHVGRLRSDLDNGNNSFQY43)::FLAG::KLLGTGDGSFSIDEKTGDIFAMQKLDREKQSLYILRAQVIDTTIGKAVEPESEEVIRVSDVNDNEPRELDEPYEAIVPEMSPEGTFraCDH19(44-770)VIKVTANDADDPTSGYHARILYNLEQGQPYFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPGALSGTTTISIKLSDINDNKPIFKESFYRFTISESAPSGTTIGKIMAYDDDIGENAEMDYSIEDDESQIFDIVIDNETQEGIVILKKKVDFEHQNHYGIRVKVKNCHVDEELAPAHVNASTTYIKVQVEDEDEPPTFLLPYYIFEIPEGKPYGTMVGTVSAVDPDRRQSPMRYSLIGSKMFDINGNGTIVTTNLLDREVSAWYNLSVTATETYNVQQISSAHVYVQVLNINDHAPEFSQLYETYVCENAESGEIIQTISAIDRDESIEDHHEYENHSVEDTNNSSFILTDNQDNTAVILSNRAGESLKEETVEYMIILIADNGIPPLTSTNTLTIQVCDCGDSRSTETCTSKELLFIMGFKAEAIIAIVICVMVIEGFIFLILALKQRRKETLFPEKTEDFRENIFCYDDEGGGEEDSEAFDIIELRQSTVMRERKPRKSRSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDSSAPPFDSLQTFAYEGTGSSAGSLSSLGSSVTDQEDDFDYLNDLGPCFKRLANMFGSAVQPDN 1465 (1- artificial aaMNYCFLKHWILMIPLLWPCLKVSETLKAEKARRTVPSTWRAKRDYKDDDDKAWVWRPFVVLEEMDDIQCVGKLRSDLDNGNNSFQY43)::FLAG::KLLGIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTIGKAVETESEFVIRVLDINDNEPRELDEPYEAIVPEMSPEGTFmuCDH19(44-VIKVTANDADDPSTGYHARILYNLERGQPYFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPGALSGTTTVSIKLSDINDN323)::raCDH19KPIFKESFYRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSIEDDDSKIFDIIIDNDTQEGIVILKKKVDFEHQNHYGIRAKVKN(324-CHVDEELAPAHVNASTTYIKVQVEDEDEPPVFLLPYYILEIPEGKPYGTIVGTVSATDPDRRQSPMRYYLTGSKMFDINDNGTIIT327)::muCDH19TNMLDREVSAWYNLTVTATETYNVQQISSAHVYVQVFNINDNAPEFSQFYETYVCENAESGEIVQIISAIDRDESIEDHHEYENHS(328-770)LEDTNNSSFMLTDNQDNTAVILSNRTGENLKEEPVEYMIILIADNGIPSLTSTNTLTIQVCDCGDSRNTETCANKGLLFIMGFRTEAIIAIMICVMVIFGEFFLILALKQRRKETLFPEKTEDFRENIFCYDDEGGGEEDSEAFDIVELRQSTVMRERKPQRSKSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFGSAVQPNN 1466 muCDH19(1- artificial aaMNYCFLKHWILMIPLLWPCLKVSETLKAEKARRTVPSTWRAKRDYKDDDDKAWVWRPFVVLEEMDDIQCVGKLRSDLDNGNNSFQY43)::FLAG::KLLGIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTIGKAVETESEFVIRVLDINDNEPRELDEPYEAIVPEMSPEGTFmuCDH19(44-VIKVTANDADDPSTGYHARILYNLERGQPYFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPGALSGTTTVSIKLSDINDN770)::raCDH19KPIFKESFYRFTISESAPIGTSIGKIMAYDDDIGENAEMEYSIEDDDSKIFDIIIDNDTQEGIVILKKKVDFEQQSYYGIRAKVKN(290,299,308)CHVDEELAPAHVNASTTYIKVQVEDEDEPPVFLLPYYILEIPEGKPYGTIVGTVSATDPDRRQSPMRYYLTGSKMFDINDNGTIITTNMLDREVSAWYNLTVTATETYNVQQISSAHVYVQVFNINDNAPEFSQFYETYVCENAESGEIVQIISAIDRDESIEDHHEYENHSLEDTNNSSFMLTDNQDNTAVILSNRTGENLKEEPVEYMIILIADNGIPSLTSTNTLTIQVCDCGDSRNTETCANKGLLFIMGFRTEAIIAIMICVMVIFGEFFLILALKQRRKETLFPEKTEDFRENIFCYDDEGGGEEDSEAFDIVELRQSTVMRERKPQRSKSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFGSAVQPNN 1467 muCDH19(1- artificial aaMNYCFLKHWILMIPLLWPCLKVSETLKAEKARRTVPSTWRAKRDYKDDDDKAWVWRPFVVLEEMDDIQCVGKLRSDLDNGNNSFQY43)::FLAG::KLLGIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTTIGKAVETESEFVIRVLDINDNEPRELDEPYEAIVPEMSPEGTFmuCDH19(44-VIKVTANDADDPSTGYHARILYNLERGQPYFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPGALSGTTTVSIKLSDINDN770):: huCDH19KPIFKESFYRFTISESAPTGTSIGKIMAYDDDIGENAEMEYSIEDDDSKIFDIIIDNDTQEGIVILKKKVDFEQQSYYGIRAKVKN(271)CHVDEELAPAHVNASTTYIKVQVEDEDEPPVFLLPYYILEIPEGKPYGTIVGTVSATDPDRRQSPMRYYLTGSKMFDINDNGTIITTNMLDREVSAWYNLTVTATETYNVQQISSAHVYVQVFNINDNAPEFSQFYETYVCENAESGEIVQIISAIDRDESIEDHHEYENHSLEDTNNSSFMLTDNQDNTAVILSNRTGENLKEEPVEYMIILIADNGIPSLTSTNTLTIQVCDCGDSRNTETCANKGLLFIMGFRTEAIIAIMICVMVIFGEFFLILALKQRRKETLFPEKTEDFRENIFCYDDEGGGEEDSEAFDIVELRQSTVMRERKPQRSKSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFGSAVQPNN 1468 VH of CDH19 artificial ntCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTT14302 CC x I2CCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT 1469 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSL14302 CC x I2C RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS 1470 VL of CDH19artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA14302 CC x I2CAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1471VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14302 CC x I2C CQAWESSTVVFGCGTKLTVL 1472 VH-VL of artificial ntCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCDH19 14302CAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATACC x I2CAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1473 VH-VL ofartificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLCDH19 14302RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTCC x I2CSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVL1474 CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLCC x I2CRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1475 CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLx F12q0RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGETENSYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKGRFTISRDDSKNTAYLQMNSLKTEDTAVYYCVRHGNFGNSYVSWWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL1476 CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLCC x F12q0RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGETENSYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKGRFTISRDDSKNTAYLQMNSLKTEDTAVYYCVRHGNFGNSYVSWWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL1477 VH of CDH19 artificial ntCGGCTGATCGAGGACATCTGCCTGCCCAGATGGGGCTGCCTGTGGGAGGACGACCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGT21-14302 xGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGI2CCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT1478 VH of CDH19 artificial AARLIEDICLPRWGCLWEDDQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRF21-14302 x TISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS I2C1479 VL of CDH19 artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA21-14302 xAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCI2CCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1480VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY21-14302 x CQAWESSTVVFGGGTKLTVL I2C 1481 VH-VL of artificial ntCGGCTGATCGAGGACATCTGCCTGCCCAGATGGGGCTGCCTGTGGGAGGACGACCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTCDH19 21-GGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGG14302 x I2CCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1482 VH-VL of artificial AARLIEDICLPRWGCLWEDDQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFCDH19 21-TISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSP14302 x I2CGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVL 1483 CDH19 21- artificial aaRLIEDICLPRWGCLWEDDQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRF14302 x I2CTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH 1484 VH of CDH19 artificial ntCGGCTGATCGAGGACATCTGCCTGCCCAGATGGGGCTGCCTGTGGGAGGACGACCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGT21-14302 CC xGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGI2CCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT1485 VH of CDH19 artificial AARLIEDICLPRWGCLWEDDQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRF21-14302 CC x TISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSI2C 1486 VL of CDH19 artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA21-14302 CC xAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCI2CCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1487VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY21-14302 CC x CQAWESSTVVFGCGTKLTVL I2C 1488 VH-VL of artificial ntCGGCTGATCGAGGACATCTGCCTGCCCAGATGGGGCTGCCTGTGGGAGGACGACCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTCDH19 21-GGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGG14302 CC x I2CCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1489 VH-VL of artificial AARLIEDICLPRWGCLWEDDQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRFCDH19 21-TISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSP14302 CC x I2CGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVL 1490 CDH19 21- artificial aaRLIEDICLPRWGCLWEDDQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRF14302 CC x I2CTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH 1491 CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLx I2C-21RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLRLIEDICLPRWGCLWEDDHHHHHH 1492 CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLCC x I2C-21RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLRLIEDICLPRWGCLWEDDHHHHHH 1493 VH of CDH19 artificial ntCAACGTTTCTGTACCGGTCACTTCGGTGGTCTGTACCCGTGTAATGGTGGTGGTGGTGGTTCGCAGGTGCAGTTGGTGGAGTCTGG14302 x I2C xGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGFcBYTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT 1494 VH of CDH19 artificial AAQRFCTGHEGGLYPCNGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVK14302x I2C xDRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS FcBY 1495VL of CDH19 artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA14302 x I2C xAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCFcBYCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1496VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14302x I2C x CQAWESSTVVFGGGTKLTVL FcBY 1497 VH-VL of artificial ntCAACGTTTCTGTACCGGTCACTTCGGTGGTCTGTACCCGTGTAATGGTGGTGGTGGTGGTTCGCAGGTGCAGTTGGTGGAGTCTGGCDH19 14302GGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGx I2C x FcBYTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1498 VH-VL of artificial AAQRFCTGHFGGLYPCNGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKCDH19 14302DRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSx I2C x FcBYVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVL 1499 CDH19 14302 artificial aaQRFCTGHFGGLYPCNGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKx I2C x FcBYDRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLGGGGSQRFCTGHFGGLHPCNGHHHHHH 1500 VH of CDH19 artificial ntCAACGTTTCTGTACCGGTCACTTCGGTGGTCTGTACCCGTGTAATGGTGGTGGTGGTGGTTCGCAGGTGCAGTTGGTGGAGTCTGG14302 CC x I2CGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGx FcBYTCCGCCAGGCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT 1501 VH of CDH19 artificial AAQRFCTGHFGGLYPCNGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVK14302 CC x I2CDRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS x FcBY 1502VL of CDH19 artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA14302 CC x I2CAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCx FcBYCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1503VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14302 CC x I2C CQAWESSTVVFGCGTKLTVL x FcBY 1504 VH-VL of artificial ntCAACGTTTCTGTACCGGTCACTTCGGTGGTCTGTACCCGTGTAATGGTGGTGGTGGTGGTTCGCAGGTGCAGTTGGTGGAGTCTGGCDH19 14302GGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGCC x I2C xTCCGCCAGGCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGFcBYGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1505 VH-VL of artificial AAQRFCTGHFGGLYPCNGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKCDH19 14302DRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSCC x I2C xVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFFcBY GCGTKLTVL 1506 CDH19 14302 artificial aaQRFCTGHFGGLYPCNGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKCC x I2C xDRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSFcBYVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLGGGGSQRFCTGHFGGLHPCNGHHHHHH 1507 VH of CDH19 artificial ntCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTT14303 CC x I2CCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAAAAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT 1508 VH of CDH19 artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMKSL14303 CC x I2C RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS 1509 VL of CDH19artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA14303 CC x I2CAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1510VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14303 CC x I2C CQAWESSTVVFGCGTKLTVL 1511 VH-VL of artificial ntCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCDH19 14303CAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATACC x I2CAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAAAAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1512 VH-VL ofartificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMKSLCDH19 14303RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTCC x I2CSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVL1513 CDH19 14303 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMKSLCC x I2CRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNEGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1514 CDH19 14303 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMKSLx F12q0RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGETENSYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKGRFTISRDDSKNTAYLQMNSLKTEDTAVYYCVRHGNFGNSYVSWWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL1515 CDH19 14303 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMKSLCC x F12q0RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGETENSYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKGRFTISRDDSKNTAYLQMNSLKTEDTAVYYCVRHGNFGNSYVSWWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL1516 CDH19 14303 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMKSLx I2C-21RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNEGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLRLIEDICLPRWGCLWEDDHHHHHH 1517 CDH19 14303 artificial aaQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMKSLCC x I2C-21RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNEGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLRLIEDICLPRWGCLWEDDHHHHHH 1518 VH of CDH19 artificial ntCAACGTTTCTGTACCGGTCACTTCGGTGGTCTGTACCCGTGTAATGGTGGTGGTGGTGGTTCGCAGGTGCAGTTGGTGGAGTCTGG14303 x I2C xGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGFcBYTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAAAAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT 1519 VH of CDH19 artificial AAQRFCTGHEGGLYPCNGGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVK14303x I2C xDRFTISRDNSKNTLYLQMKSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS FcBY 1520VL of CDH19 artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA14303 x I2C xAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCFcBYCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1521VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14303x I2C x CQAWESSTVVFGGGTKLTVL FcBY 1522 VH-VL of artificial ntCAACGTTTCTGTACCGGTCACTTCGGTGGTCTGTACCCGTGTAATGGTGGTGGTGGTGGTTCGCAGGTGCAGTTGGTGGAGTCTGGCDH19 14303GGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGx I2C x FcBYTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAAAAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1523 VH-VL of artificial AAQRFCTGHFGGLYPCNGGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKCDH19 14303DRFTISRDNSKNTLYLQMKSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSx I2C x FcBYVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVL 1524 CDH19 14303 artificial aaQRFCTGHFGGLYPCNGGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKx I2C x FcBYDRFTISRDNSKNTLYLQMKSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLGGGGSQRFCTGHFGGLHPCNGHHHHHH 1525 VH of CDH19 artificial ntCAACGTTTCTGTACCGGTCACTTCGGTGGTCTGTACCCGTGTAATGGTGGTGGTGGTGGTTCGCAGGTGCAGTTGGTGGAGTCTGG14303 CC x I2CGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGx FcBYTCCGCCAGGCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAAAAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT 1526 VH of CDH19 artificial AAQRFCTGHFGGLYPCNGGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVK14303 CC x I2CDRFTISRDNSKNTLYLQMKSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS x FcBY 1527VL of CDH19 artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA14303 CC x I2CAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCx FcBYCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1528VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14303 CC x I2C CQAWESSTVVFGCGTKLTVL x FcBY 1529 VH-VL of artificial ntCAACGTTTCTGTACCGGTCACTTCGGTGGTCTGTACCCGTGTAATGGTGGTGGTGGTGGTTCGCAGGTGCAGTTGGTGGAGTCTGGCDH19 14303GGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGCC x I2C xTCCGCCAGGCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGFcBYGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAAAAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1530 VH-VL of artificial AAQRFCTGHFGGLYPCNGGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKCDH19 14303DRFTISRDNSKNTLYLQMKSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSCC x I2C xVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFFcBY GCGTKLTVL 1531 CDH19 14303 artificial aaQRFCTGHFGGLYPCNGGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKCC x I2C xDRFTISRDNSKNTLYLQMKSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSFcBYVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLGGGGSQRFCTGHFGGLHPCNGHHHHHH 1532 VH of CDH19 artificial ntCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTT14039 CC x I2CCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT 1533 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMNSL14039 CC x I2C RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS 1534 VL of CDH19artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA14039 CC x I2CAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1535VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14039 CC x I2C CQAWESSTVVFGCGTKLTVL 1536 VH-VL of artificial ntCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCDH19 14039CAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATACC x I2CAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1537 VH-VL ofartificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMNSLCDH19 14039RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTCC x I2CSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVL1538 CDH19 14039 artificialQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMNSLCC x I2CRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNEGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1539 CDH19 14039 artificialQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMNSLx F12q0RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGETENSYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKGRFTISRDDSKNTAYLQMNSLKTEDTAVYYCVRHGNFGNSYVSWWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL1540 CDH19 14039 artificialQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMNSLCC x F12q0RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGETENSYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKGRFTISRDDSKNTAYLQMNSLKTEDTAVYYCVRHGNFGNSYVSWWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL1541 VH of CDH19 artificial ntCGGCTGATCGAGGACATCTGCCTGCCCAGATGGGGCTGCCTGTGGGAGGACGACCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGT21-14039 xGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGI2CCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT1542 VH of CDH19 artificial AARLIEDICLPRWGCLWEDDQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRF21-14039 x TISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS I2C1543 VL of CDH19 artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA21-14039 xAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCI2CCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1544VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY21-14039 x CQAWESSTVVFGGGTKLTVL I2C 1545 VH-VL of artificial ntCGGCTGATCGAGGACATCTGCCTGCCCAGATGGGGCTGCCTGTGGGAGGACGACCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTCDH19 21-GGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGG14039 x I2CCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1546 VH-VL of artificial AARLIEDICLPRWGCLWEDDQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFCDH19 21-TISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSP14039x I2CGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVL 1547 CDH19 21- artificialRLIEDICLPRWGCLWEDDQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRF14039x I2CTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH 1548 VH of CDH19 artificial ntCGGCTGATCGAGGACATCTGCCTGCCCAGATGGGGCTGCCTGTGGGAGGACGACCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGT21-14039 CC xGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGI2CCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT1549 VH of CDH19 artificial AARLIEDICLPRWGCLWEDDQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKDRF21-14039 CC x TISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSI2C 1550 VL of CDH19 artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA21-14039 CC xAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCI2CCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1551VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY21-14039 CC x CQAWESSTVVFGCGTKLTVL I2C 1552 VH-VL of artificial ntCGGCTGATCGAGGACATCTGCCTGCCCAGATGGGGCTGCCTGTGGGAGGACGACCAGGTGCAGTTGGTGGAGTCTGGGGGAGGCGTCDH19 21-GGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGG14039 CC x I2CCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1553 VH-VL of artificial AARLIEDICLPRWGCLWEDDQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKDRFCDH19 21-TISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSP14039 CC x I2CGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVL 1554 CDH19 21- artificialRLIEDICLPRWGCLWEDDQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKDRF14039 CC x I2CTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH 1555 CDH19 14039 artificialQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMNSLx I2C-21RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLRLIEDICLPRWGCLWEDDHHHHHH 1556 CDH19 14039 artificialQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMNSLCC x I2C-21RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLRLIEDICLPRWGCLWEDDHHHHHH 1557 VH of CDH19 artificial ntCAACGTTTCTGTACCGGTCACTTCGGTGGTCTGTACCCGTGTAATGGTGGTGGTGGTGGTTCGCAGGTGCAGTTGGTGGAGTCTGG14039 x I2C xGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGFcBYTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT 1558 VH of CDH19 artificial AAQRFCTGHFGGLYPCNGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVK14039x I2C xDRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS FcBY 1559VL of CDH19 artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA14039 x I2C xAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCFcBYCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1560VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14039 x I2C x CQAWESSTVVFGGGTKLTVL FcBY 1561 VH-VL of artificial ntCAACGTTTCTGTACCGGTCACTTCGGTGGTCTGTACCCGTGTAATGGTGGTGGTGGTGGTTCGCAGGTGCAGTTGGTGGAGTCTGGCDH19 14039GGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGx I2C x FcBYTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCGGAGGGACCAAGCTGACCGTCCTA 1562 VH-VL of artificial AAQRFCTGHFGGLYPCNGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKCDH19 14039DRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSx I2C x FcBYVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVL 1563 CDH19 14039 artificialQRFCTGHFGGLYPCNGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKx I2C x FcBYDRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLGGGGSQRFCTGHFGGLHPCNGHHHHHH 1564 VH of CDH19 artificial ntCAACGTTTCTGTACCGGTCACTTCGGTGGTCTGTACCCGTGTAATGGTGGTGGTGGTGGTTCGCAGGTGCAGTTGGTGGAGTCTGG14039 CC x I2CGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGx FcBYTCCGCCAGGCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGT 1565 VH of CDH19 artificial AAQRFCTGHFGGLYPCNGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVK14039 CC x I2CDRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS x FcBY 1566VL of CDH19 artificial ntTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGA14039 CC x I2CAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCx FcBYCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1567VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY14039 CC x I2C CQAWESSTVVFGCGTKLTVL x FcBY 1568 VH-VL of artificial ntCAACGTTTCTGTACCGGTCACTTCGGTGGTCTGTACCCGTGTAATGGTGGTGGTGGTGGTTCGCAGGTGCAGTTGGTGGAGTCTGGCDH19 14039GGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGCC x I2C xTCCGCCAGGCTCCAGGCAAGTGTCTGGAGTGGGTGGCATTTATATGGTATGAGGGAAGTAATAAATACTATGCAGAGTCCGTGAAGFcBYGACCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAATAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAAGGGCCGGTATAATAGGAACTATAGGCTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCTAGTGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCCTATGAACTGACTCAGCCACCCTCAGTGTCCGTGTCCCCAGGACAGACAGCCAGCATCACCTGCTCTGGAGATAGGTTGGGGGAAAAATATACTAGCTGGTATCAGCAGAGGCCAGGCCAGTCCCCTTTGCTGGTCATCTATCAAGATACCAAGCGGCCCTCAGGGATCCCTGAGCGATTCTCTGGCTCCAACTCTGGTAACACAGCCACTCTGACCATCAGCGGGACCCAGGCTATGGATGAGGCTGACTATTACTGTCAGGCGTGGGAGAGCAGCACTGTGGTATTCGGCTGCGGGACCAAGCTGACCGTCCTA 1569 VH-VL of artificial AAQRFCTGHEGGLYPCNGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKCDH19 14039DRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSCC x I2C xVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFFcBY GCGTKLTVL 1570 CDH19 14039 artificialQRFCTGHEGGLYPCNGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYEGSNKYYAESVKCC x I2C xDRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSFcBYVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLGGGGSQRFCTGHFGGLHPCNGHHHHHH 1571 CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLx I2C-156RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVEGGGTKLTVLGGGGSGGGSRDWDEDVFGGGTPVGGHHHHHH 1572 CDH19 14302 artificial aaQRFVTGHEGGLYPANGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGETFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKx I2C-LFcBYDRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLGGGGSQRFCTGHFGGLHPCNGHHHHHH 1573 CDH19 14302 artificial aaQRFVTGHEGGLYPANGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGETFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKx I2C-LFcBY-DRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVS156VSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLGGGGSQRFCTGHEGGLHPCNGGGGGSGGGSRDWDEDVEGGGTPVGGHHHHHH 1574CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLx I2C-Cys-LoopRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLGCGGGGCHHHHHH1575 CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLx I2C-HALBRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLPGGGGSDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGLDYHHHHHH1576 CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLx I2C-GS-RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTD3HSASWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLPGGGGSEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGLHHHHHH 1577 CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLx I2C-3G5-RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTD3HSASWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLPGGGGSGGGGSGGGGSEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGLHHHHHH 1578 CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLx I2C-GS-RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTD3HSA-156SWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLPGGGGSEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGLGGGGSGGGSRDWDFDVFGGGTPVGGHHHHHH 1579 CDH19 14302artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLx I2C-3G5-RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTD3HSA-156SWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLPGGGGSGGGGSGGGGSEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGLGGGGSGGGSRDWDFDVFGGGTPVGGHHHHHH 1580CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLx I2C-GS-RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTD3HSA-21SWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLPGGGGSEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGLGGGGSGGGSRLIEDICLPRWGCLWEDDHHHHHH 1581CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLx I2C-3G5-RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTD3HSA-21SWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLPGGGGSGGGGSGGGGSEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGLGGGGSGGGSRLIEDICLPRWGCLWEDDHHHHHH 1582CDR-H1 of artificial AA SYYWS CDH19 65231.002 1583 CDR-H2 of artificialAA YIYYSGSTNYNPSLKS CDH19 65231.002 1584 CDR-H3 of artificial AADQRRIAAAGTHFYGMDV CDH19 65231.002 1585 CDR-L1 of artificial AARASQSVSSSYLA CDH19 65231.002 1586 CDR-L2 of artificial AA GTSSRAT CDH1965231.002 1587 CDR-L3 of artificial AA QQYGSSPFT CDH19 65231.002 1588VH of CDH19 artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGCCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGACTCCAT65231.002CACCTCCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACTCCGGCTCCACCAACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCAGGGACCAGCGGAGAATCGCCGCTGCCGGCACCCACTTCTACGGCATGGATGTGTGGGGCCAGGGCACCCTCGTGACCGTGTCTAGC 1589 VH of CDH19 artificial AAQVQLQESGPGLAKPSETLSLTCTVSGDSITSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVT65231.002 AADTAVYYCARDQRRIAAAGTHFYGMDVWGQGTLVTVSS 1590 VL of CDH19artificial NTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGT65231.002GTCCTCCTCCTACCTGGCCTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCACCTCCTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCAGCCCCTTCACCTTCGGCGGAGGCACCAAGGTGGAAATCAAGTCC1591 VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGTSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAV65231.002 YYCQQYGSSPFTFGGGTKVEIKS 1592 VH-VL of artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGCCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGACTCCATCDH19CACCTCCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACTCCGGCTCCACCA65231.002ACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCAGGGACCAGCGGAGAATCGCCGCTGCCGGCACCCACTTCTACGGCATGGATGTGTGGGGCCAGGGCACCCTCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGTGTCCTCCTCCTACCTGGCCTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCACCTCCTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCAGCCCCTTCACCTTCGGCGGAGGCACCAAGGTGGAAATCAAGTCC 1593VH-VL of artificial AAQVQLQESGPGLAKPSETLSLTCTVSGDSITSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTCDH19AADTAVYYCARDQRRIAAAGTHFYGMDVWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSS65231.002YLAWYQQKPGQAPRLLIYGTSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPFTFGGGTKVEIKS1594 CDH19 artificial AAQVQLQESGPGLAKPSETLSLTCTVSGDSITSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVT65231.002 xAADTAVYYCARDQRRIAAAGTHFYGMDVWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSI2CYLAWYQQKPGQAPRLLIYGTSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPFTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1595 CDR-H1 of artificial AA SYYWS CDH19 65231.003 1596 CDR-H2 ofartificial AA YIYYSGSTNYNPSLKS CDH19 65231.003 1597 CDR-H3 of artificialAA DQRRIAAAGTHFYGMDV CDH19 65231.003 1598 CDR-L1 of artificial AARASQSVSSSYLA CDH19 65231.003 1599 CDR-L2 of artificial AA GTSSRAT CDH1965231.003 1600 CDR-L3 of artificial AA QQYGSSPFT CDH19 65231.003 1601VH of CDH19 artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGCCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCAT65231.003CACCTCCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACTCCGGCTCCACCAACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCAGGGACCAGCGGAGAATCGCCGCTGCCGGCACCCACTTCTACGGCATGGATGTGTGGGGCCAGGGCACCCTCGTGACCGTGTCTAGC 1602 VH of CDH19 artificial AAQVQLQESGPGLAKPSETLSLTCTVSGGSITSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVT65231.003 AADTAVYYCARDQRRIAAAGTHFYGMDVWGQGTLVTVSS 1603 VL of CDH19artificial NTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGT65231.003GTCCTCCTCCTACCTGGCCTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCACCTCCTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCAGCCCCTTCACCTTCGGCCAAGGCACCAAGGTGGAAATCAAGTCC1604 VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGTSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAV65231.003 YYCQQYGSSPFTFGQGTKVEIKS 1605 VH-VL of artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGCCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCATCDH19CACCTCCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACTCCGGCTCCACCA65231.003ACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCAGGGACCAGCGGAGAATCGCCGCTGCCGGCACCCACTTCTACGGCATGGATGTGTGGGGCCAGGGCACCCTCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGTGTCCTCCTCCTACCTGGCCTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCACCTCCTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCAGCCCCTTCACCTTCGGCCAAGGCACCAAGGTGGAAATCAAGTCC 1606VH-VL of artificial AAQVQLQESGPGLAKPSETLSLTCTVSGGSITSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTCDH19AADTAVYYCARDQRRIAAAGTHFYGMDVWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSS65231.003YLAWYQQKPGQAPRLLIYGTSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPFTFGQGTKVEIKS1607 CDH19 artificial AAQVQLQESGPGLAKPSETLSLTCTVSGGSITSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVT65231.003 xAADTAVYYCARDQRRIAAAGTHFYGMDVWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSI2CYLAWYQQKPGQAPRLLIYGTSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPFTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1608 CDR-H1 of artificial AA SYYWS CDH19 65234.001 1609 CDR-H2 ofartificial AA YIYYIGSTNYNPSLKS CDH19 65234.001 1610 CDR-H3 of artificialAA DSRYRSGWYDAFDI CDH19 65234.001 1611 CDR-L1 of artificial AARASQSVAGSYLA CDH19 65234.001 1612 CDR-L2 of artificial AA GASSRAT CDH1965234.001 1613 CDR-L3 of artificial AA QQYGKSPIT CDH19 65234.001 1614VH of CDH19 artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCAT65234.001CAACTCCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACATCGGCTCCACCAACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCCTGTACTACTGCGCCAGAGACTCCCGGTACAGATCCGGGTGGTACGACGCCTTCGACATCTGGGGCCAGGGCACCATGGTCACCGTGTCCTCT 1615 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVT65234.001 AADTALYYCARDSRYRSGWYDAFDIWGQGTMVTVSS 1616 VL of CDH19artificial NTGATATCGTGCTGACCCAGTCCCCCGGCACCCTGTCTCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCTCAGTCCGT65234.001GGCCGGCTCCTACCTGGCTTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCTAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCCGTGTACTATTGCCAGCAGTACGGCAAGTCCCCCATCACCTTCGGCCAGGGAACCCGGCTGGAAATGAAGTCC1617 VL of CDH19 artificial AADIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAV65234.001 YYCQQYGKSPITFGQGTRLEMKS 1618 VH-VL of artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCATCDH19CAACTCCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACATCGGCTCCACCA65234.001ACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCCTGTACTACTGCGCCAGAGACTCCCGGTACAGATCCGGGTGGTACGACGCCTTCGACATCTGGGGCCAGGGCACCATGGTCACCGTGTCCTCTGGTGGCGGAGGCTCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCCGATATCGTGCTGACCCAGTCCCCCGGCACCCTGTCTCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCTCAGTCCGTGGCCGGCTCCTACCTGGCTTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCTAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCCGTGTACTATTGCCAGCAGTACGGCAAGTCCCCCATCACCTTCGGCCAGGGAACCCGGCTGGAAATGAAGTCC 1619 VH-VL ofartificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTCDH19AADTALYYCARDSRYRSGWYDAFDIWGQGTMVTVSSGGGGSGGGGSGGGGSDIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLA65234.001WYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKS1620 CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVT65234.001 xAADTALYYCARDSRYRSGWYDAFDIWGQGTMVTVSSGGGGSGGGGSGGGGSDIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAI2CWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1621 CDR-H1 of artificial AA SYYWS CDH19 65234.004 1622 CDR-H2 ofartificial AA YIYYIGSTNYNPSLKS CDH19 65234.004 1623 CDR-H3 of artificialAA ESRYRSGWYDAFDI CDH19 65234.004 1624 CDR-L1 of artificial AARASQSVAGSYLA CDH19 65234.004 1625 CDR-L2 of artificial AA GASSRAT CDH1965234.004 1626 CDR-L3 of artificial AA QQYGKSPIT CDH19 65234.004 1627VH of CDH19 artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCAT65234.004CAGCTCCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACATCGGCTCCACCAACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCCTGTACTACTGCGCCAGAGAGTCCCGGTACAGATCCGGGTGGTACGACGCCTTCGACATCTGGGGCCAGGGCACCATGGTCACCGTGTCCTCT 1628 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVT65234.004 AADTALYYCARESRYRSGWYDAFDIWGQGTMVTVSS 1629 VL of CDH19artificial NTGATATCGTGCTGACCCAGTCCCCCGGCACCCTGTCTCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCTCAGTCCGT65234.004GGCCGGCTCCTACCTGGCTTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCTAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCCGTGTACTATTGCCAGCAGTACGGCAAGTCCCCCATCACCTTCGGCCAGGGAACCCGGCTGGAAATGAAGTCC1630 VL of CDH19 artificial AADIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAV65234.004 YYCQQYGKSPITFGQGTRLEMKS 1631 VH-VL of artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCATCDH19CAGCTCCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACATCGGCTCCACCA65234.004ACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCCTGTACTACTGCGCCAGAGAGTCCCGGTACAGATCCGGGTGGTACGACGCCTTCGACATCTGGGGCCAGGGCACCATGGTCACCGTGTCCTCTGGTGGCGGAGGCTCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCCGATATCGTGCTGACCCAGTCCCCCGGCACCCTGTCTCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCTCAGTCCGTGGCCGGCTCCTACCTGGCTTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCTAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCCGTGTACTATTGCCAGCAGTACGGCAAGTCCCCCATCACCTTCGGCCAGGGAACCCGGCTGGAAATGAAGTCC 1632 VH-VL ofartificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTCDH19AADTALYYCARESRYRSGWYDAFDIWGQGTMVTVSSGGGGSGGGGSGGGGSDIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLA65234.004WYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKS1633 CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVT65234.004 xAADTALYYCARESRYRSGWYDAFDIWGQGTMVTVSSGGGGSGGGGSGGGGSDIVLTQSPGTLSLSPGERATLSCRASQSVAGSYLAI2CWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGKSPITFGQGTRLEMKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1634 CDR-H1 of artificial AA SYFIH CDH19 65235.005 1635 CDR-H2 ofartificial AA IINPISVSTSYAQKFQG CDH19 65235.005 1636 CDR-H3 ofartificial AA GGIQLWLHLDY CDH19 65235.005 1637 CDR-L1 of artificial AASGSRSNIGSNFVN CDH19 65235.005 1638 CDR-L2 of artificial AA TNNQRPS CDH1965235.005 1639 CDR-L3 of artificial AA ATYDESMQGWV CDH19 65235.005 1640VH of CDH19 artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGTGTCCGGCTACACCTT65235.005CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCACCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTACATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACCTGGACTATTGGGGCCAGGGCACCCTGGTCACCGTGTCCTCT 1641 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVYMELSSL65235.005 RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS 1642 VL of CDH19 artificialNTCAGTCTGCCCTGACCCAGCCTCCCTCCGTCACCGGCACACCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT65235.005CGGCTCCAACTTCGTGAACTGGTACCAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGGCCGACTACTACTGTGCCACCTACGACGAGTCCATGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC1643 VL of CDH19 artificial AAQSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD65235.005 YYCATYDESMQGWVFGGGTKLTVLS 1644 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGTGTCCGGCTACACCTTCDH19CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCA65234.005CCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTACATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACCTGGACTATTGGGGCCAGGGCACCCTGGTCACCGTGTCCTCTGGTGGCGGAGGCTCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCCCAGTCTGCCCTGACCCAGCCTCCCTCCGTCACCGGCACACCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTACCAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGGCCGACTACTACTGTGCCACCTACGACGAGTCCATGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1645 VH-VL ofartificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVYMELSSLCDH19RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWY65234.005QQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATYDESMQGWVFGGGTKLTVLS1646 CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVYMELSSL65234.005 xRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYI2CQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATYDESMQGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1647 CDR-H1 of artificial AA SYFIH CDH19 65235.002 1648 CDR-H2 ofartificial AA IINPISVSTSYAQKFQG CDH19 65235.002 1649 CDR-H3 ofartificial AA GGIQLWLHLDY CDH19 65235.002 1650 CDR-L1 of artificial AASGSRSNIGSNFVN CDH19 65235.002 1651 CDR-L2 of artificial AA TNNQRPS CDH1965235.002 1652 CDR-L3 of artificial AA ATWDDSMNGWV CDH19 65235.002 1653VH of CDH19 artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGTGTCCGGCTACACCTT65235.002CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCACCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTTCATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACCTGGACTATTGGGGCCAGGGCACCCTGGTCACCGTGTCCTCT 1654 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSL65235.002 RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS 1655 VL of CDH19 artificialNTCAGTCTGCCCTGACCCAGCCTCCCTCCGTCACCGGCACACCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT65235.002CGGCTCCAACTTCGTGAACTGGTACCAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGGCCGACTACTACTGTGCCACCTGGGACGACTCCATGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC1656 VL of CDH19 artificial AAQSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD65235.002 YYCATWDDSMNGWVFGGGTKLTVLS 1657 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGTGTCCGGCTACACCTTCDH19CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCA65235.002CCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTTCATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACCTGGACTATTGGGGCCAGGGCACCCTGGTCACCGTGTCCTCTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTCAGTCTGCCCTGACCCAGCCTCCCTCCGTCACCGGCACACCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTACCAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGGCCGACTACTACTGTGCCACCTGGGACGACTCCATGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1658 VH-VL ofartificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLCDH19RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWY65235.002QQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSMNGWVFGGGTKLTVLS1659 CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSL65235.002 xRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYI2CQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDDSMNGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1660 CDR-H1 of artificial AA SYFIH CDH19 65235.003 1661 CDR-H2 ofartificial AA IINPISVSTSYAQKFQG CDH19 65235.003 1662 CDR-H3 ofartificial AA GGIQLWLHLDY CDH19 65235.003 1663 CDR-L1 of artificial AASGSRSNIGSNFVN CDH19 65235.003 1664 CDR-L2 of artificial AA TNNQRPS CDH1965235.003 1665 CDR-L3 of artificial AA ATWDESMQGWV CDH19 65235.003 1666VH of CDH19 artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGTGTCCGGCTACACCTT65235.003CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCACCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTTCATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACCTGGACTATTGGGGCCAGGGCACCCTGGTCACCGTGTCCTCT 1667 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSL65235.003 RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS 1668 VL of CDH19 artificialNTCAGTCTGCCCTGACCCAGCCTCCCTCCGTCACCGGCACACCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT65235.003CGGCTCCAACTTCGTGAACTGGTACCAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGGCCGACTACTACTGTGCCACCTGGGACGAGTCCATGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC1669 VL of CDH19 artificial AAQSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD65235.003 YYCATWDESMQGWVFGGGTKLTVLS 1670 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGTGTCCGGCTACACCTTCDH19CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCA65235.003CCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTTCATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACCTGGACTATTGGGGCCAGGGCACCCTGGTCACCGTGTCCTCTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTCAGTCTGCCCTGACCCAGCCTCCCTCCGTCACCGGCACACCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTACCAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGGCCGACTACTACTGTGCCACCTGGGACGAGTCCATGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1671 VH-VL ofartificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSLCDH19RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWY65235.003QQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDESMQGWVFGGGTKLTVLS1672 CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVFMELSSL65235.003 xRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSVTGTPGQRVTISCSGSRSNIGSNFVNWYI2CQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDESMQGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1673 CDR-H1 of artificial AA SYAMN CDH19 65236.001 1674 CDR-H2 ofartificial AA TISGGGANTYYADSVKG CDH19 65236.001 1675 CDR-H3 ofartificial AA GGMGGYYYGMDV CDH19 65236.001 1676 CDR-L1 of artificial AARASQSISSNLA CDH19 65236.001 1677 CDR-L2 of artificial AA GAFTRAT CDH1965236.001 1678 CDR-L3 of artificial AA QQYNYWPLT CDH19 65236.001 1679VH of CDH19 artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65236.001CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACACCTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGCCGACACCGCCGTGTACCACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGC 1680 VH of CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTESSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSL65236.001 RAADTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSS 1681 VL of CDH19artificial NTGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCAT65236.001CTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGAGTGTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGCAGTCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1682VL of CDH19 artificial AAEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVY65236.001 YCQQYNYWPLTFGGGTKVEIKS 1683 VH-VL of artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACA65236.001CCTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGCCGACACCGCCGTGTACCACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGCGGTGGTGGTTCTGGCGGAGGCGGCTCCGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCATCTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGAGTGTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGCAGTCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1684 VH-VL of artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSLCDH19RAADTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWF65236.001QQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKS1685 CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSL65236.001 xRAADTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFI2CQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1686 CDR-H1 of artificial AA SYAMN CDH19 65236.007 1687 CDR-H2 ofartificial AA TISGGGANTYYAESVKG CDH19 65236.007 1688 CDR-H3 ofartificial AA GGMGGYYYGMDV CDH19 65236.007 1689 CDR-L1 of artificial AARASQSISSNLA CDH19 65236.007 1690 CDR-L2 of artificial AA GAFTRAT CDH1965236.007 1691 CDR-L3 of artificial AA QQYNYWPLT CDH19 65236.007 1692VH of CDH19 artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65236.007CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACACCTACTACGCCGAGTCCGTGAAGGGCCGGTTCACCATCTCCTCCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACCACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCCTCGTGACCGTGTCTAGC 1693 VH of CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYAESVKGRFTISSDNSKSTLYLQMNSL65236.007 RAEDTAVYHCAKGGMGGYYYGMDVWGQGTLVTVSS 1694 VL of CDH19artificial NTGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCAT65236.007CTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGATTCTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGGAGCCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1695VL of CDH19 artificial AAEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVY65236.007 YCQQYNYWPLTFGGGTKVEIKS 1696 VH-VL of artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACA65236.007CCTACTACGCCGAGTCCGTGAAGGGCCGGTTCACCATCTCCTCCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACCACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCCTCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGCGGTGGTGGTTCTGGCGGAGGCGGCTCCGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCATCTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGATTCTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGGAGCCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1697 VH-VL of artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYAESVKGRFTISSDNSKSTLYLQMNSLCDH19RAEDTAVYHCAKGGMGGYYYGMDVWGQGTLVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWF65236.007QQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKS1698 CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYAESVKGRFTISSDNSKSTLYLQMNSL65236.007 xRAEDTAVYHCAKGGMGGYYYGMDVWGQGTLVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFI2CQQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1699 CDR-H1 of artificial AA SYAMN CDH19 65236.009 1700 CDR-H2 ofartificial AA TISGGGANTYYADSVKG CDH19 65236.009 1701 CDR-H3 ofartificial AA GGMGGYYYGMDV CDH19 65236.009 1702 CDR-L1 of artificial AARASQSISSNLA CDH19 65236.009 1703 CDR-L2 of artificial AA GAFTRAT CDH1965236.009 1704 CDR-L3 of artificial AA QQYNYWPLT CDH19 65236.009 1705VH of CDH19 artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65236.009CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACACCTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACTACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGC 1706 VH of CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTESSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSL65236.009 RAEDTAVYYCAKGGMGGYYYGMDVWGQGTTVTVSS 1707 VL of CDH19artificial NTGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCAT65236.009CTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGAGTGTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGCAGTCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1708VL of CDH19 artificial AAEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVY65236.009 YCQQYNYWPLTFGGGTKVEIKS 1709 VH-VL of artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACA65236.009CCTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACTACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGCGGTGGTGGTTCTGGCGGAGGCGGCTCCGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCATCTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGAGTGTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGCAGTCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1710 VH-VL of artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTESSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSLCDH19RAEDTAVYYCAKGGMGGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWF65236.009QQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKS1711 CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTESSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSL65236.009 xRAEDTAVYYCAKGGMGGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFI2CQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1712 CDR-H1 of artificial AA SYAMN CDH19 65236.010 1713 CDR-H2 ofartificial AA TISGGGANTYYADSVKG CDH19 65236.010 1714 CDR-H3 ofartificial AA GGMGGYYYGMDV CDH19 65236.010 1715 CDR-L1 of artificial AARASQSISSNLA CDH19 65236.010 1716 CDR-L2 of artificial AA GAFTRAT CDH1965236.010 1717 CDR-L3 of artificial AA QQYNYWPLT CDH19 65236.010 1718VH of CDH19 artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65236.010CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACACCTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACCACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGC 1719 VH of CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTESSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSL65236.010 RAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSS 1720 VL of CDH19artificial NTGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCAT65236.010CTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGAGTGTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGGAGCCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1721VL of CDH19 artificial AAEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLEPEDFAVY65236.010 YCQQYNYWPLTFGGGTKVEIKS 1722 VH-VL of artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACA65236.010CCTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACCACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGCGGTGGTGGTTCTGGCGGAGGCGGCTCCGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCATCTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGAGTGTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGGAGCCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1723 VH-VL of artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSLCDH19RAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWF65236.010QQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKS1724 CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSL65236.010 xRAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFI2CQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1725 CDR-H1 of artificial AA SYAMN CDH19 65236.011 1726 CDR-H2 ofartificial AA TISGGGANTYYADSVKG CDH19 65236.011 1727 CDR-H3 ofartificial AA GGMGGYYYGMDV CDH19 65236.011 1728 CDR-L1 of artificial AARASQSISSNLA CDH19 65236.011 1729 CDR-L2 of artificial AA GAFTRAT CDH1965236.011 1730 CDR-L3 of artificial AA QQYNYWPLT CDH19 65236.011 1731VH of CDH19 artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65236.011CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACACCTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACCACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGC 1732 VH of CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTESSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSL65236.011 RAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSS 1733 VL of CDH19artificial NTGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCAT65236.011CTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGATTCTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGGAGCCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1734VL of CDH19 artificial AAEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVY65236.011 YCQQYNYWPLTFGGGTKVEIKS 1735 VH-VL of artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACA65236.011CCTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACCACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGCGGTGGTGGTTCTGGCGGAGGCGGCTCCGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCATCTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGATTCTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGGAGCCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1736 VH-VL of artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTESSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSLCDH19RAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWF65236.011QQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKS1737 CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTESSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSL65236.011 xRAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFI2CQQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1738 CDR-H1 of artificial AA SYAMN CDH19 65236.012 1739 CDR-H2 ofartificial AA TISGGGANTYYAESVKG CDH19 65236.012 1740 CDR-H3 ofartificial AA GGMGGYYYGMDV CDH19 65236.012 1741 CDR-L1 of artificial AARASQSISSNLA CDH19 65236.012 1742 CDR-L2 of artificial AA GAFTRAT CDH1965236.012 1743 CDR-L3 of artificial AA QQYNYWPLT CDH19 65236.012 1744VH of CDH19 artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65236.012CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACACCTACTACGCCGAGTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACCACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGC 1745 VH of CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTESSYAMNWVRQAPGKGLEWVSTISGGGANTYYAESVKGRFTISRDNSKSTLYLQMNSL65236.012 RAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSS 1746 VL of CDH19artificial NTGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCAT65236.012CTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGATTCTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGGAGCCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1747VL of CDH19 artificial AAEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVY65236.012 YCQQYNYWPLTFGGGTKVEIKS 1748 VH-VL of artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACA65236.012CCTACTACGCCGAGTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACCACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGCGGTGGTGGTTCTGGCGGAGGCGGCTCCGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCATCTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGATTCTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGGAGCCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1749 VH-VL of artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYAESVKGRFTISRDNSKSTLYLQMNSLCDH19RAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWF65236.012QQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKS1750 CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYAESVKGRFTISRDNSKSTLYLQMNSL65236.012 xRAEDTAVYHCAKGGMGGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFI2CQQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1751 CDR-H1 of artificial AA SYAMN CDH19 65236.013 1752 CDR-H2 ofartificial AA TISGGGANTYYADSVKG CDH19 65236.013 1753 CDR-H3 ofartificial AA GGMGGYYYGMDV CDH19 65236.013 1754 CDR-L1 of artificial AARASQSISSNLA CDH19 65236.013 1755 CDR-L2 of artificial AA GAFTRAT CDH1965236.013 1756 CDR-L3 of artificial AA QQYNYWPLT CDH19 65236.013 1757VH of CDH19 artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65236.013CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACACCTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGCCGACACCGCCGTGTACTACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGC 1758 VH of CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSL65236.013 RAADTAVYYCAKGGMGGYYYGMDVWGQGTTVTVSS 1759 VL of CDH19artificial NTGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCAT65236.013CTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGAGTGTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGCAGTCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1760VL of CDH19 artificial AAEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVY65236.013 YCQQYNYWPLTFGGGTKVEIKS 1761 VH-VL of artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACA65236.013CCTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGCCGACACCGCCGTGTACTACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGCGGTGGTGGTTCTGGCGGAGGCGGCTCCGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCATCTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGAGTGTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGCAGTCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1762 VH-VL of artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSLCDH19RAADTAVYYCAKGGMGGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWF65236.013QQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKS1763 CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYADSVKGRFTISRDNSKSTLYLQMNSL65236.013 xRAADTAVYYCAKGGMGGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFI2CQQKPGQAPRLLIYGAFTRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNYWPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1764 CDR-H1 of artificial AA SYAMN CDH19 65236.014 1765 CDR-H2 ofartificial AA TISGGGANTYYAESVKG CDH19 65236.014 1766 CDR-H3 ofartificial AA GGMGGYYYGMDV CDH19 65236.014 1767 CDR-L1 of artificial AARASQSISSNLA CDH19 65236.014 1768 CDR-L2 of artificial AA GAFTRAT CDH1965236.014 1769 CDR-L3 of artificial AA QQYNYWPLT CDH19 65236.014 1770VH of CDH19 artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65236.014CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACACCTACTACGCCGAGTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACCACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCCTCGTGACCGTGTCTAGC 1771 VH of CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTESSYAMNWVRQAPGKGLEWVSTISGGGANTYYAESVKGRFTISRDNSKSTLYLQMNSL65236.014 RAEDTAVYHCAKGGMGGYYYGMDVWGQGTLVTVSS 1772 VL of CDH19artificial NTGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCAT65236.014CTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGATTCTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGGAGCCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1773VL of CDH19 artificial AAEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFQQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVY65236.014 YCQQYNYWPLTFGGGTKVEIKS 1774 VH-VL of artificial NTCAGGTGCAGCTGCTGGAATCCGGCGGAGGACTGGTGCAGCCTGGCGGCTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGCCATGAACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGTCCACCATCAGCGGCGGAGGCGCCAACA65236.014CCTACTACGCCGAGTCCGTGAAGGGCCGGTTCACCATCTCCCGCGACAACTCCAAGTCCACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACCACTGTGCTAAGGGCGGCATGGGCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCCTCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGCGGTGGTGGTTCTGGCGGAGGCGGCTCCGAGATCGTGATGACCCAGTCCCCCGTGACCCTGTCCCTGAGCCTGGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCATCTCCAGCAACCTGGCCTGGTTCCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTTTACCCGGGCCACCGGCATCCCTGCCAGATTCTCTGGCTCCGGCTCCGGCACCGAGTTCACCCTGACCATCAGCTCCCTGGAGCCCGAGGACTTTGCCGTGTACTACTGCCAGCAGTACAACTACTGGCCCCTGACCTTCGGAGGCGGCACCAAGGTGGAAATCAAGTCC 1775 VH-VL of artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYAESVKGRFTISRDNSKSTLYLQMNSLCDH19RAEDTAVYHCAKGGMGGYYYGMDVWGQGTLVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWF65236.014QQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKS1776 CDH19 artificial AAQVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVSTISGGGANTYYAESVKGRFTISRDNSKSTLYLQMNSL65236.014 xRAEDTAVYHCAKGGMGGYYYGMDVWGQGTLVTVSSGGGGSGGGGSGGGGSEIVMTQSPVTLSLSLGERATLSCRASQSISSNLAWFI2CQQKPGQAPRLLIYGAFTRATGIPARFSGSGSGTEFTLTISSLEPEDFAVYYCQQYNYWPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1777 CDR-H1 of artificial AA RYGIH CDH19 65237.001 1778 CDR-H2 ofartificial AA VIWYDGSNKYYADSVKG CDH19 65237.001 1779 CDR-H3 ofartificial AA RAGIPGTTGYYYGMDV CDH19 65237.001 1780 CDR-L1 of artificialAA SGDRLGEKYVS CDH19 65237.001 1781 CDR-L2 of artificial AA QDNKWPSCDH19 65237.001 1782 CDR-L3 of artificial AA QAWDSSTVV CDH19 65237.0011783 VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCCGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65237.001CTCCAGATACGGCATCCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACACGGGCCGAGGACTCCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCCCCGGCACCACCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGC 1784 VH of CDH19 artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSL65237.001 RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSS 1785 VL of CDH19artificial NTTCTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGA65237.001GAAATACGTGAGCTGGTATCAGCAGAAGCCCGGCCAGTCCCCCATCCTGGTCATCTACCAGGACAACAAGTGGCCCTCCGGCATCCCTGAGCGGTTCTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCTGGGACTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1786VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYY65237.001 CQAWDSSTVVFGGGTKLTVLS 1787 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCCGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGATACGGCATCCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACA65237.001AGTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGCCGAGGACTCCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCCCCGGCACCACCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGAGAAATACGTGAGCTGGTATCAGCAGAAGCCCGGCCAGTCCCCCATCCTGGTCATCTACCAGGACAACAAGTGGCCCTCCGGCATCCCTGAGCGGTTCTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCTGGGACTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1788 VH-VL ofartificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLCDH19RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYV65237.001SWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLS1789 CDH19 artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSL65237.001 xRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYVI2CSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1790 CDR-H1 of artificial AA RYGIH CDH19 65237b.001 1791 CDR-H2 ofartificial AA VIWYEGSNKYYAESVKG CDH19 65237b.001 1792 CDR-H3 ofartificial AA RAGIPGTTGYYYGMDV CDH19 65237b.001 1793 CDR-L1 ofartificial AA SGDRLGEKYVS CDH19 65237b.001 1794 CDR-L2 of artificial AAQDNKWPS CDH19 65237b.001 1795 CDR-L3 of artificial AA QAWESSTVV CDH1965237b.001 1796 VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65237b.001CTCCAGATACGGCATCCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGAGGGCTCCAACAAGTACTACGCCGAGTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGCCGAGGACTCCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCCCCGGCACCACCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGC 1797 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTESRYGIHWVRQAPGKGLEWVAVIWYEGSNKYYAESVKGRFTISRDNSKNTLYLQMNSL65237b.001 RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSS 1798 VL of CDH19artificial NTTCTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGA65237b.001GAAATACGTGAGCTGGTATCAGCAGAAGCCCGGCCAGTCCCCCATCCTGGTCATCTACCAGGACAACAAGTGGCCCTCCGGCATCCCTGAGCGGTTCTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCTGGGAGTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1799VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYY65237b.001 CQAWESSTVVFGGGTKLTVLS 1800 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGATACGGCATCCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGAGGGCTCCAACA65237b.001AGTACTACGCCGAGTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGCCGAGGACTCCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCCCCGGCACCACCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGAGAAATACGTGAGCTGGTATCAGCAGAAGCCCGGCCAGTCCCCCATCCTGGTCATCTACCAGGACAACAAGTGGCCCTCCGGCATCCCTGAGCGGTTCTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCTGGGAGTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1801 VH-VL ofartificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTESRYGIHWVRQAPGKGLEWVAVIWYEGSNKYYAESVKGRFTISRDNSKNTLYLQMNSLCDH19RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYV65237b.001SWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLS1802 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTESRYGIHWVRQAPGKGLEWVAVIWYEGSNKYYAESVKGRFTISRDNSKNTLYLQMNSL65237b.001 xRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYVI2CSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1803 CDR-H1 of artificial AA RYGIH CDH19 65237.002 1804 CDR-H2 ofartificial AA VIWYDGSNKYYADSVKG CDH19 65237.002 1805 CDR-H3 ofartificial AA RAGIPGTTGYYYGMDV CDH19 65237.002 1806 CDR-L1 of artificialAA SGDRLGEKYVS CDH19 65237.002 1807 CDR-L2 of artificial AA QDNKWPSCDH19 65237.002 1808 CDR-L3 of artificial AA QAWDSSTVV CDH19 65237.0021809 VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65237.002CTCCAGATACGGCATCCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACAAGTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGCCGAGGACTCCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCCCCGGCACCACCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGC 1810 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTESRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSL65237.002 RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSS 1811 VL of CDH19artificial NTTCTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGA65237.002GAAATACGTGAGCTGGTATCAGCAGAAGCCCGGCCAGTCCCCCATCCTGGTCATCTACCAGGACAACAAGTGGCCCTCCGGCATCCCTGAGCGGTTCTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCTGGGACTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1812VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYVSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYY65237.002 CQAWDSSTVVFGGGTKLTVLS 1813 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGATACGGCATCCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACA65237.002AGTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGCCGAGGACTCCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCCCCGGCACCACCGGCTACTACTACGGCATGGATGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGAGAAATACGTGAGCTGGTATCAGCAGAAGCCCGGCCAGTCCCCCATCCTGGTCATCTACCAGGACAACAAGTGGCCCTCCGGCATCCCTGAGCGGTTCTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCTGGGACTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1814 VH-VL ofartificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLCDH19RAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYV65237.002SWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLS1815 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSRYGIHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSL65237.002 xRAEDSAVYYCARRAGIPGTTGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYVI2CSWYQQKPGQSPILVIYQDNKWPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1816 CDR-H1 of artificial AA SSGYYWS CDH19 65238.002 1817 CDR-H2 ofartificial AA YIYYTGSAYYNPSLKS CDH19 65238.002 1818 CDR-H3 of artificialAA DGSSGWYFQY CDH19 65238.002 1819 CDR-L1 of artificial AA RASRQISSSYLACDH19 65238.002 1820 CDR-L2 of artificial AA GPSSRAT CDH19 65238.0021821 CDR-L3 of artificial AA QQYGSSFT CDH19 65238.002 1822 VH of CDH19artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACCCTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCAT65238.002CTCCTCCTCCGGCTACTACTGGTCCTGGATCCGGCAGCCCCCCGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACACCGGCTCCGCCTACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCAGAGATGGCTCCAGCGGCTGGTACTTCCAGTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1823 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSS65238.002 VTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSS 1824 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCCGGCACCCTGTCTCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCCGGGCCTCCCGGCAGAT65238.002CTCCTCCAGCTACCTGGCTTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCCCTAGCTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCCGTGTACTATTGCCAGCAGTACGGCTCCTCCTTCACCTTCGGCCAGGGCACCAAGGTGGACATCAAGTCC 1825VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAV65238.002 YYCQQYGSSFTFGQGTKVDIKS 1826 VH-VL of artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACCCTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCATCDH19CTCCTCCTCCGGCTACTACTGGTCCTGGATCCGGCAGCCCCCCGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACACCGGCT65238.002CCGCCTACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCAGAGATGGCTCCAGCGGCTGGTACTTCCAGTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCCGGCACCCTGTCTCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCCGGGCCTCCCGGCAGATCTCCTCCAGCTACCTGGCTTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCCCTAGCTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCCGTGTACTATTGCCAGCAGTACGGCTCCTCCTTCACCTTCGGCCAGGGCACCAAGGTGGACATCAAGTCC 1827 VH-VL of artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSCDH19VTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWY65238.002QQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGQGTKVDIKS1828 CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSS65238.002 xVTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYI2CQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGQGTKVDIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1829 CDR-H1 of artificial AA SSGYYWS CDH19 65238.004 1830 CDR-H2 ofartificial AA YIYYTGSAYYNPSLKS CDH19 65238.004 1831 CDR-H3 of artificialAA DGSSGWYFQY CDH19 65238.004 1832 CDR-L1 of artificial AA RASRQISSSYLACDH19 65238.004 1833 CDR-L2 of artificial AA GPSSRAT CDH19 65238.0041834 CDR-L3 of artificial AA QQYGSSFT CDH19 65238.004 1835 VH of CDH19artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACCCTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCAT65238.004CTCCTCCTCCGGCTACTACTGGTCCTGGATCCGGCAGCCCCCCGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACACCGGCTCCGCCTACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCAGAGATGGCTCCAGCGGCTGGTACTTCCAGTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1836 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSS65238.004 VTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSS 1837 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCCGGCACCCTGTCTCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCCGGGCCTCCCGGCAGAT65238.004CTCCTCCAGCTACCTGGCTTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCCCTAGCTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCCGTGTACTATTGCCAGCAGTACGGCTCCTCCTTCACCTTCGGCCCTGGCACCAAGGTGGACATCAAGTCC 1838VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAV65238.004 YYCQQYGSSFTEGPGTKVDIKS 1839 VH-VL of artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACCCTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCATCDH19CTCCTCCTCCGGCTACTACTGGTCCTGGATCCGGCAGCCCCCCGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACACCGGCT65238.004CCGCCTACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCAGAGATGGCTCCAGCGGCTGGTACTTCCAGTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCCGGCACCCTGTCTCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCCGGGCCTCCCGGCAGATCTCCTCCAGCTACCTGGCTTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCCCTAGCTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCCGGCTGGAACCCGAGGACTTCGCCGTGTACTATTGCCAGCAGTACGGCTCCTCCTTCACCTTCGGCCCTGGCACCAAGGTGGACATCAAGTCC 1840 VH-VL of artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSSCDH19VTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWY65238.004QQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGPGTKVDIKS1841 CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSSGYYWSWIRQPPGKGLEWIGYIYYTGSAYYNPSLKSRVTISVDTSKNQFSLKLSS65238.004 xVTAADTAVYYCARDGSSGWYFQYWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASRQISSSYLAWYI2CQQKPGQAPRLLIYGPSSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSFTFGPGTKVDIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1842 CDR-H1 of artificial AA SYDMH CDH19 65240.002 1843 CDR-H2 ofartificial AA VISYDGTNEYYADSVKG CDH19 65240.002 1844 CDR-H3 ofartificial AA ERYFDWSFDY CDH19 65240.002 1845 CDR-L1 of artificial AARASQSVSNTYLA CDH19 65240.002 1846 CDR-L2 of artificial AA GASSRAT CDH1965240.002 1847 CDR-L3 of artificial AA QQYSNSWT CDH19 65240.002 1848VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65240.002CTCCAGCTACGACATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATCTCCTACGACGGCACCAACGAGTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACACCTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCGGTACTTCGACTGGTCCTTCGACTACTGGGGCCAGGGCACCCTGGTGTCCGTGTCTAGC 1849 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSL65240.002 RAEDTAVYYCARERYFDWSFDYWGQGTLVSVSS 1850 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCGT65240.002GTCCAACACCTACCTGGCCTGGTATCAGCAGCGCCCTGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCTGGCACCGACTTCACCCTGACCATCTCCAGCCTGGAACCCGAGGATTTCGCTGTGTACTATTGCCAGCAGTACTCCAACTCCTGGACCTTCGGACAGGGCACCAAGGTGGAAATCAAGTCC 1851VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAV65240.002 YYCQQYSNSWTFGQGTKVEIKS 1852 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGACATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATCTCCTACGACGGCACCAACG65240.002AGTACTACGCCGACTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACACCTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCGGTACTTCGACTGGTCCTTCGACTACTGGGGCCAGGGCACCCTGGTGTCCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCGTGTCCAACACCTACCTGGCCTGGTATCAGCAGCGCCCTGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCTGGCACCGACTTCACCCTGACCATCTCCAGCCTGGAACCCGAGGATTTCGCTGTGTACTATTGCCAGCAGTACTCCAACTCCTGGACCTTCGGACAGGGCACCAAGGTGGAAATCAAGTCC 1853 VH-VL of artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSLCDH19RAEDTAVYYCARERYFDWSFDYWGQGTLVSVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQ65240.002QRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKS1854 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYDGTNEYYADSVKGRFTISRDTSKNTLYLQMNSL65240.002 xRAEDTAVYYCARERYFDWSFDYWGQGTLVSVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQI2CQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1855 CDR-H1 of artificial AA SYDMH CDH19 65240.003 1856 CDR-H2 ofartificial AA VISYEGTNEYYAESVKG CDH19 65240.003 1857 CDR-H3 ofartificial AA ERYFDWSFDY CDH19 65240.003 1858 CDR-L1 of artificial AARASQSVSNTYLA CDH19 65240.003 1859 CDR-L2 of artificial AA GASSRAT CDH1965240.003 1860 CDR-L3 of artificial AA QQYSNSWT CDH19 65240.003 1861VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65240.003CTCCAGCTACGACATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATCTCCTACGAGGGCACCAACGAGTACTACGCCGAGTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACACCTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCGGTACTTCGACTGGTCCTTCGACTACTGGGGCCAGGGCACCCTGGTGTCCGTGTCTAGC 1862 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYEGTNEYYAESVKGRFTISRDTSKNTLYLQMNSL65240.003 RAEDTAVYYCARERYFDWSFDYWGQGTLVSVSS 1863 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCGT65240.003GTCCAACACCTACCTGGCCTGGTATCAGCAGCGCCCTGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCTGGCACCGACTTCACCCTGACCATCTCCAGCCTGGAACCCGAGGATTTCGCTGTGTACTATTGCCAGCAGTACTCCAACTCCTGGACCTTCGGACAGGGCACCAAGGTGGAAATCAAGTCC 1864VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAV65240.003 YYCQQYSNSWTFGQGTKVEIKS 1865 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGACATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATCTCCTACGAGGGCACCAACG65240.003AGTACTACGCCGAGTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACACCTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCGGTACTTCGACTGGTCCTTCGACTACTGGGGCCAGGGCACCCTGGTGTCCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCGTGTCCAACACCTACCTGGCCTGGTATCAGCAGCGCCCTGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCTGGCACCGACTTCACCCTGACCATCTCCAGCCTGGAACCCGAGGATTTCGCTGTGTACTATTGCCAGCAGTACTCCAACTCCTGGACCTTCGGACAGGGCACCAAGGTGGAAATCAAGTCC 1866 VH-VL of artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYEGTNEYYAESVKGRFTISRDTSKNTLYLQMNSLCDH19RAEDTAVYYCARERYFDWSFDYWGQGTLVSVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQ65240.003QRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKS1867 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYEGTNEYYAESVKGRFTISRDTSKNTLYLQMNSL65240.003 xRAEDTAVYYCARERYFDWSFDYWGQGTLVSVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQI2CQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1868 CDR-H1 of artificial AA SYDMH CDH19 65240.004 1869 CDR-H2 ofartificial AA VISYEGTNEYYAESVKG CDH19 65240.004 1870 CDR-H3 ofartificial AA ERYFDWSFDY CDH19 65240.004 1871 CDR-L1 of artificial AARASQSVSNTYLA CDH19 65240.004 1872 CDR-L2 of artificial AA GASSRAT CDH1965240.004 1873 CDR-L3 of artificial AA QQYSNSWT CDH19 65240.004 1874VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65240.004CTCCAGCTACGACATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATCTCCTACGAGGGCACCAACGAGTACTACGCCGAGTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACACCTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCGGTACTTCGACTGGTCCTTCGACTACTGGGGCCAGGGCACCCTGGTGTCCGTGTCTAGC 1875 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYEGTNEYYAESVKGRFTISRDTSKNTLYLQMNSL65240.004 RAEDTAVYYCARERYFDWSFDYWGQGTLVSVSS 1876 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCGT65240.004GTCCAACACCTACCTGGCCTGGTATCAGCAGAAGCCTGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCTGGCACCGACTTCACCCTGACCATCTCCAGCCTGGAACCCGAGGATTTCGCTGTGTACTATTGCCAGCAGTACTCCAACTCCTGGACCTTCGGACAGGGCACCAAGGTGGAAATCAAGTCC 1877VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAV65240.004 YYCQQYSNSWTFGQGTKVEIKS 1878 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGACATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATCTCCTACGAGGGCACCAACG65240.004AGTACTACGCCGAGTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACACCTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCGGTACTTCGACTGGTCCTTCGACTACTGGGGCCAGGGCACCCTGGTGTCCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCGTGTCCAACACCTACCTGGCCTGGTATCAGCAGAAGCCTGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCTGGCACCGACTTCACCCTGACCATCTCCAGCCTGGAACCCGAGGATTTCGCTGTGTACTATTGCCAGCAGTACTCCAACTCCTGGACCTTCGGACAGGGCACCAAGGTGGAAATCAAGTCC 1879 VH-VL of artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYEGTNEYYAESVKGRFTISRDTSKNTLYLQMNSLCDH19RAEDTAVYYCARERYFDWSFDYWGQGTLVSVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQ65240.004QKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKS1880 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYDMHWVRQAPGKGLEWVAVISYEGTNEYYAESVKGRFTISRDTSKNTLYLQMNSL65240.004 xRAEDTAVYYCARERYFDWSFDYWGQGTLVSVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQI2CQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1881 CDR-H1 of artificial AA SYDMH CDH19 65240.005 1882 CDR-H2 ofartificial AA VISYEGTNEYYAESVKG CDH19 65240.005 1883 CDR-H3 ofartificial AA ERYFDWSFDY CDH19 65240.005 1884 CDR-L1 of artificial AARASQSVSNTYLA CDH19 65240.005 1885 CDR-L2 of artificial AA GASSRAT CDH1965240.005 1886 CDR-L3 of artificial AA QQYSNSWT CDH19 65240.005 1887VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65240.005CTCCAGCTACGACATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATCTCCTACGAGGGCACCAACGAGTACTACGCCGAGTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACACCTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCGGTACTTCGACTGGTCCTTCGACTACTGGGGCCAGGGCACCCTGGTGACCGTGTCTAGC 1888 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTESSYDMHWVRQAPGKGLEWVAVISYEGTNEYYAESVKGRFTISRDTSKNTLYLQMNSL65240.005 RAEDTAVYYCARERYFDWSFDYWGQGTLVTVSS 1889 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCGT65240.005GTCCAACACCTACCTGGCCTGGTATCAGCAGAAGCCTGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCTGGCACCGACTTCACCCTGACCATCTCCAGCCTGGAACCCGAGGATTTCGCTGTGTACTATTGCCAGCAGTACTCCAACTCCTGGACCTTCGGACAGGGCACCAAGGTGGAAATCAAGTCC 1890VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAV65240.005 YYCQQYSNSWTFGQGTKVEIKS 1891 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGACATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCGTGATCTCCTACGAGGGCACCAACG65240.005AGTACTACGCCGAGTCCGTGAAGGGCCGGTTCACCATCTCCCGGGACACCTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGCGCCAGAGAGCGGTACTTCGACTGGTCCTTCGACTACTGGGGCCAGGGCACCCTGGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCTTGCCGGGCCTCCCAGTCCGTGTCCAACACCTACCTGGCCTGGTATCAGCAGAAGCCTGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCTGGCACCGACTTCACCCTGACCATCTCCAGCCTGGAACCCGAGGATTTCGCTGTGTACTATTGCCAGCAGTACTCCAACTCCTGGACCTTCGGACAGGGCACCAAGGTGGAAATCAAGTCC 1892 VH-VL of artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTESSYDMHWVRQAPGKGLEWVAVISYEGTNEYYAESVKGRFTISRDTSKNTLYLQMNSLCDH19RAEDTAVYYCARERYFDWSFDYWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQ65240.005QKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKS1893 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTESSYDMHWVRQAPGKGLEWVAVISYEGTNEYYAESVKGRFTISRDTSKNTLYLQMNSL65240.005 xRAEDTAVYYCARERYFDWSFDYWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSNTYLAWYQI2CQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYSNSWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1894 CDR-H1 of artificial AA SYFIH CDH19 65246.004 1895 CDR-H2 ofartificial AA IINPISVSTSYAQKFQG CDH19 65246.004 1896 CDR-H3 ofartificial AA GGIQLWLHFDY CDH19 65246.004 1897 CDR-L1 of artificial AASGSSSNIGSNFVN CDH19 65246.004 1898 CDR-L2 of artificial AA TNNQRPS CDH1965246.004 1899 CDR-L3 of artificial AA ATWDESLQGWV CDH19 65246.004 1900VH of CDH19 artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGTGTCCGGCTACACCTT65246.004CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCACCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTACATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1901 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVYMELSSL65246.004 RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS 1902 VL of CDH19 artificialNTCAGTCTGCCCTGACCCAGCCTCCTTCTGCCACCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCTCCTCCAACAT65246.004CGGCTCCAACTTCGTGAACTGGTACCAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGGCCGACTACTACTGTGCCACCTGGGACGAGTCCCTGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC1903 VL of CDH19 artificial AAQSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD65246.004 YYCATWDESLQGWVFGGGTKLTVLS 1904 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGTGTCCGGCTACACCTTCDH19CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCA65246.004CCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTACATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCTCAGTCTGCCCTGACCCAGCCTCCTTCTGCCACCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCTCCTCCAACATCGGCTCCAACTTCGTGAACTGGTACCAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGGCCGACTACTACTGTGCCACCTGGGACGAGTCCCTGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1905 VH-VL ofartificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVYMELSSLCDH19RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWY65246.004QQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDESLQGWVFGGGTKLTVLS1906 CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVYMELSSL65246.004 xRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYI2CQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATWDESLQGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1907 CDR-H1 of artificial AA SYFIH CDH19 65247.004 1908 CDR-H2 ofartificial AA IINPISVSTSYAQKFQG CDH19 65247.004 1909 CDR-H3 ofartificial AA GGIQLWLHLDY CDH19 65247.004 1910 CDR-L1 of artificial AASGSSSNIGSNFVN CDH19 65247.004 1911 CDR-L2 of artificial AA TNNQRPS CDH1965247.004 1912 CDR-L3 of artificial AA ATYDESMQGWV CDH19 65247.004 1913VH of CDH19 artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGCGGGTGTCCTGCAAGGTGTCCGGCTACACCTT65247.004CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCACCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTACATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACCTGGACTATTGGGGCCAGGGCACCCTGGTCACCGTGTCCTCT 1914 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVYMELSSL65247.004 RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSS 1915 VL of CDH19 artificialNTCAGTCTGCCCTGACCCAGCCTCCTTCCGCTACCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCTCCTCCAACAT65247.004CGGCTCCAACTTCGTGAACTGGTACCAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGGCCGACTACTACTGTGCCACCTACGACGAGTCCATGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC1916 VL of CDH19 artificial AAQSALTQPPSATGTPGQRVTISCSGSSSNIGSNFVNWYQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD65247.004 YYCATYDESMQGWVFGGGTKLTVLS 1917 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGCGGGTGTCCTGCAAGGTGTCCGGCTACACCTTCDH19CACCAGCTACTTCATCCACTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCTATCTCCGTGTCCA65247.004CCTCCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGGGACACCTCCACCTCCACCGTGTACATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACCTGGACTATTGGGGCCAGGGCACCCTGGTCACCGTGTCCTCTGGTGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGCGGATCTCAGTCTGCCCTGACCCAGCCTCCTTCCGCTACCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCTCCTCCAACATCGGCTCCAACTTCGTGAACTGGTACCAGCAGCTGCCCGGCACCGCCCCCAAGGTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCCGAGGACGAGGCCGACTACTACTGTGCCACCTACGACGAGTCCATGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1918 VH-VL ofartificial AAQVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVYMELSSLCDH19RSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSATGTPGQRVTISCSGSSSNIGSNEVNWY65247.004QQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATYDESMQGWVFGGGTKLTVLS1919 CDH19 artificial AAQVQLVQSGAEVKKPGASVRVSCKVSGYTFTSYFIHWVRQAPGQGLEWMGIINPISVSTSYAQKFQGRVTMTRDTSTSTVYMELSSL65247.004 xRSEDTAVYYCARGGIQLWLHLDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSALTQPPSATGTPGQRVTISCSGSSSNIGSNEVNWYI2CQQLPGTAPKVLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCATYDESMQGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1920 CDR-H1 of artificial AA GYYWS CDH19 65249.002 1921 CDR-H2 ofartificial AA YIYYIGSTNYNPSLKS CDH19 65249.002 1922 CDR-H3 of artificialAA DGSSGWYRWFDP CDH19 65249.002 1923 CDR-L1 of artificial AARASQSVSSSYLA CDH19 65249.002 1924 CDR-L2 of artificial AA GASSRAT CDH1965249.002 1925 CDR-L3 of artificial AA QQYGNSPLT CDH19 65249.002 1926VH of CDH19 artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCAT65249.002CTCCGGCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACATCGGCTCCACCAACTACAACCCCAGCCTGAAGTCCAGAGTGACCATGTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCAGAGATGGCTCCTCCGGCTGGTATCGTTGGTTCGACCCTTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1927 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSVDTSKNQFSLKLSSVT65249.002 AADTAVYYCARDGSSGWYRWFDPWGQGTLVTVSS 1928 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGT65249.002GTCCTCCTCCTACCTGGCTTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTTCGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCTCCCGGCTGGAACCCGAGGACTTCGCTGTGTACTACTGCCAGCAGTACGGCAACAGCCCCCTGACCTTCGGCCAAGGCACCAAGGTGGAAATCAAGTCC1929 VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAV65249.002 YYCQQYGNSPLTFGQGTKVEIKS 1930 VH-VL of artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCATCDH19CTCCGGCTACTACTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACATCGGCTCCACCA65249.002ACTACAACCCCAGCCTGAAGTCCAGAGTGACCATGTCCGTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCAGAGATGGCTCCTCCGGCTGGTATCGTTGGTTCGACCCTTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGTGTCCTCCTCCTACCTGGCTTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTTCGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCTCCCGGCTGGAACCCGAGGACTTCGCTGTGTACTACTGCCAGCAGTACGGCAACAGCCCCCTGACCTTCGGCCAAGGCACCAAGGTGGAAATCAAGTCC 1931 VH-VL of artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSVDTSKNQFSLKLSSVTCDH19AADTAVYYCARDGSSGWYRWFDPWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWY65249.002QQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGNSPLTFGQGTKVEIKS1932 CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWSWIRQPPGKGLEWIGYIYYIGSTNYNPSLKSRVTMSVDTSKNQFSLKLSSVT65249.002 xAADTAVYYCARDGSSGWYRWFDPWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYI2CQQKPGQAPRLLIFGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGNSPLTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1933 CDR-H1 of artificial AA SYYMS CDH19 65250.003 1934 CDR-H2 ofartificial AA IIHPSGGDTTYAQKFQG CDH19 65250.003 1935 CDR-H3 ofartificial AA GGIKLWLHFDY CDH19 65250.003 1936 CDR-L1 of artificial AASGSRSNIGSNFVN CDH19 65250.003 1937 CDR-L2 of artificial AA TNNQRPS CDH1965250.003 1938 CDR-L3 of artificial AA AVYDDSLNGWV CDH19 65250.003 1939VH of CDH19 artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCCGGTACACCTT65250.003CACCAGCTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCCACCCCTCTGGCGGCGACACCACCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCGGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCAAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1940 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSL65250.003 RSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSS 1941 VL of CDH19 artificialNTCAGTCCGTGCTGACCCAGCCTCCTTCCGCCTCCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT65250.003CGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTACGACGACTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC1942 VL of CDH19 artificial AAQSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD65250.003 YYCAVYDDSLNGWVFGGGTKLTVLS 1943 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCCGGTACACCTTCDH19CACCAGCTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCCACCCCTCTGGCGGCGACA65250.003CCACCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCGGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCAAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCCAGTCCGTGCTGACCCAGCCTCCTTCCGCCTCCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTACGACGACTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1944 VH-VL ofartificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLCDH19RSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWY65250.003QQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDDSLNGWVFGGGTKLTVLS1945 CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSL65250.003 xRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYI2CQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDDSLNGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1946 CDR-H1 of artificial AA SYYMS CDH19 65250.004 1947 CDR-H2 ofartificial AA IIHPSGGDTTYAQKFQG CDH19 65250.004 1948 CDR-H3 ofartificial AA GGIKLWLHFDY CDH19 65250.004 1949 CDR-L1 of artificial AASGSRSNIGSNFVN CDH19 65250.004 1950 CDR-L2 of artificial AA TNNQRPS CDH1965250.004 1951 CDR-L3 of artificial AA AVYDESLQGWV CDH19 65250.004 1952VH of CDH19 artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCCGGTACACCTT65250.004CACCAGCTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCCACCCCTCTGGCGGCGACACCACCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCGGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCAAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1953 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSL65250.004 RSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSS 1954 VL of CDH19 artificialNTCAGTCCGTGCTGACCCAGCCTCCTTCCGCCTCCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT65250.004CGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTACGACGAGTCCCTGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC1955 VL of CDH19 artificial AAQSVLTQPPSASGTPGQRVTISCSGSRSNIGSNEVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD65250.004 YYCAVYDESLQGWVFGGGTKLTVLS 1956 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCCGGTACACCTTCDH19CACCAGCTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCCACCCCTCTGGCGGCGACA65250.004CCACCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCGGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCAAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCCAGTCCGTGCTGACCCAGCCTCCTTCCGCCTCCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTACGACGAGTCCCTGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1957 VH-VL ofartificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSLCDH19RSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWY65250.004QQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDESLQGWVFGGGTKLTVLS1958 CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTGDTSTSTVYMELSSL65250.004 xRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYI2CQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDESLQGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1959 CDR-H1 of artificial AA SYYMS CDH19 65250.005 1960 CDR-H2 ofartificial AA IIHPSGGDTTYAQKFQG CDH19 65250.005 1961 CDR-H3 ofartificial AA GGIKLWLHFDY CDH19 65250.005 1962 CDR-L1 of artificial AASGSRSNIGSNFVN CDH19 65250.005 1963 CDR-L2 of artificial AA TNNQRPS CDH1965250.005 1964 CDR-L3 of artificial AA AVYDESLQGWV CDH19 65250.005 1965VH of CDH19 artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCGGGTACACCTT65250.005CACCAGCTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCCACCCCTCTGGCGGCGACACCACCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCAAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1966 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTRDTSTSTVYMELSSL65250.005 RSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSS 1967 VL of CDH19 artificialNTCAGTCCGTGCTGACCCAGCCTCCTTCCGCCTCCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT65250.005CGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTACGACGAGTCCCTGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC1968 VL of CDH19 artificial AAQSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD65250.005 YYCAVYDESLQGWVFGGGTKLTVLS 1969 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCGGGTACACCTTCDH19CACCAGCTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCCACCCCTCTGGCGGCGACA65250.005CCACCTACGCCCAGAAATTCCAGGGCAGAGTGACCATGACCCGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCAAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCCAGTCCGTGCTGACCCAGCCTCCTTCCGCCTCCGGCACCCCTGGCCAGCGCGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACAACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTACGACGAGTCCCTGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1970 VH-VL ofartificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTRDTSTSTVYMELSSLCDH19RSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWY65250.005QQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDESLQGWVFGGGTKLTVLS1971 CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMSWVRQAPGQGLEWMGIIHPSGGDTTYAQKFQGRVTMTRDTSTSTVYMELSSL65250.005 xRSEDTAVYYCARGGIKLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQRVTISCSGSRSNIGSNFVNWYI2CQQLPGTAPKLLIYTNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDESLQGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1972 CDR-H1 of artificial AA NYYMS CDH19 65251.002 1973 CDR-H2 ofartificial AA IINPSGGDSTYAQKFQG CDH19 65251.002 1974 CDR-H3 ofartificial GGIQLWLHFDY CDH19 65251.002 1975 CDR-L1 of artificial AASGSRSNIGSNFVN CDH19 65251.002 1976 CDR-L2 of artificial AA TNYQRPS CDH1965251.002 1977 CDR-L3 of artificial AA AVWDESLNGWV CDH19 65251.002 1978VH of CDH19 artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCCGGTACACCTT65251.002CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACTCCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCGGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1979 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSL65251.002 RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS 1980 VL of CDH19 artificialNTCAGTCTGTGCTGACCCAGCCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT65251.002CGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTGGGACGAGTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC1981 VL of CDH19 artificial AAQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNEVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD65251.002 YYCAVWDESLNGWVFGGGTKLTVLS 1982 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCCGGTACACCTTCDH19CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACT65251.002CCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCGGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCCAGTCTGTGCTGACCCAGCCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTGGGACGAGTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1983 VH-VL ofartificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSLCDH19RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNEVNWY65251.002QQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDESLNGWVFGGGTKLTVLS1984 CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSL65251.002 xRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNEVNWYI2CQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDESLNGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1985 CDR-H1 of artificial AA NYYMS CDH19 65251.003 1986 CDR-H2 ofartificial AA IINPSGGDSTYAQKFQG CDH19 65251.003 1987 CDR-H3 ofartificial AA GGIQLWLHFDY CDH19 65251.003 1988 CDR-L1 of artificial AASGSRSNIGSNFVN CDH19 65251.003 1989 CDR-L2 of artificial AA TNYQRPS CDH1965251.003 1990 CDR-L3 of artificial AA AVWDESLQGWV CDH19 65251.003 1991VH of CDH19 artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCCGGTACACCTT65251.003CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACTCCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCGGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 1992 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSL65251.003 RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS 1993 VL of CDH19 artificialNTCAGTCTGTGCTGACCCAGCCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT65251.003CGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTGGGACGAGTCCCTGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC1994 VL of CDH19 artificial AAQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD65251.003 YYCAVWDESLQGWVFGGGTKLTVLS 1995 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCCGGTACACCTTCDH19CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACT65251.003CCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCGGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCCAGTCTGTGCTGACCCAGCCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTGGGACGAGTCCCTGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 1996 VH-VL ofartificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSLCDH19RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWY65251.003QQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDESLQGWVFGGGTKLTVLS1997 CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSL65251.003 xRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYI2CQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDESLQGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH1998 CDR-H1 of artificial AA NYYMS CDH19 65251.004 1999 CDR-H2 ofartificial AA IINPSGGDSTYAQKFQG CDH19 65251.004 2000 CDR-H3 ofartificial AA GGIQLWLHFDY CDH19 65251.004 2001 CDR-L1 of artificial AASGSRSNIGSNFVN CDH19 65251.004 2002 CDR-L2 of artificial AA TNYQRPS CDH1965251.004 2003 CDR-L3 of artificial AA AVYDESLQGWV CDH19 65251.004 2004VH of CDH19 artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCCGGTACACCTT65251.004CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACTCCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCGGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 2005 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSL65251.004 RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS 2006 VL of CDH19 artificialNTCAGTCTGTGCTGACCCAGCCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT65251.004CGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTACGACGAGTCCCTGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC2007 VL of CDH19 artificial AAQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD65251.004 YYCAVYDESLQGWVFGGGTKLTVLS 2008 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCCGGTACACCTTCDH19CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACT65251.004CCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCGGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCCAGTCTGTGCTGACCCAGCCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTACGACGAGTCCCTGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 2009 VH-VL ofartificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSLCDH19RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNEVNWY65251.004QQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDESLQGWVFGGGTKLTVLS2010 CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASRYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTGDTSTSTVYMELSSL65251.004 xRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNEVNWYI2CQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDESLQGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH2011 CDR-H1 of artificial AA NYYMS CDH19 65251.005 2012 CDR-H2 ofartificial AA IINPSGGDSTYAQKFQG CDH19 65251.005 2013 CDR-H3 ofartificial AA GGIQLWLHFDY CDH19 65251.005 2014 CDR-L1 of artificial AASGSRSNIGSNFVN CDH19 65251.005 2015 CDR-L2 of artificial AA TNYQRPS CDH1965251.005 2016 CDR-L3 of artificial AA AVWDDSLNGWV CDH19 65251.005 2017VH of CDH19 artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCGGGTACACCTT65251.005CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACTCCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCCGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 2018 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTRDTSTSTVYMELSSL65251.005 RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS 2019 VL of CDH19 artificialNTCAGTCTGTGCTGACCCAGCCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT65251.005CGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTGGGACGACTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC2020 VL of CDH19 artificial AAQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD65251.005 YYCAVWDDSLNGWVFGGGTKLTVLS 2021 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCGGGTACACCTTCDH19CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACT65251.005CCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCCGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCCAGTCTGTGCTGACCCAGCCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTGGGACGACTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 2022 VH-VL ofartificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTRDTSTSTVYMELSSLCDH19RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWY65251.005QQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLS2023 CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTRDTSTSTVYMELSSL65251.005 xRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYI2CQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDDSLNGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH2024 CDR-H1 of artificial AA NYYMS CDH19 65251.006 2025 CDR-H2 ofartificial AA IINPSGGDSTYAQKFQG CDH19 65251.006 2026 CDR-H3 ofartificial AA GGIQLWLHFDY CDH19 65251.006 2027 CDR-L1 of artificial AASGSRSNIGSNFVN CDH19 65251.006 2028 CDR-L2 of artificial AA TNYQRPS CDH1965251.006 2029 CDR-L3 of artificial AA AVWDESLNGWV CDH19 65251.006 2030VH of CDH19 artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCGGGTACACCTT65251.006CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACTCCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCCGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 2031 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTRDTSTSTVYMELSSL65251.006 RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS 2032 VL of CDH19 artificialNTCAGTCTGTGCTGACCCAGCCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT65251.006CGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTGGGACGAGTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC2033 VL of CDH19 artificial AAQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD65251.006 YYCAVWDESLNGWVFGGGTKLTVLS 2034 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCGGGTACACCTTCDH19CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACT65251.006CCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCCGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCCAGTCTGTGCTGACCCAGCCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTGGGACGAGTCCCTGAACGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 2035 VH-VL ofartificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTRDTSTSTVYMELSSLCDH19RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWY65251.006QQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDESLNGWVFGGGTKLTVLS2036 CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTRDTSTSTVYMELSSL65251.006 xRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYI2CQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDESLNGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH2037 CDR-H1 of artificial AA NYYMS CDH19 65251.007 2038 CDR-H2 ofartificial AA IINPSGGDSTYAQKFQG CDH19 65251.007 2039 CDR-H3 ofartificial AA GGIQLWLHFDY CDH19 65251.007 2040 CDR-L1 of artificial AASGSRSNIGSNFVN CDH19 65251.007 2041 CDR-L2 of artificial AA TNYQRPS CDH1965251.007 2042 CDR-L3 of artificial AA AVWDESLQGWV CDH19 65251.007 2043VH of CDH19 artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCGGGTACACCTT65251.007CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACTCCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCCGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 2044 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTRDTSTSTVYMELSSL65251.007 RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS 2045 VL of CDH19 artificialNTCAGTCTGTGCTGACCCAGCCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT65251.007CGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTGGGACGAGTCCCTGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC2046 VL of CDH19 artificial AAQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD65251.007 YYCAVWDESLQGWVFGGGTKLTVLS 2047 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCGGGTACACCTTCDH19CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACT65251.007CCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCCGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCCAGTCTGTGCTGACCCAGCCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTGGGACGAGTCCCTGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 2048 VH-VL ofartificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTRDTSTSTVYMELSSLCDH19RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWY65251.007QQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDESLQGWVFGGGTKLTVLS2049 CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTRDTSTSTVYMELSSL65251.007 xRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYI2CQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVWDESLQGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH2050 CDR-H1 of artificial AA NYYMS CDH19 65251.008 2051 CDR-H2 ofartificial AA IINPSGGDSTYAQKFQG CDH19 65251.008 2052 CDR-H3 ofartificial AA GGIQLWLHFDY CDH19 65251.008 2053 CDR-L1 of artificial AASGSRSNIGSNFVN CDH19 65251.008 2054 CDR-L2 of artificial AA TNYQRPS CDH1965251.008 2055 CDR-L3 of artificial AA AVYDESLQGWV CDH19 65251.008 2056VH of CDH19 artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCGGGTACACCTT65251.008CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACTCCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCCGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 2057 VH of CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTRDTSTSTVYMELSSL65251.008 RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSS 2058 VL of CDH19 artificialNTCAGTCTGTGCTGACCCAGCCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACAT65251.008CGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTACGACGAGTCCCTGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC2059 VL of CDH19 artificial AAQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAD65251.008 YYCAVYDESLQGWVFGGGTKLTVLS 2060 VH-VL of artificial NTCAGGTGCAGCTGGTGCAGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCCGTGAAGGTGTCCTGCAAGGCCTCCGGGTACACCTTCDH19CACCAACTACTACATGTCCTGGGTCCGACAGGCCCCAGGCCAGGGCCTGGAATGGATGGGCATCATCAACCCCTCTGGCGGCGACT65251.008CCACCTACGCCCAGAAGTTCCAGGGCCGGCTGACCATGACCCGCGACACCTCCACCTCCACCGTGTATATGGAACTGTCCTCCCTGCGGAGCGAGGACACCGCCGTGTACTACTGCGCCAGAGGCGGCATCCAGCTGTGGCTGCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCCAGTCTGTGCTGACCCAGCCCCCTTCCGCCTCTGGCACCCCTGGCCAGAAAGTGACCATCTCCTGCTCCGGCTCCCGGTCCAACATCGGCTCCAACTTCGTGAACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACACCAACTACCAGCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCCATCTCCGGCCTGCAGTCTGAGGACGAGGCCGACTACTACTGTGCCGTGTACGACGAGTCCCTGCAGGGCTGGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 2061 VH-VL ofartificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTRDTSTSTVYMELSSLCDH19RSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWY65251.008QQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDESLQGWVFGGGTKLTVLS2062 CDH19 artificial AAQVQLVQSGAEVKKPGASVKVSCKASGYTFTNYYMSWVRQAPGQGLEWMGIINPSGGDSTYAQKFQGRLTMTRDTSTSTVYMELSSL65251.008 xRSEDTAVYYCARGGIQLWLHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSASGTPGQKVTISCSGSRSNIGSNFVNWYI2CQQLPGTAPKLLIYTNYQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAVYDESLQGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH2063 CDR-H1 of artificial AA SYDMD CDH19 65252.005 2064 CDR-H2 ofartificial AA VIWYDGSNKYYADSVRG CDH19 65252.005 2065 CDR-H3 ofartificial AA ETGEGWYFDL CDH19 65252.005 2066 CDR-L1 of artificial AARASQSVSSSYLA CDH19 65252.005 2067 CDR-L2 of artificial AA GASSRAT CDH1965252.005 2068 CDR-L3 of artificial AA QQYGSSWT CDH19 65252.005 2069VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTT65252.005CTCCTCCTACGACATGGACTGGGTCCGACAGACCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACAAGTACTACGCCGACTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCAGAGGCACCCTGGTCACCGTGTCTAGC 2070 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGESESSYDMDWVRQTPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSL65252.005 RVEDTAVYYCARETGEGWYFDLWGRGTLVTVSS 2071 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGT65252.005GTCCTCCTCCTACCTGGCCTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2072VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAV65252.005 YYCQQYGSSWTFGQGTKVEIKS 2073 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTTCDH19CTCCTCCTACGACATGGACTGGGTCCGACAGACCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACA65252.005AGTACTACGCCGACTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCAGAGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGTGTCCTCCTCCTACCTGGCCTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2074 VH-VL of artificial AAQVQLVESGGGVVQPGGSLRLSCAASGESESSYDMDWVRQTPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLCDH19RVEDTAVYYCARETGEGWYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQ65252.005QKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTFGQGTKVEIKS2075 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQTPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSL65252.005 xRVEDTAVYYCARETGEGWYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQI2CQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH2076 CDR-H1 of artificial AA SYDMD CDH19 65252.006 2077 CDR-H2 ofartificial AA VIWYDGSNKYYADSVRG CDH19 65252.006 2078 CDR-H3 ofartificial AA ETGEGWYFDL CDH19 65252.006 2079 CDR-L1 of artificial AARASQSVSSSYLA CDH19 65252.006 2080 CDR-L2 of artificial AA GASSRAT CDH1965252.006 2081 CDR-L3 of artificial AA QQYGSSWT CDH19 65252.006 2082VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTT65252.006CTCCTCCTACGACATGGACTGGGTCCGACAGGCCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACAAGTACTACGCCGACTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCAGAGGCACCCTGGTCACCGTGTCTAGC 2083 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSL65252.006 RVEDTAVYYCARETGEGWYFDLWGRGTLVTVSS 2084 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGT65252.006GTCCTCCTCCTACCTGGCCTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2085VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAV65252.006 YYCQQYGSSWTFGQGTKVEIKS 2086 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTTCDH19CTCCTCCTACGACATGGACTGGGTCCGACAGGCCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACA65252.006AGTACTACGCCGACTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCAGAGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGTGTCCTCCTCCTACCTGGCCTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2087 VH-VL of artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLCDH19RVEDTAVYYCARETGEGWYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQ65252.006QKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTFGQGTKVEIKS2088 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSL65252.006 xRVEDTAVYYCARETGEGWYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQI2CQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH2089 CDR-H1 of artificial AA SYDMD CDH19 65252.007 2090 CDR-H2 ofartificial AA VIWYDGSNKYYADSVRG CDH19 65252.007 2091 CDR-H3 ofartificial AA ETGEGWYFDL CDH19 65252.007 2092 CDR-L1 of artificial AARASQSVSSSYLA CDH19 65252.007 2093 CDR-L2 of artificial AA GASSRAT CDH1965252.007 2094 CDR-L3 of artificial AA QQYGSSWT CDH19 65252.007 2095VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTT65252.007CTCCTCCTACGACATGGACTGGGTCCGACAGGCCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACAAGTACTACGCCGACTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCCAAGGCACCCTGGTCACCGTGTCTAGC 2096 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSL65252.007 RVEDTAVYYCARETGEGWYFDLWGQGTLVTVSS 2097 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGT65252.007GTCCTCCTCCTACCTGGCCTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2098VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAV65252.007 YYCQQYGSSWTFGQGTKVEIKS 2099 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTTCDH19CTCCTCCTACGACATGGACTGGGTCCGACAGGCCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACA65252.007AGTACTACGCCGACTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCCAAGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGTGTCCTCCTCCTACCTGGCCTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2100 VH-VL of artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLCDH19RVEDTAVYYCARETGEGWYFDLWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQ65252.007QKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTFGQGTKVEIKS2101 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSL65252.007 xRVEDTAVYYCARETGEGWYFDLWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQI2CQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRETISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNEGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVEGGGTKLTVLHHHHHH2102 CDR-H1 of artificial AA SYDMD CDH19 65252.008 2103 CDR-H2 ofartificial AA VIWYEGSNKYYAESVRG CDH19 65252.008 2104 CDR-H3 ofartificial AA ETGEGWYFDL CDH19 65252.008 2105 CDR-L1 of artificial AARASQSVSSSYLA CDH19 65252.008 2106 CDR-L2 of artificial AA GASSRAT CDH1965252.008 2107 CDR-L3 of artificial AA QQYGSSWT CDH19 65252.008 2108VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTT65252.008CTCCTCCTACGACATGGACTGGGTCCGACAGGCCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGAGGGCTCCAACAAGTACTACGCCGAGTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCCAAGGCACCCTGGTCACCGTGTCTAGC 2109 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGESESSYDMDWVRQAPGKGLEWVAVIWYEGSNKYYAESVRGRFTISRDNSKNTLFLQMNSL65252.008 RVEDTAVYYCARETGEGWYFDLWGQGTLVTVSS 2110 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGT65252.008GTCCTCCTCCTACCTGGCCTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2111VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAV65252.008 YYCQQYGSSWTFGQGTKVEIKS 2112 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTTCDH19CTCCTCCTACGACATGGACTGGGTCCGACAGGCCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGAGGGCTCCAACA65252.008AGTACTACGCCGAGTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCCAAGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGTGTCCTCCTCCTACCTGGCCTGGTATCAGCAGAAGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2113 VH-VL of artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYEGSNKYYAESVRGRFTISRDNSKNTLFLQMNSLCDH19RVEDTAVYYCARETGEGWYFDLWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQ65252.008QKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTFGQGTKVEIKS2114 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYEGSNKYYAESVRGRFTISRDNSKNTLFLQMNSL65252.008 xRVEDTAVYYCARETGEGWYFDLWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQI2CQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH2115 CDR-H1 of artificial AA SYDMD CDH19 65252.009 2116 CDR-H2 ofartificial AA VIWYDGSNKYYADSVRG CDH19 65252.009 2117 CDR-H3 ofartificial AA ETGEGWYFDL CDH19 65252.009 2118 CDR-L1 of artificial AARASQSVSSSYLA CDH19 65252.009 2119 CDR-L2 of artificial AA GASSRAT CDH1965252.009 2120 CDR-L3 of artificial AA QQYGSSWT CDH19 65252.009 2121VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTT65252.009CTCCTCCTACGACATGGACTGGGTCCGACAGACCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACAAGTACTACGCCGACTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCAGAGGCACCCTGGTCACCGTGTCTAGC 2122 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQTPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSL65252.009 RVEDTAVYYCARETGEGWYFDLWGRGTLVTVSS 2123 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGT65252.009GTCCTCCTCCTACCTGGCCTGGTATCAGCAGAGGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2124VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAV65252.009 YYCQQYGSSWTFGQGTKVEIKS 2125 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTTCDH19CTCCTCCTACGACATGGACTGGGTCCGACAGACCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACA65252.009AGTACTACGCCGACTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCAGAGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGTGTCCTCCTCCTACCTGGCCTGGTATCAGCAGAGGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2126 VH-VL of artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQTPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLCDH19RVEDTAVYYCARETGEGWYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQ65252.009QRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTFGQGTKVEIKS2127 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQTPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSL65252.009 xRVEDTAVYYCARETGEGWYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQI2CQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH2128 CDR-H1 of artificial AA SYDMD CDH19 65252.010 2129 CDR-H2 ofartificial AA VIWYDGSNKYYADSVRG CDH19 65252.010 2130 CDR-H3 ofartificial AA ETGEGWYFDL CDH19 65252.010 2131 CDR-L1 of artificial AARASQSVSSSYLA CDH19 65252.010 2132 CDR-L2 of artificial AA GASSRAT CDH1965252.010 2133 CDR-L3 of artificial AA QQYGSSWT CDH19 65252.010 2134VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTT65252.010CTCCTCCTACGACATGGACTGGGTCCGACAGGCCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACAAGTACTACGCCGACTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCAGAGGCACCCTGGTCACCGTGTCTAGC 2135 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSL65252.010 RVEDTAVYYCARETGEGWYFDLWGRGTLVTVSS 2136 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGT65252.010GTCCTCCTCCTACCTGGCCTGGTATCAGCAGAGGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2137VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAV65252.010 YYCQQYGSSWTFGQGTKVEIKS 2138 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTTCDH19CTCCTCCTACGACATGGACTGGGTCCGACAGGCCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACA65252.010AGTACTACGCCGACTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCAGAGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGTGTCCTCCTCCTACCTGGCCTGGTATCAGCAGAGGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2139 VH-VL of artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLCDH19RVEDTAVYYCARETGEGWYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQ65252.010QRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTFGQGTKVEIKS2140 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSL65252.010 xRVEDTAVYYCARETGEGWYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQI2CQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH2141 CDR-H1 of artificial AA SYDMD CDH19 65252.011 2142 CDR-H2 ofartificial AA VIWYDGSNKYYADSVRG CDH19 65252.011 2143 CDR-H3 ofartificial AA ETGEGWYFDL CDH19 65252.011 2144 CDR-L1 of artificial AARASQSVSSSYLA CDH19 65252.011 2145 CDR-L2 of artificial AA GASSRAT CDH1965252.011 2146 CDR-L3 of artificial AA QQYGSSWT CDH19 65252.011 2147VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTT65252.011CTCCTCCTACGACATGGACTGGGTCCGACAGGCCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACAAGTACTACGCCGACTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCCAAGGCACCCTGGTCACCGTGTCTAGC 2148 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSL65252.011 RVEDTAVYYCARETGEGWYFDLWGQGTLVTVSS 2149 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGT65252.011GTCCTCCTCCTACCTGGCCTGGTATCAGCAGAGGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2150VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAV65252.011 YYCQQYGSSWTFGQGTKVEIKS 2151 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTTCDH19CTCCTCCTACGACATGGACTGGGTCCGACAGGCCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGACGGCTCCAACA65252.011AGTACTACGCCGACTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCCAAGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGTGTCCTCCTCCTACCTGGCCTGGTATCAGCAGAGGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2152 VH-VL of artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSLCDH19RVEDTAVYYCARETGEGWYFDLWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQ65252.011QRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTFGQGTKVEIKS2153 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFSFSSYDMDWVRQAPGKGLEWVAVIWYDGSNKYYADSVRGRFTISRDNSKNTLFLQMNSL65252.011 xRVEDTAVYYCARETGEGWYFDLWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQI2CQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH2154 CDR-H1 of artificial AA SYDMD CDH19 65252.012 2155 CDR-H2 ofartificial AA VIWYEGSNKYYAESVRG CDH19 65252.012 2156 CDR-H3 ofartificial AA ETGEGWYFDL CDH19 65252.012 2157 CDR-L1 of artificial AARASQSVSSSYLA CDH19 65252.012 2158 CDR-L2 of artificial AA GASSRAT CDH1965252.012 2159 CDR-L3 of artificial AA QQYGSSWT CDH19 65252.012 2160VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTT65252.012CTCCTCCTACGACATGGACTGGGTCCGACAGGCCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGAGGGCTCCAACAAGTACTACGCCGAGTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCCAAGGCACCCTGGTCACCGTGTCTAGC 2161 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGESESSYDMDWVRQAPGKGLEWVAVIWYEGSNKYYAESVRGRFTISRDNSKNTLFLQMNSL65252.012 RVEDTAVYYCARETGEGWYFDLWGQGTLVTVSS 2162 VL of CDH19 artificialNTGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGT65252.012GTCCTCCTCCTACCTGGCCTGGTATCAGCAGAGGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2163VL of CDH19 artificial AAEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAV65252.012 YYCQQYGSSWTFGQGTKVEIKS 2164 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGTGCCGCCTCCGGCTTCAGCTTCDH19CTCCTCCTACGACATGGACTGGGTCCGACAGGCCCCCGGCAAGGGCCTGGAATGGGTGGCCGTGATTTGGTACGAGGGCTCCAACA65252.012AGTACTACGCCGAGTCCGTGCGGGGCAGATTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTTTCTGCAGATGAACTCCCTGCGGGTGGAAGATACCGCCGTGTACTACTGCGCCAGAGAGACAGGCGAGGGCTGGTACTTCGACCTGTGGGGCCAAGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCGAGATCGTGCTGACCCAGTCCCCTGGCACCCTGTCCCTGAGCCCTGGCGAGAGAGCCACCCTGTCCTGCAGAGCCTCCCAGTCCGTGTCCTCCTCCTACCTGGCCTGGTATCAGCAGAGGCCCGGCCAGGCCCCTCGGCTGCTGATCTACGGCGCCTCTTCCAGAGCCACCGGCATCCCTGACCGGTTCTCCGGCTCTGGCTCCGGCACCGACTTCACCCTGACCATCAGCTCGCTGGAACCCGAGGACTTCGCTGTGTACTATTGCCAGCAGTACGGCTCCTCCTGGACCTTCGGCCAGGGCACCAAGGTGGAAATCAAGTCC 2165 VH-VL of artificial AAQVQLVESGGGVVQPGGSLRLSCAASGESESSYDMDWVRQAPGKGLEWVAVIWYEGSNKYYAESVRGRFTISRDNSKNTLFLQMNSLCDH19RVEDTAVYYCARETGEGWYFDLWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQ65252.012QRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTEGQGTKVEIKS2166 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGESESSYDMDWVRQAPGKGLEWVAVIWYEGSNKYYAESVRGRFTISRDNSKNTLFLQMNSL65252.012 xRVEDTAVYYCARETGEGWYFDLWGQGTLVTVSSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQI2CQRPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISSLEPEDFAVYYCQQYGSSWTEGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRETISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNEGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVEGGGTKLTVLHHHHHH2167 CDR-H1 of artificial AA SYSWS CDH19 65253.003 2168 CDR-H2 ofartificial AA YIYYSGSTNYNPSLKS CDH19 65253.003 2169 CDR-H3 of artificialAA NWAFHFDY CDH19 65253.003 2170 CDR-L1 of artificial AA TGSSSNIGTGYDVHCDH19 65253.003 2171 CDR-L2 of artificial AA GNSNRPS CDH19 65253.0032172 CDR-L3 of artificial AA QSYESSLSGWV CDH19 65253.003 2173VH of CDH19 artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCAT65253.003CTCCTCCTACTCTTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACTCCGGCTCCACCAACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCCTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCCGGAACTGGGCCTTCCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGC 2174 VH of CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVT65253.003 AADTAVYYCARNWAFHFDYWGQGTLVTVSS 2175 VL of CDH19 artificial NTCAGTCTGTGCTGACCCAGCCTCCCTCTGTGTCTGGCGCCCCTGGCCAGCGCGTGACCATTTCCTGCACCGGCTCCTCCAGCAACAT65253.003CGGCACCGGCTACGACGTGCACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACGGCAACTCCAACCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCTATCACCGGCCTGCAGGCTGAGGACGAGGCCGACTACTACTGCCAGTCCTACGAGTCCTCCCTGTCCGGCTGGGTGTTCGGCGGAGGCACCAAACTGACCGTGCTGTCC2176 VL of CDH19 artificial AAQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEA65253.003 DYYCQSYESSLSGWVFGGGTKLTVLS 2177 VH-VL of artificial NTCAGGTGCAGCTGCAGGAATCCGGCCCTGGCCTGGTCAAGCCCTCCGAGACACTGTCCCTGACCTGCACCGTGTCCGGCGGCTCCATCDH19CTCCTCCTACTCTTGGTCCTGGATCCGGCAGCCCCCTGGCAAGGGCCTGGAATGGATCGGCTACATCTACTACTCCGGCTCCACCA65253.003ACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCTCCCTGGACACCTCCAAGAACCAGTTCTCCCTGAAGCTGTCCTCCGTGACCGCCGCTGACACCGCCGTGTACTACTGCGCCCGGAACTGGGCCTTCCACTTCGACTACTGGGGCCAGGGCACCCTGGTCACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCCAGTCTGTGCTGACCCAGCCTCCCTCTGTGTCTGGCGCCCCTGGCCAGCGCGTGACCATTTCCTGCACCGGCTCCTCCAGCAACATCGGCACCGGCTACGACGTGCACTGGTATCAGCAGCTGCCCGGCACCGCCCCCAAGCTGCTGATCTACGGCAACTCCAACCGGCCCTCCGGCGTGCCCGACCGGTTCTCTGGCTCCAAGTCTGGCACCTCCGCCTCCCTGGCTATCACCGGCCTGCAGGCTGAGGACGAGGCCGACTACTACTGCCAGTCCTACGAGTCCTCCCTGTCCGGCTGGGTGTTCGGCGGAGGCACCAAACTGACCGTGCTGTCC 2178 VH-VL of artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVTCDH19AADTAVYYCARNWAFHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQL65253.003PGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYESSLSGWVFGGGTKLTVLS2179 CDH19 artificial AAQVQLQESGPGLVKPSETLSLTCTVSGGSISSYSWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISLDTSKNQFSLKLSSVT65253.003 xAADTAVYYCARNWAFHFDYWGQGTLVTVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGTGYDVHWYQQLI2CPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYESSLSGWVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH2180 CDR-H1 of artificial AA SYGMH CDH19 65254.001 2181 CDR-H2 ofartificial AA FIWYDGSNKYYADSVKD CDH19 65254.001 2182 CDR-H3 ofartificial AA RAGIIGTIGYYYGMDV CDH19 65254.001 2183 CDR-L1 of artificialAA SGDRLGEKYTS CDH19 65254.001 2184 CDR-L2 of artificial AA QDTKRPSCDH19 65254.001 2185 CDR-L3 of artificial AA QAWDSSTVV CDH19 65254.0012186 VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCCGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65254.001CTCCAGCTACGGCATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCTTCATTTGGTACGACGGCTCCAACAAGTACTACGCCGACTCCGTGAAGGACCGGTTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTACCTGCAGATGAAGTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCATCGGCACCATCGGCTACTACTACGGCATGGACGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGC 2187 VH of CDH19 artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSL65254.001 RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS 2188 VL of CDH19artificial NTTCTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGA65254.001GAAGTACACCAGTTGGTATCAGCAGCGGCCTGGCCAGTCCCCCCTGCTGGTCATCTACCAGGACACCAAGCGGCCCTCCGGCATCCCTGAGCGGTTCTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCTGGGACTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 2189VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY65254.001 CQAWDSSTVVFGGGTKLTVLS 2190 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCCGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGGCATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCTTCATTTGGTACGACGGCTCCAACA65254.001AGTACTACGCCGACTCCGTGAAGGACCGGTTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTACCTGCAGATGAAGTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCATCGGCACCATCGGCTACTACTACGGCATGGACGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGAGAAGTACACCAGTTGGTATCAGCAGCGGCCTGGCCAGTCCCCCCTGCTGGTCATCTACCAGGACACCAAGCGGCCCTCCGGCATCCCTGAGCGGTTCTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCTGGGACTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 2191 VH-VL ofartificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSLCDH19RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYT65254.001SWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLS2192 CDH19 artificial AAQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSL65254.001 xRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTI2CSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGETENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH2193 CDR-H1 of artificial AA SYGMH CDH19 65254.003 2194 CDR-H2 ofartificial AA FIWYDGSNKYYADSVKD CDH19 65254.003 2195 CDR-H3 ofartificial AA RAGIIGTIGYYYGMDV CDH19 65254.003 2196 CDR-L1 of artificialAA SGDRLGEKYTS CDH19 65254.003 2197 CDR-L2 of artificial AA QDTKRPSCDH19 65254.003 2198 CDR-L3 of artificial AA QAWDSSTVV CDH19 65254.0032199 VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65254.003CTCCAGCTACGGCATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCTTCATTTGGTACGACGGCTCCAACAAGTACTACGCCGACTCCGTGAAGGACCGGTTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTACCTGCAGATGAAGTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCATCGGCACCATCGGCTACTACTACGGCATGGACGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGC 2200 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSL65254.003 RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS 2201 VL of CDH19artificial NTTCTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGA65254.003GAAGTACACCAGTTGGTATCAGCAGCGGCCTGGCCAGTCCCCCCTGCTGGTCATCTACCAGGACACCAAGCGGCCCTCCGGCATCCCTGAGCGGTTCTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCTGGGACTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 2202VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY65254.003 CQAWDSSTVVFGGGTKLTVLS 2203 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGGCATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCTTCATTTGGTACGACGGCTCCAACA65254.003AGTACTACGCCGACTCCGTGAAGGACCGGTTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTACCTGCAGATGAAGTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCATCGGCACCATCGGCTACTACTACGGCATGGACGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGAGAAGTACACCAGTTGGTATCAGCAGCGGCCTGGCCAGTCCCCCCTGCTGGTCATCTACCAGGACACCAAGCGGCCCTCCGGCATCCCTGAGCGGTTCTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCTGGGACTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 2204 VH-VL ofartificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSLCDH19RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYT65254.003SWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLS2205 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMKSL65254.003 xRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTI2CSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH2206 CDR-H1 of artificial AA SYGMH CDH19 65254.007 2207 CDR-H2 ofartificial AA FIWYEGSNKYYAESVKD CDH19 65254.007 2208 CDR-H3 ofartificial AA RAGIIGTIGYYYGMDV CDH19 65254.007 2209 CDR-L1 of artificialAA SGDRLGEKYTS CDH19 65254.007 2210 CDR-L2 of artificial AA QDTKRPSCDH19 65254.007 2211 CDR-L3 of artificial AA QAWESSTVV CDH19 65254.0072212 VH of CDH19 artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTT65254.007CTCCAGCTACGGCATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCTTCATTTGGTACGAGGGCTCCAACAAGTACTACGCCGAGTCCGTGAAGGACCGGTTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTACCTGCAGATGAATTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCATCGGCACCATCGGCTACTACTACGGCATGGACGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGC 2213 VH of CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMNSL65254.007 RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSS 2214 VL of CDH19artificial NTTCTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGA65254.007GAAGTACACCAGTTGGTATCAGCAGCGGCCTGGCCAGTCCCCCCTGCTGGTCATCTACCAGGACACCAAGCGGCCCTCCGGCATCCCTGAGCGGTTCTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCTGGGAGTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 2215VL of CDH19 artificial AASYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYY65254.007 CQAWESSTVVFGGGTKLTVLS 2216 VH-VL of artificial NTCAGGTGCAGCTGGTGGAATCCGGCGGAGGCGTGGTGCAGCCTGGCGGGTCCCTGAGACTGTCTTGCGCCGCCTCCGGCTTCACCTTCDH19CTCCAGCTACGGCATGCACTGGGTCCGACAGGCCCCTGGCAAGGGCCTGGAATGGGTGGCCTTCATTTGGTACGAGGGCTCCAACA65254.007AGTACTACGCCGAGTCCGTGAAGGACCGGTTCACCATCTCCCGGGACAACTCCAAGAACACCCTGTACCTGCAGATGAATTCCCTGCGGGCCGAGGACACCGCCGTGTACTACTGTGCCAGAAGGGCCGGCATCATCGGCACCATCGGCTACTACTACGGCATGGACGTGTGGGGCCAGGGCACCACCGTGACCGTGTCTAGCGGAGGCGGAGGATCTGGTGGCGGTGGTTCTGGCGGCGGAGGCTCCTCTTACGAGCTGACCCAGCCCCCCTCCGTGTCCGTGTCTCCTGGCCAGACCGCCTCCATCACCTGTTCTGGCGACCGGCTGGGCGAGAAGTACACCAGTTGGTATCAGCAGCGGCCTGGCCAGTCCCCCCTGCTGGTCATCTACCAGGACACCAAGCGGCCCTCCGGCATCCCTGAGCGGTTCTCCGGCTCCAACTCCGGCAACACCGCCACCCTGACCATCTCCGGCACCCAGGCCATGGACGAGGCCGACTACTACTGCCAGGCCTGGGAGTCCTCCACCGTGGTGTTCGGCGGAGGCACCAAGCTGACCGTGCTGTCC 2217 VH-VL ofartificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMNSLCDH19RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYT65254.007SWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLS2218 CDH19 artificial AAQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAFIWYEGSNKYYAESVKDRFTISRDNSKNTLYLQMNSL65254.007 xRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTI2CSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGGGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLHHHHHH2219 CDH19 14302 artificial aaQRFVTGHFGGLYPANGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKCC x I2C-LFcBYDRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNEGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLGGGGSQRFCTGHFGGLHPCNGHHHHHH 2220 CDH19 14302 artificial aaQRFVTGHFGGLYPANGGGGGSQVQLVESGGGVVQPGGSLRLSCAASGFTFSSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKCC x I2C-DRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSLFcBY-156VSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNEGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLGGGGSQRFCTGHFGGLHPCNGGGGGSGGGSRDWDFDVFGGGTPVGGHHHHHH 2221CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLCC x I2C-Cys-RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTLoopSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLGCGGGGCHHHHHH2222 CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLCC x I2C-HALBRAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTSWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLPGGGGSDAHKSEVAHREKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGLDYHHHHHH2223 CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLCC x I2C-GS-RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTD3HSASWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLPGGGGSEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGLHHHHHH 2224 CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLCC x I2C-3GS-RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTD3HSASWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLPGGGGSGGGGSGGGGSEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGLHHHHHH 2225 CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLCC x I2C-GS-RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTD3HSA-156SWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLPGGGGSEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL GGGGSGGGS RDWDFDVFGGGTPVGG HHHHHH 2226CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLCC x I2C-3GS-RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTD3HSA-156SWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLPGGGGSGGGGSGGGGSEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL GGGGSGGGS RDWDFDVFGGGTPVGG HHHHHH 2227CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLCC x I2C-GS-RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTD3HSA-21SWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLPGGGGSEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL GGGGSGGGS RLIEDICLPRWGCLWEDD HHHHHH 2228CDH19 14302 artificial aaQVQLVESGGGVVQPGGSLRLSCAASGFTESSYGMHWVRQAPGKCLEWVAFIWYDGSNKYYADSVKDRFTISRDNSKNTLYLQMNSLCC x I2C-3GS-RAEDTAVYYCARRAGIIGTIGYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSSYELTQPPSVSVSPGQTASITCSGDRLGEKYTD3HSA-21SWYQQRPGQSPLLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWESSTVVFGCGTKLTVLSGGGGSEVQLVESGGGLVQPGGSLKLSCAASGFTENKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVLPGGGGSGGGGSGGGGSEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL GGGGSGGGS RLIEDICLPRWGCLWEDD HHHHHH

1. An isolated multispecific antibody construct or an oligomer thereofcomprising a first binding domain which binds to human CDH19 on thesurface of a target cell and a second binding domain which binds tohuman CD3 on the surface of a T cell, wherein the first binding domaincomprises a VH region comprising CDR-H1, CDR-H2 and CDR-H3 and a VLregion comprising CDR-L1, CDR-L2 and CDR-L3 selected from the groupconsisting of: (a) CDR-H1 as set forth in SEQ ID NO: 124, CDR-H2 as setforth in SEQ ID NO: 125, CDR-H3 as set forth in SEQ ID NO: 126, CDR-L1as set forth in SEQ ID NO: 292, CDR-L2 as set forth in SEQ ID NO: 293and CDR-L3 as set forth in SEQ ID NO: 294; (b) CDR-H1 as set forth inSEQ ID NO: 130, CDR-H2 as set forth in SEQ ID NO: 131, CDR-H3 as setforth in SEQ ID NO: 132, CDR-L1 as set forth in SEQ ID NO: 298, CDR-L2as set forth in SEQ ID NO: 299 and CDR-L3 as set forth in SEQ ID NO:300; (c) CDR-H1 as set forth in SEQ ID NO: 136, CDR-H2 as set forth inSEQ ID NO: 137, CDR-H3 as set forth in SEQ ID NO: 138, CDR-L1 as setforth in SEQ ID NO: 304, CDR-L2 as set forth in SEQ ID NO: 305 andCDR-L3 as set forth in SEQ ID NO: 306; (d) CDR-H1 as set forth in SEQ IDNO: 142, CDR-H2 as set forth in SEQ ID NO: 143, CDR-H3 as set forth inSEQ ID NO: 144, CDR-L1 as set forth in SEQ ID NO: 310, CDR-L2 as setforth in SEQ ID NO: 311 and CDR-L3 as set forth in SEQ ID NO: 312; (e)CDR-H1 as set forth in SEQ ID NO: 148, CDR-H2 as set forth in SEQ ID NO:149, CDR-H3 as set forth in SEQ ID NO: 150, CDR-L1 as set forth in SEQID NO: 316, CDR-L2 as set forth in SEQ ID NO: 317 and CDR-L3 as setforth in SEQ ID NO: 318; (f) CDR-H1 as set forth in SEQ ID NO: 166,CDR-H2 as set forth in SEQ ID NO: 167, CDR-H3 as set forth in SEQ ID NO:168, CDR-L1 as set forth in SEQ ID NO: 334, CDR-L2 as set forth in SEQID NO: 335 and CDR-L3 as set forth in SEQ ID NO: 336; (g) CDR-H1 as setforth in SEQ ID NO: 94, CDR-H2 as set forth in SEQ ID NO: 95, CDR-H3 asset forth in SEQ ID NO: 910, CDR-L1 as set forth in SEQ ID NO: 262,CDR-L2 as set forth in SEQ ID NO: 263 and CDR-L3 as set forth in SEQ IDNO: 264; (h) CDR-H1 as set forth in SEQ ID NO: 124, CDR-H2 as set forthin SEQ ID NO: 125, CDR-H3 as set forth in SEQ ID NO: 915, CDR-L1 as setforth in SEQ ID NO: 292, CDR-L2 as set forth in SEQ ID NO: 293 andCDR-L3 as set forth in SEQ ID NO: 294; (i) CDR-H1 as set forth in SEQ IDNO: 124, CDR-H2 as set forth in SEQ ID NO: 125, CDR-H3 as set forth inSEQ ID NO: 915, CDR-L1 as set forth in SEQ ID NO: 292, CDR-L2 as setforth in SEQ ID NO: 293 and CDR-L3 as set forth in SEQ ID NO: 929; (j)CDR-H1 as set forth in SEQ ID NO: 166, CDR-H2 as set forth in SEQ ID NO:167, CDR-H3 as set forth in SEQ ID NO: 168, CDR-L1 as set forth in SEQID NO: 334, CDR-L2 as set forth in SEQ ID NO: 335 and CDR-L3 as setforth in SEQ ID NO: 336; (k) CDR-H1 as set forth in SEQ ID NO: 166,CDR-H2 as set forth in SEQ ID NO: 167, CDR-H3 as set forth in SEQ ID NO:168, CDR-L1 as set forth in SEQ ID NO: 334, CDR-L2 as set forth in SEQID NO: 335 and CDR-L3 as set forth in SEQ ID NO: 942; (l) CDR-H1 as setforth in SEQ ID NO: 166, CDR-H2 as set forth in SEQ ID NO: 167, CDR-H3as set forth in SEQ ID NO: 168, CDR-L1 as set forth in SEQ ID NO: 334,CDR-L2 as set forth in SEQ ID NO: 335 and CDR-L3 as set forth in SEQ IDNO: 943; (m) CDR-H1 as set forth in SEQ ID NO: 148, CDR-H2 as set forthin SEQ ID NO: 149, CDR-H3 as set forth in SEQ ID NO: 150, CDR-L1 as setforth in SEQ ID NO: 316, CDR-L2 as set forth in SEQ ID NO: 317 andCDR-L3 as set forth in SEQ ID NO: 318; (n) CDR-H1 as set forth in SEQ IDNO: 148, CDR-H2 as set forth in SEQ ID NO: 149, CDR-H3 as set forth inSEQ ID NO: 150, CDR-L1 as set forth in SEQ ID NO: 316, CDR-L2 as setforth in SEQ ID NO: 317 and CDR-L3 as set forth in SEQ ID NO: 937; (o)CDR-H1 as set forth in SEQ ID NO: 142, CDR-H2 as set forth in SEQ ID NO:143, CDR-H3 as set forth in SEQ ID NO: 144, CDR-L1 as set forth in SEQID NO: 310, CDR-L2 as set forth in SEQ ID NO: 311 and CDR-L3 as setforth in SEQ ID NO: 935; (p) CDR-H1 as set forth in SEQ ID NO: 142,CDR-H2 as set forth in SEQ ID NO: 143, CDR-H3 as set forth in SEQ ID NO:918, CDR-L1 as set forth in SEQ ID NO: 310, CDR-L2 as set forth in SEQID NO: 311 and CDR-L3 as set forth in SEQ ID NO: 936; (q) CDR-H1 as setforth in SEQ ID NO: 136, CDR-H2 as set forth in SEQ ID NO: 137, CDR-H3as set forth in SEQ ID NO: 138, CDR-L1 as set forth in SEQ ID NO: 304,CDR-L2 as set forth in SEQ ID NO: 305 and CDR-L3 as set forth in SEQ IDNO: 933; (r) CDR-H1 as set forth in SEQ ID NO: 136, CDR-H2 as set forthin SEQ ID NO: 137, CDR-H3 as set forth in SEQ ID NO: 917, CDR-L1 as setforth in SEQ ID NO: 304, CDR-L2 as set forth in SEQ ID NO: 305 andCDR-L3 as set forth in SEQ ID NO: 934; (s) CDR-H1 as set forth in SEQ IDNO: 130, CDR-H2 as set forth in SEQ ID NO: 131, CDR-H3 as set forth inSEQ ID NO: 132, CDR-L1 as set forth in SEQ ID NO: 298, CDR-L2 as setforth in SEQ ID NO: 299 and CDR-L3 as set forth in SEQ ID NO: 930; (t)CDR-H1 as set forth in SEQ ID NO: 130, CDR-H2 as set forth in SEQ ID NO:131, CDR-H3 as set forth in SEQ ID NO: 916, CDR-L1 as set forth in SEQID NO: 298, CDR-L2 as set forth in SEQ ID NO: 299 and CDR-L3 as setforth in SEQ ID NO: 931; (u) CDR-H1 as set forth in SEQ ID NO: 130,CDR-H2 as set forth in SEQ ID NO: 131, CDR-H3 as set forth in SEQ ID NO:916, CDR-L1 as set forth in SEQ ID NO: 298, CDR-L2 as set forth in SEQID NO: 299 and CDR-L3 as set forth in SEQ ID NO: 932; (v) CDR-H1 as setforth in SEQ ID NO: 1009, CDR-H2 as set forth in SEQ ID NO: 1010, CDR-H3as set forth in SEQ ID NO: 1011, CDR-L1 as set forth in SEQ ID NO: 1012,CDR-L2 as set forth in SEQ ID NO: 1013 and CDR-L3 as set forth in SEQ IDNO: 1014; (w) CDR-H1 as set forth in SEQ ID NO: 1022, CDR-H2 as setforth in SEQ ID NO: 1023, CDR-H3 as set forth in SEQ ID NO: 1024, CDR-L1as set forth in SEQ ID NO: 1025, CDR-L2 as set forth in SEQ ID NO: 1026and CDR-L3 as set forth in SEQ ID NO: 1027; (x) CDR-H1 as set forth inSEQ ID NO: 1035, CDR-H2 as set forth in SEQ ID NO: 1036, CDR-H3 as setforth in SEQ ID NO: 1037, CDR-L1 as set forth in SEQ ID NO: 1038, CDR-L2as set forth in SEQ ID NO: 1039 and CDR-L3 as set forth in SEQ ID NO:1040; (y) CDR-H1 as set forth in SEQ ID NO: 1074, CDR-H2 as set forth inSEQ ID NO: 1075, CDR-H3 as set forth in SEQ ID NO: 1076, CDR-L1 as setforth in SEQ ID NO: 1077, CDR-L2 as set forth in SEQ ID NO: 1078 andCDR-L3 as set forth in SEQ ID NO: 1079; (z) CDR-H1 as set forth in SEQID NO: 1100, CDR-H2 as set forth in SEQ ID NO: 1101, CDR-H3 as set forthin SEQ ID NO: 1102, CDR-L1 as set forth in SEQ ID NO: 1103, CDR-L2 asset forth in SEQ ID NO: 1104 and CDR-L3 as set forth in SEQ ID NO: 1105;(aa) CDR-H1 as set forth in SEQ ID NO: 1100, CDR-H2 as set forth in SEQID NO: 1101, CDR-H3 as set forth in SEQ ID NO: 1102, CDR-L1 as set forthin SEQ ID NO: 1103, CDR-L2 as set forth in SEQ ID NO: 1104 and CDR-L3 asset forth in SEQ ID NO: 1105; (ab) CDR-H1 as set forth in SEQ ID NO:1113, CDR-H2 as set forth in SEQ ID NO: 1114, CDR-H3 as set forth in SEQID NO: 1115, CDR-L1 as set forth in SEQ ID NO: 1116, CDR-L2 as set forthin SEQ ID NO: 1117 and CDR-L3 as set forth in SEQ ID NO: 1118; (ac)CDR-H1 as set forth in SEQ ID NO: 1243, CDR-H2 as set forth in SEQ IDNO: 1244, CDR-H3 as set forth in SEQ ID NO: 1245, CDR-L1 as set forth inSEQ ID NO: 1246, CDR-L2 as set forth in SEQ ID NO: 1247 and CDR-L3 asset forth in SEQ ID NO: 1248; (ad) CDR-H1 as set forth in SEQ ID NO:1256, CDR-H2 as set forth in SEQ ID NO: 1257, CDR-H3 as set forth in SEQID NO: 1258, CDR-L1 as set forth in SEQ ID NO: 1259, CDR-L2 as set forthin SEQ ID NO: 1260 and CDR-L3 as set forth in SEQ ID NO: 1261; (ae)CDR-H1 as set forth in SEQ ID NO: 1269, CDR-H2 as set forth in SEQ IDNO: 1270, CDR-H3 as set forth in SEQ ID NO: 1271, CDR-L1 as set forth inSEQ ID NO: 1272, CDR-L2 as set forth in SEQ ID NO: 1273 and CDR-L3 asset forth in SEQ ID NO: 1274; (af) CDR-H1 as set forth in SEQ ID NO:1282, CDR-H2 as set forth in SEQ ID NO: 1283, CDR-H3 as set forth in SEQID NO: 1284, CDR-L1 as set forth in SEQ ID NO: 1285, CDR-L2 as set forthin SEQ ID NO: 1286 and CDR-L3 as set forth in SEQ ID NO: 1287; (ag)CDR-H1 as set forth in SEQ ID NO: 1295, CDR-H2 as set forth in SEQ IDNO: 1296, CDR-H3 as set forth in SEQ ID NO: 1297, CDR-L1 as set forth inSEQ ID NO: 1298, CDR-L2 as set forth in SEQ ID NO: 1299 and CDR-L3 asset forth in SEQ ID NO: 1300; (ah) CDR-H1 as set forth in SEQ ID NO:1647, CDR-H2 as set forth in SEQ ID NO: 1648, CDR-H3 as set forth in SEQID NO: 1649, CDR-L1 as set forth in SEQ ID NO: 1650, CDR-L2 as set forthin SEQ ID NO: 1651 and CDR-L3 as set forth in SEQ ID NO: 1652; (ai)CDR-H1 as set forth in SEQ ID NO: 1660, CDR-H2 as set forth in SEQ IDNO: 1661, CDR-H3 as set forth in SEQ ID NO: 1662, CDR-L1 as set forth inSEQ ID NO: 1663, CDR-L2 as set forth in SEQ ID NO: 1664 and CDR-L3 asset forth in SEQ ID NO: 1665; (aj) CDR-H1 as set forth in SEQ ID NO:1894, CDR-H2 as set forth in SEQ ID NO: 1895, CDR-H3 as set forth in SEQID NO: 1896, CDR-L1 as set forth in SEQ ID NO: 1897, CDR-L2 as set forthin SEQ ID NO: 1898 and CDR-L3 as set forth in SEQ ID NO: 1899; (ak)CDR-H1 as set forth in SEQ ID NO: 1907, CDR-H2 as set forth in SEQ IDNO: 1908, CDR-H3 as set forth in SEQ ID NO: 1909, CDR-L1 as set forth inSEQ ID NO: 1910, CDR-L2 as set forth in SEQ ID NO: 1911 and CDR-L3 asset forth in SEQ ID NO: 1912; (al) CDR-H1 as set forth in SEQ ID NO:1933, CDR-H2 as set forth in SEQ ID NO: 1934, CDR-H3 as set forth in SEQID NO: 1935, CDR-L1 as set forth in SEQ ID NO: 1936, CDR-L2 as set forthin SEQ ID NO: 1937 and CDR-L3 as set forth in SEQ ID NO: 1938; (am)CDR-H1 as set forth in SEQ ID NO: 1946, CDR-H2 as set forth in SEQ IDNO: 1947, CDR-H3 as set forth in SEQ ID NO: 1948, CDR-L1 as set forth inSEQ ID NO: 1949, CDR-L2 as set forth in SEQ ID NO: 1950 and CDR-L3 asset forth in SEQ ID NO: 1951; (an) CDR-H1 as set forth in SEQ ID NO:1959, CDR-H2 as set forth in SEQ ID NO: 1960, CDR-H3 as set forth in SEQID NO: 1961, CDR-L1 as set forth in SEQ ID NO: 1962, CDR-L2 as set forthin SEQ ID NO: 1963 and CDR-L3 as set forth in SEQ ID NO: 1964; (ao)CDR-H1 as set forth in SEQ ID NO: 1972, CDR-H2 as set forth in SEQ IDNO: 1973, CDR-H3 as set forth in SEQ ID NO: 1974, CDR-L1 as set forth inSEQ ID NO: 1975, CDR-L2 as set forth in SEQ ID NO: 1976 and CDR-L3 asset forth in SEQ ID NO: 1977; (ap) CDR-H1 as set forth in SEQ ID NO:1985, CDR-H2 as set forth in SEQ ID NO: 1986, CDR-H3 as set forth in SEQID NO: 1987, CDR-L1 as set forth in SEQ ID NO: 1988, CDR-L2 as set forthin SEQ ID NO: 1989 and CDR-L3 as set forth in SEQ ID NO: 1990; (aq)CDR-H1 as set forth in SEQ ID NO: 1998, CDR-H2 as set forth in SEQ IDNO: 1999, CDR-H3 as set forth in SEQ ID NO: 2000, CDR-L1 as set forth inSEQ ID NO: 2001, CDR-L2 as set forth in SEQ ID NO: 2002 and CDR-L3 asset forth in SEQ ID NO: 2003; (ar) CDR-H1 as set forth in SEQ ID NO:2011, CDR-H2 as set forth in SEQ ID NO: 2012, CDR-H3 as set forth in SEQID NO: 2013, CDR-L1 as set forth in SEQ ID NO: 2014, CDR-L2 as set forthin SEQ ID NO: 2015 and CDR-L3 as set forth in SEQ ID NO: 2016; (as)CDR-H1 as set forth in SEQ ID NO: 2024, CDR-H2 as set forth in SEQ IDNO: 2025, CDR-H3 as set forth in SEQ ID NO: 2026, CDR-L1 as set forth inSEQ ID NO: 2027, CDR-L2 as set forth in SEQ ID NO: 2028 and CDR-L3 asset forth in SEQ ID NO: 2029; (at) CDR-H1 as set forth in SEQ ID NO:2037, CDR-H2 as set forth in SEQ ID NO: 2038, CDR-H3 as set forth in SEQID NO: 2039, CDR-L1 as set forth in SEQ ID NO: 2040, CDR-L2 as set forthin SEQ ID NO: 2041 and CDR-L3 as set forth in SEQ ID NO: 2042; and (au)CDR-H1 as set forth in SEQ ID NO: 2050, CDR-H2 as set forth in SEQ IDNO: 2051, CDR-H3 as set forth in SEQ ID NO: 2052, CDR-L1 as set forth inSEQ ID NO: 2053, CDR-L2 as set forth in SEQ ID NO: 2054 and CDR-L3 asset forth in SEQ ID NO:
 2055. 2. (canceled)
 3. The antibody construct orthe oligomer thereof according to claim 1, wherein the first bindingdomain comprises a VH region comprising the amino acid sequence setforth in SEQ ID NO: 342, SEQ ID NO: 366, SEQ ID NO: 370, SEQ ID NO: 344,SEQ ID NO: 372, SEQ ID NO: 368, SEQ ID NO: 496, SEQ ID NO: 497, SEQ IDNO: 498, SEQ ID NO: 499, SEQ ID NO: 500, SEQ ID NO: 508, SEQ ID NO: 509,SEQ ID NO: 510, SEQ ID NO: 511, SEQ ID NO: 512, SEQ ID NO: 519, SEQ IDNO: 520, SEQ ID NO: 521, SEQ ID NO: 522, SEQ ID NO: 523, SEQ ID NO: 524,SEQ ID NO: 525, SEQ ID NO: 526, SEQ ID NO: 527, SEQ ID NO: 528, SEQ IDNO: 529, SEQ ID NO: 530, SEQ ID NO: 531, SEQ ID NO: 532, SEQ ID NO: 533,SEQ ID NO: 534, SEQ ID NO: 535, SEQ ID NO: 536, SEQ ID NO: 537, SEQ IDNO: 538, SEQ ID NO: 1016, SEQ ID NO: 1029, SEQ ID NO: 1042, SEQ ID NO:1081, SEQ ID NO: 1107, SEQ ID NO: 1120, SEQ ID NO: 1250, SEQ ID NO:1263, SEQ ID NO: 1276, SEQ ID NO: 1289, SEQ ID NO: 1302, SEQ ID NO:1654, SEQ ID NO: 1667, SEQ ID NO: 1901, SEQ ID NO: 1914, SEQ ID NO:1940, SEQ ID NO: 1953, SEQ ID NO: 1966, SEQ ID NO: 1979, SEQ ID NO:1992, SEQ ID NO: 2005, SEQ ID NO: 2018, SEQ ID NO: 2031, SEQ ID NO:2044, or SEQ ID NO:
 2057. 4. The antibody construct or the oligomerthereof according to claim 1, wherein the first binding domain comprisesa VL region comprising the amino acid sequence set forth in SEQ ID NO:398, SEQ ID NO: 422, SEQ ID NO: 426, SEQ ID NO: 400, SEQ ID NO: 428, SEQID NO: 424, SEQ ID NO: 591, SEQ ID NO: 592, SEQ ID NO: 593, SEQ ID NO:594, SEQ ID NO: 595, SEQ ID NO: 603, SEQ ID NO: 604, SEQ ID NO: 605, SEQID NO: 606, SEQ ID NO: 607, SEQ ID NO: 614, SEQ ID NO: 615, SEQ ID NO:616, SEQ ID NO: 617, SEQ ID NO: 618, SEQ ID NO: 619, SEQ ID NO: 620, SEQID NO: 621, SEQ ID NO: 622, SEQ ID NO: 623, SEQ ID NO: 624, SEQ ID NO:625, SEQ ID NO: 626, SEQ ID NO: 627, SEQ ID NO: 628, SEQ ID NO: 629, SEQID NO: 630, SEQ ID NO: 631, SEQ ID NO: 632, SEQ ID NO: 633, SEQ ID NO:1018, SEQ ID NO: 1031, SEQ ID NO: 1044, SEQ ID NO: 1083, SEQ ID NO:1109, SEQ ID NO: 1122, SEQ ID NO: 1252, SEQ ID NO: 1265, SEQ ID NO:1278, SEQ ID NO: 1291, SEQ ID NO: 1304, SEQ ID NO: 1656, SEQ ID NO:1669, SEQ ID NO: 1903, SEQ ID NO: 1916, SEQ ID NO: 1942, SEQ ID NO:1955, SEQ ID NO: 1968, SEQ ID NO: 1981, SEQ ID NO: 1994, SEQ ID NO:2007, SEQ ID NO: 2020, SEQ ID NO: 2033, SEQ ID NO: 2046, or SEQ ID NO:2059.
 5. The antibody construct or the oligomer thereof according toclaim 1, wherein the first binding domain comprises a VH region and a VLregion comprising SEQ ID NOs: 342+398, SEQ ID NOs: 366+422, SEQ ID NOs:370+426, SEQ ID NOs: 344+400, SEQ ID NOs: 372+428, SEQ ID NOs: 368+424,SEQ ID NOs: 496+591, SEQ ID NOs: 497+592, SEQ ID NOs: 498+593, SEQ IDNOs: 499+594, SEQ ID NOs: 500+595, SEQ ID NOs: 508+603, SEQ ID NOs:509+604, SEQ ID NOs: 510+605, SEQ ID NOs: 511+606, SEQ ID NOs: 512+607,SEQ ID NOs: 519+614, SEQ ID NOs: 520+615, SEQ ID NOs: 521+6106, SEQ IDNOs: 522+6117, SEQ ID NOs: 523+61122, SEQ ID NOs: 524+619, SEQ ID NOs:525+620, SEQ ID NOs: 526+621, SEQ ID NOs: 527+622, SEQ ID NOs: 528+623,SEQ ID NOs: 529+624, SEQ ID NOs: 530+625, SEQ ID NOs: 531+626, SEQ IDNOs: 532+627, SEQ ID NOs: 533+628, SEQ ID NOs: 534+629, SEQ ID NOs:535+630, SEQ ID NOs: 536+631, SEQ ID NOs: 537+632, SEQ ID NOs: 538+633,SEQ ID NOs: 1016+1018, SEQ ID NOs: 1029+1031, SEQ ID NOs: 1042+1044, SEQID NOs: 1081+1083, SEQ ID NOs: 1107+1109, SEQ ID NOs: 1120+1122, SEQ IDNOs: 1250+1252, SEQ ID NOs: 1263+1265, SEQ ID NOs: 1276+1278, SEQ IDNOs: 1289+1291, SEQ ID NOs: 1302+1304, SEQ ID NOs: 1654+1656, SEQ IDNOs: 1667+1669, SEQ ID NOs: 1901+1903, SEQ ID NOs: 1914+1916, SEQ IDNOs: 1940+1942, SEQ ID NOs: 1953+1955, SEQ ID NOs: 1966+1968, SEQ IDNOs: 1979+1981, SEQ ID NOs: 1992+1994, SEQ ID NOs: 2005+2007, SEQ IDNOs: 2018+2020, SEQ ID NOs: 2031+2033, SEQ ID NOs: 2044+2046, or SEQ IDNOs: 2057+2059.
 6. The antibody construct or the oligomer thereofaccording to claim 1, wherein the antibody construct or the oligomerthereof is in a format selected from the group consisting of a singlechain bispecific antibody (scFv)₂, scFv-single domain mAb, and adiabody.
 7. The antibody construct or the oligomer thereof according toclaim 6, wherein the first binding domain comprises an amino acidsequence selected from the group consisting of SEQ ID NO: 1020, SEQ IDNO: 1033, SEQ ID NO: 1046, SEQ ID NO:1085, SEQ ID NO:1111, SEQ IDNO:1124, SEQ ID NO: 1254, SEQ ID NO: 1267, SEQ ID NO: 1280, SEQ ID NO:1293, SEQ ID NO: 1306, SEQ ID NO: 1658, SEQ ID NO: 1671, SEQ ID NO:1905, SEQ ID NO: 1918, SEQ ID NO: 1944, SEQ ID NO: 1957, SEQ ID NO:1970, SEQ ID NO: 1983, SEQ ID NO: 1996, SEQ ID NO: 2009, SEQ ID NO:2022, SEQ ID NO: 2035, SEQ ID NO: 2048, and SEQ ID NO:
 2061. 8. Theantibody construct or the oligomer thereof according to claim 1, whereinthe second binding domain binds to human CD3 epsilon and to any ofCallithrix jacchus, Saguinus oediupus and/or Saimiri sciureus CD3epsilon.
 9. The antibody construct or the oligomer thereof according toclaim 8, comprising the amino acid sequence selected from the groupconsisting of SEQ ID NO: 1021, SEQ ID NO: 1034, SEQ ID NO: 1047, SEQ IDNO: 1086, SEQ ID NO: 1112, SEQ ID NO: 1125, SEQ ID NO: 1255, SEQ ID NO:1268, SEQ ID NO: 1281, SEQ ID NO: 1294, SEQ ID NO: 1307, SEQ ID NO:1659, SEQ ID NO: 1672, SEQ ID NO: 1906, SEQ ID NO: 1919, SEQ ID NO:1945, SEQ ID NO: 1958, SEQ ID NO: 1971, SEQ ID NO: 1984, SEQ ID NO:1997, SEQ ID NO: 2010, SEQ ID NO: 2023, SEQ ID NO: 2036, SEQ ID NO:2049, and SEQ ID NO:
 2062. 10. A nucleic acid encoding the antibodyconstruct or the oligomer thereof of claim
 1. 11. A vector comprisingthe nucleic acid of claim
 10. 12. A host cell transformed or transfectedwith the nucleic acid of claim
 10. 13. A process producing an antibodyconstruct or an oligomer thereof, said process comprising culturing thehost cell of claim 12 under conditions allowing the expression of theantibody construct or the oligomer thereof.
 14. A composition comprisingthe antibody construct or the oligomer thereof of claim 1 and a carrier,stabilizer and/or excipient.
 15. (canceled)
 16. A method for treating orameliorating a melanoma disease, comprising the step of administering toa subject in need thereof an effective amount of the antibody constructor the oligomer thereof of claim
 1. 17. The method according to claim16, wherein the melanoma disease is selected from the group consistingof superficial spreading melanoma, lentigo maligna, lentigo malignamelanoma, acral lentiginous melanoma and nodular melanoma.
 18. A kitcomprising the antibody construct or the oligomer thereof of claim 1 and(a) a container for housing the antibody construct or the oligomerthereof, (b) a syringe for delivering the antibody construct or theoligomer thereof, or (c) a combination of (a) and (b).
 19. The method ofclaim 16, wherein the melanoma disease is a metastatic melanoma disease.